{"id":"https://openalex.org/W3044515858","doi":"https://doi.org/10.1016/j.jid.2020.06.027","title":"Label-Free Quantification of Pharmacokinetics in Skin with Stimulated Raman Scattering Microscopy and Deep Learning","display_name":"Label-Free Quantification of Pharmacokinetics in Skin with Stimulated Raman Scattering Microscopy and Deep Learning","publication_year":2020,"publication_date":"2020-07-22","ids":{"openalex":"https://openalex.org/W3044515858","doi":"https://doi.org/10.1016/j.jid.2020.06.027","mag":"3044515858","pmid":"https://pubmed.ncbi.nlm.nih.gov/32710899"},"language":"en","primary_location":{"id":"doi:10.1016/j.jid.2020.06.027","doi":"https://doi.org/10.1016/j.jid.2020.06.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2020.06.027","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.jid.2020.06.027","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030682358","display_name":"Amin Feizpour","orcid":"https://orcid.org/0000-0002-5094-8559","observed_orcids":["https://orcid.org/0000-0002-5094-8559"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amin Feizpour","raw_affiliation_strings":["Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5094-8559","affiliations":[{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064876078","display_name":"Troels Torben Marstrand","orcid":"https://orcid.org/0000-0002-8290-223X","observed_orcids":["https://orcid.org/0000-0002-8290-223X"]},"institutions":[{"id":"https://openalex.org/I4210165112","display_name":"Leo Pharma (Denmark)","ror":"https://ror.org/05tzrdd39","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210124980","https://openalex.org/I4210165112"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Troels Marstrand","raw_affiliation_strings":["LEO Pharma, Ballerup, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8290-223X","affiliations":[{"raw_affiliation_string":"LEO Pharma, Ballerup, Denmark","institution_ids":["https://openalex.org/I4210165112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109124018","display_name":"Louise Bastholm Jensen","orcid":"https://orcid.org/0000-0001-7335-6233","observed_orcids":["https://orcid.org/0000-0001-7335-6233"]},"institutions":[{"id":"https://openalex.org/I4210165112","display_name":"Leo Pharma (Denmark)","ror":"https://ror.org/05tzrdd39","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210124980","https://openalex.org/I4210165112"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Louise Bastholm","raw_affiliation_strings":["LEO Pharma, Ballerup, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-7335-6233","affiliations":[{"raw_affiliation_string":"LEO Pharma, Ballerup, Denmark","institution_ids":["https://openalex.org/I4210165112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004723816","display_name":"Stefan Eirefelt","orcid":"https://orcid.org/0000-0002-4858-6552","observed_orcids":["https://orcid.org/0000-0002-4858-6552"]},"institutions":[{"id":"https://openalex.org/I4210165112","display_name":"Leo Pharma (Denmark)","ror":"https://ror.org/05tzrdd39","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210124980","https://openalex.org/I4210165112"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Stefan Eirefelt","raw_affiliation_strings":["LEO Pharma, Ballerup, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-4858-6552","affiliations":[{"raw_affiliation_string":"LEO Pharma, Ballerup, Denmark","institution_ids":["https://openalex.org/I4210165112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073936872","display_name":"Conor L. Evans","orcid":"https://orcid.org/0000-0003-2185-6505","observed_orcids":["https://orcid.org/0000-0003-2185-6505"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Conor L. Evans","raw_affiliation_strings":["Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: evans.conor@mgh.harvard.edu","Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2185-6505","affiliations":[{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: evans.conor@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073936872"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":3.5039,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.94354293,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"141","issue":"2","first_page":"395","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-pharmacokinetics","display_name":"skin pharmacokinetics","score":0.9570000171661377},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.824999988079071},{"id":"https://openalex.org/keywords/stimulated-raman-scattering-microscopy","display_name":"stimulated Raman scattering microscopy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/label-free-imaging","display_name":"label-free imaging","score":0.8539999723434448},{"id":"https://openalex.org/keywords/convolutional-neural-networks","display_name":"convolutional neural networks","score":0.9160000085830688},{"id":"https://openalex.org/keywords/drug-flux","display_name":"drug flux","score":0.6010000109672546},{"id":"https://openalex.org/keywords/partition-coefficient","display_name":"partition coefficient","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cell-junctions","display_name":"cell junctions","score":0.4580000042915344},{"id":"https://openalex.org/keywords/cell-type-identification","display_name":"cell type annotation","score":0.5090000033378601},{"id":"https://openalex.org/keywords/inflammatory-skin-diseases","display_name":"inflammatory skin diseases","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7389659285545349},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.671718955039978},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5095112919807434},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43004706501960754},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4174475073814392},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39600884914398193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2391686737537384},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21604272723197937}],"mesh":[{"descriptor_ui":"D000069416","descriptor_name":"Intravital Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073758","descriptor_name":"Nonlinear Optical Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062211","descriptor_name":"Spatio-Temporal Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jid.2020.06.027","doi":"https://doi.org/10.1016/j.jid.2020.06.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2020.06.027","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},{"id":"pmid:32710899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32710899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of investigative dermatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jid.2020.06.027","doi":"https://doi.org/10.1016/j.jid.2020.06.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2020.06.027","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324998","display_name":"LEO Pharma Research Foundation","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W29865278","https://openalex.org/W1557925576","https://openalex.org/W1561210178","https://openalex.org/W1869204496","https://openalex.org/W1901129140","https://openalex.org/W1976709832","https://openalex.org/W1978537309","https://openalex.org/W1981760171","https://openalex.org/W1990210867","https://openalex.org/W2007539416","https://openalex.org/W2039639008","https://openalex.org/W2047852588","https://openalex.org/W2050433651","https://openalex.org/W2055625108","https://openalex.org/W2080617238","https://openalex.org/W2096138335","https://openalex.org/W2115318086","https://openalex.org/W2132298953","https://openalex.org/W2147163301","https://openalex.org/W2148691803","https://openalex.org/W2160760798","https://openalex.org/W2258519056","https://openalex.org/W2407092926","https://openalex.org/W2558981100","https://openalex.org/W2593436234","https://openalex.org/W2610071914","https://openalex.org/W2733151091","https://openalex.org/W2783391114","https://openalex.org/W2810036723","https://openalex.org/W2889793736","https://openalex.org/W2892531758","https://openalex.org/W2897906088","https://openalex.org/W2900637971","https://openalex.org/W2903170002","https://openalex.org/W2946176479","https://openalex.org/W2966705460","https://openalex.org/W4240821889"],"related_works":["https://openalex.org/W2969747628","https://openalex.org/W2980457825","https://openalex.org/W3135129761","https://openalex.org/W3095009124","https://openalex.org/W7133589251","https://openalex.org/W4387679346","https://openalex.org/W4214940504","https://openalex.org/W3215262887","https://openalex.org/W4324295738","https://openalex.org/W2055625108"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-29T00:00:00"}