{"id":"https://openalex.org/W3044409355","doi":"https://doi.org/10.2174/1386207323666200720093245","title":"Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients","display_name":"Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients","publication_year":2020,"publication_date":"2020-07-21","ids":{"openalex":"https://openalex.org/W3044409355","doi":"https://doi.org/10.2174/1386207323666200720093245","mag":"3044409355","pmid":"https://pubmed.ncbi.nlm.nih.gov/32691706"},"language":"en","primary_location":{"id":"doi:10.2174/1386207323666200720093245","doi":"https://doi.org/10.2174/1386207323666200720093245","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1386207323666200720093245","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry & High Throughput Screening","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002275747","display_name":"Ahmet G\u00fczel\u00e7i\u00e7ek","orcid":"https://orcid.org/0000-0002-9733-3957","observed_orcids":["https://orcid.org/0000-0002-9733-3957"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ahmet Guzelcicek","raw_affiliation_strings":["Department of Pediatrics, Faculty of Medicine, Harran University, Sanliurfa,Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9733-3957","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Faculty of Medicine, Harran University, Sanliurfa,Turkey","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048026376","display_name":"Ataman G\u00f6nel","orcid":"https://orcid.org/0000-0001-7200-1537","observed_orcids":["https://orcid.org/0000-0001-7200-1537"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ataman G\u00f6nel","raw_affiliation_strings":["Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa,Turkey"],"raw_orcid":"https://orcid.org/0000-0001-7200-1537","affiliations":[{"raw_affiliation_string":"Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa,Turkey","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085388960","display_name":"\u0130smail Koyuncu","orcid":"https://orcid.org/0000-0002-9469-4757","observed_orcids":["https://orcid.org/0000-0002-9469-4757"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ismail Koyuncu","raw_affiliation_strings":["Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa,Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9469-4757","affiliations":[{"raw_affiliation_string":"Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa,Turkey","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078221320","display_name":"Gulyara \u00c7i\u011fdem","orcid":"https://orcid.org/0000-0002-4888-1172","observed_orcids":["https://orcid.org/0000-0002-4888-1172"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gulyara Cigdem","raw_affiliation_strings":["Department of Neurosurgery, Faculty of Medicine, Harran University, Sanliurfa,Turkey"],"raw_orcid":"https://orcid.org/0000-0002-4888-1172","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Faculty of Medicine, Harran University, Sanliurfa,Turkey","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018563386","display_name":"Do\u011fan K\u00f6se","orcid":"https://orcid.org/0000-0002-2903-2976","observed_orcids":["https://orcid.org/0000-0002-2903-2976"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dogan Kose","raw_affiliation_strings":["Department of Pediatrics, Faculty of Medicine, Harran University, Sanliurfa,Turkey"],"raw_orcid":"https://orcid.org/0000-0002-2903-2976","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Faculty of Medicine, Harran University, Sanliurfa,Turkey","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075614174","display_name":"Mehmet Karada\u011f","orcid":"https://orcid.org/0000-0001-9539-4193","observed_orcids":["https://orcid.org/0000-0001-9539-4193"]},"institutions":[{"id":"https://openalex.org/I46000314","display_name":"Mustafa Kemal University","ror":"https://ror.org/056hcgc41","country_code":"TR","type":"education","lineage":["https://openalex.org/I46000314"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Karadag","raw_affiliation_strings":["Department of Biostatistics, Mustafa Kemal University, Faculty of Medicine, Hatay,Turkey"],"raw_orcid":"https://orcid.org/0000-0001-9539-4193","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Mustafa Kemal University, Faculty of Medicine, Hatay,Turkey","institution_ids":["https://openalex.org/I46000314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039860768","display_name":"Dursun \u00c7ADIRCI","orcid":"https://orcid.org/0000-0003-0969-382X","observed_orcids":["https://orcid.org/0000-0003-0969-382X"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dursun Cadirci","raw_affiliation_strings":["Department of Family Medicine, Faculty of Medicine, Harran University, Sanliurfa,Turkey"],"raw_orcid":"https://orcid.org/0000-0003-0969-382X","affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Faculty of Medicine, Harran University, Sanliurfa,Turkey","institution_ids":["https://openalex.org/I80538482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002275747"],"corresponding_institution_ids":["https://openalex.org/I80538482"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08297162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"24","issue":"3","first_page":"409","last_page":"414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrocephalus","display_name":"hydrocephalus","score":1.0},{"id":"https://openalex.org/keywords/s100b","display_name":"S100B","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cytokeratin-18","display_name":"cytokeratin 18","score":0.7990000247955322},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/brain-specific-proteins","display_name":"brain-specific proteins","score":0.8090000152587891},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7870000004768372},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.4860000014305115},{"id":"https://openalex.org/keywords/pediatric-hydrocephalus","display_name":"pediatric hydrocephalus","score":0.7960000038146973},{"id":"https://openalex.org/keywords/blood-protein-levels","display_name":"blood protein levels","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2778134817","wikidata":"https://www.wikidata.org/wiki/Q193003","display_name":"Hydrocephalus","level":2,"score":0.911617636680603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5877989530563354},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5197510123252869},{"id":"https://openalex.org/C2909856348","wikidata":"https://www.wikidata.org/wiki/Q193003","display_name":"Congenital hydrocephalus","level":3,"score":0.4477859437465668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40151524543762207},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36269229650497437},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22001594305038452}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006849","descriptor_name":"Hydrocephalus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053538","descriptor_name":"Keratin-18","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D064568","descriptor_name":"S100 Calcium Binding Protein beta Subunit","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1386207323666200720093245","doi":"https://doi.org/10.2174/1386207323666200720093245","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1386207323666200720093245","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry & High Throughput Screening","raw_type":"journal-article"},{"id":"pmid:32691706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32691706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial chemistry & high throughput screening","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5099999904632568}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W15575661","https://openalex.org/W1968621846","https://openalex.org/W1971124807","https://openalex.org/W1972617504","https://openalex.org/W1974421752","https://openalex.org/W1975156153","https://openalex.org/W1975579930","https://openalex.org/W1976375605","https://openalex.org/W1981209372","https://openalex.org/W1981991262","https://openalex.org/W2004696798","https://openalex.org/W2011275709","https://openalex.org/W2021576901","https://openalex.org/W2025222670","https://openalex.org/W2039994762","https://openalex.org/W2048394665","https://openalex.org/W2056298279","https://openalex.org/W2057379069","https://openalex.org/W2070035561","https://openalex.org/W2071695496","https://openalex.org/W2076855848","https://openalex.org/W2084533933","https://openalex.org/W2085497155","https://openalex.org/W2088589538","https://openalex.org/W2122358025","https://openalex.org/W2139343352","https://openalex.org/W2150652709","https://openalex.org/W2156162077","https://openalex.org/W2158393943","https://openalex.org/W2166460680","https://openalex.org/W2167594207","https://openalex.org/W2229582722","https://openalex.org/W2290380888","https://openalex.org/W2804164712","https://openalex.org/W2901334593","https://openalex.org/W2944282596","https://openalex.org/W2979613315","https://openalex.org/W2988385432","https://openalex.org/W3032708866"],"related_works":["https://openalex.org/W2084533933","https://openalex.org/W2588460859","https://openalex.org/W7135508279","https://openalex.org/W2186453120","https://openalex.org/W4361268180","https://openalex.org/W4407813812","https://openalex.org/W2116827945","https://openalex.org/W7162760410","https://openalex.org/W2076235538","https://openalex.org/W1974247973"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hydrocephalus,":[1],"a":[2,70],"common":[3],"brain":[4,11],"disorder":[5,18],"in":[6,39,50,134,140,149,170,200,217],"children,":[7],"can":[8,211],"cause":[9],"permanent":[10],"damage.":[12],"A":[13,77],"timely":[14],"diagnosis":[15,219],"of":[16,24,32,47,54,89,106,130,151,167,184,195,220],"this":[17,25],"is":[19],"crucial.":[20],"OBJECTIVE:":[21],"The":[22,58,104,138],"aim":[23],"study":[26,59],"was":[27,60,83,113,124,158],"to":[28,85,95,109,126,204],"evaluate":[29],"the":[30,45,51,63,87,90,98,101,107,110,116,121,128,131,141,168,171,185,193,205,218],"levels":[31,46,194],"S-100,":[33],"CK-18,":[34,92,162,179],"and":[35,69,93,100,120,143,154,163,180],"NSE":[36],"brainspecific":[37],"proteins":[38,49,197],"patients":[40,68,202],"with":[41,115],"hydrocephalus.":[42,221],"We":[43],"examined":[44],"these":[48,196],"blood":[52],"samples":[53],"hydrocephalic":[55],"patients.":[56],"METHODS:":[57],"conducted":[61],"on":[62],"hydrocephalus":[64,99,142,172,201],"(n":[65,74],"=":[66,75],"31)":[67],"healthy":[71,206],"control":[72,102,144,186],"group":[73,173],"30).":[76],"Receiver":[78],"Operating":[79],"Characteristic":[80],"(ROC)":[81],"curve":[82],"used":[84,125],"assess":[86],"validity":[88],"NSE,":[91,161,178],"S100B":[94,164,181],"differentiate":[96],"between":[97],"groups.":[103,137],"suitability":[105],"data":[108],"normal":[111,132],"distribution":[112,133],"tested":[114],"Shapiro":[117],"Wilk":[118],"test,":[119],"Student":[122],"t-test":[123],"compare":[127],"characteristics":[129],"two":[135],"independent":[136],"individuals":[139,169],"groups":[145],"had":[146],"similar":[147],"values":[148,166,183],"terms":[150],"age,":[152],"height,":[153],"weight.":[155],"RESULTS:":[156],"It":[157],"observed":[159],"that":[160,192],"mean":[165,182],"were":[174],"significantly":[175,199],"higher":[176],"than":[177],"group.":[187,207],"CONCLUSION:":[188],"Experiments":[189],"have":[190],"shown":[191],"increase":[198],"compared":[203],"These":[208],"three":[209],"parameters":[210],"be":[212],"considered":[213],"as":[214],"important":[215],"markers":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-07-29T00:00:00"}