{"id":"https://openalex.org/W3044401720","doi":"https://doi.org/10.1038/s41598-020-68777-7","title":"Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib","display_name":"Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib","publication_year":2020,"publication_date":"2020-07-21","ids":{"openalex":"https://openalex.org/W3044401720","doi":"https://doi.org/10.1038/s41598-020-68777-7","mag":"3044401720","pmid":"https://pubmed.ncbi.nlm.nih.gov/32694701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7374542"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-68777-7","doi":"https://doi.org/10.1038/s41598-020-68777-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-68777-7","pdf_url":"https://www.nature.com/articles/s41598-020-68777-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-68777-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101961938","display_name":"Amy M. Buckley","orcid":"https://orcid.org/0000-0002-5080-8580","observed_orcids":["https://orcid.org/0000-0002-5080-8580"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Amy M. Buckley","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061083564","display_name":"Margaret R. Dunne","orcid":"https://orcid.org/0000-0002-2816-5064","observed_orcids":["https://orcid.org/0000-0002-2816-5064"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Margaret R. Dunne","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-2816-5064","affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032626903","display_name":"Maria E. Morrissey","orcid":"https://orcid.org/0000-0002-6683-760X","observed_orcids":["https://orcid.org/0000-0002-6683-760X"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Maria E. Morrissey","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102988098","display_name":"Susan A. Kennedy","orcid":"https://orcid.org/0009-0003-3592-4967","observed_orcids":["https://orcid.org/0009-0003-3592-4967"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Susan A. Kennedy","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058135274","display_name":"Aoife A. Nolan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Aoife Nolan","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024262881","display_name":"Maria Davern","orcid":"https://orcid.org/0000-0003-2278-5497","observed_orcids":["https://orcid.org/0000-0003-2278-5497"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Maria Davern","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110725093","display_name":"Emma K. Foley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Emma K. Foley","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110601577","display_name":"Niamh E. Clarke","orcid":"https://orcid.org/0009-0007-5022-2890","observed_orcids":["https://orcid.org/0009-0007-5022-2890"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Niamh Clarke","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016890096","display_name":"Joanne Lysaght","orcid":"https://orcid.org/0000-0003-3363-3763","observed_orcids":["https://orcid.org/0000-0003-3363-3763"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Joanne Lysaght","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-3363-3763","affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000574895","display_name":"Narayanasamy Ravi","orcid":"https://orcid.org/0000-0001-9794-622X","observed_orcids":["https://orcid.org/0000-0001-9794-622X"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Narayanasamy Ravi","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040645190","display_name":"Dermot O\u2019Toole","orcid":"https://orcid.org/0000-0001-6404-991X","observed_orcids":["https://orcid.org/0000-0001-6404-991X","https://orcid.org/0000-0001-8745-8484"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Dermot O\u2019Toole","raw_affiliation_strings":["Department of Clinical Medicine, Trinity Translational Medicine Institute, St. James\u2019s Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Trinity Translational Medicine Institute, St. James\u2019s Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108621775","display_name":"F MacCarthy","orcid":"https://orcid.org/0000-0002-6759-0960","observed_orcids":["https://orcid.org/0000-0002-6759-0960"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Finbar MacCarthy","raw_affiliation_strings":["Department of Clinical Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033082307","display_name":"John Vincent Reynolds","orcid":"https://orcid.org/0000-0002-5501-9521","observed_orcids":["https://orcid.org/0000-0002-5501-9521"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"John V. Reynolds","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021655948","display_name":"Breand\u00e1n N. Kennedy","orcid":"https://orcid.org/0000-0001-7991-4689","observed_orcids":["https://orcid.org/0000-0001-7991-4689"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Breand\u00e1n N. Kennedy","raw_affiliation_strings":["UCD Conway Institute and UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-7991-4689","affiliations":[{"raw_affiliation_string":"UCD Conway Institute and UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023152070","display_name":"Jacintha N O'Sullivan","orcid":"https://orcid.org/0000-0001-8622-9858","observed_orcids":["https://orcid.org/0000-0001-8622-9858"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Jacintha O\u2019Sullivan","raw_affiliation_strings":["Department of Surgery, Trinity Translational Medicine Institute, St. James\u2019s Hospital, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trinity Translational Medicine Institute, St. James\u2019s Hospital, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023152070"],"corresponding_institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.4712,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.48823681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"12105","last_page":"12105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.800000011920929},{"id":"https://openalex.org/keywords/oxygen-consumption-rate","display_name":"oxygen consumption rate","score":0.871999979019165},{"id":"https://openalex.org/keywords/extracellular-acidification-rate","display_name":"extracellular acidification rate","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7570000290870667},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.8100000023841858},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.7789999842643738},{"id":"https://openalex.org/keywords/thymic-stromal-lymphopoietin","display_name":"thymic stromal lymphopoietin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8399999737739563},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.8059999942779541},{"id":"https://openalex.org/keywords/il-17b","display_name":"IL-17B","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.878000020980835},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8259999752044678},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7383502721786499},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.6008639335632324},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4877096116542816},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.43336454033851624},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41171547770500183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34587299823760986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3393917381763458},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26915931701660156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1809312403202057},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17619100213050842},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17326688766479492},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41598-020-68777-7","doi":"https://doi.org/10.1038/s41598-020-68777-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-68777-7","pdf_url":"https://www.nature.com/articles/s41598-020-68777-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:32694701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32694701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7374542","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7374542/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:rune.une.edu.au:1959.11/61215","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1959.11/61215","pdf_url":"https://rune.une.edu.au/web/retrieve/b5a823ea-7f77-4d08-b761-aab6a42cdabf","source":{"id":"https://openalex.org/S7407055448","display_name":"RUNE (Research UNE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:http://www.rian.ie/194577/","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2262/95610","pdf_url":"http://hdl.handle.net/2262/95610","source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Buckley, A.M., Dunne, M.R., Morrissey, M.E., Kennedy, S.A., Nolan, A., Davern, M., Foley, E.K., Clarke, N., Lysaght, J., Ravi, N., O'Toole, D., MacCarthy, F., Reynolds, J.V., Kennedy, B.N., O'Sullivan, J., Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib, Scientific reports, 2020 Jul 21;10(1):12105","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:e0a0a6fa4475406c8c5b27eb5adbbaa8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e0a0a6fa4475406c8c5b27eb5adbbaa8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)","raw_type":"article"},{"id":"pmh:oai:tara.tcd.ie:2262/95610","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2262/95610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:www.lenus.ie:10147/630555","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10147/630555","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific reports","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-68777-7","doi":"https://doi.org/10.1038/s41598-020-68777-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-68777-7","pdf_url":"https://www.nature.com/articles/s41598-020-68777-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1967856243","display_name":null,"funder_award_id":"HRB ILP-POR-2017-055","funder_id":"https://openalex.org/F4320312041","funder_display_name":"Health Research Board"},{"id":"https://openalex.org/G4775768442","display_name":null,"funder_award_id":"CRF13MOR","funder_id":"https://openalex.org/F4320320839","funder_display_name":"Irish Cancer Society"},{"id":"https://openalex.org/G5954370663","display_name":null,"funder_award_id":"CRS15BUC","funder_id":"https://openalex.org/F4320320839","funder_display_name":"Irish Cancer Society"}],"funders":[{"id":"https://openalex.org/F4320312041","display_name":"Health Research Board","ror":"https://ror.org/003hb2249"},{"id":"https://openalex.org/F4320320839","display_name":"Irish Cancer Society","ror":"https://ror.org/03844ds60"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3044401720.pdf","grobid_xml":"https://content.openalex.org/works/W3044401720.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W199994346","https://openalex.org/W1107917109","https://openalex.org/W1559357581","https://openalex.org/W1911187237","https://openalex.org/W1983060527","https://openalex.org/W1983925309","https://openalex.org/W1995697484","https://openalex.org/W1996251823","https://openalex.org/W2023300506","https://openalex.org/W2024203129","https://openalex.org/W2030637794","https://openalex.org/W2038159244","https://openalex.org/W2041486092","https://openalex.org/W2047703873","https://openalex.org/W2053725511","https://openalex.org/W2055829364","https://openalex.org/W2069982506","https://openalex.org/W2072451938","https://openalex.org/W2073243487","https://openalex.org/W2087844366","https://openalex.org/W2095987251","https://openalex.org/W2111985610","https://openalex.org/W2122625574","https://openalex.org/W2133309292","https://openalex.org/W2133993814","https://openalex.org/W2135668977","https://openalex.org/W2164948224","https://openalex.org/W2192044866","https://openalex.org/W2234115940","https://openalex.org/W2271940440","https://openalex.org/W2304994032","https://openalex.org/W2514862430","https://openalex.org/W2531172483","https://openalex.org/W2549976854","https://openalex.org/W2562133517","https://openalex.org/W2592038517","https://openalex.org/W2655262992","https://openalex.org/W2765258947","https://openalex.org/W2774325261","https://openalex.org/W2774949562","https://openalex.org/W2791235391","https://openalex.org/W2795356318","https://openalex.org/W2801551831","https://openalex.org/W2889445272","https://openalex.org/W2889928022","https://openalex.org/W2890994610","https://openalex.org/W2909413347","https://openalex.org/W2910259404","https://openalex.org/W2946811918","https://openalex.org/W3010081575"],"related_works":["https://openalex.org/W2969939568","https://openalex.org/W2889646199","https://openalex.org/W4299603953","https://openalex.org/W2803472528","https://openalex.org/W1980750337","https://openalex.org/W3139270801","https://openalex.org/W1983925309","https://openalex.org/W7166338924","https://openalex.org/W7124469809","https://openalex.org/W3203236506"],"abstract_inverted_index":{"Oesophageal":[0],"cancer":[1,9],"is":[2,44,172],"the":[3,31,183,223,244,254],"6th":[4],"most":[5],"common":[6],"cause":[7],"of":[8,16,90,101,225,247,260],"related":[10],"death":[11],"worldwide.":[12],"The":[13,164],"current":[14],"standard":[15],"care":[17],"for":[18,242],"oesophageal":[19],"adenocarcinoma":[20],"(OAC)":[21],"focuses":[22],"on":[23],"neoadjuvant":[24],"therapy":[25],"with":[26,178],"chemoradiation":[27],"or":[28,230,234],"chemotherapy,":[29],"however":[30],"5-year":[32],"survival":[33],"rates":[34],"remain":[35],"at":[36],"<":[37],"20%.":[38],"To":[39],"improve":[40],"treatment":[41],"outcomes":[42],"it":[43],"critical":[45],"to":[46,58,94,141],"further":[47],"investigate":[48],"OAC":[49,77,124,131,161,169,264],"tumour":[50,78,184,248],"biology,":[51],"metabolic":[52,56,74,137,245],"phenotype":[53],"and":[54,158,193,206,212,252,257],"their":[55,136,142],"adaptation":[57],"different":[59],"oxygen":[60,84],"tensions.":[61],"In":[62],"this":[63],"study,":[64],"by":[65],"using":[66,72],"human":[67],"ex-vivo":[68,262],"explants":[69],"we":[70,107],"demonstrated":[71],"real-time":[73,140,251],"profiling":[75,243],"that":[76],"biopsies":[79,126,132,171,249],"have":[80],"a":[81,88,99,109,149,239],"significantly":[82,120,134,199,272],"higher":[83],"consumption":[85],"rate":[86,97,138,246],"(OCR),":[87],"measure":[89,100],"oxidative":[91],"phosphorylation":[92],"compared":[93],"extracellular":[95],"acidification":[96],"(ECAR),":[98],"glycolysis":[102],"(p":[103,127,155,203,209,214],"=":[104,128,156,204,210,215],"0.0004).":[105],"Previously,":[106],"identified":[108],"small":[110],"molecule":[111],"compound,":[112],"pyrazinib":[113,147,218,261,271],"which":[114],"enhanced":[115,273],"radiosensitivity":[116,274],"in":[117,123,139,152,160,182,250,263,275],"OAC.":[118,276],"Pyrazinib":[119,198],"inhibited":[121,200],"OCR":[122,154,174],"treatment-na\u00efve":[125,162,170],"0.0139).":[129],"Furthermore,":[130],"can":[133],"adapt":[135],"environment.":[143],"Under":[144],"hypoxic":[145],"conditions":[146],"produced":[148],"significant":[150],"reduction":[151],"both":[153],"0.0313)":[157],"ECAR":[159],"biopsies.":[163],"inflammatory":[165],"secretome":[166],"profile":[167],"from":[168],"heterogeneous.":[173],"was":[175],"positively":[176],"correlated":[177],"three":[179],"secreted":[180],"factors":[181],"conditioned":[185],"media:":[186],"vascular":[187],"endothelial":[188],"factor":[189],"A":[190],"(VEGF-A),":[191],"IL-1RA":[192],"thymic":[194],"stromal":[195],"lymphopoietin":[196],"(TSLP).":[197],"IL-1\u03b2":[201],"secretion":[202],"0.0377)":[205],"increased":[207],"IL-3":[208],"0.0020)":[211],"IL-17B":[213],"0.0181).":[216],"Importantly,":[217],"did":[219],"not":[220],"directly":[221],"alter":[222],"expression":[224],"dendritic":[226],"cell":[227],"maturation":[228],"markers":[229],"reduce":[231],"T-cell":[232],"viability":[233],"activation":[235],"markers.":[236],"We":[237],"present":[238],"new":[240],"method":[241],"demonstrate":[253],"novel":[255],"anti-metabolic":[256],"anti-inflammatory":[258],"action":[259],"tumours,":[265],"supporting":[266],"previous":[267],"findings":[268],"in-vitro":[269],"whereby":[270]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-07-29T00:00:00"}
