{"id":"https://openalex.org/W3044339796","doi":"https://doi.org/10.1126/science.aav3751","title":"Simultaneous cross-evaluation of heterogeneous E. coli datasets via mechanistic simulation","display_name":"Simultaneous cross-evaluation of heterogeneous E. coli datasets via mechanistic simulation","publication_year":2020,"publication_date":"2020-07-24","ids":{"openalex":"https://openalex.org/W3044339796","doi":"https://doi.org/10.1126/science.aav3751","mag":"3044339796","pmid":"https://pubmed.ncbi.nlm.nih.gov/32703847","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7990026"},"language":"en","primary_location":{"id":"doi:10.1126/science.aav3751","doi":"https://doi.org/10.1126/science.aav3751","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.aav3751","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7990026/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086624424","display_name":"Derek N. Macklin","orcid":"https://orcid.org/0000-0002-7257-0315","observed_orcids":["https://orcid.org/0000-0002-7257-0315"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek N. Macklin","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-7257-0315","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023723252","display_name":"Travis A. Ahn-Horst","orcid":"https://orcid.org/0000-0002-3049-3366","observed_orcids":["https://orcid.org/0000-0002-3049-3366"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis A. Ahn-Horst","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-3049-3366","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143631","display_name":"Heejo Choi","orcid":"https://orcid.org/0000-0002-2848-0267","observed_orcids":["https://orcid.org/0000-0002-2848-0267"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heejo Choi","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-2848-0267","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013996275","display_name":"Nicholas A. Ruggero","orcid":"https://orcid.org/0000-0002-5034-9716","observed_orcids":["https://orcid.org/0000-0002-5034-9716"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas A. Ruggero","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-5034-9716","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105987099","display_name":"Javier Carrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Carrera","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John C. Mason","orcid":"https://orcid.org/0000-0002-4289-7464","observed_orcids":["https://orcid.org/0000-0002-4289-7464"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Mason","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-4289-7464","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051506451","display_name":"Gwanggyu Sun","orcid":"https://orcid.org/0000-0002-2649-7807","observed_orcids":["https://orcid.org/0000-0002-2649-7807"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gwanggyu Sun","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-2649-7807","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036760070","display_name":"Eran Agmon","orcid":"https://orcid.org/0000-0003-1279-2474","observed_orcids":["https://orcid.org/0000-0003-1279-2474"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eran Agmon","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0003-1279-2474","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075349234","display_name":"Mialy M. DeFelice","orcid":"https://orcid.org/0000-0002-7197-6292","observed_orcids":["https://orcid.org/0000-0002-7197-6292"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mialy M. DeFelice","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-7197-6292","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089421006","display_name":"Inbal Maayan","orcid":"https://orcid.org/0000-0003-4907-0723","observed_orcids":["https://orcid.org/0000-0003-4907-0723"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inbal Maayan","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0003-4907-0723","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042851368","display_name":"Keara M. Lane","orcid":"https://orcid.org/0000-0002-8737-0455","observed_orcids":["https://orcid.org/0000-0002-8737-0455"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keara Lane","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053713841","display_name":"Ryan K. Spangler","orcid":"https://orcid.org/0000-0002-6080-3142","observed_orcids":["https://orcid.org/0000-0002-6080-3142"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan K. Spangler","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065867697","display_name":"Taryn E. Gillies","orcid":"https://orcid.org/0000-0001-6223-9357","observed_orcids":["https://orcid.org/0000-0001-6223-9357"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taryn E. Gillies","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0001-6223-9357","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059624212","display_name":"Morgan L Paull","orcid":"https://orcid.org/0000-0001-6852-1636","observed_orcids":["https://orcid.org/0000-0001-6852-1636"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan L. Paull","raw_affiliation_strings":["Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0001-6852-1636","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001954627","display_name":"Sajia Akhter","orcid":"https://orcid.org/0000-0003-0793-0625","observed_orcids":["https://orcid.org/0000-0003-0793-0625"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sajia Akhter","raw_affiliation_strings":["Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0003-0793-0625","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053800499","display_name":"Samuel R. Bray","orcid":"https://orcid.org/0000-0002-9696-6920","observed_orcids":["https://orcid.org/0000-0002-9696-6920"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel R. Bray","raw_affiliation_strings":["Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-9696-6920","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091668355","display_name":"Daniel S. Weaver","orcid":"https://orcid.org/0000-0002-2906-3019","observed_orcids":["https://orcid.org/0000-0002-2906-3019"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Weaver","raw_affiliation_strings":["SRI International, Menlo Park, CA 94025, USA"],"raw_orcid":"https://orcid.org/0000-0002-2906-3019","affiliations":[{"raw_affiliation_string":"SRI International, Menlo Park, CA 94025, USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011903148","display_name":"Ingrid M. Keseler","orcid":"https://orcid.org/0000-0003-1738-6117","observed_orcids":["https://orcid.org/0000-0003-1738-6117"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingrid M. Keseler","raw_affiliation_strings":["SRI International, Menlo Park, CA 94025, USA"],"raw_orcid":"https://orcid.org/0000-0003-1738-6117","affiliations":[{"raw_affiliation_string":"SRI International, Menlo Park, CA 94025, USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082071104","display_name":"Peter D. Karp","orcid":"https://orcid.org/0000-0002-5876-6418","observed_orcids":["https://orcid.org/0000-0002-5876-6418"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter D. Karp","raw_affiliation_strings":["SRI International, Menlo Park, CA 94025, USA"],"raw_orcid":"https://orcid.org/0000-0002-5876-6418","affiliations":[{"raw_affiliation_string":"SRI International, Menlo Park, CA 94025, USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052776560","display_name":"Jerry H. Morrison","orcid":"https://orcid.org/0000-0001-9414-6999","observed_orcids":["https://orcid.org/0000-0001-9414-6999"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry H. Morrison","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0001-9414-6999","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064086976","display_name":"Markus W. Covert","orcid":"https://orcid.org/0000-0002-5993-8912","observed_orcids":["https://orcid.org/0000-0002-5993-8912"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Markus W. Covert","raw_affiliation_strings":["Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","Department of Bioengineering, Stanford University, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-5993-8912","affiliations":[{"raw_affiliation_string":"Allen Discovery Center at Stanford University, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064086976"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":6.7178,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.98381722,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"369","issue":"6502","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.4961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.4961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mechanistic-simulation","display_name":"mechanistic simulation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-doubling-time","display_name":"cell doubling time","score":0.7609999775886536},{"id":"https://openalex.org/keywords/metabolic-parameters","display_name":"metabolic parameters","score":0.8040000200271606},{"id":"https://openalex.org/keywords/essential-proteins","display_name":"essential proteins","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8579999804496765},{"id":"https://openalex.org/keywords/data-integration","display_name":"data integration","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7118706107139587},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.6752440929412842},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.526283323764801},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5124712586402893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41796454787254333},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38857632875442505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3338004946708679},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32017332315444946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11080774664878845}],"mesh":[{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1126/science.aav3751","doi":"https://doi.org/10.1126/science.aav3751","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.aav3751","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:32703847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32703847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7990026","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7990026/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1781905","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1781905","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1800910","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1800910","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7990026","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7990026/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2173270962","display_name":"MARC PREDOCTORAL FELLOWSHIP","funder_award_id":"F31GM010715","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2187493578","display_name":"COMPUTATIONAL SCIENCE GRADUATE FELLOWSHIP PROGRAM","funder_award_id":"DEFG0297ER25308","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3823084741","display_name":"Deep Curation via an Integrated Whole-Cell Computational Model","funder_award_id":"R01LM013229","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G4580178314","display_name":null,"funder_award_id":"70NANB15H192 (JIMB Training Grant Graduate Fellowship)","funder_id":"https://openalex.org/F4320332178","funder_display_name":"National Institute of Standards and Technology"},{"id":"https://openalex.org/G468420501","display_name":"A Gene-Complete Computational Model of Yeast","funder_award_id":"DP1LM011510","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G5006553817","display_name":"The EcoCyc Model Organism Database for Escherichia coli","funder_award_id":"R01GM077678","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5760277475","display_name":"Systems Biology of Collective Cell Decisions","funder_award_id":"P50GM107615","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5873497360","display_name":"The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]","funder_award_id":"U24GM077678","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6942868959","display_name":null,"funder_award_id":"5DP1LM01150","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7726343511","display_name":"STANFORD NIST JIMB TRAINING GRANT","funder_award_id":"70NANB15H192","funder_id":"https://openalex.org/F4320332178","funder_display_name":"National Institute of Standards and Technology"},{"id":"https://openalex.org/G8033696891","display_name":"A Gene-Complete Computational Model of Yeast","funder_award_id":"DP1OD006413","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000017368","display_name":null,"funder_award_id":"GM077678","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306208","display_name":"Agilent Foundation","ror":"https://ror.org/02tryst02"},{"id":"https://openalex.org/F4320306216","display_name":"Paul G. Allen Family Foundation","ror":"https://ror.org/01degd278"},{"id":"https://openalex.org/F4320308507","display_name":"Stanford University","ror":"https://ror.org/00f54p054"},{"id":"https://openalex.org/F4320312638","display_name":"Thomas and Stacey Siebel Foundation","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332178","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W208046272","https://openalex.org/W1490014096","https://openalex.org/W1552342234","https://openalex.org/W1555159335","https://openalex.org/W1587428630","https://openalex.org/W1781531090","https://openalex.org/W1798528872","https://openalex.org/W1862404147","https://openalex.org/W1897139626","https://openalex.org/W1939195520","https://openalex.org/W1972863608","https://openalex.org/W1976043669","https://openalex.org/W1976692246","https://openalex.org/W1981100467","https://openalex.org/W1982309495","https://openalex.org/W1985161570","https://openalex.org/W1986366456","https://openalex.org/W1987777080","https://openalex.org/W1989104313","https://openalex.org/W1990148399","https://openalex.org/W1992292657","https://openalex.org/W1995791498","https://openalex.org/W1999574084","https://openalex.org/W2003153311","https://openalex.org/W2004235182","https://openalex.org/W2024167557","https://openalex.org/W2030157562","https://openalex.org/W2045780029","https://openalex.org/W2053080660","https://openalex.org/W2053460598","https://openalex.org/W2061659241","https://openalex.org/W2070878494","https://openalex.org/W2071056869","https://openalex.org/W2078355959","https://openalex.org/W2081567538","https://openalex.org/W2081781433","https://openalex.org/W2082578449","https://openalex.org/W2085203527","https://openalex.org/W2086707601","https://openalex.org/W2087346416","https://openalex.org/W2088537888","https://openalex.org/W2088550607","https://openalex.org/W2098145231","https://openalex.org/W2104846587","https://openalex.org/W2109563298","https://openalex.org/W2109636601","https://openalex.org/W2111967267","https://openalex.org/W2112515372","https://openalex.org/W2114746743","https://openalex.org/W2122638857","https://openalex.org/W2124019798","https://openalex.org/W2124737787","https://openalex.org/W2131067724","https://openalex.org/W2134153749","https://openalex.org/W2134440848","https://openalex.org/W2140055375","https://openalex.org/W2147189708","https://openalex.org/W2148037929","https://openalex.org/W2152164604","https://openalex.org/W2162115836","https://openalex.org/W2168134766","https://openalex.org/W2170427655","https://openalex.org/W2170806980","https://openalex.org/W2180334400","https://openalex.org/W2186373804","https://openalex.org/W2191824721","https://openalex.org/W2240061877","https://openalex.org/W2258657513","https://openalex.org/W2268897882","https://openalex.org/W2273741954","https://openalex.org/W2288271511","https://openalex.org/W2311016706","https://openalex.org/W2327011266","https://openalex.org/W2399953365","https://openalex.org/W2413214195","https://openalex.org/W2485910554","https://openalex.org/W2561960911","https://openalex.org/W2563408447","https://openalex.org/W2766821438","https://openalex.org/W2800627455","https://openalex.org/W2801253816","https://openalex.org/W2914948079","https://openalex.org/W2950681580","https://openalex.org/W4230967317"],"related_works":["https://openalex.org/W3080740603","https://openalex.org/W3090603309","https://openalex.org/W2152164604","https://openalex.org/W7098908788","https://openalex.org/W2914819453","https://openalex.org/W2441170455","https://openalex.org/W2007859434","https://openalex.org/W2003643556","https://openalex.org/W1964398464","https://openalex.org/W2041347999"],"abstract_inverted_index":{"enabled":[0],"us":[1],"to":[2,48,82,93],"integrate":[3],"and":[4,36,68],"cross-evaluate":[5],"a":[6,46,90],"massive,":[7],"heterogeneous":[8],"dataset":[9],"based":[10],"on":[11],"measurements":[12],"reported":[13],"by":[14,40],"various":[15],"groups":[16],"over":[17],"decades.":[18],"We":[19],"identified":[20],"inconsistencies":[21],"with":[22,61,65],"functional":[23],"consequences":[24],"across":[25],"the":[26,30,34,75,78],"data,":[27],"including":[28],"that":[29,53,69],"total":[31],"output":[32],"of":[33,96],"ribosomes":[35],"RNA":[37],"polymerases":[38],"described":[39],"data":[41,88],"are":[42,57,72],"not":[43],"sufficient":[44],"for":[45],"cell":[47,76,79],"reproduce":[49],"measured":[50,54],"doubling":[51],"times,":[52],"metabolic":[55],"parameters":[56],"neither":[58],"fully":[59],"compatible":[60],"each":[62],"other":[63],"nor":[64],"overall":[66],"growth,":[67],"essential":[70],"proteins":[71],"absent":[73],"during":[74],"cycle-and":[77],"is":[80],"robust":[81],"this":[83,101],"absence.":[84],"Finally,":[85],"considering":[86],"these":[87],"as":[89],"whole":[91],"leads":[92],"successful":[94],"predictions":[95],"new":[97],"experimental":[98],"outcomes,":[99],"in":[100],"case":[102],"protein":[103],"half-lives.":[104]},"counts_by_year":[{"year":2026,"cited_by_count":32},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-07-29T00:00:00"}
