{"id":"https://openalex.org/W3044091925","doi":"https://doi.org/10.1038/s41598-020-69248-9","title":"Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer\u2019s disease","display_name":"Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer\u2019s disease","publication_year":2020,"publication_date":"2020-07-22","ids":{"openalex":"https://openalex.org/W3044091925","doi":"https://doi.org/10.1038/s41598-020-69248-9","mag":"3044091925","pmid":"https://pubmed.ncbi.nlm.nih.gov/32699290","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7376092"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-69248-9","doi":"https://doi.org/10.1038/s41598-020-69248-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69248-9","pdf_url":"https://www.nature.com/articles/s41598-020-69248-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-69248-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079195884","display_name":"Nobuyuki Kobayashi","orcid":"https://orcid.org/0000-0001-8627-515X","observed_orcids":["https://orcid.org/0000-0001-8627-515X"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nobuyuki Kobayashi","raw_affiliation_strings":["Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan. kobayashi-n@jikei.ac.jp","Department of Virology, The Jikei University School of Medicine, Tokyo, Japan. kobayashi-n@jikei.ac.jp","Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan","Department of Virology, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan. kobayashi-n@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Virology, The Jikei University School of Medicine, Tokyo, Japan. kobayashi-n@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Virology, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064812413","display_name":"Shunichiro Shinagawa","orcid":"https://orcid.org/0000-0002-5952-6141","observed_orcids":["https://orcid.org/0000-0002-5952-6141"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunichiro Shinagawa","raw_affiliation_strings":["Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038152306","display_name":"Hidehito Niimura","orcid":"https://orcid.org/0000-0002-2124-5643","observed_orcids":["https://orcid.org/0000-0002-2124-5643"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidehito Niimura","raw_affiliation_strings":["Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019179344","display_name":"Hisashi Kida","orcid":"https://orcid.org/0000-0002-7712-1105","observed_orcids":["https://orcid.org/0000-0002-7712-1105"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Kida","raw_affiliation_strings":["Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055174569","display_name":"Tomoyuki Nagata","orcid":"https://orcid.org/0000-0002-8731-9887","observed_orcids":["https://orcid.org/0000-0002-8731-9887"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Nagata","raw_affiliation_strings":["Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079225739","display_name":"Kenji Tagai","orcid":"https://orcid.org/0000-0002-4551-1491","observed_orcids":["https://orcid.org/0000-0002-4551-1491"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Tagai","raw_affiliation_strings":["Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111413437","display_name":"Kazuya Shimada","orcid":"https://orcid.org/0000-0002-1075-9219","observed_orcids":["https://orcid.org/0000-0002-1075-9219"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Shimada","raw_affiliation_strings":["Department of Virology, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101441135","display_name":"Naomi Oka","orcid":"https://orcid.org/0000-0002-9745-7546","observed_orcids":["https://orcid.org/0000-0002-9745-7546"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naomi Oka","raw_affiliation_strings":["Department of Virology, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003209892","display_name":"Ryo Shikimoto","orcid":"https://orcid.org/0000-0002-7410-3067","observed_orcids":["https://orcid.org/0000-0002-7410-3067"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Shikimoto","raw_affiliation_strings":["Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042074794","display_name":"Yoshihiro Noda","orcid":"https://orcid.org/0000-0002-2155-0357","observed_orcids":["https://orcid.org/0000-0002-2155-0357"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Noda","raw_affiliation_strings":["Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057023665","display_name":"Shinichiro Nakajima","orcid":"https://orcid.org/0000-0002-2601-2195","observed_orcids":["https://orcid.org/0000-0002-2601-2195","https://orcid.org/0000-0003-4229-1910"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichiro Nakajima","raw_affiliation_strings":["Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033519257","display_name":"Masaru Mimura","orcid":"https://orcid.org/0000-0002-3874-5273","observed_orcids":["https://orcid.org/0000-0002-3874-5273"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Mimura","raw_affiliation_strings":["Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037410712","display_name":"Masahiro Shigeta","orcid":"https://orcid.org/0009-0004-4643-8662","observed_orcids":["https://orcid.org/0009-0004-4643-8662"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Shigeta","raw_affiliation_strings":["Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025881963","display_name":"Kazuhiro Kondo","orcid":"https://orcid.org/0000-0002-3731-6258","observed_orcids":["https://orcid.org/0000-0002-3731-6258"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Kondo","raw_affiliation_strings":["Department of Virology, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079195884"],"corresponding_institution_ids":["https://openalex.org/I115498069"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":2.775,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.90638586,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"12217","last_page":"12217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.671999990940094},{"id":"https://openalex.org/keywords/amnestic-mild-cognitive-impairment","display_name":"amnestic mild cognitive impairment","score":0.9539999961853027},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/early-diagnosis-of-dementia","display_name":"early diagnosis of dementia","score":0.703000009059906},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7732810974121094},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7499138712882996},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7483582496643066},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6650118827819824},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6325732469558716},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.600476861000061},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.5079877972602844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5063477754592896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43786224722862244},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4374512732028961},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4015081524848938},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.398785263299942},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3519018292427063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.286429762840271},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27320462465286255},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16369059681892395},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12420520186424255}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-020-69248-9","doi":"https://doi.org/10.1038/s41598-020-69248-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69248-9","pdf_url":"https://www.nature.com/articles/s41598-020-69248-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7376092","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7376092","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32699290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32699290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-69248-9","doi":"https://doi.org/10.1038/s41598-020-69248-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69248-9","pdf_url":"https://www.nature.com/articles/s41598-020-69248-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2379499390","display_name":"Significance for DNA methylation in Alzheimer's Disease","funder_award_id":"17K10318","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G375309764","display_name":"Elucidation of the mechanism of behavioral and psychological symptoms in Alzheimer's disease patients using DNA methylation","funder_award_id":"17K10317","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5712384255","display_name":null,"funder_award_id":"18dk0207025h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6880746497","display_name":"Excitatory Inhibitory Imbalance in Treatment-resistant Schizophrenia: TMS-EEG+MRS study","funder_award_id":"18H02755","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7883257175","display_name":"Toward reconstructing psychiatric disorders based on brain structure and function: International joint research project","funder_award_id":"20KK0193","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3044091925.pdf","grobid_xml":"https://content.openalex.org/works/W3044091925.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1847168837","https://openalex.org/W1974047233","https://openalex.org/W1981342309","https://openalex.org/W2011364876","https://openalex.org/W2021468604","https://openalex.org/W2044994860","https://openalex.org/W2055237453","https://openalex.org/W2098442878","https://openalex.org/W2112150247","https://openalex.org/W2113708991","https://openalex.org/W2115017507","https://openalex.org/W2121091193","https://openalex.org/W2156220037","https://openalex.org/W2167840686","https://openalex.org/W2228889533","https://openalex.org/W2329336071","https://openalex.org/W2338471433","https://openalex.org/W2566350735","https://openalex.org/W2767280000","https://openalex.org/W2773154268","https://openalex.org/W2790890754","https://openalex.org/W2902636119","https://openalex.org/W2999096542","https://openalex.org/W4240214838"],"related_works":["https://openalex.org/W2566350735","https://openalex.org/W3096626989","https://openalex.org/W4390194838","https://openalex.org/W2896075151","https://openalex.org/W2228889533","https://openalex.org/W4413113133","https://openalex.org/W4401960707","https://openalex.org/W579143072","https://openalex.org/W7154153233","https://openalex.org/W4389664693"],"abstract_inverted_index":{"Early":[0],"diagnosis":[1],"of":[2,31,63,80],"dementia":[3,89],"including":[4],"Alzheimer's":[5],"disease":[6,85],"(AD)":[7],"is":[8,73],"an":[9],"urgent":[10],"medical":[11],"and":[12,46,87,104,115,131],"welfare":[13],"issue.":[14],"However,":[15],"to":[16,56,68,145,160],"date,":[17],"no":[18],"simple":[19],"biometrics":[20],"have":[21],"been":[22],"available.":[23],"We":[24,91],"reported":[25],"that":[26,153],"blood":[27,93],"DNA":[28],"methylation":[29,72,95,155],"levels":[30,96,156],"the":[32],"COASY":[33,71,94,154],"gene,":[34],"which":[35],"encodes":[36],"coenzyme":[37],"A":[38],"synthase,":[39],"were":[40,124,135],"increased":[41],"in":[42,97,127,138,162],"individuals":[43,105,128],"with":[44,60,75,83,106,121,129,148],"AD":[45,82,111,139,146],"amnestic":[47],"mild":[48],"cognitive":[49],"impairment":[50],"(aMCI).":[51],"The":[52],"present":[53],"study":[54],"sought":[55],"replicate":[57],"these":[58],"findings":[59,151],"larger":[61],"numbers":[62],"samples.":[64],"Another":[65],"objective":[66],"was":[67],"clarify":[69],"whether":[70],"associated":[74],"neurodegeneration":[76,161],"through":[77],"a":[78],"comparison":[79],"AD,":[81],"cardiovascular":[84,142],"(CVD),":[86],"vascular":[88],"(VaD).":[90],"measured":[92],"normal":[98],"controls":[99],"(NCs)":[100],"(n":[101,108,112,117],"=":[102,109,113,118],"200),":[103],"aMCI":[107,130],"22),":[110],"151),":[114],"VaD":[116],"21).":[119],"Compared":[120],"NCs,":[122],"they":[123,134],"significantly":[125,136],"higher":[126,137],"AD.":[132,163],"Further,":[133],"patients":[140,147],"without":[141],"diseases":[143],"compared":[144],"them.":[149],"These":[150],"suggest":[152],"may":[157],"be":[158],"related":[159]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-29T00:00:00"}