{"id":"https://openalex.org/W3044036007","doi":null,"title":"Selective impairment in executive functions: A test of the selective executive deficit hypothesis in adults with treatment-discontinued phenylketonuria","display_name":"Selective impairment in executive functions: A test of the selective executive deficit hypothesis in adults with treatment-discontinued phenylketonuria","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W3044036007","mag":"3044036007"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10099571","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10099571/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040006519","display_name":"Galya Goodman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Galya Goodman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040006519"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.1316000074148178,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylketonuria","display_name":"phenylketonuria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.7020000219345093},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dorsolateral-prefrontal-cortex","display_name":"dorsolateral prefrontal cortex","score":0.949999988079071},{"id":"https://openalex.org/keywords/working-memory-load","display_name":"working memory load","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sustained-attention","display_name":"sustained attention","score":0.9710000157356262},{"id":"https://openalex.org/keywords/reward-learning","display_name":"reward learning","score":0.8769999742507935},{"id":"https://openalex.org/keywords/phenylalanine","display_name":"phenylalanine","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2775968953","wikidata":"https://www.wikidata.org/wiki/Q783092","display_name":"Executive functions","level":3,"score":0.7882137298583984},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.7855316400527954},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7730922698974609},{"id":"https://openalex.org/C2780508717","wikidata":"https://www.wikidata.org/wiki/Q72788","display_name":"Dorsolateral prefrontal cortex","level":4,"score":0.6503963470458984},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6489372849464417},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5431933999061584},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5213912129402161},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5075603723526001},{"id":"https://openalex.org/C126139899","wikidata":"https://www.wikidata.org/wiki/Q4818236","display_name":"Attentional control","level":3,"score":0.5016539096832275},{"id":"https://openalex.org/C2779985164","wikidata":"https://www.wikidata.org/wiki/Q5419936","display_name":"Executive dysfunction","level":4,"score":0.5006179809570312},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4374730885028839},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.3683593273162842},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3423336148262024},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.08895444869995117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10099571","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10099571/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:3044036007","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10099571/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047964023","https://openalex.org/W3090518908","https://openalex.org/W2081486656","https://openalex.org/W2014883692","https://openalex.org/W4241330305","https://openalex.org/W2119242730","https://openalex.org/W2040390829","https://openalex.org/W2085637806","https://openalex.org/W4320406341","https://openalex.org/W7217861875"],"abstract_inverted_index":{"Executive":[0],"functions":[1,37,69,113],"are":[2,100],"processes":[3],"involved":[4],"in":[5,26,35,43,50,57,68,128,130,167,204,225],"the":[6,18,44,58,72,118,131,205,217,222],"everyday":[7],"control":[8,179,223,229],"of":[9,23,55,84,137,140,148,172,202,207,209],"thoughts":[10],"and":[11,13,76,97,156,177],"actions":[12],"have":[14,29,114],"been":[15,115],"linked":[16,30,70,116],"to":[17,32,39,63,102,105,117,126,145,162,169,182,194,227],"prefrontal":[19,45,74,120,164],"cortex.":[20,46],"Recent":[21],"models":[22],"cognitive":[24],"functioning":[25],"Phenylketonuria":[27],"(PKU)":[28],"it":[31],"selective":[33,80],"impairment":[34],"executive":[36,81,173,187,219],"due":[38],"depleted":[40],"dopamine":[41,110,129],"levels":[42,54],"This":[47,133],"is":[48,61,123],"caused,":[49],"part,":[51],"by":[52,109],"elevated":[53],"Phenylalanine":[56],"blood.":[59],"Dopamine":[60],"thought":[62],"play":[64],"a":[65,138,146,178],"central":[66],"role":[67],"with":[71,143,190],"lateral":[73],"cortex":[75,165],"associated":[77],"pathways.":[78],"The":[79],"deficit":[82],"hypothesis":[83],"PKU":[85,144,191],"suggests":[86],"that":[87,89],"measures":[88],"place":[90],"high":[91],"demands":[92,185],"on":[93,159,186,198,216],"active":[94],"working":[95,211],"memory":[96,212],"sustained":[98],"attention":[99],"likely":[101],"be":[103,195],"sensitive":[104,125,161],"any":[106],"impairments":[107],"mediated":[108],"depletion.":[111],"These":[112],"dorsolateral":[119,163],"cortex,":[121],"which":[122],"particularly":[124],"fluctuations":[127],"brain.":[132],"study":[134],"compared":[135],"performance":[136],"group":[139,147],"treatment-discontinued":[141],"adults":[142],"healthy":[149,228],"controls":[150],"matched":[151],"for":[152],"age,":[153],"sex,":[154],"IQ":[155],"educational":[157],"background":[158],"tasks":[160,199],"functioning,":[166,174],"comparison":[168,226],"another":[170],"test":[171],"reward-based":[175],"learning,":[176],"task,":[180,224],"considered":[181],"make":[183],"minimal":[184],"functions.":[188],"Adults":[189],"were":[192],"shown":[193],"selectively":[196],"impaired":[197],"requiring":[200],"monitoring":[201],"information":[203],"context":[206],"processing":[208],"higher":[210],"loads,":[213],"but":[214],"not":[215],"alternative":[218],"task":[220],"or":[221],"participants.":[230]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2020-07-29T00:00:00"}
