{"id":"https://openalex.org/W3044035800","doi":"https://doi.org/10.1111/bcp.14500","title":"Impairment of endoxifen formation in tamoxifen\u2010treated premenopausal breast cancer patients carrying reduced\u2010function CYP2D6 alleles","display_name":"Impairment of endoxifen formation in tamoxifen\u2010treated premenopausal breast cancer patients carrying reduced\u2010function CYP2D6 alleles","publication_year":2020,"publication_date":"2020-07-26","ids":{"openalex":"https://openalex.org/W3044035800","doi":"https://doi.org/10.1111/bcp.14500","mag":"3044035800","pmid":"https://pubmed.ncbi.nlm.nih.gov/32713032","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9328423"},"language":"en","primary_location":{"id":"doi:10.1111/bcp.14500","doi":"https://doi.org/10.1111/bcp.14500","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.14500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14500","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14500","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Linda Thor\u00e9n","orcid":"https://orcid.org/0000-0003-1541-6191","observed_orcids":["https://orcid.org/0000-0003-1541-6191"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210094988","display_name":"Stockholm South General Hospital","ror":"https://ror.org/00ncfk576","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210094988"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Linda Thor\u00e9n","raw_affiliation_strings":["Department of Clinical Science and Education at S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden","Department of Oncology South General Hospital  Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1541-6191","affiliations":[{"raw_affiliation_string":"Department of Clinical Science and Education at S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden","institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210094988"]},{"raw_affiliation_string":"Department of Oncology South General Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I4210094988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065073643","display_name":"Jonatan D. Lindh","orcid":"https://orcid.org/0000-0001-7198-7269","observed_orcids":["https://orcid.org/0000-0001-7198-7269"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonatan D. Lindh","raw_affiliation_strings":["Department of Laboratory Medicine, Clinical Pharmacology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Clinical Pharmacology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053993938","display_name":"Gerd Ackehed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gerd Ackehed","raw_affiliation_strings":["Department of Laboratory Medicine, Clinical Pharmacology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Clinical Pharmacology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001695375","display_name":"Marianne Kristiansen Kringen","orcid":"https://orcid.org/0000-0002-4760-1693","observed_orcids":["https://orcid.org/0000-0002-4760-1693"]},"institutions":[{"id":"https://openalex.org/I184531372","display_name":"OsloMet \u2013 Oslo Metropolitan University","ror":"https://ror.org/04q12yn84","country_code":"NO","type":"education","lineage":["https://openalex.org/I184531372"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Marianne Kristiansen Kringen","raw_affiliation_strings":["Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway","Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I4210117451"]},{"raw_affiliation_string":"Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway","institution_ids":["https://openalex.org/I184531372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053177403","display_name":"Per N Hall","orcid":"https://orcid.org/0000-0002-5640-9126","observed_orcids":["https://orcid.org/0000-0002-5640-9126"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Hall","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071571360","display_name":"Jonas C. S. Bergh","orcid":"https://orcid.org/0000-0001-5526-1847","observed_orcids":["https://orcid.org/0000-0001-5526-1847"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonas Bergh","raw_affiliation_strings":["Department of Oncology-Pathology, Karolinska Institutet and Breast Cancer Center, Cancer Theme, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institutet and Breast Cancer Center, Cancer Theme, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043781386","display_name":"Espen Molden","orcid":"https://orcid.org/0000-0001-6190-2751","observed_orcids":["https://orcid.org/0000-0001-6190-2751"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Espen Molden","raw_affiliation_strings":["Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway","Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0001-6190-2751","affiliations":[{"raw_affiliation_string":"Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I4210117451"]},{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114374848","display_name":"Sara Margolin","orcid":"https://orcid.org/0000-0002-5526-5570","observed_orcids":["https://orcid.org/0000-0002-5526-5570"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210094988","display_name":"Stockholm South General Hospital","ror":"https://ror.org/00ncfk576","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210094988"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sara Margolin","raw_affiliation_strings":["Department of Clinical Science and Education at S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden","Department of Oncology South General Hospital  Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Science and Education at S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden","institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210094988"]},{"raw_affiliation_string":"Department of Oncology South General Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I4210094988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017537112","display_name":"Erik Eliasson","orcid":"https://orcid.org/0000-0002-4707-4256","observed_orcids":["https://orcid.org/0000-0002-4707-4256"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Erik Eliasson","raw_affiliation_strings":["Department of Laboratory Medicine, Clinical Pharmacology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Clinical Pharmacology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210094988"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":4.0685,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.94700373,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"87","issue":"3","first_page":"1243","last_page":"1252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoxifen","display_name":"endoxifen","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.949999988079071},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9380000233650208},{"id":"https://openalex.org/keywords/premenopausal-breast-cancer","display_name":"premenopausal breast cancer","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tamoxifen-metabolism","display_name":"tamoxifen metabolism","score":0.675000011920929},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/genotype-based-dosing","display_name":"genotype-based dosing","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tamoxifen-metabolites","display_name":"tamoxifen metabolites","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.9365037679672241},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.8324266076087952},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6127046346664429},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6013187766075134},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.556935727596283},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5420582890510559},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5413134098052979},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5076755285263062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5044528245925903},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.46226397156715393},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3594825267791748},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.352230966091156},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3337487578392029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21155217289924622},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17518985271453857},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.13703343272209167},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.07505932450294495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/bcp.14500","doi":"https://doi.org/10.1111/bcp.14500","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.14500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14500","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9328423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9328423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:32713032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32713032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/bcp.14500","doi":"https://doi.org/10.1111/bcp.14500","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.14500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14500","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1741621020","display_name":null,"funder_award_id":"19 0189 Us 01 H","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G3515687318","display_name":null,"funder_award_id":"19 0292 PJ 01 H","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G4739927680","display_name":null,"funder_award_id":"ALF20190536","funder_id":"https://openalex.org/F4320322570","funder_display_name":"Stockholms L\u00e4ns Landsting"},{"id":"https://openalex.org/G7073960695","display_name":null,"funder_award_id":"ALF2017-1341","funder_id":"https://openalex.org/F4320322570","funder_display_name":"Stockholms L\u00e4ns Landsting"},{"id":"https://openalex.org/G7293515827","display_name":null,"funder_award_id":"ALF20180419","funder_id":"https://openalex.org/F4320322570","funder_display_name":"Stockholms L\u00e4ns Landsting"}],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322570","display_name":"Stockholms L\u00e4ns Landsting","ror":"https://ror.org/02zrae794"},{"id":"https://openalex.org/F4320324250","display_name":"Cancerf\u00f6reningen i Stockholm","ror":"https://ror.org/00m8d6786"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3044035800.pdf","grobid_xml":"https://content.openalex.org/works/W3044035800.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W48187314","https://openalex.org/W1494910732","https://openalex.org/W1836143067","https://openalex.org/W1961026612","https://openalex.org/W1964945591","https://openalex.org/W1978470279","https://openalex.org/W2043411261","https://openalex.org/W2044702943","https://openalex.org/W2069469265","https://openalex.org/W2082048952","https://openalex.org/W2089348163","https://openalex.org/W2104019649","https://openalex.org/W2104708747","https://openalex.org/W2114156993","https://openalex.org/W2120384798","https://openalex.org/W2120713508","https://openalex.org/W2122090386","https://openalex.org/W2127660956","https://openalex.org/W2135502243","https://openalex.org/W2147099166","https://openalex.org/W2154067964","https://openalex.org/W2161977537","https://openalex.org/W2167100085","https://openalex.org/W2261996569","https://openalex.org/W2605348885","https://openalex.org/W2739614594","https://openalex.org/W2746583846","https://openalex.org/W2787844984","https://openalex.org/W2792046032","https://openalex.org/W2800158156","https://openalex.org/W2806866264","https://openalex.org/W2883008315","https://openalex.org/W2895853627","https://openalex.org/W2911741858","https://openalex.org/W2914126669","https://openalex.org/W2917216616","https://openalex.org/W2944067094","https://openalex.org/W2981329862","https://openalex.org/W2992000242","https://openalex.org/W2998062010"],"related_works":["https://openalex.org/W2971549068","https://openalex.org/W4408176718","https://openalex.org/W1754092853","https://openalex.org/W2053639830","https://openalex.org/W6980890375","https://openalex.org/W2076741971","https://openalex.org/W2746583846","https://openalex.org/W2324873334","https://openalex.org/W2982496952","https://openalex.org/W2340132318"],"abstract_inverted_index":{"AIMS:":[0],"Tamoxifen":[1],"is":[2],"bioactivated":[3],"to":[4,15],"endoxifen":[5,11,113,118,170,195,209,223],"by":[6,54,79],"polymorphic":[7],"CYP2D6-dependent":[8],"metabolism.":[9],"Here,":[10],"levels":[12,70,114,171,196,210,224],"were":[13,42,77,202,214,225],"compared":[14],"CYP2D6":[16,52,109,160,234],"diplotypes,":[17],"tentative":[18],"target":[19],"concentrations":[20],"and":[21,73,88,111,152],"side":[22,89,200,212],"effects.":[23],"METHODS:":[24],"In":[25,98,192],"total,":[26],"118":[27],"Swedish":[28],"premenopausal":[29],"breast":[30],"cancer":[31],"patients":[32,133,180,193],"diagnosed":[33],"2006-2014,":[34],"with":[35,134,194],"on-going":[36],"postoperative":[37],"tamoxifen":[38,72],"treatment":[39,87],"January":[40],"2017,":[41],"included.":[43],"Biobanked":[44],"DNA":[45],"from":[46,94,164],"peripheral":[47],"blood":[48],"was":[49,91,115,129,145,172],"used":[50],"for":[51,126,182,250],"genotyping":[53],"TaqMan":[55],"real-time":[56],"polymerase":[57],"chain":[58],"reaction":[59],"(CYP2D6*1,":[60],"*3,":[61],"*4,":[62],"*5,":[63],"*6,":[64],"*9,":[65],"*10,":[66],"*41,":[67],"*1xN).":[68],"Plasma":[69],"of":[71,102,154,176,233,240],"3":[74],"major":[75],"metabolites":[76],"quantified":[78],"liquid":[80],"chromatography-tandem":[81],"mass":[82],"spectrometry.":[83],"Clinical":[84],"information":[85],"on":[86],"effects":[90,201,213],"retrospectively":[92],"obtained":[93],"medical":[95],"records.":[96],"RESULTS:":[97],"the":[99,123,146,185],"final":[100],"analysis":[101],"114":[103],"patients,":[104],"a":[105,141,158,217],"clear":[106],"relationship":[107],"between":[108,174],"genotype":[110],"plasma":[112],"evident.":[116],"Low":[117],"(1.6-5.2":[119],"ng/mL),":[120],"i.e.":[121],"below":[122],"suggested":[124],"threshold":[125],"clinical":[127],"efficacy,":[128],"found":[130],"in":[131,169,216,229,238],"all":[132,230],"2":[135,138,177,241],"reduced-function":[136,149,242],"alleles,":[137],"null-alleles,":[139,235],"or":[140,184,205],"null/reduced-function":[142],"combination.":[143],"CYP2D6*41":[144,183],"most":[147],"common":[148],"allele":[150],"(82%)":[151],"17":[153],"21":[155],"CYP2D6*41-carriers":[156],"exhibited":[157],"lower":[159],"activity":[161],"than":[162],"predicted":[163],"published":[165],"guidelines.":[166],"No":[167],"difference":[168],"observed":[173,226],"carriers":[175,232,239],"null-alleles":[178],"vs":[179],"homozygous":[181,231],"corresponding":[186],"heterozygous":[187],"combination":[188],"(P":[189],"=":[190],".338).":[191],"<5.9":[197],"ng/mL":[198],"(36/114),":[199],"either":[203],"mild":[204],"absent.":[206],"At":[207],"higher":[208],"moderate-to-severe":[211],"reported":[215],"concentration-dependent":[218],"manner.":[219],"CONCLUSION:":[220],"Significantly":[221],"reduced":[222],"not":[227],"only":[228],"but":[236],"also":[237],"alleles.":[243],"This":[244],"finding":[245],"may":[246],"be":[247],"highly":[248],"relevant":[249],"future,":[251],"genotype-based":[252],"dose":[253],"considerations.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-07-29T00:00:00"}