{"id":"https://openalex.org/W3043890405","doi":"https://doi.org/10.1016/j.csbj.2020.07.015","title":"Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs","display_name":"Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3043890405","doi":"https://doi.org/10.1016/j.csbj.2020.07.015","mag":"3043890405","pmid":"https://pubmed.ncbi.nlm.nih.gov/32802271","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7403891"},"language":"en","primary_location":{"id":"doi:10.1016/j.csbj.2020.07.015","doi":"https://doi.org/10.1016/j.csbj.2020.07.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2020.07.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2001037020303470/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2001037020303470/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101815628","display_name":"Lingyan Zhou","orcid":"https://orcid.org/0000-0002-4529-7018","observed_orcids":["https://orcid.org/0000-0002-4529-7018"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Yan Zhou","raw_affiliation_strings":["Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076228539","display_name":"Yanghui Zhu","orcid":"https://orcid.org/0000-0002-1186-6104","observed_orcids":["https://orcid.org/0000-0002-1186-6104"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang-Hui Zhu","raw_affiliation_strings":["Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357614","display_name":"Xiaoyu Wang","orcid":"https://orcid.org/0000-0002-6800-1275","observed_orcids":["https://orcid.org/0000-0002-6800-1275","https://orcid.org/0009-0005-5143-6909","https://orcid.org/0009-0002-5728-9469"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Yu Wang","raw_affiliation_strings":["Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104153424","display_name":"Chao Shen","orcid":"https://orcid.org/0000-0001-7369-9164","observed_orcids":["https://orcid.org/0000-0001-7369-9164"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Shen","raw_affiliation_strings":["Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000511598","display_name":"Xiawei Wei","orcid":"https://orcid.org/0000-0002-6513-6422","observed_orcids":["https://orcid.org/0000-0002-6513-6422"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia-Wei Wei","raw_affiliation_strings":["Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089420346","display_name":"Ting Xu","orcid":"https://orcid.org/0000-0001-8727-9259","observed_orcids":["https://orcid.org/0000-0001-8727-9259"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ting Xu","raw_affiliation_strings":["Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076381011","display_name":"Zhiyao He","orcid":"https://orcid.org/0000-0001-7888-211X","observed_orcids":["https://orcid.org/0000-0001-7888-211X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi-Yao He","raw_affiliation_strings":["Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076381011","https://openalex.org/A5089420346"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"],"apc_list":{"value":2472,"currency":"USD","value_usd":2472},"apc_paid":{"value":2472,"currency":"USD","value_usd":2472},"fwci":0.7062,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.55196712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"18","issue":null,"first_page":"1980","last_page":"1999"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.10819999873638153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.6129999756813049},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antifouling","display_name":"antifouling","score":0.968999981880188},{"id":"https://openalex.org/keywords/hydration-shell","display_name":"hydration shell","score":0.5130000114440918},{"id":"https://openalex.org/keywords/ion-dipole-interactions","display_name":"ion-dipole interactions","score":0.9190000295639038},{"id":"https://openalex.org/keywords/phosphorylcholine","display_name":"phosphorylcholine","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sulfobetaine","display_name":"sulfobetaine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/carboxybetaine","display_name":"carboxybetaine","score":0.996999979019165},{"id":"https://openalex.org/keywords/zwitterionic-peptides","display_name":"zwitterionic peptides","score":0.8330000042915344},{"id":"https://openalex.org/keywords/stimuli-responsive-drug-delivery","display_name":"stimuli-responsive drug delivery","score":0.8569999933242798},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6694686412811279},{"id":"https://openalex.org/C2778743342","wikidata":"https://www.wikidata.org/wiki/Q245115","display_name":"Zwitterion","level":3,"score":0.6377109885215759},{"id":"https://openalex.org/C6047279","wikidata":"https://www.wikidata.org/wiki/Q1439821","display_name":"Biofouling","level":3,"score":0.6294031739234924},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6214361190795898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5739589929580688},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.5305899381637573},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.5293738842010498},{"id":"https://openalex.org/C2776833585","wikidata":"https://www.wikidata.org/wiki/Q7187582","display_name":"Phosphorylcholine","level":2,"score":0.507260262966156},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.49133625626564026},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.41243910789489746},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36892712116241455},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26859450340270996},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.20716476440429688},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.19811856746673584},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.14725470542907715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14714455604553223},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13473063707351685}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.csbj.2020.07.015","doi":"https://doi.org/10.1016/j.csbj.2020.07.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2020.07.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2001037020303470/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:32802271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32802271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and structural biotechnology journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7403891","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7403891/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comput Struct Biotechnol J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:36d74b1ee69f41029ab92be0ad104d9b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/36d74b1ee69f41029ab92be0ad104d9b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1980-1999 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.csbj.2020.07.015","doi":"https://doi.org/10.1016/j.csbj.2020.07.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2020.07.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2001037020303470/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1580609649","display_name":"Alcohol Brand Research Among Underage Drinkers","funder_award_id":"R01AA020309","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2730670151","display_name":null,"funder_award_id":"ZYJC18028","funder_id":"https://openalex.org/F4320322990","funder_display_name":"Sichuan University"},{"id":"https://openalex.org/G2839003733","display_name":null,"funder_award_id":"ZYJC18028","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G4016657198","display_name":null,"funder_award_id":"81602699","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5327689620","display_name":null,"funder_award_id":"1.3.5 project","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G5476267420","display_name":null,"funder_award_id":"2019YFG0266","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G7899741169","display_name":null,"funder_award_id":"1.3.5","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G8046414712","display_name":null,"funder_award_id":"81602699","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320333335","display_name":"Sichuan Province Science and Technology Support Program","ror":null},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null},{"id":"https://openalex.org/F4320336042","display_name":"West China Hospital, Sichuan University","ror":"https://ror.org/007mrxy13"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043890405.pdf","grobid_xml":"https://content.openalex.org/works/W3043890405.grobid-xml"},"referenced_works_count":201,"referenced_works":["https://openalex.org/W198567551","https://openalex.org/W848448822","https://openalex.org/W1012237817","https://openalex.org/W1121126846","https://openalex.org/W1164398545","https://openalex.org/W1547949248","https://openalex.org/W1867902790","https://openalex.org/W1966330133","https://openalex.org/W1968212620","https://openalex.org/W1970479425","https://openalex.org/W1970898345","https://openalex.org/W1973504612","https://openalex.org/W1974888306","https://openalex.org/W1975556125","https://openalex.org/W1977626304","https://openalex.org/W1982044972","https://openalex.org/W1987070131","https://openalex.org/W1987665445","https://openalex.org/W1988466810","https://openalex.org/W1990073131","https://openalex.org/W1992796636","https://openalex.org/W1994340285","https://openalex.org/W1995748522","https://openalex.org/W1999393639","https://openalex.org/W2002025851","https://openalex.org/W2003770685","https://openalex.org/W2005235137","https://openalex.org/W2006153327","https://openalex.org/W2010828967","https://openalex.org/W2012069959","https://openalex.org/W2012544502","https://openalex.org/W2016129077","https://openalex.org/W2016214516","https://openalex.org/W2016548996","https://openalex.org/W2022983883","https://openalex.org/W2024934649","https://openalex.org/W2025201877","https://openalex.org/W2026077248","https://openalex.org/W2026474823","https://openalex.org/W2028614873","https://openalex.org/W2028893730","https://openalex.org/W2028935199","https://openalex.org/W2029940588","https://openalex.org/W2032555145","https://openalex.org/W2032993907","https://openalex.org/W2033281188","https://openalex.org/W2034520377","https://openalex.org/W2035816944","https://openalex.org/W2036570425","https://openalex.org/W2037128514","https://openalex.org/W2040161324","https://openalex.org/W2041388051","https://openalex.org/W2043397035","https://openalex.org/W2043854890","https://openalex.org/W2045260522","https://openalex.org/W2046170661","https://openalex.org/W2047342341","https://openalex.org/W2047715691","https://openalex.org/W2052668018","https://openalex.org/W2053058794","https://openalex.org/W2054045589","https://openalex.org/W2057084135","https://openalex.org/W2057441531","https://openalex.org/W2058109807","https://openalex.org/W2058426479","https://openalex.org/W2059308235","https://openalex.org/W2059465566","https://openalex.org/W2060090884","https://openalex.org/W2061435221","https://openalex.org/W2066349600","https://openalex.org/W2068736626","https://openalex.org/W2070813581","https://openalex.org/W2074880818","https://openalex.org/W2075816778","https://openalex.org/W2077003104","https://openalex.org/W2077100353","https://openalex.org/W2077308388","https://openalex.org/W2078354005","https://openalex.org/W2079254959","https://openalex.org/W2079347827","https://openalex.org/W2080840413","https://openalex.org/W2082080210","https://openalex.org/W2082809243","https://openalex.org/W2086047928","https://openalex.org/W2086431690","https://openalex.org/W2090854525","https://openalex.org/W2091169206","https://openalex.org/W2092476230","https://openalex.org/W2093480017","https://openalex.org/W2095582941","https://openalex.org/W2097349369","https://openalex.org/W2099721021","https://openalex.org/W2100857282","https://openalex.org/W2101332331","https://openalex.org/W2101826716","https://openalex.org/W2104007357","https://openalex.org/W2104993070","https://openalex.org/W2105310619","https://openalex.org/W2111901647","https://openalex.org/W2118615978","https://openalex.org/W2120085804","https://openalex.org/W2123183032","https://openalex.org/W2123571664","https://openalex.org/W2123647020","https://openalex.org/W2125107461","https://openalex.org/W2135244514","https://openalex.org/W2143787638","https://openalex.org/W2144118351","https://openalex.org/W2149784998","https://openalex.org/W2158479359","https://openalex.org/W2160905697","https://openalex.org/W2166792549","https://openalex.org/W2167263245","https://openalex.org/W2171384411","https://openalex.org/W2175506968","https://openalex.org/W2176055767","https://openalex.org/W2177205490","https://openalex.org/W2221844625","https://openalex.org/W2229999029","https://openalex.org/W2265203886","https://openalex.org/W2268074951","https://openalex.org/W2281857120","https://openalex.org/W2285839304","https://openalex.org/W2289158769","https://openalex.org/W2295022485","https://openalex.org/W2298401137","https://openalex.org/W2302351455","https://openalex.org/W2305766308","https://openalex.org/W2314335208","https://openalex.org/W2316287488","https://openalex.org/W2316552164","https://openalex.org/W2318680867","https://openalex.org/W2318803175","https://openalex.org/W2326135482","https://openalex.org/W2326797829","https://openalex.org/W2328082795","https://openalex.org/W2330354757","https://openalex.org/W2333281222","https://openalex.org/W2333549545","https://openalex.org/W2335158450","https://openalex.org/W2354807172","https://openalex.org/W2402319960","https://openalex.org/W2425407891","https://openalex.org/W2483216148","https://openalex.org/W2535136734","https://openalex.org/W2546589574","https://openalex.org/W2552166386","https://openalex.org/W2560987571","https://openalex.org/W2562126198","https://openalex.org/W2584563437","https://openalex.org/W2587114059","https://openalex.org/W2588524377","https://openalex.org/W2596915721","https://openalex.org/W2598091501","https://openalex.org/W2615218473","https://openalex.org/W2618042632","https://openalex.org/W2700421244","https://openalex.org/W2742715679","https://openalex.org/W2745522709","https://openalex.org/W2746757605","https://openalex.org/W2770340446","https://openalex.org/W2780719111","https://openalex.org/W2785118524","https://openalex.org/W2790923997","https://openalex.org/W2800563928","https://openalex.org/W2801430335","https://openalex.org/W2801998423","https://openalex.org/W2802727705","https://openalex.org/W2809122721","https://openalex.org/W2809493104","https://openalex.org/W2809791255","https://openalex.org/W2810173410","https://openalex.org/W2810384209","https://openalex.org/W2889914575","https://openalex.org/W2897366366","https://openalex.org/W2898826636","https://openalex.org/W2900487476","https://openalex.org/W2900705394","https://openalex.org/W2902702379","https://openalex.org/W2903335235","https://openalex.org/W2904990515","https://openalex.org/W2905129136","https://openalex.org/W2906515356","https://openalex.org/W2920742877","https://openalex.org/W2921117033","https://openalex.org/W2923698402","https://openalex.org/W2948285287","https://openalex.org/W2948647713","https://openalex.org/W2950733835","https://openalex.org/W2954483880","https://openalex.org/W2964090597","https://openalex.org/W2972569294","https://openalex.org/W2976030570","https://openalex.org/W2991696409","https://openalex.org/W2997125990","https://openalex.org/W3002993580","https://openalex.org/W3015804616","https://openalex.org/W3025068037","https://openalex.org/W3029123196","https://openalex.org/W3037156997","https://openalex.org/W4253763513"],"related_works":["https://openalex.org/W7052498431","https://openalex.org/W4389900051","https://openalex.org/W3210951944","https://openalex.org/W4415529706","https://openalex.org/W4407163491","https://openalex.org/W2077442464","https://openalex.org/W2055114378","https://openalex.org/W7053316914","https://openalex.org/W4409405934","https://openalex.org/W2568521868"],"abstract_inverted_index":{"Zwitterions":[0],"consist":[1],"of":[2,48,106,121,131,134],"equal":[3],"molar":[4],"cationic":[5],"and":[6,9,23,31,43,53,93,108,124,129,153],"anionic":[7],"moieties":[8],"thus":[10],"exhibit":[11],"overall":[12],"electroneutrality.":[13],"Zwitterionic":[14],"materials":[15,58,98],"include":[16],"phosphorylcholine,":[17],"sulfobetaine,":[18],"carboxybetaine,":[19],"zwitterionic":[20,57,97,135],"amino":[21],"acids/peptides,":[22],"other":[24],"mix-charged":[25],"zwitterions":[26,122],"that":[27],"could":[28],"form":[29],"dense":[30],"stable":[32],"hydration":[33,51],"shells":[34],"through":[35],"the":[36,104,117,127,155],"strong":[37],"ion-dipole":[38],"interaction":[39],"among":[40],"water":[41],"molecules":[42],"zwitterions.":[44],"As":[45],"a":[46],"result":[47],"their":[49,84,140],"remarkable":[50],"capability":[52],"low":[54,87],"interfacial":[55],"energy,":[56],"have":[59,99],"become":[60],"ideal":[61],"choices":[62],"for":[63,103],"designing":[64],"therapeutic":[65,109,161],"vectors":[66],"to":[67],"prevent":[68],"undesired":[69],"biosorption":[70],"especially":[71],"nonspecific":[72],"biomacromolecules":[73],"during":[74],"circulation,":[75],"which":[76],"was":[77],"termed":[78],"antifouling":[79,119],"capability.":[80],"And":[81],"along":[82],"with":[83],"great":[85],"biocompatibility,":[86],"cytotoxicity,":[88],"negligible":[89],"immunogenicity,":[90],"systematic":[91],"stability":[92],"long":[94],"circulation":[95],"time,":[96],"been":[100],"widely":[101],"utilized":[102],"delivery":[105,146],"drugs":[107],"genes.":[110],"In":[111],"this":[112],"review,":[113],"we":[114,138],"first":[115],"summarized":[116],"possible":[118],"mechanism":[120],"briefly,":[123],"separately":[125],"introduced":[126],"features":[128],"advantages":[130],"each":[132],"type":[133],"materials.":[136],"Then":[137],"highlighted":[139],"applications":[141],"in":[142,160],"stimuli-responsive":[143],"\"intelligent\"":[144],"drug":[145],"systems":[147],"as":[148,150],"well":[149],"tumor-targeting":[151],"carriers":[152],"stressed":[154],"multifunctional":[156],"role":[157],"they":[158],"played":[159],"gene":[162],"delivery.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-07-29T00:00:00"}
