{"id":"https://openalex.org/W3043879409","doi":"https://doi.org/10.1007/s12094-020-02455-y","title":"Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells in vitro and in vivo","display_name":"Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells in vitro and in vivo","publication_year":2020,"publication_date":"2020-07-20","ids":{"openalex":"https://openalex.org/W3043879409","doi":"https://doi.org/10.1007/s12094-020-02455-y","mag":"3043879409","pmid":"https://pubmed.ncbi.nlm.nih.gov/32691366"},"language":"en","primary_location":{"id":"doi:10.1007/s12094-020-02455-y","doi":"https://doi.org/10.1007/s12094-020-02455-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12094-020-02455-y","pdf_url":null,"source":{"id":"https://openalex.org/S179824187","display_name":"Clinical & Translational Oncology","issn_l":"1699-048X","issn":["1699-048X","1699-3055"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108760312","display_name":"Jiacheng Zhang","orcid":"https://orcid.org/0009-0009-3784-8359","observed_orcids":["https://orcid.org/0009-0009-3784-8359"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405281830","display_name":"Jiangsu Normal University Kewen College","ror":"https://ror.org/04ynj2n67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281830"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. J. Zhang","raw_affiliation_strings":["Department of Urology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian People's Hospital of Nanjing Drum-Tower Hospital Group, No. 138, Huanghe South Road, Sucheng District, Suqian City, Jiangsu Province, China","Department of Urology, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, TianNing District, Changzhou City, Jiangsu Province, China","Jiangsu Normal University Kewen College, No. 101 Shanghai Road, Tongshan New District, Xuzhou City, Jiangsu Province, China","Department of Urology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian People\u2019s Hospital of Nanjing Drum-Tower Hospital Group, Suqian City, China","Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou City, China","Jiangsu Normal University Kewen College, Xuzhou City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian People's Hospital of Nanjing Drum-Tower Hospital Group, No. 138, Huanghe South Road, Sucheng District, Suqian City, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, TianNing District, Changzhou City, Jiangsu Province, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Jiangsu Normal University Kewen College, No. 101 Shanghai Road, Tongshan New District, Xuzhou City, Jiangsu Province, China","institution_ids":["https://openalex.org/I4405281830"]},{"raw_affiliation_string":"Department of Urology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian People\u2019s Hospital of Nanjing Drum-Tower Hospital Group, Suqian City, China","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou City, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Jiangsu Normal University Kewen College, Xuzhou City, China","institution_ids":["https://openalex.org/I4405281830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073398186","display_name":"Longjun Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405281830","display_name":"Jiangsu Normal University Kewen College","ror":"https://ror.org/04ynj2n67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281830"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. J. Cai","raw_affiliation_strings":["Department of Urology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian People's Hospital of Nanjing Drum-Tower Hospital Group, No. 138, Huanghe South Road, Sucheng District, Suqian City, Jiangsu Province, China","Jiangsu Normal University Kewen College, No. 101 Shanghai Road, Tongshan New District, Xuzhou City, Jiangsu Province, China","Department of Urology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian People\u2019s Hospital of Nanjing Drum-Tower Hospital Group, Suqian City, China","Jiangsu Normal University Kewen College, Xuzhou City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian People's Hospital of Nanjing Drum-Tower Hospital Group, No. 138, Huanghe South Road, Sucheng District, Suqian City, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Jiangsu Normal University Kewen College, No. 101 Shanghai Road, Tongshan New District, Xuzhou City, Jiangsu Province, China","institution_ids":["https://openalex.org/I4405281830"]},{"raw_affiliation_string":"Department of Urology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian People\u2019s Hospital of Nanjing Drum-Tower Hospital Group, Suqian City, China","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Jiangsu Normal University Kewen College, Xuzhou City, China","institution_ids":["https://openalex.org/I4405281830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058390330","display_name":"Kun Pang","orcid":"https://orcid.org/0000-0002-9063-8483","observed_orcids":["https://orcid.org/0000-0002-9063-8483","https://orcid.org/0009-0003-5961-5616"]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"K. Pang","raw_affiliation_strings":["Department of Urology, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China","Department of Urology, Xuzhou Central Hospital, Xuzhou City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210132906"]},{"raw_affiliation_string":"Department of Urology, Xuzhou Central Hospital, Xuzhou City, China","institution_ids":["https://openalex.org/I4210132906"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Dong","raw_affiliation_strings":["Department of Urology, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China","Department of Urology, Xuzhou Central Hospital, Xuzhou City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210132906"]},{"raw_affiliation_string":"Department of Urology, Xuzhou Central Hospital, Xuzhou City, China","institution_ids":["https://openalex.org/I4210132906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068282378","display_name":"Z. G. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z. G. Zhang","raw_affiliation_strings":["Department of Urology, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China","Department of Urology, Xuzhou Central Hospital, Xuzhou City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210132906"]},{"raw_affiliation_string":"Department of Urology, Xuzhou Central Hospital, Xuzhou City, China","institution_ids":["https://openalex.org/I4210132906"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. B. Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. B. Li","raw_affiliation_strings":["Department of Urology, Taizhou Traditional Chinese Medicine Hospital, No. 86, Jichuan East Road, Hailing District, Taizhou City, Jiangsu Province, China","Department of Urology, Taizhou Traditional Chinese Medicine Hospital, Taizhou City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Taizhou Traditional Chinese Medicine Hospital, No. 86, Jichuan East Road, Hailing District, Taizhou City, Jiangsu Province, China","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, Taizhou Traditional Chinese Medicine Hospital, Taizhou City, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073018572","display_name":"Ruoran Li","orcid":"https://orcid.org/0009-0007-9574-0376","observed_orcids":["https://orcid.org/0009-0007-9574-0376"]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"R. Li","raw_affiliation_strings":["Department of Central Laboratory, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China","Department of Central Laboratory, Xuzhou Central Hospital, Xuzhou City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Central Laboratory, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210132906"]},{"raw_affiliation_string":"Department of Central Laboratory, Xuzhou Central Hospital, Xuzhou City, China","institution_ids":["https://openalex.org/I4210132906"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101819827","display_name":"Conghui Han","orcid":"https://orcid.org/0000-0001-7908-569X","observed_orcids":["https://orcid.org/0000-0001-7908-569X"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"C. H. Han","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, TianNing District, Changzhou City, Jiangsu Province, China. ucqcs0@163.com","Department of Urology, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China. ucqcs0@163.com","Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou City, China","Department of Urology, Xuzhou Central Hospital, Xuzhou City, China"],"raw_orcid":"https://orcid.org/0000-0001-7908-569X","affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, TianNing District, Changzhou City, Jiangsu Province, China. ucqcs0@163.com","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Urology, Xuzhou Central Hospital, No. 199, Jiefang South Road, Quanshan District, Xuzhou City, Jiangsu Province, China. ucqcs0@163.com","institution_ids":["https://openalex.org/I4210132906"]},{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou City, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Urology, Xuzhou Central Hospital, Xuzhou City, China","institution_ids":["https://openalex.org/I4210132906"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101819827"],"corresponding_institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210132906"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":2.6786,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.8990031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"3","first_page":"601","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.10899999737739563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.061900001019239426,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paeonol","display_name":"paeonol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/t24-cells","display_name":"T24 cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/5637-cells","display_name":"5637 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.6729999780654907},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8820000290870667},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2778833331","wikidata":"https://www.wikidata.org/wiki/Q7124105","display_name":"Paeonol","level":3,"score":0.9574041366577148},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7631096839904785},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6718630194664001},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6096836924552917},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5884215235710144},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.572507381439209},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5082897543907166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45735540986061096},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45484694838523865},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4437969923019409},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4321834444999695},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4011969566345215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3147420883178711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30616796016693115},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18247288465499878},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18154290318489075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10382089018821716},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000098","descriptor_name":"Acetophenones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12094-020-02455-y","doi":"https://doi.org/10.1007/s12094-020-02455-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12094-020-02455-y","pdf_url":null,"source":{"id":"https://openalex.org/S179824187","display_name":"Clinical & Translational Oncology","issn_l":"1699-048X","issn":["1699-048X","1699-3055"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Oncology","raw_type":"journal-article"},{"id":"pmid:32691366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32691366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1572671100","https://openalex.org/W1959848155","https://openalex.org/W1960709440","https://openalex.org/W1974992441","https://openalex.org/W2003927915","https://openalex.org/W2005055360","https://openalex.org/W2008104426","https://openalex.org/W2015194118","https://openalex.org/W2020595733","https://openalex.org/W2024500826","https://openalex.org/W2028961521","https://openalex.org/W2030811868","https://openalex.org/W2036029010","https://openalex.org/W2041821070","https://openalex.org/W2046138191","https://openalex.org/W2054318449","https://openalex.org/W2074618914","https://openalex.org/W2093977679","https://openalex.org/W2099347347","https://openalex.org/W2121959112","https://openalex.org/W2133661134","https://openalex.org/W2140674576","https://openalex.org/W2171620999","https://openalex.org/W2336271794","https://openalex.org/W2404729507","https://openalex.org/W2415721097","https://openalex.org/W2419098006","https://openalex.org/W2554230680","https://openalex.org/W2588351016","https://openalex.org/W2742535624","https://openalex.org/W2750320760","https://openalex.org/W2758807308","https://openalex.org/W2802103192","https://openalex.org/W2884987394","https://openalex.org/W2885771228","https://openalex.org/W2887131843","https://openalex.org/W2911188335","https://openalex.org/W2941184640","https://openalex.org/W4292199349","https://openalex.org/W4296146232"],"related_works":["https://openalex.org/W2554230680","https://openalex.org/W2797029537","https://openalex.org/W2351321231","https://openalex.org/W3037047818","https://openalex.org/W2378276379","https://openalex.org/W6991853093","https://openalex.org/W2886621909","https://openalex.org/W2515234458","https://openalex.org/W2765659254","https://openalex.org/W3034264884"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-07-29T00:00:00"}