{"id":"https://openalex.org/W3043869134","doi":"https://doi.org/10.3390/toxins12080472","title":"Scavenging Intracellular ROS Attenuates p-Cresyl Sulfate-Triggered Osteogenesis through MAPK Signaling Pathway and NF-\u03baB Activation in Human Arterial Smooth Muscle Cells","display_name":"Scavenging Intracellular ROS Attenuates p-Cresyl Sulfate-Triggered Osteogenesis through MAPK Signaling Pathway and NF-\u03baB Activation in Human Arterial Smooth Muscle Cells","publication_year":2020,"publication_date":"2020-07-24","ids":{"openalex":"https://openalex.org/W3043869134","doi":"https://doi.org/10.3390/toxins12080472","mag":"3043869134","pmid":"https://pubmed.ncbi.nlm.nih.gov/32722241","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7472002"},"language":"en","primary_location":{"id":"doi:10.3390/toxins12080472","doi":"https://doi.org/10.3390/toxins12080472","is_oa":true,"landing_page_url":"https://doi.org/10.3390/toxins12080472","pdf_url":"https://www.mdpi.com/2072-6651/12/8/472/pdf?version=1595831651","source":{"id":"https://openalex.org/S128990672","display_name":"Toxins","issn_l":"2072-6651","issn":["2072-6651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6651/12/8/472/pdf?version=1595831651","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001412814","display_name":"Jia\u2010Feng Chang","orcid":"https://orcid.org/0000-0002-9903-7473","observed_orcids":["https://orcid.org/0000-0002-9903-7473"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I25251306","display_name":"Yuanpei University","ror":"https://ror.org/02jb3jv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I25251306"]},{"id":"https://openalex.org/I4210098629","display_name":"En Chu Kong Hospital","ror":"https://ror.org/015a6df35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210098629"]},{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jia-Feng Chang","raw_affiliation_strings":["Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan","Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan","Division of Nephrology, Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan","Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan","Graduate Institute of Aerospace and Undersea Medicine, Academy of Medicine, National Defense Medical Center, Taipei 114, Taiwan","Renal Care Joint Foundation, New Taipei City 220, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-9903-7473","affiliations":[{"raw_affiliation_string":"Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan","institution_ids":["https://openalex.org/I25251306"]},{"raw_affiliation_string":"Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan","institution_ids":["https://openalex.org/I4210098629"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan","institution_ids":["https://openalex.org/I4210158385","https://openalex.org/I47519274"]},{"raw_affiliation_string":"Graduate Institute of Aerospace and Undersea Medicine, Academy of Medicine, National Defense Medical Center, Taipei 114, Taiwan","institution_ids":["https://openalex.org/I68171755"]},{"raw_affiliation_string":"Renal Care Joint Foundation, New Taipei City 220, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072005810","display_name":"Chih\u2010Yu Hsieh","orcid":"https://orcid.org/0000-0001-9770-6779","observed_orcids":["https://orcid.org/0000-0001-9770-6779"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Yu Hsieh","raw_affiliation_strings":["Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan","Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan","Renal Care Joint Foundation, New Taipei City 220, Taiwan","School of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-9770-6779","affiliations":[{"raw_affiliation_string":"Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan","institution_ids":["https://openalex.org/I4210158385","https://openalex.org/I47519274"]},{"raw_affiliation_string":"Renal Care Joint Foundation, New Taipei City 220, Taiwan","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108380823","display_name":"Jian-Chiun Liou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jian-Chiun Liou","raw_affiliation_strings":["School of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004663085","display_name":"Shih-Hao Liu","orcid":"https://orcid.org/0000-0003-4633-1430","observed_orcids":["https://orcid.org/0000-0003-4633-1430"]},"institutions":[{"id":"https://openalex.org/I4210098629","display_name":"En Chu Kong Hospital","ror":"https://ror.org/015a6df35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210098629"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Hao Liu","raw_affiliation_strings":["Division of Pathology, En-Chu-Kong Hospital, New Taipei City 237, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, En-Chu-Kong Hospital, New Taipei City 237, Taiwan","institution_ids":["https://openalex.org/I4210098629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022169678","display_name":"Chi\u2010Feng Hung","orcid":"https://orcid.org/0000-0003-3478-5451","observed_orcids":["https://orcid.org/0000-0003-3478-5451"]},"institutions":[{"id":"https://openalex.org/I114150738","display_name":"Fu Jen Catholic University","ror":"https://ror.org/04je98850","country_code":"TW","type":"education","lineage":["https://openalex.org/I114150738"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Feng Hung","raw_affiliation_strings":["School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan","institution_ids":["https://openalex.org/I114150738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075292315","display_name":"Kuo\u2010Cheng Lu","orcid":"https://orcid.org/0000-0002-7062-8560","observed_orcids":["https://orcid.org/0000-0002-7062-8560"]},"institutions":[{"id":"https://openalex.org/I4210097004","display_name":"Taipei Tzu Chi Hospital","ror":"https://ror.org/00q017g63","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210097004"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo-Cheng Lu","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan","institution_ids":["https://openalex.org/I4210097004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102755590","display_name":"Chih-Cheng Lin","orcid":"https://orcid.org/0000-0002-7972-6810","observed_orcids":["https://orcid.org/0000-0002-7972-6810"]},"institutions":[{"id":"https://openalex.org/I25251306","display_name":"Yuanpei University","ror":"https://ror.org/02jb3jv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I25251306"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Cheng Lin","raw_affiliation_strings":["Department of Biotechnology and Pharmaceutical, Yuanpei University, Hsinchu 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Pharmaceutical, Yuanpei University, Hsinchu 300, Taiwan","institution_ids":["https://openalex.org/I25251306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100858493","display_name":"Chang\u2010Chin Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25251306","display_name":"Yuanpei University","ror":"https://ror.org/02jb3jv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I25251306"]},{"id":"https://openalex.org/I4210098629","display_name":"En Chu Kong Hospital","ror":"https://ror.org/015a6df35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210098629"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chang-Chin Wu","raw_affiliation_strings":["Department of Biomedical Engineering, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan","Department of Orthopaedic Surgery, En-Chu-Kong Hospital, New Taipei City 237, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan","institution_ids":["https://openalex.org/I25251306"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, En-Chu-Kong Hospital, New Taipei City 237, Taiwan","institution_ids":["https://openalex.org/I4210098629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055924774","display_name":"Shuk\u2010Man Ka","orcid":"https://orcid.org/0000-0002-6013-4401","observed_orcids":["https://orcid.org/0000-0002-6013-4401"]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shuk-Man Ka","raw_affiliation_strings":["Graduate Institute of Aerospace and Undersea Medicine, Academy of Medicine, National Defense Medical Center, Taipei 114, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Aerospace and Undersea Medicine, Academy of Medicine, National Defense Medical Center, Taipei 114, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101135256","display_name":"Li-Li Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098629","display_name":"En Chu Kong Hospital","ror":"https://ror.org/015a6df35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210098629"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Li Wen","raw_affiliation_strings":["Department of Clinical Laboratory, En Chu Kong Hospital, New Taipei City 237, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, En Chu Kong Hospital, New Taipei City 237, Taiwan","institution_ids":["https://openalex.org/I4210098629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103110708","display_name":"Mai-Szu Wu","orcid":"https://orcid.org/0000-0002-5110-0568","observed_orcids":["https://orcid.org/0000-0002-5110-0568"]},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mai-Szu Wu","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan","Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan","institution_ids":["https://openalex.org/I4210158385","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015260770","display_name":"Cai\u2010Mei Zheng","orcid":"https://orcid.org/0000-0003-0370-3951","observed_orcids":["https://orcid.org/0000-0003-0370-3951"]},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cai-Mei Zheng","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan","Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-0370-3951","affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan","institution_ids":["https://openalex.org/I4210158385","https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021128897","display_name":"Wen\u2010Chin Ko","orcid":"https://orcid.org/0000-0002-7109-832X","observed_orcids":["https://orcid.org/0000-0002-7109-832X"]},"institutions":[{"id":"https://openalex.org/I114150738","display_name":"Fu Jen Catholic University","ror":"https://ror.org/04je98850","country_code":"TW","type":"education","lineage":["https://openalex.org/I114150738"]},{"id":"https://openalex.org/I4210129488","display_name":"Cathay General Hospital","ror":"https://ror.org/03c8c9n80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210129488"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wen-Chin Ko","raw_affiliation_strings":["Division of Cardiac Electrophysiology, Department of Cardiovascular Center, Cathay General Hospital, Taipei 106, Taiwan","School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Electrophysiology, Department of Cardiovascular Center, Cathay General Hospital, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I4210129488"]},{"raw_affiliation_string":"School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan","institution_ids":["https://openalex.org/I114150738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5021128897"],"corresponding_institution_ids":["https://openalex.org/I114150738","https://openalex.org/I4210129488"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":2.2027,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.88771033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"12","issue":"8","first_page":"472","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-cresyl-sulfate","display_name":"p-cresyl sulfate","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/arterial-smooth-muscle-cells","display_name":"arterial smooth muscle cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.6359999775886536},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.972000002861023},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.996999979019165},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":1.0},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.824999988079071},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6647533178329468},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.5732153654098511},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.537603497505188},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5358356833457947},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5172951221466064},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5100725293159485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49529948830604553},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4640454649925232},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4502869248390198},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4321794807910919},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.3295963406562805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3158612847328186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2720264196395874},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003408","descriptor_name":"Cresols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013463","descriptor_name":"Sulfuric Acid Esters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D061205","descriptor_name":"Vascular Calcification","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D061205","descriptor_name":"Vascular Calcification","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/toxins12080472","doi":"https://doi.org/10.3390/toxins12080472","is_oa":true,"landing_page_url":"https://doi.org/10.3390/toxins12080472","pdf_url":"https://www.mdpi.com/2072-6651/12/8/472/pdf?version=1595831651","source":{"id":"https://openalex.org/S128990672","display_name":"Toxins","issn_l":"2072-6651","issn":["2072-6651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins","raw_type":"journal-article"},{"id":"pmid:32722241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32722241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7472002","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7472002/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b79b970933db4a6dbe3c536d5351b85a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b79b970933db4a6dbe3c536d5351b85a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxins, Vol 12, Iss 8, p 472 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/toxins12080472","doi":"https://doi.org/10.3390/toxins12080472","is_oa":true,"landing_page_url":"https://doi.org/10.3390/toxins12080472","pdf_url":"https://www.mdpi.com/2072-6651/12/8/472/pdf?version=1595831651","source":{"id":"https://openalex.org/S128990672","display_name":"Toxins","issn_l":"2072-6651","issn":["2072-6651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043869134.pdf","grobid_xml":"https://content.openalex.org/works/W3043869134.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W915675152","https://openalex.org/W1860160715","https://openalex.org/W2025589168","https://openalex.org/W2044505412","https://openalex.org/W2098915805","https://openalex.org/W2101912981","https://openalex.org/W2105898297","https://openalex.org/W2107616906","https://openalex.org/W2117951926","https://openalex.org/W2124591820","https://openalex.org/W2158862897","https://openalex.org/W2168987491","https://openalex.org/W2308529899","https://openalex.org/W2313044475","https://openalex.org/W2336158238","https://openalex.org/W2560063226","https://openalex.org/W2789358880","https://openalex.org/W2790654167","https://openalex.org/W2805352006","https://openalex.org/W2883796579","https://openalex.org/W2891284285","https://openalex.org/W2891594773","https://openalex.org/W2899214546","https://openalex.org/W2901651687","https://openalex.org/W2930835088","https://openalex.org/W2939307768","https://openalex.org/W3013553722","https://openalex.org/W3014575216"],"related_works":["https://openalex.org/W4282000735","https://openalex.org/W2081431999","https://openalex.org/W2044505412","https://openalex.org/W3089002884","https://openalex.org/W2804440585","https://openalex.org/W2997481362","https://openalex.org/W7203642874","https://openalex.org/W2511250950","https://openalex.org/W2971323837","https://openalex.org/W3182060456"],"abstract_inverted_index":{"Osteogenesis":[0],"in":[1,39,43,154,192,199,235],"human":[2,76],"arterial":[3,56],"smooth":[4],"muscle":[5],"cell":[6],"(HASMC)":[7],"is":[8],"a":[9,212],"key":[10],"feature":[11],"of":[12,20,27,51,150,205,220],"uremic":[13],"vascular":[14],"calcification":[15],"(UVC).":[16],"Concerning":[17],"pro-oxidant":[18],"properties":[19],"p-cresyl":[21],"sulfate":[22],"(PCS),":[23],"the":[24,203,218],"therapeutic":[25,231],"effect":[26],"reactive":[28],"oxygen":[29],"species":[30],"(ROS)":[31],"scavenger":[32,159],"on":[33,48],"PCS":[34,72,117,132,172,208,223],"triggered":[35],"inflammatory":[36],"signaling":[37,162],"transduction":[38],"osteogenesis":[40,69,174],"was":[41,80],"investigated":[42],"this":[44],"translational":[45,221],"research.":[46],"Based":[47],"severity":[49],"level":[50],"chronic":[52],"kidney":[53],"disease":[54],"(CKD),":[55],"specimens":[57],"with":[58,71,94,116,122],"immunohistochemistry":[59],"stain":[60],"were":[61],"quantitatively":[62],"analyzed":[63],"for":[64,233],"UVC,":[65,77],"oxidative":[66,125],"injury":[67],"and":[68,110,130,143,152,164,182,188,214,224],"along":[70],"concentrations.":[73],"To":[74],"mimic":[75],"HASMC":[78,200],"model":[79],"used":[81],"to":[82,147,185],"explore":[83],"whether":[84],"PCS-induced":[85],"ROS":[86,158,226],"could":[87,201,227],"trigger":[88],"mitogen-activated":[89],"protein":[90],"kinase":[91,137,140],"(MAPK)":[92],"pathways":[93,181],"nuclear":[95],"factor-\u03baB":[96],"(NF-\u03baB)":[97],"translocation":[98,146,184],"that":[99],"drive":[100,186],"context-specific":[101],"gene/protein":[102],"expression,":[103],"including":[104],"Runt-related":[105],"transcription":[106],"factor":[107],"2":[108],"(Runx2)":[109],"alkaline":[111],"phosphatase":[112],"(ALP).":[113],"In":[114],"parallel":[115],"accumulation,":[118],"CKD":[119,236],"arteries":[120],"corresponded":[121],"UVC":[123,234],"severity,":[124],"DNA":[126],"damage":[127],"(8-hydroxy-2\u2032-deoxyguanosine),":[128],"Runx2":[129,151,187],"ALP.":[131],"directly":[133],"phosphorylated":[134],"extracellular":[135],"signal-regulated":[136],"(ERK)/c-Jun":[138],"N-terminal":[139],"(JNK)/P38":[141],"(pERK/pJNK/pP38)":[142],"modulated":[144],"NF-\u03baB":[145,183],"promote":[148],"expressions":[149],"ALP":[153,189],"HASMC.":[155],"Notably,":[156],"intracellular":[157,177,225],"attenuated":[160],"pERK":[161],"cascade":[163],"downstream":[165],"osteogenic":[166],"differentiation.":[167],"Collectively,":[168],"our":[169],"data":[170],"demonstrate":[171],"induces":[173],"through":[175],"triggering":[176],"ROS,":[178],"pERK/pJNK/pP38":[179],"MAPK":[180],"expressions,":[190],"culminating":[191],"UVC.":[193],"Beyond":[194],"mineral":[195],"dysregulation,":[196],"osteocytic":[197],"conversion":[198],"be":[202],"stimulation":[204],"PCS.":[206],"Thus":[207],"may":[209],"act":[210],"as":[211,229],"pro-osteogenic":[213],"pro-calcific":[215],"toxin.":[216],"From":[217],"perspective":[219],"medicine,":[222],"serve":[228],"potential":[230],"targets":[232],"patients.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-07-29T00:00:00"}
