{"id":"https://openalex.org/W3043867880","doi":"https://doi.org/10.1016/j.biopha.2020.110473","title":"Neurochemical, neurobehavioral and histochemical effects of therapeutic dose of l-dopa on striatal neurons in rats: Protective effect of virgin coconut oil","display_name":"Neurochemical, neurobehavioral and histochemical effects of therapeutic dose of l-dopa on striatal neurons in rats: Protective effect of virgin coconut oil","publication_year":2020,"publication_date":"2020-07-21","ids":{"openalex":"https://openalex.org/W3043867880","doi":"https://doi.org/10.1016/j.biopha.2020.110473","mag":"3043867880","pmid":"https://pubmed.ncbi.nlm.nih.gov/32707436"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2020.110473","doi":"https://doi.org/10.1016/j.biopha.2020.110473","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2020.110473","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332220306661/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0753332220306661/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100784644","display_name":"Ahmed M. Shehata","orcid":"https://orcid.org/0000-0002-0718-6050","observed_orcids":["https://orcid.org/0000-0002-0718-6050"]},"institutions":[{"id":"https://openalex.org/I4210136593","display_name":"National Organization for Drug Control and Research","ror":"https://ror.org/0407ex783","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210136593","https://openalex.org/I4210160667","https://openalex.org/I4405259620"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed M. Shehata","raw_affiliation_strings":["PhysiologyDepartment, National Organization for Drug Control and Research (NODCAR), Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhysiologyDepartment, National Organization for Drug Control and Research (NODCAR), Giza, Egypt","institution_ids":["https://openalex.org/I4210136593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046526118","display_name":"Omar Abdel-hamed Ahmed-Farid","orcid":"https://orcid.org/0000-0002-1020-5777","observed_orcids":["https://orcid.org/0000-0002-1020-5777"]},"institutions":[{"id":"https://openalex.org/I4210136593","display_name":"National Organization for Drug Control and Research","ror":"https://ror.org/0407ex783","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210136593","https://openalex.org/I4210160667","https://openalex.org/I4405259620"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Omar A. Ahmed-Farid","raw_affiliation_strings":["PhysiologyDepartment, National Organization for Drug Control and Research (NODCAR), Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhysiologyDepartment, National Organization for Drug Control and Research (NODCAR), Giza, Egypt","institution_ids":["https://openalex.org/I4210136593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023630798","display_name":"Hanan A. Rizk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136593","display_name":"National Organization for Drug Control and Research","ror":"https://ror.org/0407ex783","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210136593","https://openalex.org/I4210160667","https://openalex.org/I4405259620"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hanan A. Rizk","raw_affiliation_strings":["Histology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt","institution_ids":["https://openalex.org/I4210136593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046105340","display_name":"Sara Saber","orcid":"https://orcid.org/0000-0003-2813-8266","observed_orcids":["https://orcid.org/0000-0003-2813-8266"]},"institutions":[{"id":"https://openalex.org/I4210136593","display_name":"National Organization for Drug Control and Research","ror":"https://ror.org/0407ex783","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210136593","https://openalex.org/I4210160667","https://openalex.org/I4405259620"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sara M. Saber","raw_affiliation_strings":["Pharmacology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt","institution_ids":["https://openalex.org/I4210136593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027290169","display_name":"Fawzy Mohamed Lashin","orcid":"https://orcid.org/0000-0003-4380-0211","observed_orcids":["https://orcid.org/0000-0003-4380-0211"]},"institutions":[{"id":"https://openalex.org/I4210136593","display_name":"National Organization for Drug Control and Research","ror":"https://ror.org/0407ex783","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210136593","https://openalex.org/I4210160667","https://openalex.org/I4405259620"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fawzy M. Lashin","raw_affiliation_strings":["Biochemistry Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt","institution_ids":["https://openalex.org/I4210136593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019372522","display_name":"Lamberto Re","orcid":"https://orcid.org/0000-0003-4825-1573","observed_orcids":["https://orcid.org/0000-0003-4825-1573"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lamberto Re","raw_affiliation_strings":["Clinical Pharmacology, Medinat, Ancona, Italy. Electronic address: lambertore@lambertore.com","Clinical Pharmacology, Medinat, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Medinat, Ancona, Italy. Electronic address: lambertore@lambertore.com","institution_ids":[]},{"raw_affiliation_string":"Clinical Pharmacology, Medinat, Ancona, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019372522"],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.5243,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.8396886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"130","issue":null,"first_page":"110473","last_page":"110473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13361","display_name":"Coconut Research and Applications","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levodopa","display_name":"levodopa","score":0.8510000109672546},{"id":"https://openalex.org/keywords/virgin-coconut-oil","display_name":"virgin coconut oil","score":0.8519999980926514},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8930000066757202},{"id":"https://openalex.org/keywords/striatal-neurons","display_name":"striatal neurons","score":0.6690000295639038},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.5070000290870667},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9879999756813049},{"id":"https://openalex.org/keywords/energy-crisis","display_name":"energy crisis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9290000200271606},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.753000020980835},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9210000038146973},{"id":"https://openalex.org/keywords/carbidopa","display_name":"carbidopa","score":0.6940000057220459},{"id":"https://openalex.org/keywords/neurobehavioral-changes","display_name":"neurobehavioral abnormalities","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7394497990608215},{"id":"https://openalex.org/C2776754145","wikidata":"https://www.wikidata.org/wiki/Q71133637","display_name":"Carbidopa","level":5,"score":0.7314362525939941},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.7204852104187012},{"id":"https://openalex.org/C2777996180","wikidata":"https://www.wikidata.org/wiki/Q216235","display_name":"Coconut oil","level":2,"score":0.6259729862213135},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.5844113230705261},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5643125772476196},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5390922427177429},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.46485957503318787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3975662589073181},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3702352046966553},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.33378204703330994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3138299584388733},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2965559959411621},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17746105790138245},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08670279383659363},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074263","descriptor_name":"Coconut Oil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002230","descriptor_name":"Carbidopa","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biopha.2020.110473","doi":"https://doi.org/10.1016/j.biopha.2020.110473","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2020.110473","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332220306661/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:32707436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32707436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:df30a17e6fbb4d02a7024ea33c41387b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/df30a17e6fbb4d02a7024ea33c41387b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, Vol 130, Iss , Pp 110473- (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2020.110473","doi":"https://doi.org/10.1016/j.biopha.2020.110473","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2020.110473","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332220306661/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043867880.pdf","grobid_xml":"https://content.openalex.org/works/W3043867880.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W399988028","https://openalex.org/W1486406365","https://openalex.org/W1883004117","https://openalex.org/W1964876794","https://openalex.org/W1982256598","https://openalex.org/W1982379270","https://openalex.org/W1999410714","https://openalex.org/W2001546859","https://openalex.org/W2005680736","https://openalex.org/W2011190309","https://openalex.org/W2018681635","https://openalex.org/W2028903190","https://openalex.org/W2030935054","https://openalex.org/W2040134578","https://openalex.org/W2040281422","https://openalex.org/W2050742296","https://openalex.org/W2056160062","https://openalex.org/W2083048709","https://openalex.org/W2085424855","https://openalex.org/W2093487114","https://openalex.org/W2113317893","https://openalex.org/W2137968195","https://openalex.org/W2149097284","https://openalex.org/W2239329077","https://openalex.org/W2261292266","https://openalex.org/W2273655726","https://openalex.org/W2294301440","https://openalex.org/W2311693884","https://openalex.org/W2342373162","https://openalex.org/W2461018964","https://openalex.org/W2471024759","https://openalex.org/W2476895759","https://openalex.org/W2515838470","https://openalex.org/W2581547460","https://openalex.org/W2590025652","https://openalex.org/W2607309065","https://openalex.org/W2620727498","https://openalex.org/W2735172895","https://openalex.org/W2742359605","https://openalex.org/W2772717716","https://openalex.org/W2782119756","https://openalex.org/W2782873098","https://openalex.org/W2783345465","https://openalex.org/W2783483586","https://openalex.org/W2799818237","https://openalex.org/W2804125886","https://openalex.org/W2809921676","https://openalex.org/W2873344332","https://openalex.org/W2886487705","https://openalex.org/W2897460483","https://openalex.org/W2901825414","https://openalex.org/W2903971492","https://openalex.org/W2920258340","https://openalex.org/W2943471410","https://openalex.org/W2951065602","https://openalex.org/W2951381348","https://openalex.org/W2967931963","https://openalex.org/W2968211438","https://openalex.org/W2969045726","https://openalex.org/W2969542925","https://openalex.org/W2970686919","https://openalex.org/W3008956023","https://openalex.org/W3046111689","https://openalex.org/W4285719527","https://openalex.org/W6766773997","https://openalex.org/W6767045529","https://openalex.org/W6767356828"],"related_works":["https://openalex.org/W2094297446","https://openalex.org/W2042252169","https://openalex.org/W1976724667","https://openalex.org/W2928525938","https://openalex.org/W2077163040","https://openalex.org/W4399592892","https://openalex.org/W2117876568","https://openalex.org/W2094007633","https://openalex.org/W2117053539","https://openalex.org/W2391164295"],"abstract_inverted_index":{"Despite":[0],"the":[1,11,34,61,66,76,91,140,197,206,213],"fact":[2],"that":[3,182,217],"levodopa":[4],"has":[5],"proven":[6],"its":[7,22,156],"effectiveness":[8],"in":[9,46,124,139,196],"treating":[10],"symptoms":[12],"of":[13,38,52,85,105,142,153,209],"Parkinson's":[14],"disease":[15],"(PD),":[16],"increasing":[17],"concerns":[18],"have":[19],"emerged":[20],"about":[21],"possible":[23,35],"long-term":[24],"toxic":[25],"effects":[26,208],"on":[27],"dopamine":[28,144],"(DA)":[29],"neurons.":[30],"The":[31,107,176],"study":[32,215],"investigated":[33],"ameliorative":[36],"effect":[37],"virgin":[39,71,96,218],"coconut":[40,72,97,201,219],"oil":[41,73,98,202,220],"against":[42,225],"l-dopa-":[43],"induced":[44,170],"neurotoxicity":[45],"adult":[47],"rats.":[48],"A":[49],"total":[50],"number":[51],"40":[53],"rats":[54],"were":[55,110],"divided":[56],"into":[57],"four":[58],"groups.":[59],"Briefly,":[60],"first":[62],"served":[63],"as":[64],"control,":[65],"second":[67],"was":[68,79],"orally":[69],"administered":[70,80,100],"(1.42":[74],"mL/kg),":[75],"third":[77],"group":[78,93,117],"a":[81,101,185,222],"single":[82,102],"daily":[83,103],"dose":[84,104],"l-dopa/carbidopa":[86],"(100/10":[87],"mg/kg/day,":[88],"p.o)":[89],"and":[90,121,145,147,155,163,173,178,188],"fourth":[92],"pre-treated":[94],"with":[95,150],"then":[99],"l-dopa/carbidopa.":[106],"different":[108],"treatments":[109],"extended":[111],"for":[112],"30":[113],"days.":[114],"l-dopa":[115,134,159,168,183],"treated":[116],"exhibited":[118],"aggressive":[119],"behavior":[120],"behavioral":[122],"abnormalities":[123],"open":[125],"field":[126],"test":[127],"compared":[128],"to":[129],"control":[130],"group.":[131],"In":[132,166,211],"addition,":[133,167],"treatment":[135,160,169],"caused":[136,184],"significant":[137],"increase":[138],"levels":[141],"striatal":[143,198],"norepinephrine":[146],"their":[148],"metabolites":[149],"concomitant":[151],"decrease":[152],"serotonin":[154],"metabolite.":[157],"Moreover,":[158],"increased":[161,189],"histamine":[162],"GABA":[164],"levels.":[165],"oxidative":[171],"stress":[172],"energy":[174],"crisis.":[175],"histological":[177],"immunohistochemical":[179],"studies":[180],"showed":[181],"remarkable":[186],"neurodegeneration":[187],"glial":[190],"fibrillary":[191],"acidic":[192],"protein":[193],"(GFAP)":[194],"immunoexpression":[195],"area.":[199],"Virgin":[200],"co-treatment":[203],"significantly":[204],"minimized":[205],"harmful":[207],"l-dopa.":[210],"conclusion,":[212],"present":[214],"revealed":[216],"provided":[221],"notable":[223],"protection":[224],"l-dopa's":[226],"untoward":[227],"effects.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-29T00:00:00"}
