{"id":"https://openalex.org/W3043865279","doi":"https://doi.org/10.21037/atm-20-2037","title":"Metabolic reprograming of tumor-associated macrophages","display_name":"Metabolic reprograming of tumor-associated macrophages","publication_year":2020,"publication_date":"2020-08-01","ids":{"openalex":"https://openalex.org/W3043865279","doi":"https://doi.org/10.21037/atm-20-2037","mag":"3043865279","pmid":"https://pubmed.ncbi.nlm.nih.gov/32953830","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7475460"},"language":"en","primary_location":{"id":"doi:10.21037/atm-20-2037","doi":"https://doi.org/10.21037/atm-20-2037","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm-20-2037","pdf_url":"https://atm.amegroups.com/article/viewFile/47750/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://atm.amegroups.com/article/viewFile/47750/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031629042","display_name":"Abhishek Puthenveetil","orcid":"https://orcid.org/0000-0002-6310-3328","observed_orcids":["https://orcid.org/0000-0002-6310-3328"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhishek Puthenveetil","raw_affiliation_strings":["Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India","mity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India","institution_ids":["https://openalex.org/I191972202"]},{"raw_affiliation_string":"mity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India","institution_ids":["https://openalex.org/I191972202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073728973","display_name":"Shweta Dubey","orcid":"https://orcid.org/0000-0002-0457-9692","observed_orcids":["https://orcid.org/0000-0002-0457-9692","https://orcid.org/0009-0000-5496-8963"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shweta Dubey","raw_affiliation_strings":["Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India","mity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India","institution_ids":["https://openalex.org/I191972202"]},{"raw_affiliation_string":"mity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India","institution_ids":["https://openalex.org/I191972202"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073728973"],"corresponding_institution_ids":["https://openalex.org/I191972202"],"apc_list":null,"apc_paid":null,"fwci":1.2443,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.79716088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"8","issue":"16","first_page":"1030","last_page":"1030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":1.0},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9819999933242798},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6729999780654907},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.847000002861023},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5529999732971191},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6746129989624023},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6565040946006775},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6423969864845276},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.572121262550354},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5650013089179993},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.5167309641838074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5150103569030762},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48380082845687866},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.47204598784446716},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.45671549439430237},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.45156314969062805},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4114738702774048},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36850690841674805},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3304286003112793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2837451696395874},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.25515931844711304},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1190347671508789},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/atm-20-2037","doi":"https://doi.org/10.21037/atm-20-2037","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm-20-2037","pdf_url":"https://atm.amegroups.com/article/viewFile/47750/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7475460","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7475460","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Transl Med","raw_type":"Text"},{"id":"pmid:32953830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32953830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of translational medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/atm-20-2037","doi":"https://doi.org/10.21037/atm-20-2037","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm-20-2037","pdf_url":"https://atm.amegroups.com/article/viewFile/47750/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320737","display_name":"Amity University","ror":"https://ror.org/02n9z0v62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043865279.pdf","grobid_xml":"https://content.openalex.org/works/W3043865279.grobid-xml"},"referenced_works_count":194,"referenced_works":["https://openalex.org/W193748226","https://openalex.org/W900373682","https://openalex.org/W1483271435","https://openalex.org/W1486200716","https://openalex.org/W1531083786","https://openalex.org/W1544341564","https://openalex.org/W1548584275","https://openalex.org/W1589766395","https://openalex.org/W1598422965","https://openalex.org/W1642873092","https://openalex.org/W1757395087","https://openalex.org/W1772301402","https://openalex.org/W1911385032","https://openalex.org/W1964083798","https://openalex.org/W1964899672","https://openalex.org/W1969057487","https://openalex.org/W1970766774","https://openalex.org/W1975959171","https://openalex.org/W1987520066","https://openalex.org/W1989090840","https://openalex.org/W1991129425","https://openalex.org/W1991429659","https://openalex.org/W1992248421","https://openalex.org/W1994234362","https://openalex.org/W2012885541","https://openalex.org/W2014708931","https://openalex.org/W2018488144","https://openalex.org/W2026067651","https://openalex.org/W2026878412","https://openalex.org/W2033820276","https://openalex.org/W2038009564","https://openalex.org/W2040589111","https://openalex.org/W2049513468","https://openalex.org/W2050636009","https://openalex.org/W2056648518","https://openalex.org/W2056950140","https://openalex.org/W2058631111","https://openalex.org/W2058648826","https://openalex.org/W2059476255","https://openalex.org/W2060672294","https://openalex.org/W2061123122","https://openalex.org/W2063041942","https://openalex.org/W2063632665","https://openalex.org/W2065747552","https://openalex.org/W2067031028","https://openalex.org/W2068793888","https://openalex.org/W2070855360","https://openalex.org/W2074171009","https://openalex.org/W2076272449","https://openalex.org/W2078166317","https://openalex.org/W2080860848","https://openalex.org/W2085246510","https://openalex.org/W2086261536","https://openalex.org/W2092184212","https://openalex.org/W2095647702","https://openalex.org/W2097293713","https://openalex.org/W2098308961","https://openalex.org/W2105724560","https://openalex.org/W2106102605","https://openalex.org/W2106545303","https://openalex.org/W2109424201","https://openalex.org/W2110015442","https://openalex.org/W2112601576","https://openalex.org/W2112740421","https://openalex.org/W2113264551","https://openalex.org/W2114248398","https://openalex.org/W2115974802","https://openalex.org/W2120621109","https://openalex.org/W2121294918","https://openalex.org/W2122874141","https://openalex.org/W2125648352","https://openalex.org/W2129526111","https://openalex.org/W2132117833","https://openalex.org/W2133536768","https://openalex.org/W2135141709","https://openalex.org/W2138110344","https://openalex.org/W2138326965","https://openalex.org/W2138590199","https://openalex.org/W2141487097","https://openalex.org/W2144575277","https://openalex.org/W2146971577","https://openalex.org/W2149360266","https://openalex.org/W2151713361","https://openalex.org/W2152381037","https://openalex.org/W2153586956","https://openalex.org/W2154708203","https://openalex.org/W2159803625","https://openalex.org/W2162166699","https://openalex.org/W2163169932","https://openalex.org/W2163175900","https://openalex.org/W2166760323","https://openalex.org/W2169083371","https://openalex.org/W2211754517","https://openalex.org/W2216262028","https://openalex.org/W2223535266","https://openalex.org/W2257787258","https://openalex.org/W2270388924","https://openalex.org/W2271019093","https://openalex.org/W2344237909","https://openalex.org/W2414840542","https://openalex.org/W2427645657","https://openalex.org/W2460752692","https://openalex.org/W2461513545","https://openalex.org/W2466831165","https://openalex.org/W2468925656","https://openalex.org/W2474232167","https://openalex.org/W2486415076","https://openalex.org/W2487956862","https://openalex.org/W2519020116","https://openalex.org/W2530067632","https://openalex.org/W2534854440","https://openalex.org/W2548602591","https://openalex.org/W2550646651","https://openalex.org/W2553056474","https://openalex.org/W2560396365","https://openalex.org/W2560880769","https://openalex.org/W2562261475","https://openalex.org/W2565995236","https://openalex.org/W2577696913","https://openalex.org/W2582686270","https://openalex.org/W2587532232","https://openalex.org/W2590692536","https://openalex.org/W2593886437","https://openalex.org/W2600317738","https://openalex.org/W2607103422","https://openalex.org/W2609512644","https://openalex.org/W2609919582","https://openalex.org/W2611360243","https://openalex.org/W2616112277","https://openalex.org/W2616687840","https://openalex.org/W2622166486","https://openalex.org/W2623605515","https://openalex.org/W2636131768","https://openalex.org/W2725383737","https://openalex.org/W2731908234","https://openalex.org/W2735344772","https://openalex.org/W2740653964","https://openalex.org/W2743002757","https://openalex.org/W2747888169","https://openalex.org/W2757381139","https://openalex.org/W2760375764","https://openalex.org/W2761190232","https://openalex.org/W2762280203","https://openalex.org/W2766550318","https://openalex.org/W2768762463","https://openalex.org/W2771984155","https://openalex.org/W2773028871","https://openalex.org/W2773924394","https://openalex.org/W2774267942","https://openalex.org/W2774325261","https://openalex.org/W2782998220","https://openalex.org/W2793124274","https://openalex.org/W2793688609","https://openalex.org/W2799441834","https://openalex.org/W2803060899","https://openalex.org/W2805252210","https://openalex.org/W2806253608","https://openalex.org/W2883594834","https://openalex.org/W2884256602","https://openalex.org/W2887123907","https://openalex.org/W2887549163","https://openalex.org/W2889189861","https://openalex.org/W2889258202","https://openalex.org/W2895690205","https://openalex.org/W2895724778","https://openalex.org/W2898415660","https://openalex.org/W2898826594","https://openalex.org/W2899358783","https://openalex.org/W2899435407","https://openalex.org/W2904307134","https://openalex.org/W2904635368","https://openalex.org/W2914311347","https://openalex.org/W2914484796","https://openalex.org/W2916952453","https://openalex.org/W2934055254","https://openalex.org/W2938195179","https://openalex.org/W2939093246","https://openalex.org/W2946172068","https://openalex.org/W2946878207","https://openalex.org/W2946898593","https://openalex.org/W2950705205","https://openalex.org/W2957498182","https://openalex.org/W2960078024","https://openalex.org/W2970058039","https://openalex.org/W2980823965","https://openalex.org/W2982346128","https://openalex.org/W2983352093","https://openalex.org/W2984799663","https://openalex.org/W2990721973","https://openalex.org/W3003989858","https://openalex.org/W3006205919","https://openalex.org/W4236081746","https://openalex.org/W4249980792","https://openalex.org/W6684172825"],"related_works":["https://openalex.org/W4386946055","https://openalex.org/W4324258675","https://openalex.org/W4413001257","https://openalex.org/W7140122343","https://openalex.org/W7160963725","https://openalex.org/W7153107940","https://openalex.org/W7154456233","https://openalex.org/W4392894274","https://openalex.org/W4381996255","https://openalex.org/W3036511616"],"abstract_inverted_index":{"A":[0,69],"large":[1],"body":[2],"of":[3,58,72,99,109],"scientific":[4],"evidence":[5],"corroborated":[6],"by":[7],"clinical":[8],"and":[9,25,39,48,65,74,120],"animal":[10],"model":[11],"experiments":[12],"indicates":[13],"that":[14],"tumor-associated":[15],"macrophages":[16],"(TAMs)":[17],"play":[18],"a":[19,29,54],"crucial":[20],"role":[21],"in":[22,35,50,78,87,112,128,135],"tumor":[23,36],"development":[24],"progression.":[26],"TAMs":[27,52,79],"are":[28,53,137],"key":[30],"immune":[31,84,117],"cell":[32],"type":[33],"present":[34],"microenvironment":[37],"(TME)":[38],"associated":[40],"with":[41],"poor":[42],"prognosis,":[43],"drug":[44],"resistance,":[45],"enhanced":[46],"angiogenesis":[47],"metastasis":[49],"cancer.":[51,88],"phenotypically":[55],"diverse":[56],"population":[57],"myeloid":[59],"cells":[60,119],"which":[61],"display":[62],"tremendous":[63],"plasticity":[64],"dynamic":[66],"metabolic":[67,76,110,126],"nature.":[68],"complete":[70],"interpretation":[71],"pro-tumoral":[73],"anti-tumoral":[75],"switch":[77],"is":[80],"essential":[81],"to":[82],"understand":[83],"evasion":[85],"mechanisms":[86,95],"Recent":[89],"studies":[90],"have":[91],"also":[92,138],"implicated":[93],"epigenetic":[94],"as":[96],"significantly":[97],"regulators":[98],"TAM":[100,133],"functions.":[101],"In":[102],"this":[103],"review":[104],"we":[105],"provide":[106],"an":[107],"overview":[108],"circuitry":[111],"TAMs,":[113],"its":[114],"impact":[115],"on":[116],"effector":[118],"interventions":[121],"aimed":[122],"at":[123],"rewiring":[124],"the":[125],"circuits":[127],"TAMs.":[129],"Mechanisms":[130],"responsible":[131],"for":[132],"polarization":[134],"cancer":[136],"discussed.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-29T00:00:00"}