{"id":"https://openalex.org/W3043826913","doi":"https://doi.org/10.1016/s2055-6640(20)31355-8","title":"Ingenol derivatives are potent reactivators of latent HIV","display_name":"Ingenol derivatives are potent reactivators of latent HIV","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W3043826913","doi":"https://doi.org/10.1016/s2055-6640(20)31355-8","mag":"3043826913"},"language":"en","primary_location":{"id":"doi:10.1016/s2055-6640(20)31355-8","doi":"https://doi.org/10.1016/s2055-6640(20)31355-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)31355-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2055664020313558/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2055664020313558/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042773644","display_name":"Vicente Planelles","orcid":"https://orcid.org/0000-0002-5318-2982","observed_orcids":["https://orcid.org/0000-0002-5318-2982"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Planelles","raw_affiliation_strings":["Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036762753","display_name":"Adam M. Spivak","orcid":"https://orcid.org/0000-0003-1815-7893","observed_orcids":["https://orcid.org/0000-0003-1815-7893"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.M. Spivak","raw_affiliation_strings":["Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063904033","display_name":"Erin T. Larragoite","orcid":"https://orcid.org/0000-0001-5061-2521","observed_orcids":["https://orcid.org/0000-0001-5061-2521"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.T. Larragoite","raw_affiliation_strings":["Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033598125","display_name":"Camille L. Novis","orcid":"https://orcid.org/0000-0002-9111-3662","observed_orcids":["https://orcid.org/0000-0002-9111-3662"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.L. Novis","raw_affiliation_strings":["Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076669199","display_name":"L.J. Martins A. Bosque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.J. Martins A. Bosque","raw_affiliation_strings":["Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25885084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-latency","display_name":"HIV-1 latency","score":0.9539999961853027},{"id":"https://openalex.org/keywords/latency-reactivation","display_name":"latency reactivation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.906000018119812},{"id":"https://openalex.org/keywords/h3k4me3","display_name":"H3K4me3","score":0.949999988079071},{"id":"https://openalex.org/keywords/h3k9ac","display_name":"H3K9ac","score":0.996999979019165},{"id":"https://openalex.org/keywords/traf4","display_name":"TRAF4","score":0.906000018119812},{"id":"https://openalex.org/keywords/nfix","display_name":"NFIX","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6288831830024719},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34926676750183105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2449934482574463},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.20062768459320068}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/s2055-6640(20)31355-8","doi":"https://doi.org/10.1016/s2055-6640(20)31355-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)31355-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2055664020313558/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a649c45bc73244d98fdb35b1585f7536","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a649c45bc73244d98fdb35b1585f7536","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virus Eradication, Vol 1, Iss , Pp 22- (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s2055-6640(20)31355-8","doi":"https://doi.org/10.1016/s2055-6640(20)31355-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)31355-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2055664020313558/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043826913.pdf","grobid_xml":"https://content.openalex.org/works/W3043826913.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3044939643","https://openalex.org/W2612989990","https://openalex.org/W7161382854","https://openalex.org/W6977357377","https://openalex.org/W2068613687","https://openalex.org/W7161384689","https://openalex.org/W3044865796","https://openalex.org/W6940028982","https://openalex.org/W6902427772","https://openalex.org/W6902462504"],"abstract_inverted_index":{"CD4+":[0],"T":[1],"cell":[2],"line":[3],"(A3.01)":[4],"and":[5,12,20,27,33,44,53,65,73,100,118,137,152,175,189],"HIV-1":[6,62,192],"latently":[7],"infected":[8],"cells":[9,64],"(ACH2,":[10],"J1.1,":[11],"NCHA1)":[13],"were":[14,35,77,87,106,129,140,154],"aligned":[15],"to":[16,164],"hg18":[17],"using":[18],"bowtie":[19],"analyzed":[21],"with":[22,167],"SICER,":[23],"CEAS,":[24],"HOMER,":[25],"WebGestalt,":[26,126],"PCViz.Results:":[28],"Chromosomes":[29],"16,":[30],"17,":[31],"19":[32],"22":[34],"significantly":[36],"enriched":[37],"for":[38,79,158],"histone":[39,173],"modifications":[40,174],"in":[41,61,89,107,125,132,141,178,186],"both":[42],"decreased":[43,47],"increased":[45,67],"islands.38":[46],"islands":[48,52,56,68,72,76],"from":[49,69],"126":[50],"H3K4me3":[51,71],"302":[54],"H3K9ac":[55,75],"common":[57],"at":[58],"specific":[59,179],"chromosomes":[60,180],"latent":[63],"41":[66,138],"130":[70],"164":[74],"selected":[78,155],"functional":[80],"annotation.In":[81],"Gene":[82],"Ontology":[83],"analysis,":[84],"38":[85,127],"genes":[86,105,128,139],"involved":[88,131],"regulation":[90,94,99],"of":[91,95,172,191],"biological":[92,98],"process,":[93,97],"cellular":[96],"purinergic":[101],"receptor":[102],"signaling":[103],"pathway.41":[104],"nucleic":[108],"acid":[109],"binding,":[110],"calcium":[111],"activated":[112],"cation":[113],"channel":[114],"activity,":[115],"DNA":[116],"binding":[117],"zinc":[119],"ion":[120],"binding.By":[121],"pathway":[122],"commons":[123],"analysis":[124],"strongly":[130],"p63":[133],"transcription":[134,145],"factor":[135],"network":[136],"RNA":[142],"polymerase":[143],"\u2162":[144],"termination":[146],"pathway.TOP2A,":[147],"ITGB4,":[148],"TRAF4,":[149],"SEC14L2,":[150],"NFIC":[151],"NFIX":[153],"as":[156],"candidates":[157],"HIV":[159],"latency.Additionally,":[160],"TRAF4":[161],"was":[162],"found":[163],"directly":[165],"interact":[166],"NFIX.Conclusions:":[168],"The":[169],"unique":[170],"enrichment":[171],"its":[176],"cross-talk":[177],"might":[181],"play":[182],"a":[183],"crucial":[184],"role":[185],"the":[187],"establishment":[188],"maintenance":[190],"latency.":[193]},"counts_by_year":[],"updated_date":"2026-08-23T07:36:19.812096","created_date":"2020-07-29T00:00:00"}