{"id":"https://openalex.org/W3043809798","doi":"https://doi.org/10.17925/usn.2020.16.1.25","title":"The Upper Nasal Space\u2014A Novel Delivery Route Ideal for Central Nervous System Drugs","display_name":"The Upper Nasal Space\u2014A Novel Delivery Route Ideal for Central Nervous System Drugs","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3043809798","doi":"https://doi.org/10.17925/usn.2020.16.1.25","mag":"3043809798"},"language":"en","primary_location":{"id":"doi:10.17925/usn.2020.16.1.25","doi":"https://doi.org/10.17925/usn.2020.16.1.25","is_oa":true,"landing_page_url":"https://doi.org/10.17925/usn.2020.16.1.25","pdf_url":"https://touchneurology.com/wp-content/uploads/sites/3/2020/07/touchNEURO_US_16.1_p25-31.pdf","source":{"id":"https://openalex.org/S2764952420","display_name":"touchREVIEWS in Neurology","issn_l":"1758-4000","issn":["1758-4000","1758-4019","2752-5465"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40"],"host_organization":"https://openalex.org/P4404675657","host_organization_name":"Touch Medical Media","host_organization_lineage":["https://openalex.org/P4404675657"],"host_organization_lineage_names":["Touch Medical Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://touchneurology.com/wp-content/uploads/sites/3/2020/07/touchNEURO_US_16.1_p25-31.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037010626","display_name":"John Hoekman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116022","display_name":"Impel Neuropharma (United States)","ror":"https://ror.org/02ck4xq38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hoekman","raw_affiliation_strings":["Impel NeuroPharma, Inc., Seattle, WA, USA","Impel NeuroPharma, Inc., 201 Elliott Avenue West, Suite 260, Seattle, WA 98119, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Impel NeuroPharma, Inc., Seattle, WA, USA","institution_ids":["https://openalex.org/I4210116022"]},{"raw_affiliation_string":"Impel NeuroPharma, Inc., 201 Elliott Avenue West, Suite 260, Seattle, WA 98119, USA","institution_ids":["https://openalex.org/I4210116022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062655427","display_name":"Sutapa Ray","orcid":"https://orcid.org/0000-0003-4234-2124","observed_orcids":["https://orcid.org/0000-0003-4234-2124"]},"institutions":[{"id":"https://openalex.org/I4210116022","display_name":"Impel Neuropharma (United States)","ror":"https://ror.org/02ck4xq38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sutapa Ray","raw_affiliation_strings":["Impel NeuroPharma, Inc., Seattle, WA, USA","Impel NeuroPharma, Inc., 201 Elliott Avenue West, Suite 260, Seattle, WA 98119, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Impel NeuroPharma, Inc., Seattle, WA, USA","institution_ids":["https://openalex.org/I4210116022"]},{"raw_affiliation_string":"Impel NeuroPharma, Inc., 201 Elliott Avenue West, Suite 260, Seattle, WA 98119, USA","institution_ids":["https://openalex.org/I4210116022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103077601","display_name":"Sheena K. Aurora","orcid":"https://orcid.org/0000-0002-9425-1710","observed_orcids":["https://orcid.org/0000-0002-9425-1710","https://orcid.org/0000-0002-4534-4937"]},"institutions":[{"id":"https://openalex.org/I4210116022","display_name":"Impel Neuropharma (United States)","ror":"https://ror.org/02ck4xq38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheena K Aurora","raw_affiliation_strings":["Impel NeuroPharma, Inc., Seattle, WA, USA","Seattle , WA , USA","Impel NeuroPharma, Inc., 201 Elliott Avenue West, Suite 260, Seattle, WA 98119, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Impel NeuroPharma, Inc., Seattle, WA, USA","institution_ids":["https://openalex.org/I4210116022"]},{"raw_affiliation_string":"Seattle , WA , USA","institution_ids":[]},{"raw_affiliation_string":"Impel NeuroPharma, Inc., 201 Elliott Avenue West, Suite 260, Seattle, WA 98119, USA","institution_ids":["https://openalex.org/I4210116022"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003930087","display_name":"Stephen Bevan Shrewsbury","orcid":"https://orcid.org/0000-0001-9892-3695","observed_orcids":["https://orcid.org/0000-0001-9892-3695"]},"institutions":[{"id":"https://openalex.org/I4210116022","display_name":"Impel Neuropharma (United States)","ror":"https://ror.org/02ck4xq38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116022"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen B Shrewsbury","raw_affiliation_strings":["Impel NeuroPharma, Inc., 201 Elliott Avenue West, Suite 260, Seattle, WA 98119, USA","Impel NeuroPharma, Inc., Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Impel NeuroPharma, Inc., 201 Elliott Avenue West, Suite 260, Seattle, WA 98119, USA","institution_ids":["https://openalex.org/I4210116022"]},{"raw_affiliation_string":"Impel NeuroPharma, Inc., Seattle, WA, USA","institution_ids":["https://openalex.org/I4210116022"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003930087"],"corresponding_institution_ids":["https://openalex.org/I4210116022"],"apc_list":null,"apc_paid":null,"fwci":1.3628,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.74899001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mucosal-drug-delivery","display_name":"mucosal drug delivery","score":0.777999997138977},{"id":"https://openalex.org/keywords/central-nervous-system-drugs","display_name":"central nervous system drugs","score":0.8569999933242798},{"id":"https://openalex.org/keywords/acute-migraine","display_name":"acute migraine","score":0.6769999861717224},{"id":"https://openalex.org/keywords/acute-agitation","display_name":"acute agitation","score":0.722000002861023},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.5059999823570251},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8664240837097168},{"id":"https://openalex.org/C2776639384","wikidata":"https://www.wikidata.org/wiki/Q840396","display_name":"Ideal (ethics)","level":2,"score":0.6840740442276001},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.41688475012779236},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08514070510864258},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.03866976499557495},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17925/usn.2020.16.1.25","doi":"https://doi.org/10.17925/usn.2020.16.1.25","is_oa":true,"landing_page_url":"https://doi.org/10.17925/usn.2020.16.1.25","pdf_url":"https://touchneurology.com/wp-content/uploads/sites/3/2020/07/touchNEURO_US_16.1_p25-31.pdf","source":{"id":"https://openalex.org/S2764952420","display_name":"touchREVIEWS in Neurology","issn_l":"1758-4000","issn":["1758-4000","1758-4019","2752-5465"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40"],"host_organization":"https://openalex.org/P4404675657","host_organization_name":"Touch Medical Media","host_organization_lineage":["https://openalex.org/P4404675657"],"host_organization_lineage_names":["Touch Medical Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Neurology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.17925/usn.2020.16.1.25","doi":"https://doi.org/10.17925/usn.2020.16.1.25","is_oa":true,"landing_page_url":"https://doi.org/10.17925/usn.2020.16.1.25","pdf_url":"https://touchneurology.com/wp-content/uploads/sites/3/2020/07/touchNEURO_US_16.1_p25-31.pdf","source":{"id":"https://openalex.org/S2764952420","display_name":"touchREVIEWS in Neurology","issn_l":"1758-4000","issn":["1758-4000","1758-4019","2752-5465"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40"],"host_organization":"https://openalex.org/P4404675657","host_organization_name":"Touch Medical Media","host_organization_lineage":["https://openalex.org/P4404675657"],"host_organization_lineage_names":["Touch Medical Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043809798.pdf","grobid_xml":"https://content.openalex.org/works/W3043809798.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1955911053","https://openalex.org/W1973274562","https://openalex.org/W1980229633","https://openalex.org/W1995588113","https://openalex.org/W1997592535","https://openalex.org/W2002482892","https://openalex.org/W2002685901","https://openalex.org/W2024190072","https://openalex.org/W2034346357","https://openalex.org/W2044682044","https://openalex.org/W2053308896","https://openalex.org/W2061537263","https://openalex.org/W2062818994","https://openalex.org/W2072439183","https://openalex.org/W2073110936","https://openalex.org/W2077680189","https://openalex.org/W2082044892","https://openalex.org/W2099390528","https://openalex.org/W2117674127","https://openalex.org/W2150595547","https://openalex.org/W2176431310","https://openalex.org/W2291138254","https://openalex.org/W2295127278","https://openalex.org/W2314706799","https://openalex.org/W2346490116","https://openalex.org/W2530995389","https://openalex.org/W2584037975","https://openalex.org/W2614349964","https://openalex.org/W2796957864","https://openalex.org/W2898410926","https://openalex.org/W2898588982","https://openalex.org/W2909865151","https://openalex.org/W2922496801","https://openalex.org/W3039939193"],"related_works":["https://openalex.org/W3167590384","https://openalex.org/W7156922204","https://openalex.org/W4414715360","https://openalex.org/W4205580278","https://openalex.org/W4380683452","https://openalex.org/W2986872200","https://openalex.org/W4409239018","https://openalex.org/W4381594586","https://openalex.org/W7163737571","https://openalex.org/W2152530280"],"abstract_inverted_index":{"olid":[0],"oral":[1,78,187],"dosage":[2,56,188],"forms":[3,79,189],"account":[4],"for":[5,22,30,54,159,178],"up":[6],"to":[7,60,128,168],"75%":[8],"of":[9,93,135,140,181],"prescriptions,":[10],"but":[11],"their":[12],"effectiveness":[13],"may":[14,26,109,126],"be":[15,27],"limited":[16],"in":[17,45,74,130,155,184],"some":[18,31],"patients,":[19,43],"and":[20,71,100,114,118,163],"inappropriate":[21],"others.While":[23],"injectable":[24],"formulations":[25,57],"an":[28,46],"option":[29],"central":[32],"nervous":[33],"system":[34,147],"(CNS)":[35],"disorders,":[36],"injections":[37],"are":[38,80,190],"poorly":[39],"accepted":[40],"by":[41],"most":[42],"except":[44],"urgent":[47],"or":[48,69],"emergency":[49],"situation.Thus,":[50],"a":[51,89],"need":[52],"exists":[53],"non-oral":[55,144],"as":[58,64],"alternatives":[59],"treat":[61],"conditions":[62],"such":[63],"acute":[65,67],"migraine,":[66],"agitation":[68],"irritability,":[70],"OFF":[72],"episodes":[73],"Parkinson's":[75],"disease,":[76],"where":[77,186],"not":[81,191],"optimal.Nasal":[82],"drug":[83,120],"delivery":[84,146],"has":[85,132],"been":[86,133],"underutilized,":[87],"provides":[88,115],"more":[90],"rapid":[91],"onset":[92],"activity,":[94],"avoids":[95],"gastrointestinal":[96],"(GI)":[97],"tract":[98],"degradation":[99],"first-pass":[101],"hepatic":[102],"metabolism,":[103],"achieves":[104],"faster":[105],"therapeutic":[106],"plasma":[107],"levels,":[108],"reduce":[110],"GI":[111],"adverse":[112],"events,":[113],"patient":[116],"convenience":[117],"ease-of-use.However,":[119],"loss":[121],"from":[122],"the":[123,150,171,179],"nose,":[124],"which":[125],"lead":[127],"variability":[129],"absorption,":[131],"one":[134],"several":[136],"issues":[137],"limiting":[138],"use":[139],"nasal":[141,152],"delivery.An":[142],"innovative,":[143],"drug/device":[145],"that":[148],"targets":[149],"upper":[151],"space":[153],"is":[154,166],"late-stage":[156],"clinical":[157],"development":[158],"treating":[160],"CNS":[161,182],"disorders":[162,183],"its":[164],"availability":[165],"expected":[167],"expand":[169],"over":[170],"next":[172],"few":[173],"years,":[174],"providing":[175],"welcome":[176],"additions":[177],"treatment":[180],"patients":[185],"optimal.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-07-23T00:00:00"}