{"id":"https://openalex.org/W3043757002","doi":"https://doi.org/10.1186/s13287-020-01819-z","title":"Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice","display_name":"Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice","publication_year":2020,"publication_date":"2020-07-17","ids":{"openalex":"https://openalex.org/W3043757002","doi":"https://doi.org/10.1186/s13287-020-01819-z","mag":"3043757002","pmid":"https://pubmed.ncbi.nlm.nih.gov/32680566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7368692"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-020-01819-z","doi":"https://doi.org/10.1186/s13287-020-01819-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-020-01819-z","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-020-01819-z","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-020-01819-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052840928","display_name":"Parinaz Ahangar","orcid":"https://orcid.org/0000-0002-0060-3501","observed_orcids":["https://orcid.org/0000-0002-0060-3501"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Parinaz Ahangar","raw_affiliation_strings":["Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia","Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia","institution_ids":[]},{"raw_affiliation_string":"Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059125013","display_name":"Stuart J. Mills","orcid":"https://orcid.org/0000-0002-2462-7081","observed_orcids":["https://orcid.org/0000-0002-2462-7081"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stuart J. Mills","raw_affiliation_strings":["Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia","Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia","institution_ids":[]},{"raw_affiliation_string":"Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011431485","display_name":"Louise E. Smith","orcid":"https://orcid.org/0000-0003-0659-0884","observed_orcids":["https://orcid.org/0000-0003-0659-0884"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Louise E. Smith","raw_affiliation_strings":["Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia","Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia","institution_ids":[]},{"raw_affiliation_string":"Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061304152","display_name":"Xanthe L. Strudwick","orcid":"https://orcid.org/0000-0002-8557-3857","observed_orcids":["https://orcid.org/0000-0002-8557-3857"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xanthe L. Strudwick","raw_affiliation_strings":["Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023801350","display_name":"Anthony E. Ting","orcid":"https://orcid.org/0000-0002-5058-9576","observed_orcids":["https://orcid.org/0000-0002-5058-9576"]},"institutions":[{"id":"https://openalex.org/I4210129045","display_name":"Athersys (United States)","ror":"https://ror.org/03kned690","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony E. Ting","raw_affiliation_strings":["Athersys, Inc., Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Athersys, Inc., Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210129045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109856779","display_name":"Bart L. T. Vaes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bart Vaes","raw_affiliation_strings":["ReGenesys BVBA, Bio-Incubator Leuven, Gaston Geenslaan 1, 3001, Heverlee, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ReGenesys BVBA, Bio-Incubator Leuven, Gaston Geenslaan 1, 3001, Heverlee, Belgium","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066363767","display_name":"Allison June Cowin","orcid":"https://orcid.org/0000-0003-2885-2080","observed_orcids":["https://orcid.org/0000-0003-2885-2080"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Allison J. Cowin","raw_affiliation_strings":["Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia. allison.cowin@unisa.edu.au","Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia. allison.cowin@unisa.edu.au","Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2885-2080","affiliations":[{"raw_affiliation_string":"Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia. allison.cowin@unisa.edu.au","institution_ids":["https://openalex.org/I170239107"]},{"raw_affiliation_string":"Future Industries Institute, University of South Australia, Adelaide, SA, 5000, Australia. allison.cowin@unisa.edu.au","institution_ids":["https://openalex.org/I170239107"]},{"raw_affiliation_string":"Cell Therapy Manufacturing Cooperative Research Centre, Adelaide, SA, 5000, Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066363767"],"corresponding_institution_ids":["https://openalex.org/I170239107"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":3.8227,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.94416783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"299","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multipotent-adult-progenitor-cells","display_name":"multipotent adult progenitor cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.8299999833106995},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.781000018119812},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.4749999940395355},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":1.0},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.7960000038146973},{"id":"https://openalex.org/keywords/keratinocyte-migration","display_name":"keratinocyte migration","score":0.800000011920929},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.984000027179718},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.859000027179718},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.8199999928474426},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7749999761581421},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.793494701385498},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7808822393417358},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6733380556106567},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6020544767379761},{"id":"https://openalex.org/C2910776680","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Multipotent Stem Cell","level":4,"score":0.49283528327941895},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.43670228123664856},{"id":"https://openalex.org/C2780152582","wikidata":"https://www.wikidata.org/wiki/Q1340830","display_name":"Endothelial progenitor cell","level":4,"score":0.42992621660232544},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4168553054332733},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37247446179389954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3354932963848114},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3134099245071411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31280526518821716},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3097544312477112},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.24733760952949524},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23862400650978088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s13287-020-01819-z","doi":"https://doi.org/10.1186/s13287-020-01819-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-020-01819-z","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-020-01819-z","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7368692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7368692","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmid:32680566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32680566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/126844","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/126844","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1186/s13287-020-01819-z","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:ea3486e4d824405bbf0ed521f92e64a6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ea3486e4d824405bbf0ed521f92e64a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2020)","raw_type":"article"},{"id":"pmh:oai:urm_publish:9916432210901831","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11541.2/143753","pdf_url":null,"source":{"id":"https://openalex.org/S4306402528","display_name":"UniSA Research Outputs Repository (University of South Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170239107","host_organization_name":"University of South Australia","host_organization_lineage":["https://openalex.org/I170239107"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/s13287-020-01819-z","doi":"https://doi.org/10.1186/s13287-020-01819-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-020-01819-z","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-020-01819-z","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5215449178","display_name":null,"funder_award_id":"GNT#1102617","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7435736268","display_name":"New approaches for improving wound repair","funder_award_id":"1102617","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320979","display_name":"University of South Australia","ror":"https://ror.org/01p93h210"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043757002.pdf","grobid_xml":"https://content.openalex.org/works/W3043757002.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1819718829","https://openalex.org/W1857737549","https://openalex.org/W1899095474","https://openalex.org/W1963528166","https://openalex.org/W1965727192","https://openalex.org/W1987150557","https://openalex.org/W1997871127","https://openalex.org/W2006317510","https://openalex.org/W2016292322","https://openalex.org/W2023805473","https://openalex.org/W2024623214","https://openalex.org/W2029908824","https://openalex.org/W2036011070","https://openalex.org/W2037632318","https://openalex.org/W2053404797","https://openalex.org/W2063144617","https://openalex.org/W2074188863","https://openalex.org/W2074269795","https://openalex.org/W2079006707","https://openalex.org/W2081498718","https://openalex.org/W2082909405","https://openalex.org/W2085293124","https://openalex.org/W2103828946","https://openalex.org/W2107324803","https://openalex.org/W2112425800","https://openalex.org/W2145865564","https://openalex.org/W2157517144","https://openalex.org/W2158048826","https://openalex.org/W2167928913","https://openalex.org/W2200899985","https://openalex.org/W2319917718","https://openalex.org/W2336489823","https://openalex.org/W2467979029","https://openalex.org/W2511306639","https://openalex.org/W2529560023","https://openalex.org/W2568737930","https://openalex.org/W2599538813","https://openalex.org/W2609399105","https://openalex.org/W2763780391","https://openalex.org/W2800509487","https://openalex.org/W2801619901","https://openalex.org/W2805568125","https://openalex.org/W2889131405","https://openalex.org/W2902945171","https://openalex.org/W2906744823","https://openalex.org/W2923614429","https://openalex.org/W2925103058","https://openalex.org/W2965308397","https://openalex.org/W3022767352","https://openalex.org/W4300047574"],"related_works":["https://openalex.org/W4386068775","https://openalex.org/W3083993995","https://openalex.org/W2167910835","https://openalex.org/W2920805186","https://openalex.org/W2321725069","https://openalex.org/W2035676423","https://openalex.org/W2403703299","https://openalex.org/W2588161310","https://openalex.org/W2990037441","https://openalex.org/W2886358816"],"abstract_inverted_index":{"BACKGROUND:":[0],"Stem":[1],"cell":[2,270,311],"therapies":[3,17],"have":[4,300],"been":[5,19],"widely":[6],"investigated":[7],"for":[8,182,331,343],"their":[9],"healing":[10,66,83,307,345],"effects.":[11],"However,":[12],"the":[13,22,33,64,76,86,99,146,164,196,253,260,319,332],"translation":[14],"of":[15,48,59,70,78,88,94,101,125,149,157,212,262,321,327,334],"these":[16],"has":[18],"hampered":[20],"by":[21,296,308],"requirement":[23],"to":[24,32,62,74,107,163,188],"deliver":[25],"live":[26],"allogeneic":[27],"or":[28],"autologous":[29],"cells":[30,42,53,80,106,204,232,298],"directly":[31],"wound":[34,65,117,165,254,306],"in":[35,113,136,195,252,259,277],"a":[36,46,56,249,338],"clinical":[37],"setting.":[38],"Multipotent":[39],"adult":[40],"progenitor":[41],"(MAPC\u00ae":[43],"cells)":[44],"are":[45],"subpopulation":[47],"bone":[49],"marrow-derived":[50],"adherent":[51],"stem":[52,328],"that":[54,268,293],"secrete":[55],"wide":[57],"range":[58],"factors":[60,294],"known":[61],"accelerate":[63],"process.":[67],"The":[68,92,123,264],"aim":[69],"this":[71],"study":[72],"was":[73,111,132,186,272,287],"determine":[75],"impact":[77],"MAPC":[79,89,297],"secretome":[81],"on":[82,98,127,145,304],"outcomes":[84],"without":[85],"presence":[87],"cells.":[90],"METHODS:":[91],"effect":[93,124,303],"MAPC-conditioned":[95],"medium":[96],"(MAPC-CM)":[97],"capacity":[100],"keratinocytes,":[102],"fibroblasts":[103,220],"and":[104,109,119,130,154,174,178,192,202,215,228,230,256,284,313,317,324],"endothelial":[105,203,231],"migrate":[108],"proliferate":[110],"determined":[112],"vitro":[114,137],"using":[115,135],"scratch":[116,213],"closure":[118,214],"WST1":[120],"assay,":[121],"respectively.":[122],"MAPC-CM":[126,159,207,223,235,247],"collagen":[128,193],"deposition":[129,194],"angiogenesis":[131,191],"also":[133,266],"assessed":[134],"methods.":[138],"Additionally,":[139],"two":[140],"excisional":[141,242],"wounds":[142,243,335],"were":[143,160,169],"created":[144],"dorsal":[147],"surface":[148],"mice":[150],"(n":[151],"=":[152],"8/group)":[153],"100":[155],"\u03bcL":[156],"20\u00d7":[158],"intradermally":[161,244],"injected":[162,245],"margins.":[166],"Wound":[167],"tissues":[168],"collected":[170],"at":[171],"3,":[172],"7":[173],"14":[175],"days":[176],"post-wounding":[177],"stained":[179],"with":[180,206,222,234,246],"H&E":[181],"microscopic":[183],"analysis.":[184],"Immunohistochemistry":[185],"performed":[187],"investigate":[189],"inflammation,":[190],"wounds.":[197],"RESULTS:":[198],"Skin":[199],"fibroblasts,":[200],"keratinocytes":[201],"treated":[205,221,233],"all":[208],"showed":[209,236,248,267],"improved":[210],"rates":[211],"increased":[216,237],"cellular":[217],"proliferation.":[218],"Moreover,":[219],"deposited":[224],"more":[225,339],"collagens":[226,282],"I":[227,283],"III":[229,285],"capillary":[238],"tube":[239],"formation.":[240],"Murine":[241],"significant":[250],"reduction":[251],"area":[255],"an":[257,275,301],"increase":[258,276],"rate":[261],"reepithelialisation.":[263],"results":[265],"inflammatory":[269],"infiltration":[271],"decreased":[273],"while":[274],"angiogenesis,":[278],"as":[279,281],"well":[280],"expressions,":[286],"observed.":[288],"CONCLUSION:":[289],"These":[290],"findings":[291],"suggest":[292],"produced":[295],"can":[299],"important":[302],"cutaneous":[305],"affecting":[309],"skin":[310],"proliferation":[312],"migration,":[314],"balancing":[315],"inflammation":[316],"improving":[318,344],"formation":[320],"extracellular":[322],"matrix":[323],"angiogenesis.":[325],"Development":[326],"cell-free":[329],"therapy":[330],"treatment":[333],"may":[336],"be":[337],"clinically":[340],"translatable":[341],"approach":[342],"outcomes.":[346]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-23T00:00:00"}
