{"id":"https://openalex.org/W3043684530","doi":"https://doi.org/10.5812/jjm.100654","title":"The Role of Some Transcription Factors in Expression of GyrA and GyrB Following Exposure to Ciprofloxacin","display_name":"The Role of Some Transcription Factors in Expression of GyrA and GyrB Following Exposure to Ciprofloxacin","publication_year":2020,"publication_date":"2020-07-14","ids":{"openalex":"https://openalex.org/W3043684530","doi":"https://doi.org/10.5812/jjm.100654","mag":"3043684530"},"language":"en","primary_location":{"id":"doi:10.5812/jjm.100654","doi":"https://doi.org/10.5812/jjm.100654","is_oa":true,"landing_page_url":"https://doi.org/10.5812/jjm.100654","pdf_url":"https://sites.kowsarpub.com/jjm/cdn/dl/9c8bcaa4-c92b-11ea-99b3-9f9978cf9f27","source":{"id":"https://openalex.org/S2481182593","display_name":"Jundishapur Journal of Microbiology","issn_l":"2008-3645","issn":["2008-3645","2008-4161"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-70","russia-white-list-4"],"host_organization":"https://openalex.org/P4362561684","host_organization_name":"Brieflands","host_organization_lineage":["https://openalex.org/P4362561684"],"host_organization_lineage_names":["Brieflands"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jundishapur Journal of Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://sites.kowsarpub.com/jjm/cdn/dl/9c8bcaa4-c92b-11ea-99b3-9f9978cf9f27","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000468421","display_name":"Razieh Pourahmad Jaktaji","orcid":"https://orcid.org/0000-0002-5550-5669","observed_orcids":["https://orcid.org/0000-0002-5550-5669"]},"institutions":[{"id":"https://openalex.org/I127908078","display_name":"Shahrekord University","ror":"https://ror.org/051rngw70","country_code":"IR","type":"education","lineage":["https://openalex.org/I127908078"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Razieh Pourahmad Jaktaji","raw_affiliation_strings":["Department of Genetics, Faculty of Sciences, Shahrekord University, Shahrekord, Iran"],"raw_orcid":"https://orcid.org/0000-0002-5550-5669","affiliations":[{"raw_affiliation_string":"Department of Genetics, Faculty of Sciences, Shahrekord University, Shahrekord, Iran","institution_ids":["https://openalex.org/I127908078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006905115","display_name":"Seyyed Mohammad Lesani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127908078","display_name":"Shahrekord University","ror":"https://ror.org/051rngw70","country_code":"IR","type":"education","lineage":["https://openalex.org/I127908078"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Mohammad Lesani","raw_affiliation_strings":["Department of Genetics, Faculty of Sciences, Shahrekord University, Shahrekord, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Faculty of Sciences, Shahrekord University, Shahrekord, Iran","institution_ids":["https://openalex.org/I127908078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003631802","display_name":"Hoda Akhavan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127908078","display_name":"Shahrekord University","ror":"https://ror.org/051rngw70","country_code":"IR","type":"education","lineage":["https://openalex.org/I127908078"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hoda Akhavan","raw_affiliation_strings":["Department of Genetics, Faculty of Sciences, Shahrekord University, Shahrekord, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Faculty of Sciences, Shahrekord University, Shahrekord, Iran","institution_ids":["https://openalex.org/I127908078"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028671182","display_name":"Maryam Tanhaei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127908078","display_name":"Shahrekord University","ror":"https://ror.org/051rngw70","country_code":"IR","type":"education","lineage":["https://openalex.org/I127908078"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maryam Tanhaei","raw_affiliation_strings":["Department of Genetics, Faculty of Sciences, Shahrekord University, Shahrekord, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Faculty of Sciences, Shahrekord University, Shahrekord, Iran","institution_ids":["https://openalex.org/I127908078"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I127908078"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"13","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7329999804496765},{"id":"https://openalex.org/keywords/gyra","display_name":"gyrA","score":0.9120000004768372},{"id":"https://openalex.org/keywords/gyrb","display_name":"gyrB","score":1.0},{"id":"https://openalex.org/keywords/dna-gyrase","display_name":"DNA gyrase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8410000205039978},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cspa","display_name":"CspA","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sox","display_name":"SOX","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8149999976158142},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/promoter-analysis","display_name":"promoter analysis","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C167125095","wikidata":"https://www.wikidata.org/wiki/Q70551687","display_name":"DNA gyrase","level":4,"score":0.791566014289856},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6965051293373108},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6951472759246826},{"id":"https://openalex.org/C158456008","wikidata":"https://www.wikidata.org/wiki/Q412639","display_name":"DNA supercoil","level":4,"score":0.5747994184494019},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5667457580566406},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5535481572151184},{"id":"https://openalex.org/C26261996","wikidata":"https://www.wikidata.org/wiki/Q2382392","display_name":"Bacterial transcription","level":5,"score":0.535637378692627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5353971123695374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5244353413581848},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4609895348548889},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4519840478897095},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.34547287225723267},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.08687782287597656},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5812/jjm.100654","doi":"https://doi.org/10.5812/jjm.100654","is_oa":true,"landing_page_url":"https://doi.org/10.5812/jjm.100654","pdf_url":"https://sites.kowsarpub.com/jjm/cdn/dl/9c8bcaa4-c92b-11ea-99b3-9f9978cf9f27","source":{"id":"https://openalex.org/S2481182593","display_name":"Jundishapur Journal of Microbiology","issn_l":"2008-3645","issn":["2008-3645","2008-4161"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-70","russia-white-list-4"],"host_organization":"https://openalex.org/P4362561684","host_organization_name":"Brieflands","host_organization_lineage":["https://openalex.org/P4362561684"],"host_organization_lineage_names":["Brieflands"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jundishapur Journal of Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5812/jjm.100654","doi":"https://doi.org/10.5812/jjm.100654","is_oa":true,"landing_page_url":"https://doi.org/10.5812/jjm.100654","pdf_url":"https://sites.kowsarpub.com/jjm/cdn/dl/9c8bcaa4-c92b-11ea-99b3-9f9978cf9f27","source":{"id":"https://openalex.org/S2481182593","display_name":"Jundishapur Journal of Microbiology","issn_l":"2008-3645","issn":["2008-3645","2008-4161"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-70","russia-white-list-4"],"host_organization":"https://openalex.org/P4362561684","host_organization_name":"Brieflands","host_organization_lineage":["https://openalex.org/P4362561684"],"host_organization_lineage_names":["Brieflands"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jundishapur Journal of Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322969","display_name":"Shahrekord University","ror":"https://ror.org/051rngw70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043684530.pdf","grobid_xml":"https://content.openalex.org/works/W3043684530.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1522037109","https://openalex.org/W1593506705","https://openalex.org/W1970146765","https://openalex.org/W1986475965","https://openalex.org/W1993935068","https://openalex.org/W2015427539","https://openalex.org/W2018527742","https://openalex.org/W2025268256","https://openalex.org/W2042245212","https://openalex.org/W2092077402","https://openalex.org/W2094420829","https://openalex.org/W2099249565","https://openalex.org/W2101322984","https://openalex.org/W2111967267","https://openalex.org/W2135664793","https://openalex.org/W2135671499","https://openalex.org/W2139902819","https://openalex.org/W2145570359","https://openalex.org/W2153212982","https://openalex.org/W2170883440","https://openalex.org/W2178172097","https://openalex.org/W2503317918","https://openalex.org/W2786049734","https://openalex.org/W2799373046","https://openalex.org/W2799775155"],"related_works":["https://openalex.org/W2066582373","https://openalex.org/W2896140118","https://openalex.org/W422602837","https://openalex.org/W2894337529","https://openalex.org/W7073928939","https://openalex.org/W2049715604","https://openalex.org/W2144174304","https://openalex.org/W2100403564","https://openalex.org/W2161386605","https://openalex.org/W1782700290"],"abstract_inverted_index":{"Background:":[0],"GyrA":[1],"and":[2,27,35,56,87,112,138,160,168,172,219,227],"gyrB":[3,161,220],"genes":[4,72,121,162,221],"encode":[5],"DNA":[6,12],"gyrase":[7],"subunits.":[8],"This":[9],"enzyme":[10],"regulates":[11],"supercoiling.":[13],"Inhibitors":[14],"of":[15,25,31,40,54,61,70,80,89,120,145,158,170,182,195,209,217],"this":[16,41,95],"enzyme,":[17],"such":[18],"as":[19,198],"ciprofloxacin,":[20],"may":[21,232],"change":[22],"the":[23,28,52,59,68,85,97,166,179,193],"level":[24,30],"supercoiling":[26],"expression":[29,53,69,119,157,194],"genes,":[32,197],"including":[33],"gyrA":[34,55,159,218],"gyrB.":[36,57],"Objectives:":[37],"The":[38,117,156],"aims":[39],"research":[42],"were":[43],"first":[44],"to":[45,82,110,178,245],"select":[46,113],"some":[47,114],"transcription":[48,63,91,115,140,174,186,229],"factors,":[49,230],"which":[50],"regulate":[51],"Secondly,":[58],"effect":[60],"these":[62,71,90,196],"factors":[64,141,175],"was":[65,108,122,201],"investigated":[66],"on":[67,192,225,236],"in":[73,84,103,165,240],"Escherichia":[74],"coli":[75],"mutants":[76],"with":[77,205],"different":[78],"levels":[79],"resistance":[81],"ciprofloxacin":[83],"presence":[86,167],"absence":[88,169],"factors.":[92,116],"Methods:":[93],"For":[94],"purpose,":[96],"online":[98],"software":[99],"called":[100],"Promoter":[101],"Analyzer":[102],"Virtual":[104],"Footprint":[105],"version":[106],"3":[107],"used":[109],"find":[111],"relative":[118],"determined":[123],"by":[124],"quantitative":[125],"real-time":[126],"polymerase":[127],"chain":[128],"reaction":[129],"(qRT-PCR).":[130],"Results:":[131],"Theoretical":[132],"results":[133],"showed":[134],"that":[135,215],"CspA,":[136],"FhlA,":[137],"SoxS":[139,185],"(with":[142],"a":[143,206],"score":[144],"match":[146],"higher":[147,207],"than":[148],"6),":[149],"could":[150],"be":[151,233],"selected":[152],"for":[153],"further":[154],"analysis.":[155],"remained":[163],"unchanged":[164],"CspA":[171,226],"FhlA":[173,228],"following":[176,203,243],"exposure":[177,244],"low":[180],"amount":[181,208],"ciprofloxacin.":[183,210,246],"However,":[184],"activator":[187],"might":[188],"have":[189],"indirect":[190],"effects":[191],"soxS":[199],"gene":[200],"overexpressed":[202],"treatment":[204],"Conclusions:":[211],"It":[212],"is":[213,222],"concluded":[214],"overexpression":[216],"not":[223],"dependent":[224,234],"but":[231],"indirectly":[235],"regulatory":[237],"proteins":[238],"involved":[239],"oxidative":[241],"stress":[242]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-07-23T00:00:00"}