{"id":"https://openalex.org/W3043674480","doi":"https://doi.org/10.1038/s43018-020-0094-7","title":"Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma","display_name":"Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma","publication_year":2020,"publication_date":"2020-07-20","ids":{"openalex":"https://openalex.org/W3043674480","doi":"https://doi.org/10.1038/s43018-020-0094-7","mag":"3043674480","pmid":"https://pubmed.ncbi.nlm.nih.gov/35122047"},"language":"en","primary_location":{"id":"doi:10.1038/s43018-020-0094-7","doi":"https://doi.org/10.1038/s43018-020-0094-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s43018-020-0094-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210236562","display_name":"Nature Cancer","issn_l":"2662-1347","issn":["2662-1347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.research.ed.ac.uk/en/publications/09dd603d-a669-4b75-b196-099a547a63ed","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001287563","display_name":"Lukas Tamayo-Orrego","orcid":"https://orcid.org/0000-0001-7041-4848","observed_orcids":["https://orcid.org/0000-0001-7041-4848"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]},{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"Lukas Tamayo-Orrego","raw_affiliation_strings":["Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada","MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK","Montreal Clinical Research Institute, Montreal, Quebec, Canada","Integrated Program in Neuroscience, McGill University, Montreal, Canada","Montreal Clinical Research Institute, Montreal, Canada"],"raw_orcid":"https://orcid.org/0000-0001-7041-4848","affiliations":[{"raw_affiliation_string":"Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I4387154614","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Integrated Program in Neuroscience, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112580675","display_name":"David Gallo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David Gallo","raw_affiliation_strings":["Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada","Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]},{"raw_affiliation_string":"Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048297917","display_name":"Fr\u00e9d\u00e9ric Racicot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Racicot","raw_affiliation_strings":["Department of Medicine, University of Montreal, Montreal, Quebec, Canada","Montreal Clinical Research Institute, Montreal, Quebec, Canada","Department of Medicine, University of Montreal, Montreal, Canada","Montreal Clinical Research Institute, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Montreal, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Department of Medicine, University of Montreal, Montreal, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046125890","display_name":"Amandine Bemmo","orcid":"https://orcid.org/0009-0008-0095-2243","observed_orcids":["https://orcid.org/0009-0008-0095-2243"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amandine Bemmo","raw_affiliation_strings":["Montreal Clinical Research Institute, Montreal, Quebec, Canada","Montreal Clinical Research Institute, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027074869","display_name":"Sushmetha Mohan","orcid":"https://orcid.org/0000-0002-6452-7253","observed_orcids":["https://orcid.org/0000-0002-6452-7253"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sushmetha Mohan","raw_affiliation_strings":["Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada","Montreal Clinical Research Institute, Montreal, Quebec, Canada","Integrated Program in Neuroscience, McGill University, Montreal, Canada","Montreal Clinical Research Institute, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Integrated Program in Neuroscience, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071852201","display_name":"Brandon Ho","orcid":"https://orcid.org/0000-0002-7566-3007","observed_orcids":["https://orcid.org/0000-0002-7566-3007","https://orcid.org/0009-0009-3948-3656"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brandon Ho","raw_affiliation_strings":["Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada","Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]},{"raw_affiliation_string":"Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000337887","display_name":"Samer Salameh","orcid":"https://orcid.org/0000-0001-6100-8514","observed_orcids":["https://orcid.org/0000-0001-6100-8514"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Samer Salameh","raw_affiliation_strings":["Montreal Clinical Research Institute, Montreal, Quebec, Canada","Montreal Clinical Research Institute, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111338847","display_name":"T Hoang","orcid":"https://orcid.org/0000-0001-7528-9142","observed_orcids":["https://orcid.org/0000-0001-7528-9142"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Trang Hoang","raw_affiliation_strings":["Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada","Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048144016","display_name":"Andrew P. Jackson","orcid":"https://orcid.org/0000-0002-8739-2646","observed_orcids":["https://orcid.org/0000-0002-8739-2646"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew P. Jackson","raw_affiliation_strings":["MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I4387154614","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069152548","display_name":"Grant W. Brown","orcid":"https://orcid.org/0000-0002-9002-5003","observed_orcids":["https://orcid.org/0000-0002-9002-5003"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Grant W. Brown","raw_affiliation_strings":["Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada","Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9002-5003","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]},{"raw_affiliation_string":"Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058655954","display_name":"Fr\u00e9d\u00e9ric Charron","orcid":"https://orcid.org/0000-0003-3483-8672","observed_orcids":["https://orcid.org/0000-0003-3483-8672"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Fr\u00e9d\u00e9ric Charron","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. Frederic.Charron@ircm.qc.ca","Department of Medicine, University of Montreal, Montreal, Quebec, Canada. Frederic.Charron@ircm.qc.ca","Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada. Frederic.Charron@ircm.qc.ca","Montreal Clinical Research Institute, Montreal, Quebec, Canada. Frederic.Charron@ircm.qc.ca","Department of Anatomy and Cell Biology, Division of Experimental Medicine, McGill University, Montreal, Canada","Department of Medicine, University of Montreal, Montreal, Canada","Integrated Program in Neuroscience, McGill University, Montreal, Canada","Montreal Clinical Research Institute, Montreal, Canada"],"raw_orcid":"https://orcid.org/0000-0003-3483-8672","affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. Frederic.Charron@ircm.qc.ca","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Medicine, University of Montreal, Montreal, Quebec, Canada. Frederic.Charron@ircm.qc.ca","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada. Frederic.Charron@ircm.qc.ca","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Quebec, Canada. Frederic.Charron@ircm.qc.ca","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Division of Experimental Medicine, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Medicine, University of Montreal, Montreal, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Integrated Program in Neuroscience, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Montreal Clinical Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I4210158752"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5058655954"],"corresponding_institution_ids":["https://openalex.org/I4210158752","https://openalex.org/I5023651","https://openalex.org/I70931966"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":0.9689,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.71739313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"1","issue":"8","first_page":"840","last_page":"854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.7450000047683716},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.9649999737739563},{"id":"https://openalex.org/keywords/granule-cell-progenitors","display_name":"granule cell progenitors","score":0.800000011920929},{"id":"https://openalex.org/keywords/ptch1-mutation","display_name":"PTCH1 mutation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cdc7","display_name":"CDC7","score":0.7229999899864197},{"id":"https://openalex.org/keywords/replication-origin-firing","display_name":"replication origin firing","score":0.7820000052452087},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/recombination","display_name":"recombination","score":0.5920000076293945},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tumor-suppressor-loss","display_name":"tumor suppressor loss","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.7484237551689148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6620261669158936},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.6424644589424133},{"id":"https://openalex.org/C2779477247","wikidata":"https://www.wikidata.org/wiki/Q18030895","display_name":"PTCH1","level":4,"score":0.5874975919723511},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.511898398399353},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.47347986698150635},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.47203031182289124},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4255627989768982},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.396157830953598},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3692917823791504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24684327840805054},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2022341787815094},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.12436646223068237},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.11274397373199463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09260222315788269}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s43018-020-0094-7","doi":"https://doi.org/10.1038/s43018-020-0094-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s43018-020-0094-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210236562","display_name":"Nature Cancer","issn_l":"2662-1347","issn":["2662-1347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cancer","raw_type":"journal-article"},{"id":"pmid:35122047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35122047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cancer","raw_type":"Journal Article"},{"id":"pmh:oai:papyrus.bib.umontreal.ca:1866/25802","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1866/25802","pdf_url":null,"source":{"id":"https://openalex.org/S4306402422","display_name":"Papyrus : Institutional Repository (Universit\u00e9 de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70931966","host_organization_name":"Universit\u00e9 de Montr\u00e9al","host_organization_lineage":["https://openalex.org/I70931966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/09dd603d-a669-4b75-b196-099a547a63ed","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/09dd603d-a669-4b75-b196-099a547a63ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tamayo Orrego, L, Gallo, D, Racicot, F, Bemmo, A, Mohan, S, Ho, B, Salameh, S, Hoang, T, Jackson, A P, Brown, G W & Charron, F 2020, 'Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma', nature cancer. https://doi.org/10.1038/s43018-020-0094-7","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:umontreal.scholaris.ca:1866/25802","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1866/25802","pdf_url":null,"source":{"id":"https://openalex.org/S4306402422","display_name":"Papyrus : Institutional Repository (Universit\u00e9 de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70931966","host_organization_name":"Universit\u00e9 de Montr\u00e9al","host_organization_lineage":["https://openalex.org/I70931966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:pure.ed.ac.uk:openaire/09dd603d-a669-4b75-b196-099a547a63ed","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/09dd603d-a669-4b75-b196-099a547a63ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tamayo Orrego, L, Gallo, D, Racicot, F, Bemmo, A, Mohan, S, Ho, B, Salameh, S, Hoang, T, Jackson, A P, Brown, G W & Charron, F 2020, 'Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma', nature cancer. https://doi.org/10.1038/s43018-020-0094-7","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3658313726","display_name":null,"funder_award_id":"FDN334023","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8293268018","display_name":"From Microcephaly to Genome Stability,\nInflammation and Growth Regulation","funder_award_id":"MC_UU_00007/5","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1538419182","https://openalex.org/W1558536089","https://openalex.org/W1965749659","https://openalex.org/W1970471893","https://openalex.org/W1972207998","https://openalex.org/W1978281222","https://openalex.org/W1980052833","https://openalex.org/W1983341583","https://openalex.org/W1988157442","https://openalex.org/W1990194472","https://openalex.org/W2000206408","https://openalex.org/W2000285763","https://openalex.org/W2007978249","https://openalex.org/W2008628928","https://openalex.org/W2010070263","https://openalex.org/W2011334551","https://openalex.org/W2012172422","https://openalex.org/W2024218777","https://openalex.org/W2025211302","https://openalex.org/W2025555587","https://openalex.org/W2033421234","https://openalex.org/W2039379153","https://openalex.org/W2040860750","https://openalex.org/W2041156660","https://openalex.org/W2044440192","https://openalex.org/W2059971436","https://openalex.org/W2066663722","https://openalex.org/W2075126779","https://openalex.org/W2077953899","https://openalex.org/W2082559623","https://openalex.org/W2088342479","https://openalex.org/W2090431588","https://openalex.org/W2095934571","https://openalex.org/W2098176608","https://openalex.org/W2102619694","https://openalex.org/W2107632586","https://openalex.org/W2108234281","https://openalex.org/W2112582433","https://openalex.org/W2113896971","https://openalex.org/W2117649003","https://openalex.org/W2118124054","https://openalex.org/W2119657716","https://openalex.org/W2121371748","https://openalex.org/W2124679757","https://openalex.org/W2124694478","https://openalex.org/W2125003792","https://openalex.org/W2131075994","https://openalex.org/W2134526812","https://openalex.org/W2137279272","https://openalex.org/W2141458291","https://openalex.org/W2142837955","https://openalex.org/W2144141448","https://openalex.org/W2146728635","https://openalex.org/W2147270524","https://openalex.org/W2150898138","https://openalex.org/W2152640619","https://openalex.org/W2160131663","https://openalex.org/W2163229522","https://openalex.org/W2165234308","https://openalex.org/W2165860917","https://openalex.org/W2167827709","https://openalex.org/W2169086574","https://openalex.org/W2169456326","https://openalex.org/W2170551349","https://openalex.org/W2171808845","https://openalex.org/W2178538878","https://openalex.org/W2179438025","https://openalex.org/W2258517306","https://openalex.org/W2299938884","https://openalex.org/W2399794084","https://openalex.org/W2405513305","https://openalex.org/W2416768224","https://openalex.org/W2547259137","https://openalex.org/W2558601904","https://openalex.org/W2563186352","https://openalex.org/W2581259096","https://openalex.org/W2604024577","https://openalex.org/W2626440326","https://openalex.org/W2737542366","https://openalex.org/W2788084906","https://openalex.org/W2810748925","https://openalex.org/W2886241640","https://openalex.org/W2891014905","https://openalex.org/W2902131125","https://openalex.org/W2945933050","https://openalex.org/W2993772396","https://openalex.org/W4243843501"],"related_works":["https://openalex.org/W2941922482","https://openalex.org/W3076680698","https://openalex.org/W7095729553","https://openalex.org/W2011334551","https://openalex.org/W7161999464","https://openalex.org/W2010070263","https://openalex.org/W7099902592","https://openalex.org/W1983711805","https://openalex.org/W2399794084","https://openalex.org/W7028572421"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-07-23T00:00:00"}
