{"id":"https://openalex.org/W3043660183","doi":"https://doi.org/10.31549/2542-1174-2020-1-65-75","title":"The estimation of infl uence of CYP3A activity on the effi cacy and safety of fl uvoxamine in patients with depressive disorders comorbid with alcohol use disorder","display_name":"The estimation of infl uence of CYP3A activity on the effi cacy and safety of fl uvoxamine in patients with depressive disorders comorbid with alcohol use disorder","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3043660183","doi":"https://doi.org/10.31549/2542-1174-2020-1-65-75","mag":"3043660183"},"language":"en","primary_location":{"id":"doi:10.31549/2542-1174-2020-1-65-75","doi":"https://doi.org/10.31549/2542-1174-2020-1-65-75","is_oa":true,"landing_page_url":"https://doi.org/10.31549/2542-1174-2020-1-65-75","pdf_url":"https://doi.org/10.31549/2542-1174-2020-1-65-75","source":{"id":"https://openalex.org/S2764631268","display_name":"JOURNAL of SIBERIAN MEDICAL SCIENCES","issn_l":"2542-1174","issn":["2542-1174"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":"https://openalex.org/P4328141994","host_organization_name":"Editorial Office of the Journal of Siberian Medical Sciences","host_organization_lineage":["https://openalex.org/P4328141994"],"host_organization_lineage_names":["Editorial Office of the Journal of Siberian Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL of SIBERIAN MEDICAL SCIENCES","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.31549/2542-1174-2020-1-65-75","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102893869","display_name":"\u041c\u0438\u0445\u0430\u0438\u043b \u0421\u0435\u0440\u0433\u0435\u0435\u0432\u0438\u0447 \u0417\u0430\u0441\u0442\u0440\u043e\u0436\u0438\u043d","orcid":"https://orcid.org/0000-0002-3964-9726","observed_orcids":["https://orcid.org/0000-0002-3964-9726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.S. Zastrozhin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103076195","display_name":"Smirnov Vv","orcid":"https://orcid.org/0000-0002-8232-6682","observed_orcids":["https://orcid.org/0000-0002-8232-6682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V.V. Smirnov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008334588","display_name":"\u0417\u0430\u0441\u0442\u0440\u043e\u0436\u0438\u043d\u0430 \u0410\u043d\u0430\u0441\u0442\u0430\u0441\u0438\u044f \u041a\u043e\u043d\u0441\u0442\u0430\u043d\u0442\u0438\u043d\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-1622-6456","observed_orcids":["https://orcid.org/0000-0002-1622-6456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.K. Zastrozhina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026059232","display_name":"\u0415. \u0410. \u0413\u0440\u0438\u0448\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0002-5621-8266","observed_orcids":["https://orcid.org/0000-0002-5621-8266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.A. Grishina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111078904","display_name":"Kristina Ryzhikova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.A. Ryzhikova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091082456","display_name":"Valentin Yurievich Skryabin","orcid":"https://orcid.org/0000-0002-4942-8556","observed_orcids":["https://orcid.org/0000-0002-4942-8556"]},"institutions":[{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4405260047","display_name":"Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare","ror":"https://ror.org/0352ndv59","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4405260047"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.Yu. Skryabin","raw_affiliation_strings":["Moscow Research and Practical Centre for Narcology","Russian Medical Academy of Continuous Professional Education (Moscow)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow Research and Practical Centre for Narcology","institution_ids":["https://openalex.org/I4405260047"]},{"raw_affiliation_string":"Russian Medical Academy of Continuous Professional Education (Moscow)","institution_ids":["https://openalex.org/I4210108300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072317985","display_name":"\u0412. \u0412. \u0428\u0438\u043f\u0438\u0446\u044b\u043d","orcid":"https://orcid.org/0000-0003-0769-9072","observed_orcids":["https://orcid.org/0000-0003-0769-9072","https://orcid.org/0009-0008-0825-4079","https://orcid.org/0009-0009-0515-3202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V.V. Shipitsyn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058317898","display_name":"Evgeny Alekseevich Bryun","orcid":"https://orcid.org/0000-0002-8366-9732","observed_orcids":["https://orcid.org/0000-0002-8366-9732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.A. Bryun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091837013","display_name":"Dmitry Alekseevich Sychev","orcid":"https://orcid.org/0000-0002-4496-3680","observed_orcids":["https://orcid.org/0000-0002-4496-3680"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.A. Sychev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":"1","first_page":"65","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluvoxamine","display_name":"fluvoxamine","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.7429999709129333},{"id":"https://openalex.org/keywords/depressive-disorders","display_name":"depressive disorders","score":0.6190000176429749},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9869999885559082},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6700000166893005},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2780707294","wikidata":"https://www.wikidata.org/wiki/Q27795853","display_name":"Effi","level":2,"score":0.8457521200180054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48157620429992676},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.4637477993965149},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.44577646255493164},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.43088412284851074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4010927379131317},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35582563281059265},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.33634448051452637},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17930841445922852},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.059460192918777466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.056239575147628784},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.05370187759399414},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.05157199501991272},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31549/2542-1174-2020-1-65-75","doi":"https://doi.org/10.31549/2542-1174-2020-1-65-75","is_oa":true,"landing_page_url":"https://doi.org/10.31549/2542-1174-2020-1-65-75","pdf_url":"https://doi.org/10.31549/2542-1174-2020-1-65-75","source":{"id":"https://openalex.org/S2764631268","display_name":"JOURNAL of SIBERIAN MEDICAL SCIENCES","issn_l":"2542-1174","issn":["2542-1174"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":"https://openalex.org/P4328141994","host_organization_name":"Editorial Office of the Journal of Siberian Medical Sciences","host_organization_lineage":["https://openalex.org/P4328141994"],"host_organization_lineage_names":["Editorial Office of the Journal of Siberian Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL of SIBERIAN MEDICAL SCIENCES","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31549/2542-1174-2020-1-65-75","doi":"https://doi.org/10.31549/2542-1174-2020-1-65-75","is_oa":true,"landing_page_url":"https://doi.org/10.31549/2542-1174-2020-1-65-75","pdf_url":"https://doi.org/10.31549/2542-1174-2020-1-65-75","source":{"id":"https://openalex.org/S2764631268","display_name":"JOURNAL of SIBERIAN MEDICAL SCIENCES","issn_l":"2542-1174","issn":["2542-1174"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":"https://openalex.org/P4328141994","host_organization_name":"Editorial Office of the Journal of Siberian Medical Sciences","host_organization_lineage":["https://openalex.org/P4328141994"],"host_organization_lineage_names":["Editorial Office of the Journal of Siberian Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL of SIBERIAN MEDICAL SCIENCES","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043660183.pdf","grobid_xml":"https://content.openalex.org/works/W3043660183.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1520905620","https://openalex.org/W1742833546","https://openalex.org/W1973405277","https://openalex.org/W2002814172","https://openalex.org/W2082335023","https://openalex.org/W2098644261","https://openalex.org/W2105802467","https://openalex.org/W2116232595","https://openalex.org/W2156423252","https://openalex.org/W2166281097","https://openalex.org/W2313528546","https://openalex.org/W2568301711","https://openalex.org/W2594003660","https://openalex.org/W2744757105","https://openalex.org/W2777136209","https://openalex.org/W2800259946","https://openalex.org/W2810273127","https://openalex.org/W2898228799","https://openalex.org/W2973117859"],"related_works":["https://openalex.org/W2911584459","https://openalex.org/W3217527166","https://openalex.org/W4237672525","https://openalex.org/W3044343159","https://openalex.org/W4389318253","https://openalex.org/W7214165382","https://openalex.org/W3172475498","https://openalex.org/W2087863011","https://openalex.org/W1772928229","https://openalex.org/W4232110541"],"abstract_inverted_index":{"\u041e\u0446\u0435\u043d\u043a\u0430":[0],"\u0432\u043b\u0438\u044f\u043d\u0438\u044f":[1],"\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438":[2],"CYP3A":[3],"\u043d\u0430":[4],"\u043f\u0440\u043e\u0444\u0438\u043b\u044c":[5],"\u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438":[6],"\u0438":[7],"\u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438":[8],"\u0444\u043b\u0443\u0432\u043e\u043a\u0441\u0430\u043c\u0438\u043d\u0430":[9],"\u0443":[10],"\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432":[11],"\u0441":[12,16],"\u0434\u0435\u043f\u0440\u0435\u0441\u0441\u0438\u0432\u043d\u044b\u043c\u0438":[13],"\u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u0430\u043c\u0438,":[14],"\u043a\u043e\u043c\u043e\u0440\u0431\u0438\u0434\u043d\u044b\u043c\u0438":[15],"\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439":[17],"\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442\u044c\u044e":[18],"\u0417\u0430\u0441\u0442\u0440\u043e\u0436\u0438\u043d":[19],"\u041c.":[20]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-07-23T00:00:00"}