{"id":"https://openalex.org/W304359854","doi":null,"title":"Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system.","display_name":"Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system.","publication_year":1968,"publication_date":"1968-06-01","ids":{"openalex":"https://openalex.org/W304359854","mag":"304359854","pmid":"https://pubmed.ncbi.nlm.nih.gov/5662582","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1578905"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1578905","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1578905","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1578905","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051951700","display_name":"Henry Gewurz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Gewurz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007558567","display_name":"R. J. Pickering","orcid":"https://orcid.org/0000-0002-2128-1281","observed_orcids":["https://orcid.org/0000-0002-2128-1281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Pickering","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105464487","display_name":"C L Christian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Christian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020405246","display_name":"Ralph Snyderman M. D","orcid":"https://orcid.org/0009-0003-5252-5036","observed_orcids":["https://orcid.org/0009-0003-5252-5036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Snyderman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111864498","display_name":"Stephen E. Mergenhagen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Mergenhagen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112156868","display_name":"R. A. Good","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Good","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5929,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.80895942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"3","issue":"5","first_page":"437","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agammaglobulinemia","display_name":"agammaglobulinemia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/agglutination","display_name":"agglutination","score":0.6990000009536743},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immunodeficiency-diagnosis","display_name":"immunodeficiency diagnosis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/agglutinins","display_name":"agglutinins","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5050087571144104},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.4700269401073456},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42916160821914673},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.4249248504638672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4085661768913269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3722132444381714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17406022548675537},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.06880128383636475},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000371","descriptor_name":"Agglutination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000372","descriptor_name":"Agglutination Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011232","descriptor_name":"Chemical Precipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1578905","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1578905","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:5662582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5662582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:304359854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5662582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1578905","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1578905","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W62525439","https://openalex.org/W1532813778","https://openalex.org/W1965567707","https://openalex.org/W1974054467","https://openalex.org/W1975356212","https://openalex.org/W1991473086","https://openalex.org/W1999966048","https://openalex.org/W2017029740","https://openalex.org/W2021154126","https://openalex.org/W2030238097","https://openalex.org/W2030437989","https://openalex.org/W2035237054","https://openalex.org/W2044252902","https://openalex.org/W2047726406","https://openalex.org/W2051931035","https://openalex.org/W2058203662","https://openalex.org/W2080471101","https://openalex.org/W2085128918","https://openalex.org/W2097219958","https://openalex.org/W2108849412","https://openalex.org/W2137103323","https://openalex.org/W2198351528","https://openalex.org/W2318002908","https://openalex.org/W2403185327","https://openalex.org/W2404426228","https://openalex.org/W2411239092","https://openalex.org/W2733832760","https://openalex.org/W4313376178","https://openalex.org/W4322149176"],"related_works":["https://openalex.org/W2394659621","https://openalex.org/W1773463083","https://openalex.org/W2121548163","https://openalex.org/W2404410222","https://openalex.org/W2063529455","https://openalex.org/W337144911","https://openalex.org/W1982818541","https://openalex.org/W2314118427","https://openalex.org/W2027458370","https://openalex.org/W1485406306"],"abstract_inverted_index":{"In":[0],"both":[1],"C'(1q)":[2,24,45,64,78,91],"protein":[3],"and":[4,12,41,58],"agglutination":[5],"assays,":[6],"markedly":[7],"reduced":[8],"mean":[9],"titres":[10,25,46],"(27":[11],"<10%":[13],"normal,":[14,43],"respectively)":[15],"were":[16,26,47,80],"observed":[17],"in":[18,29,51,72,82,98,103,115],"Swiss":[19,87],"type":[20],"lymphopenic":[21,83],"agammaglobulinaemia.":[22],"Mean":[23],"somewhat":[27],"decreased":[28],"other":[30,52],"forms":[31],"of":[32,85,90,109],"agammaglobulinaemia,":[33],"but":[34],"not":[35],"to":[36,93,112],"the":[37,63,67,76,86,106,116],"same":[38],"degree":[39],"(78":[40],"46%":[42],"respectively).":[44],"normal":[48],"or":[49],"elevated":[50],"diseases":[53],"associated":[54],"with":[55],"repeated":[56],"infections":[57],"malignancy.":[59],"We":[60],"conclude":[61],"that":[62],"globulins,":[65],"like":[66],"immunoglobulins,":[68],"characteristically":[69],"are":[70],"deficient":[71],"agammaglobulinaemia":[73,84,110],"syndromes.":[74],"Since":[75],"greatest":[77],"deficiencies":[79],"seen":[81],"type,":[88],"titration":[89],"seems":[92,111],"be":[94,113],"a":[95],"convenient":[96],"aid":[97],"diagnosing":[99],"this":[100],"disease":[101],"early":[102],"life.":[104],"Thus,":[105],"inborn":[107],"error":[108],"reflected":[114],"complement":[117],"system.":[118]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}