{"id":"https://openalex.org/W3043549667","doi":"https://doi.org/10.1016/j.envres.2020.109971","title":"DNA methylation signature of passive smoke exposure is less pronounced than active smoking: The Understanding Society study","display_name":"DNA methylation signature of passive smoke exposure is less pronounced than active smoking: The Understanding Society study","publication_year":2020,"publication_date":"2020-07-31","ids":{"openalex":"https://openalex.org/W3043549667","doi":"https://doi.org/10.1016/j.envres.2020.109971","mag":"3043549667","pmid":"https://pubmed.ncbi.nlm.nih.gov/32745538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7536273"},"language":"en","primary_location":{"id":"doi:10.1016/j.envres.2020.109971","doi":"https://doi.org/10.1016/j.envres.2020.109971","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envres.2020.109971","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0013935120308665?via%3Dihub","source":{"id":"https://openalex.org/S173943867","display_name":"Environmental Research","issn_l":"0013-9351","issn":["0013-9351","1096-0953"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0013935120308665?via%3Dihub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046774615","display_name":"Paige M. Hulls","orcid":"https://orcid.org/0000-0002-8466-874X","observed_orcids":["https://orcid.org/0000-0002-8466-874X"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4387155195","display_name":"MRC Integrative Epidemiology Unit","ror":"https://ror.org/030qtrs05","country_code":"GB","type":"facility","lineage":["https://openalex.org/I36234482","https://openalex.org/I4210087105","https://openalex.org/I4387155195","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paige M. Hulls","raw_affiliation_strings":["Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK. Electronic address: paige.hulls@bristol.ac.uk","MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK","Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK. Electronic address: paige.hulls@bristol.ac.uk","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"]},{"raw_affiliation_string":"MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"]},{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086673309","display_name":"Frank de Vocht","orcid":"https://orcid.org/0000-0003-3631-627X","observed_orcids":["https://orcid.org/0000-0003-3631-627X","https://orcid.org/0000-0002-1998-9547"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4392738180","display_name":"NIHR Applied Research Collaboration West","ror":"https://ror.org/03pzxq793","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4392738180"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frank de Vocht","raw_affiliation_strings":["Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; NIHR Applied Research Collaboration West (NIHR ARC West), Bristol, BS1 2NT, UK. Electronic address: frank.devocht@bristol.ac.uk","NIHR Applied Research Collaboration West (NIHR ARC West), Bristol, BS1 2NT, UK","Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; NIHR Applied Research Collaboration West (NIHR ARC West), Bristol, BS1 2NT, UK. Electronic address: frank.devocht@bristol.ac.uk","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4392738180"]},{"raw_affiliation_string":"NIHR Applied Research Collaboration West (NIHR ARC West), Bristol, BS1 2NT, UK","institution_ids":["https://openalex.org/I4392738180"]},{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030412254","display_name":"Yanchun Bao","orcid":"https://orcid.org/0000-0002-6102-5098","observed_orcids":["https://orcid.org/0000-0002-6102-5098"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yanchun Bao","raw_affiliation_strings":["Institute for Social and Economic Research, University of Essex, CO4 3SQ, UK. Electronic address: ybaoa@essex.ac.uk","Institute for Social and Economic Research, University of Essex, CO4 3SQ, UK"],"raw_orcid":"https://orcid.org/0000-0002-6102-5098","affiliations":[{"raw_affiliation_string":"Institute for Social and Economic Research, University of Essex, CO4 3SQ, UK. Electronic address: ybaoa@essex.ac.uk","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"Institute for Social and Economic Research, University of Essex, CO4 3SQ, UK","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042511675","display_name":"Caroline L. Relton","orcid":"https://orcid.org/0000-0003-2052-4840","observed_orcids":["https://orcid.org/0000-0003-2052-4840","https://orcid.org/0000-0003-4036-3642","https://orcid.org/0000-0001-7272-5308"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4387155195","display_name":"MRC Integrative Epidemiology Unit","ror":"https://ror.org/030qtrs05","country_code":"GB","type":"facility","lineage":["https://openalex.org/I36234482","https://openalex.org/I4210087105","https://openalex.org/I4387155195","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caroline L. Relton","raw_affiliation_strings":["Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK. Electronic address: Caroline.Relton@bristol.ac.uk","MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK","Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK. Electronic address: Caroline.Relton@bristol.ac.uk","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"]},{"raw_affiliation_string":"MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"]},{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065571043","display_name":"Richard Michael Martin","orcid":"https://orcid.org/0000-0002-7992-7719","observed_orcids":["https://orcid.org/0000-0002-7992-7719"]},"institutions":[{"id":"https://openalex.org/I2800789647","display_name":"University Hospitals Bristol NHS Foundation Trust","ror":"https://ror.org/04nm1cv11","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800789647","https://openalex.org/I4392738148","https://openalex.org/I4405276282"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4210119147","display_name":"NIHR Bristol Biomedical Research Centre","ror":"https://ror.org/02mtt1z51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210119147","https://openalex.org/I4405276282"]},{"id":"https://openalex.org/I4387155195","display_name":"MRC Integrative Epidemiology Unit","ror":"https://ror.org/030qtrs05","country_code":"GB","type":"facility","lineage":["https://openalex.org/I36234482","https://openalex.org/I4210087105","https://openalex.org/I4387155195","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard M. Martin","raw_affiliation_strings":["Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK; NIHR Bristol Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, BS8 2BN, UK. Electronic address: Richard.Martin@bristol.ac.uk","MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK","NIHR Bristol Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, BS8 2BN, UK","Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK; NIHR Bristol Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, BS8 2BN, UK. Electronic address: Richard.Martin@bristol.ac.uk","institution_ids":["https://openalex.org/I2800789647","https://openalex.org/I36234482","https://openalex.org/I4210119147","https://openalex.org/I4387155195"]},{"raw_affiliation_string":"MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"]},{"raw_affiliation_string":"NIHR Bristol Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I2800789647","https://openalex.org/I36234482","https://openalex.org/I4210119147"]},{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072739924","display_name":"Rebecca Claire Richmond","orcid":"https://orcid.org/0000-0003-0574-5071","observed_orcids":["https://orcid.org/0000-0003-0574-5071"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4387155195","display_name":"MRC Integrative Epidemiology Unit","ror":"https://ror.org/030qtrs05","country_code":"GB","type":"facility","lineage":["https://openalex.org/I36234482","https://openalex.org/I4210087105","https://openalex.org/I4387155195","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca C. Richmond","raw_affiliation_strings":["Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK. Electronic address: Rebecca.Richmond@bristol.ac.uk","MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK","Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK"],"raw_orcid":"https://orcid.org/0000-0003-0574-5071","affiliations":[{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK. Electronic address: Rebecca.Richmond@bristol.ac.uk","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"]},{"raw_affiliation_string":"MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"]},{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5046774615"],"corresponding_institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":{"value":3550,"currency":"USD","value_usd":3550},"fwci":0.1192,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.0789616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"190","issue":null,"first_page":"109971","last_page":"109971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/passive-smoking","display_name":"passive smoking","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/epigenome-wide-association-study","display_name":"epigenome-wide association study","score":0.8539999723434448},{"id":"https://openalex.org/keywords/active-smoking","display_name":"active smoking","score":0.7300000190734863},{"id":"https://openalex.org/keywords/partner-smoking","display_name":"partner smoking","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cpg-sites","display_name":"CpG sites","score":0.7979999780654907},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8302907943725586},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7686412930488586},{"id":"https://openalex.org/C2776281542","wikidata":"https://www.wikidata.org/wiki/Q259516","display_name":"Passive smoking","level":2,"score":0.7345368266105652},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6936006546020508},{"id":"https://openalex.org/C58874564","wikidata":"https://www.wikidata.org/wiki/Q130768","display_name":"Smoke","level":2,"score":0.6190010905265808},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.610073983669281},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4754835367202759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43813759088516235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35644710063934326},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3545982837677002},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3330552577972412},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3045066297054291},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2567256987094879},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21081644296646118},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12230417132377625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.envres.2020.109971","doi":"https://doi.org/10.1016/j.envres.2020.109971","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envres.2020.109971","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0013935120308665?via%3Dihub","source":{"id":"https://openalex.org/S173943867","display_name":"Environmental Research","issn_l":"0013-9351","issn":["0013-9351","1096-0953"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7536273","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7536273","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environ Res","raw_type":"Text"},{"id":"pmid:32745538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32745538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental research","raw_type":"Journal Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/52e521d2-262c-4544-b6d5-cbfe110d865d","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/52e521d2-262c-4544-b6d5-cbfe110d865d","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hulls, P M, de Vocht , F, Bao, Y, Relton, C L, Martin, R M & Richmond, R 2020, 'DNA methylation signature of passive smoke exposure is less pronounced than active smoking : the Understanding Society study', Environmental Research, vol. 190, 109971. https://doi.org/10.1016/j.envres.2020.109971","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.essex.ac.uk:28523","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.envres.2020.109971","pdf_url":null,"source":{"id":"https://openalex.org/S4306401236","display_name":"Open Access at Essex (University of Essex)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I110002522","host_organization_name":"University of Essex","host_organization_lineage":["https://openalex.org/I110002522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/52e521d2-262c-4544-b6d5-cbfe110d865d","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/files/247410355/untitled.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hulls, P M, de Vocht , F, Bao, Y, Relton, C L, Martin, R M & Richmond, R 2020, 'DNA methylation signature of passive smoke exposure is less pronounced than active smoking : the Understanding Society study', Environmental Research, vol. 190, 109971. https://doi.org/10.1016/j.envres.2020.109971","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.envres.2020.109971","doi":"https://doi.org/10.1016/j.envres.2020.109971","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envres.2020.109971","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0013935120308665?via%3Dihub","source":{"id":"https://openalex.org/S173943867","display_name":"Environmental Research","issn_l":"0013-9351","issn":["0013-9351","1096-0953"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2103660547","display_name":"META-DAC - Managing Ethico-social and Technical issues and Administration of Data Access Committee","funder_award_id":"MR/N01104X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3181733518","display_name":"The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource","funder_award_id":"MC_PC_19009","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3344456887","display_name":null,"funder_award_id":"C18281 / A19169","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3653777572","display_name":"The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi- generation, longitudinal resource focusing on life course health and well- being.","funder_award_id":"217065/Z/19/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5270292543","display_name":null,"funder_award_id":"22171","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6788542681","display_name":null,"funder_award_id":"ES/M008592/1","funder_id":"https://openalex.org/F4320313311","funder_display_name":"University Hospitals Bristol NHS Foundation Trust"},{"id":"https://openalex.org/G6848343200","display_name":"Epigenetic Epidemiology","funder_award_id":"MC_UU_00011/5","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7492032647","display_name":"METADAC","funder_award_id":"ES/S008349/1","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"},{"id":"https://openalex.org/G7638463748","display_name":null,"funder_award_id":"ES/S008349/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G76752795","display_name":null,"funder_award_id":"19169","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8039289903","display_name":"How can biomarkers and genetics improve our understanding of society and health?","funder_award_id":"ES/M008592/1","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"},{"id":"https://openalex.org/G9000338384","display_name":null,"funder_award_id":"108902/Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G97857785","display_name":"Epigenetics: Environment, Embodiment and Equality (E4)","funder_award_id":"ES/N000498/1","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"}],"funders":[{"id":"https://openalex.org/F4320311731","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320313311","display_name":"University Hospitals Bristol NHS Foundation Trust","ror":"https://ror.org/04nm1cv11"},{"id":"https://openalex.org/F4320313398","display_name":"Understanding Society","ror":"https://ror.org/032ydsv23"},{"id":"https://openalex.org/F4320315679","display_name":"NIHR Bristol Biomedical Research Centre","ror":"https://ror.org/02mtt1z51"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320360","display_name":"University of Bristol","ror":"https://ror.org/0524sp257"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334630","display_name":"Economic and Social Research Council","ror":"https://ror.org/03n0ht308"},{"id":"https://openalex.org/F4320335836","display_name":"School for Public Health Research","ror":"https://ror.org/05c9p6d02"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043549667.pdf","grobid_xml":"https://content.openalex.org/works/W3043549667.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1974047233","https://openalex.org/W1983882432","https://openalex.org/W1997824331","https://openalex.org/W2003714149","https://openalex.org/W2050352549","https://openalex.org/W2058947040","https://openalex.org/W2066748935","https://openalex.org/W2086624992","https://openalex.org/W2095769301","https://openalex.org/W2101870168","https://openalex.org/W2102177999","https://openalex.org/W2106657714","https://openalex.org/W2110810426","https://openalex.org/W2113145879","https://openalex.org/W2118238722","https://openalex.org/W2119883345","https://openalex.org/W2128504845","https://openalex.org/W2137499573","https://openalex.org/W2142259952","https://openalex.org/W2144998962","https://openalex.org/W2169556367","https://openalex.org/W2238113724","https://openalex.org/W2263363622","https://openalex.org/W2325791728","https://openalex.org/W2330784827","https://openalex.org/W2517538986","https://openalex.org/W2523285199","https://openalex.org/W2621586846","https://openalex.org/W2745417329","https://openalex.org/W2809475529","https://openalex.org/W2909570317","https://openalex.org/W2951674154","https://openalex.org/W2953074246","https://openalex.org/W2972195784"],"related_works":["https://openalex.org/W1918724965","https://openalex.org/W7164174873","https://openalex.org/W2778862808","https://openalex.org/W2027490707","https://openalex.org/W2523220146","https://openalex.org/W2746725496","https://openalex.org/W4200382124","https://openalex.org/W4394405888","https://openalex.org/W4393555687","https://openalex.org/W2981418393"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,187],"extent":[2],"of":[3,7,32,52,71,93,108,151,165,175,183,202,229],"the":[4,17,56,83,149,173,181,226],"biological":[5],"impact":[6],"passive":[8,20,40,72,176,193,230],"smoke":[9,21,41,73,177,194,231],"exposure":[10,22,42,74,178,195],"is":[11,196,213],"unclear.":[12],"We":[13,38,64],"sought":[14],"to":[15,112,123,217],"investigate":[16],"association":[18,68],"between":[19,136],"and":[23,49,116,140,158],"DNA":[24,76,145,188,218],"methylation,":[25],"which":[26],"could":[27],"serve":[28,220],"as":[29,221],"a":[30,91,106,120,162],"biomarker":[31],"health":[33,227],"risk.":[34],"MATERIALS":[35],"AND":[36],"METHODS:":[37],"derived":[39],"from":[43],"self-reported":[44],"questionnaire":[45],"data":[46],"among":[47],"smoking":[48,95,99,110,138,142,170],"non-smoking":[50],"partners":[51],"participants":[53],"enrolled":[54],"in":[55,78,90,105,119,155,172],"UK":[57],"Household":[58],"Longitudinal":[59],"Study":[60],"'Understanding":[61],"Society'":[62],"(n=769).":[63],"performed":[65],"an":[66,134,222],"epigenome-wide":[67],"study":[69],"(EWAS)":[70],"with":[75,180,192,205],"methylation":[77,146,189,219],"peripheral":[79],"blood":[80],"measured":[81],"using":[82],"Illumina":[84],"Infinium":[85],"Methylation":[86],"EPIC":[87],"array.":[88],"RESULTS:":[89],"model":[92,107,121],"partner":[94,109],"adjusted":[96],"for":[97,133,167,209],"own":[98,137,184,203],"(model":[100,114,126],"1),":[101],"7":[102],"CpG":[103,152],"sites":[104,153],"restricted":[111,122],"non-smokers":[113],"2)":[115],"16":[117],"CpGs":[118],"regular":[124],"smokers":[125],"3).":[127],"In":[128],"addition,":[129],"there":[130],"was":[131,161],"evidence":[132],"interaction":[135],"status":[139,143],"partners'":[141],"on":[144],"levels":[147],"at":[148],"majority":[150],"identified":[154,169],"models":[156],"2":[157],"3.":[159],"There":[160],"clear":[163],"lack":[164],"enrichment":[166],"previously":[168],"signals":[171],"EWAS":[174,182],"compared":[179],"smoking.":[185],"CONCLUSION:":[186],"signature":[190],"associated":[191],"much":[197],"less":[198],"pronounced":[199],"than":[200],"that":[201,215],"smoking,":[204],"no":[206],"positive":[207],"findings":[208],"'expected'":[210],"signals.":[211],"It":[212],"unlikely":[214],"changes":[216],"important":[223],"mechanism":[224],"underlying":[225],"risks":[228],"exposure.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-07-23T00:00:00"}