{"id":"https://openalex.org/W3043358905","doi":"https://doi.org/10.1016/j.brainresbull.2020.07.011","title":"Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway","display_name":"Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway","publication_year":2020,"publication_date":"2020-07-15","ids":{"openalex":"https://openalex.org/W3043358905","doi":"https://doi.org/10.1016/j.brainresbull.2020.07.011","mag":"3043358905","pmid":"https://pubmed.ncbi.nlm.nih.gov/32679060"},"language":"en","primary_location":{"id":"doi:10.1016/j.brainresbull.2020.07.011","doi":"https://doi.org/10.1016/j.brainresbull.2020.07.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brainresbull.2020.07.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S036192302030558X/pdf","source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S036192302030558X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059931209","display_name":"Zhixian Gou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixian Gou","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033915750","display_name":"Xiaojuan Su","orcid":"https://orcid.org/0000-0001-5544-554X","observed_orcids":["https://orcid.org/0000-0001-5544-554X","https://orcid.org/0000-0002-5527-678X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojuan Su","raw_affiliation_strings":["Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children(Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children(Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xing Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Hu","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101569227","display_name":"Yue Zhou","orcid":"https://orcid.org/0000-0002-8262-9405","observed_orcids":["https://orcid.org/0000-0002-8262-9405"]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhou","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005776389","display_name":"Lin Huang","orcid":"https://orcid.org/0000-0002-4515-8253","observed_orcids":["https://orcid.org/0000-0002-4515-8253"]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Huang","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047212234","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0002-9664-3953","observed_orcids":["https://orcid.org/0000-0002-9664-3953"]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Fan","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337145","display_name":"Jing Li","orcid":"https://orcid.org/0009-0003-2507-1606","observed_orcids":["https://orcid.org/0009-0003-2507-1606"]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"last","author":{"id":null,"display_name":"Liqun Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liqun Lu","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China. Electronic address: luliqun7@sina.com","Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China. Electronic address: luliqun7@sina.com","institution_ids":["https://openalex.org/I4210127266"]},{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China","institution_ids":["https://openalex.org/I4210127266"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210127266"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":{"value":2350,"currency":"USD","value_usd":2350},"fwci":16.7232,"has_fulltext":true,"cited_by_count":143,"citation_normalized_percentile":{"value":0.99548248,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"163","issue":null,"first_page":"40","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/hypoxic-ischemic-brain-injury","display_name":"hypoxic-ischemic brain injury","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8769999742507935},{"id":"https://openalex.org/keywords/neuronal-ferroptosis","display_name":"neuronal ferroptosis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9269999861717224},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8690000176429749},{"id":"https://openalex.org/keywords/rsl3","display_name":"RSL3","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6909999847412109},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.6977943181991577},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6958505511283875},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.5852356553077698},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.5811076164245605},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5304317474365234},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.49527373909950256},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35486045479774475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35224032402038574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3488563299179077},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3473157286643982},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33835121989250183},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.33655568957328796},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.30345797538757324},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2783966064453125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23316916823387146},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.16319313645362854}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.brainresbull.2020.07.011","doi":"https://doi.org/10.1016/j.brainresbull.2020.07.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brainresbull.2020.07.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S036192302030558X/pdf","source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},{"id":"pmid:32679060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32679060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.brainresbull.2020.07.011","doi":"https://doi.org/10.1016/j.brainresbull.2020.07.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brainresbull.2020.07.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S036192302030558X/pdf","source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317436","display_name":"Chengdu Medical College","ror":"https://ror.org/01c4jmp52"},{"id":"https://openalex.org/F4320322922","display_name":"Department of Science and Technology of Sichuan Province","ror":"https://ror.org/04323m874"},{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043358905.pdf","grobid_xml":"https://content.openalex.org/works/W3043358905.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W288753122","https://openalex.org/W1761076309","https://openalex.org/W1912529006","https://openalex.org/W1923288651","https://openalex.org/W1963955851","https://openalex.org/W1989509611","https://openalex.org/W2004607162","https://openalex.org/W2009828929","https://openalex.org/W2029535496","https://openalex.org/W2032255664","https://openalex.org/W2035898183","https://openalex.org/W2058337748","https://openalex.org/W2067397372","https://openalex.org/W2067916155","https://openalex.org/W2074191005","https://openalex.org/W2078028961","https://openalex.org/W2079636765","https://openalex.org/W2093160885","https://openalex.org/W2136967026","https://openalex.org/W2150146658","https://openalex.org/W2157633141","https://openalex.org/W2233932850","https://openalex.org/W2525564145","https://openalex.org/W2583631769","https://openalex.org/W2603610617","https://openalex.org/W2788640168","https://openalex.org/W2803585367","https://openalex.org/W2856152917","https://openalex.org/W2876414845","https://openalex.org/W2895090972","https://openalex.org/W2897195419","https://openalex.org/W2903970290","https://openalex.org/W2910199240","https://openalex.org/W2939816388","https://openalex.org/W2945760234","https://openalex.org/W2969949331","https://openalex.org/W2983172503","https://openalex.org/W3001757687","https://openalex.org/W3006788897","https://openalex.org/W3007273889","https://openalex.org/W4236538876","https://openalex.org/W6755578642"],"related_works":["https://openalex.org/W4416783233","https://openalex.org/W7207609654","https://openalex.org/W2359219142","https://openalex.org/W2382528057","https://openalex.org/W2170277233","https://openalex.org/W2361889464","https://openalex.org/W7123263606","https://openalex.org/W2068007862","https://openalex.org/W184292044","https://openalex.org/W4230730379"],"abstract_inverted_index":{"Melatonin":[0],"(Mel)":[1],"has":[2,101],"neuroprotective":[3],"effects;":[4],"however,":[5],"its":[6,23],"roles":[7,24],"in":[8,27,92],"hypoxic-ischemic":[9],"brain":[10],"damage":[11],"(HIBD)":[12],"and":[13,25,45,55,77],"the":[14,53,59,88,108],"underlying":[15],"mechanisms":[16,26],"remain":[17],"unknown.":[18],"We":[19,32],"aimed":[20],"to":[21],"explore":[22],"a":[28,102],"HIBD":[29,60,106],"rat":[30],"model.":[31],"found":[33,64],"that":[34,65,97],"exogenous":[35,98],"Mel":[36,51,89,99],"treatment":[37,100],"ameliorated":[38],"HIBD-induced":[39],"pathological":[40],"changes,":[41],"inhibited":[42],"neuronal":[43,48],"ferroptosis,":[44],"promoted":[46],"hippocampal":[47],"survival.":[49],"Moreover,":[50],"improved":[52],"learning":[54],"memory":[56],"abilities":[57],"of":[58],"rats.":[61],"Further,":[62],"we":[63],"glutathione":[66],"peroxidase":[67],"4":[68],"(Gpx4)":[69],"inhibition":[70,74,84],"with":[71,75,85],"RSL3,":[72],"Akt":[73],"LY29400,":[76],"nuclear":[78],"factor":[79,81],"erythroid-2-related":[80],"2":[82],"(Nrf2)":[83],"ML385":[86],"abolished":[87],"protective":[90,103],"effects":[91],"HIBD.":[93],"Our":[94],"findings":[95],"indicate":[96],"effect":[104],"on":[105],"via":[107],"Akt/Nrf2/Gpx4":[109],"pathway.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":45},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-07-23T00:00:00"}