{"id":"https://openalex.org/W3042425372","doi":"https://doi.org/10.1084/jem.20192360","title":"Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation","display_name":"Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation","publication_year":2020,"publication_date":"2020-07-15","ids":{"openalex":"https://openalex.org/W3042425372","doi":"https://doi.org/10.1084/jem.20192360","mag":"3042425372","pmid":"https://pubmed.ncbi.nlm.nih.gov/32667968","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7478722"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20192360","doi":"https://doi.org/10.1084/jem.20192360","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20192360","pdf_url":"https://rupress.org/jem/article-pdf/217/9/e20192360/1047361/jem_20192360.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3042425372"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://rupress.org/jem/article-pdf/217/9/e20192360/1047361/jem_20192360.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074952969","display_name":"Agata Cie\u015blak","orcid":"https://orcid.org/0000-0003-1015-9448","observed_orcids":["https://orcid.org/0000-0003-1015-9448"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Agata Cieslak","raw_affiliation_strings":["Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1"],"raw_orcid":"https://orcid.org/0000-0003-1015-9448","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guillaume Charbonnier","orcid":"https://orcid.org/0000-0001-5615-1287","observed_orcids":["https://orcid.org/0000-0001-5615-1287"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Charbonnier","raw_affiliation_strings":["Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-5615-1287","affiliations":[{"raw_affiliation_string":"Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029610700","display_name":"Melania Tesio","orcid":"https://orcid.org/0000-0001-9291-0797","observed_orcids":["https://orcid.org/0000-0001-9291-0797"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Melania Tesio","raw_affiliation_strings":["Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088991680","display_name":"\u00c8ve-Lyne Mathieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eve-Lyne Mathieu","raw_affiliation_strings":["Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035030607","display_name":"Mohamed Belhocine","orcid":"https://orcid.org/0000-0001-9523-0658","observed_orcids":["https://orcid.org/0000-0001-9523-0658"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mohamed Belhocine","raw_affiliation_strings":["Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-9523-0658","affiliations":[{"raw_affiliation_string":"Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026307215","display_name":"Aurore Touzart","orcid":"https://orcid.org/0000-0002-8888-2292","observed_orcids":["https://orcid.org/0000-0002-8888-2292"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Aurore Touzart","raw_affiliation_strings":["Division of Cancer Epigenomics, German Cancer Research Center, Heidelberg, Germany 4","Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Epigenomics, German Cancer Research Center, Heidelberg, Germany 4","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069499304","display_name":"Charlotte L. Smith","orcid":"https://orcid.org/0000-0002-7209-9287","observed_orcids":["https://orcid.org/0000-0002-7209-9287"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charlotte Smith","raw_affiliation_strings":["Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056480892","display_name":"Guillaume Hypolite","orcid":"https://orcid.org/0009-0003-2788-5005","observed_orcids":["https://orcid.org/0009-0003-2788-5005"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Hypolite","raw_affiliation_strings":["Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057234657","display_name":"Guillaume P. Andrieu","orcid":"https://orcid.org/0000-0003-0289-4952","observed_orcids":["https://orcid.org/0000-0003-0289-4952"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume P. Andrieu","raw_affiliation_strings":["Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014988213","display_name":"Joost H.A. Martens","orcid":"https://orcid.org/0000-0003-2008-6537","observed_orcids":["https://orcid.org/0000-0003-2008-6537"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost H.A. Martens","raw_affiliation_strings":["Department of Molecular Biology, Faculties of Science and Medicine, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands 5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculties of Science and Medicine, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands 5","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083852130","display_name":"Eva M. Janssen\u2010Megens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eva Janssen-Megens","raw_affiliation_strings":["Department of Molecular Biology, Faculties of Science and Medicine, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands 5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculties of Science and Medicine, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands 5","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marta Gut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210132884","display_name":"Barcelona Institute of Science and Technology","ror":"https://ror.org/03kpps236","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210132884"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Gut","raw_affiliation_strings":["Centro Nacional de An\u00e1lisis Gen\u00f3mico\u2013Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain 6","Universitat Pompeu Fabra, Barcelona, Spain 7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de An\u00e1lisis Gen\u00f3mico\u2013Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain 6","institution_ids":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4210142206"]},{"raw_affiliation_string":"Universitat Pompeu Fabra, Barcelona, Spain 7","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066760172","display_name":"Ivo Glynne Gut","orcid":"https://orcid.org/0000-0001-7219-632X","observed_orcids":["https://orcid.org/0000-0001-7219-632X"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210132884","display_name":"Barcelona Institute of Science and Technology","ror":"https://ror.org/03kpps236","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210132884"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ivo Gut","raw_affiliation_strings":["Centro Nacional de An\u00e1lisis Gen\u00f3mico\u2013Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain 6","Universitat Pompeu Fabra, Barcelona, Spain 7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de An\u00e1lisis Gen\u00f3mico\u2013Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain 6","institution_ids":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4210142206"]},{"raw_affiliation_string":"Universitat Pompeu Fabra, Barcelona, Spain 7","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076973611","display_name":"Nicolas Boissel","orcid":"https://orcid.org/0000-0003-2091-7927","observed_orcids":["https://orcid.org/0000-0003-2091-7927"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4403386472","display_name":"Recherche clinique appliqu\u00e9e \u00e0 l'h\u00e9matologie","ror":"https://ror.org/01df79331","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386472"]},{"id":"https://openalex.org/I4405259871","display_name":"Institut Universitaire d'H\u00e9matologie","ror":"https://ror.org/02w653772","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4405259871"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Boissel","raw_affiliation_strings":["Universit\u00e9 Paris Diderot, Institut Universitaire d'H\u00e9matologie, EA-3518, Assistance Publique-H\u00f4pitaux de Paris, University Hospital Saint-Louis, Paris, France 8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Diderot, Institut Universitaire d'H\u00e9matologie, EA-3518, Assistance Publique-H\u00f4pitaux de Paris, University Hospital Saint-Louis, Paris, France 8","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610","https://openalex.org/I4387154366","https://openalex.org/I4403386472","https://openalex.org/I4405259871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042670578","display_name":"Arnaud Petit","orcid":"https://orcid.org/0000-0001-8363-1622","observed_orcids":["https://orcid.org/0000-0001-8363-1622"]},"institutions":[{"id":"https://openalex.org/I4210086685","display_name":"H\u00f4pital Armand-Trousseau","ror":"https://ror.org/00yfbr841","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210086685","https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arnaud Petit","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Armand Trousseau, Paris, France. 9"],"raw_orcid":"https://orcid.org/0000-0001-8363-1622","affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Armand Trousseau, Paris, France. 9","institution_ids":["https://openalex.org/I4210086685","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049857580","display_name":"Denis Puthier","orcid":"https://orcid.org/0000-0002-7240-5280","observed_orcids":["https://orcid.org/0000-0002-7240-5280"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denis Puthier","raw_affiliation_strings":["Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-7240-5280","affiliations":[{"raw_affiliation_string":"Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071962621","display_name":"Elizabeth A. Macintyre","orcid":"https://orcid.org/0000-0003-0520-0493","observed_orcids":["https://orcid.org/0000-0003-0520-0493"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elizabeth Macintyre","raw_affiliation_strings":["Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036095832","display_name":"Hendrik G. Stunnenberg","orcid":"https://orcid.org/0000-0002-0066-1576","observed_orcids":["https://orcid.org/0000-0002-0066-1576"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hendrik G. Stunnenberg","raw_affiliation_strings":["Department of Molecular Biology, Faculties of Science and Medicine, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands 5"],"raw_orcid":"https://orcid.org/0000-0002-0066-1576","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculties of Science and Medicine, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands 5","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091488339","display_name":"Salvatore Spicuglia","orcid":"https://orcid.org/0000-0002-8101-7108","observed_orcids":["https://orcid.org/0000-0002-8101-7108"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Salvatore Spicuglia","raw_affiliation_strings":["Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-8101-7108","affiliations":[{"raw_affiliation_string":"Aix-Marseille University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Theories and Approaches of Genomic Complexity, UMR1090, Marseille, France 2","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer 3 , Marseille, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046761978","display_name":"Vahid Asnafi","orcid":"https://orcid.org/0000-0002-6255-5314","observed_orcids":["https://orcid.org/0000-0002-6255-5314"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Vahid Asnafi","raw_affiliation_strings":["Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1"],"raw_orcid":"https://orcid.org/0000-0002-6255-5314","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris (Descartes), Institut Necker-Enfants Malades, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, and Laboratory of Onco-Hematology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France 1","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5046761978"],"corresponding_institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210097159"],"apc_list":null,"apc_paid":null,"fwci":3.8591,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95632565,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"217","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05420000106096268,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymopoiesis","display_name":"thymopoiesis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/enhancer-activation","display_name":"enhancer activation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.699999988079071},{"id":"https://openalex.org/keywords/enhancer-repression","display_name":"enhancer repression","score":0.7459999918937683},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.7620000243186951},{"id":"https://openalex.org/keywords/distal-regulatory-elements","display_name":"distal regulatory elements","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8411445617675781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6657355427742004},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6180857419967651},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.6149063110351562},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6124330163002014},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5974670648574829},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.551028311252594},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.48981043696403503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47132375836372375},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39549368619918823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36904945969581604},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.34014156460762024},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2342817187309265}],"mesh":[{"descriptor_ui":"D000073399","descriptor_name":"DNA Demethylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081122","descriptor_name":"Epigenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015329","descriptor_name":"Gene Rearrangement, T-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060168","descriptor_name":"Thymocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1084/jem.20192360","doi":"https://doi.org/10.1084/jem.20192360","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20192360","pdf_url":"https://rupress.org/jem/article-pdf/217/9/e20192360/1047361/jem_20192360.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:32667968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32667968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7478722","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7478722/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-03015052v1","doi":null,"is_oa":true,"landing_page_url":"https://amu.hal.science/hal-03015052","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Medicine, 2020, 217 (9), &#x27E8;10.1084/jem.20192360&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositori.upf.edu:10230/45880","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/45880","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/225041","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/225041","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/225041","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/225041","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Medicine, 217, 1 - 28","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1084/jem.20192360","doi":"https://doi.org/10.1084/jem.20192360","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20192360","pdf_url":"https://rupress.org/jem/article-pdf/217/9/e20192360/1047361/jem_20192360.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1257311468","display_name":null,"funder_award_id":"ARC PJA 20151203149","funder_id":"https://openalex.org/F4320309749","funder_display_name":"Association pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G1512583955","display_name":"INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE","funder_award_id":"ANR-11-IDEX-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2807848565","display_name":"A BLUEPRINT of Haematopoietic Epigenomes","funder_award_id":"282510","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320309911","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322646","display_name":"Fondation de France","ror":"https://ror.org/02zkxjz73"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3042425372.pdf","grobid_xml":"https://content.openalex.org/works/W3042425372.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W30485381","https://openalex.org/W159147729","https://openalex.org/W159586780","https://openalex.org/W211080140","https://openalex.org/W1591423336","https://openalex.org/W1899443405","https://openalex.org/W1966152616","https://openalex.org/W1981234527","https://openalex.org/W1982143082","https://openalex.org/W1984008787","https://openalex.org/W1991419585","https://openalex.org/W1994791278","https://openalex.org/W1996835556","https://openalex.org/W2006387432","https://openalex.org/W2006788765","https://openalex.org/W2008004759","https://openalex.org/W2008151377","https://openalex.org/W2012034410","https://openalex.org/W2015428618","https://openalex.org/W2020541351","https://openalex.org/W2028263033","https://openalex.org/W2028885330","https://openalex.org/W2037947871","https://openalex.org/W2039053594","https://openalex.org/W2041212323","https://openalex.org/W2042050831","https://openalex.org/W2043789254","https://openalex.org/W2046540572","https://openalex.org/W2052568445","https://openalex.org/W2053340870","https://openalex.org/W2053444110","https://openalex.org/W2055188073","https://openalex.org/W2060605982","https://openalex.org/W2061044132","https://openalex.org/W2063124444","https://openalex.org/W2065124806","https://openalex.org/W2080152736","https://openalex.org/W2080900647","https://openalex.org/W2086132113","https://openalex.org/W2088175344","https://openalex.org/W2089836142","https://openalex.org/W2091688007","https://openalex.org/W2095669126","https://openalex.org/W2112967184","https://openalex.org/W2119429726","https://openalex.org/W2120233483","https://openalex.org/W2124733101","https://openalex.org/W2124943390","https://openalex.org/W2127600515","https://openalex.org/W2130002948","https://openalex.org/W2132352426","https://openalex.org/W2132366130","https://openalex.org/W2133566806","https://openalex.org/W2137797307","https://openalex.org/W2141354959","https://openalex.org/W2145998060","https://openalex.org/W2146713203","https://openalex.org/W2154746182","https://openalex.org/W2155585326","https://openalex.org/W2159942968","https://openalex.org/W2160331349","https://openalex.org/W2161516715","https://openalex.org/W2161671616","https://openalex.org/W2167776710","https://openalex.org/W2191507484","https://openalex.org/W2206207244","https://openalex.org/W2223687595","https://openalex.org/W2276477110","https://openalex.org/W2331030820","https://openalex.org/W2463613583","https://openalex.org/W2544245576","https://openalex.org/W2556805640","https://openalex.org/W2594685900","https://openalex.org/W2622999795","https://openalex.org/W2768013244","https://openalex.org/W2788037203","https://openalex.org/W2796674913","https://openalex.org/W2806983506","https://openalex.org/W2809514549","https://openalex.org/W2892086796","https://openalex.org/W2912623135","https://openalex.org/W2972011121","https://openalex.org/W2986951699","https://openalex.org/W4248291937","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2071863330","https://openalex.org/W2301952875","https://openalex.org/W3045234572","https://openalex.org/W2117802802","https://openalex.org/W4200312692","https://openalex.org/W2593040232","https://openalex.org/W4391574097","https://openalex.org/W4288080424","https://openalex.org/W2889064177","https://openalex.org/W2743689884"],"abstract_inverted_index":{"Cell":[0],"differentiation":[1],"is":[2,42,77,110,128],"accompanied":[3,43],"by":[4,44,130],"epigenetic":[5,47],"changes":[6],"leading":[7],"to":[8],"precise":[9],"lineage":[10,120],"definition":[11],"and":[12,81,116,155],"cell":[13,27,40,63,105,139],"identity.":[14],"Here":[15],"we":[16,49],"present":[17],"a":[18],"comprehensive":[19],"resource":[20],"of":[21,24,34,54,66,103,126,134],"epigenomic":[22],"data":[23],"human":[25],"T":[26,39,62,104,119,138],"precursors":[28],"along":[29],"with":[30],"an":[31,79,146],"integrative":[32],"analysis":[33],"other":[35],"hematopoietic":[36],"populations.":[37],"Although":[38],"commitment":[41],"large":[45],"scale":[46],"changes,":[48],"observed":[50],"that":[51,91],"the":[52,72,92,97,123,131],"majority":[53],"distal":[55],"regulatory":[56],"elements":[57],"are":[58],"constitutively":[59],"unmethylated":[60,82],"throughout":[61],"differentiation,":[64,106],"irrespective":[65],"their":[67,108],"activation":[68,115],"status.":[69],"Among":[70],"these,":[71],"TCRA":[73,113],"gene":[74],"enhancer":[75,99,148],"(E\u03b1)":[76],"in":[78,137,153],"open":[80],"chromatin":[83],"structure":[84],"well":[85],"before":[86],"activation.":[87],"Integrative":[88],"analyses":[89],"revealed":[90],"HOXA5-9":[93],"transcription":[94],"factors":[95],"repress":[96],"E\u03b1":[98,127],"at":[100,151],"early":[101],"stages":[102],"while":[107],"decommission":[109],"required":[111],"for":[112],"locus":[114],"enforced":[117],"\u03b1\u03b2":[118],"differentiation.":[121],"Remarkably,":[122],"HOXA-mediated":[124],"repression":[125,149],"paralleled":[129],"ectopic":[132],"expression":[133],"homeodomain-related":[135],"oncogenes":[136],"acute":[140],"lymphoblastic":[141],"leukemia.":[142],"These":[143],"results":[144],"highlight":[145],"analogous":[147],"mechanism":[150],"play":[152],"normal":[154],"cancer":[156],"conditions,":[157],"but":[158],"imposing":[159],"distinct":[160],"developmental":[161],"constraints.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":33},{"year":2020,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-07-23T00:00:00"}
