{"id":"https://openalex.org/W3041713611","doi":null,"title":"The role of biometals in the neuropathology of Parkinson\u2019s disease","display_name":"The role of biometals in the neuropathology of Parkinson\u2019s disease","publication_year":2020,"publication_date":"2020-06-04","ids":{"openalex":"https://openalex.org/W3041713611","mag":"3041713611"},"language":"en","primary_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/22449","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2123/22449","pdf_url":"https://hdl.handle.net/2123/22449","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2123/22449","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006990471","display_name":"Sian Genoud","orcid":"https://orcid.org/0000-0001-8787-4541","observed_orcids":["https://orcid.org/0000-0001-8787-4541"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sian Genoud","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8787-4541","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006990471"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.12870000302791595,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/biometals","display_name":"biometals","score":0.8859999775886536},{"id":"https://openalex.org/keywords/copper-dyshomeostasis","display_name":"copper dyshomeostasis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.7269999980926514},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.972000002861023},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.7279999852180481},{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neuromelanin","display_name":"neuromelanin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.7139999866485596},{"id":"https://openalex.org/keywords/synchrotron-x-ray-fluorescence-microscopy","display_name":"synchrotron X-ray fluorescence microscopy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ptychography","display_name":"ptychography","score":0.9819999933242798},{"id":"https://openalex.org/keywords/copper-zinc-ratio","display_name":"copper/zinc ratio","score":0.6980000138282776},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.8745570778846741},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.49919939041137695},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4541440010070801},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32722729444503784},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3261796236038208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.300517201423645},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07668682932853699}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ses.library.usyd.edu.au:2123/22449","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2123/22449","pdf_url":"https://hdl.handle.net/2123/22449","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3041713611","doi":null,"is_oa":false,"landing_page_url":"https://ses.library.usyd.edu.au/handle/2123/22449","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/22449","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2123/22449","pdf_url":"https://hdl.handle.net/2123/22449","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5028170979","display_name":"Brain Tissue Resource Center for Alcohol Research","funder_award_id":"R24AA012725","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6221874794","display_name":null,"funder_award_id":"2016-2019","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7807352937","display_name":"Tracing iron from neurodevelopment to neurodegeneration in Parkinson's disease","funder_award_id":"1122981","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8286284566","display_name":"Tackling the complex pathogenesis of non-Alzheimer dementias and motor neurodegenerative disorders","funder_award_id":"1079679","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320313792","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3041713611.pdf","grobid_xml":"https://content.openalex.org/works/W3041713611.grobid-xml"},"referenced_works_count":486,"referenced_works":["https://openalex.org/W5443970","https://openalex.org/W13794526","https://openalex.org/W49996880","https://openalex.org/W78512322","https://openalex.org/W157666778","https://openalex.org/W1480429336","https://openalex.org/W1485249831","https://openalex.org/W1487208958","https://openalex.org/W1489286950","https://openalex.org/W1495825745","https://openalex.org/W1496790952","https://openalex.org/W1501828178","https://openalex.org/W1508476525","https://openalex.org/W1518778430","https://openalex.org/W1527671059","https://openalex.org/W1530657831","https://openalex.org/W1539334271","https://openalex.org/W1544137195","https://openalex.org/W1552027495","https://openalex.org/W1554681159","https://openalex.org/W1561410732","https://openalex.org/W1588992136","https://openalex.org/W1590592677","https://openalex.org/W1597055088","https://openalex.org/W1626583747","https://openalex.org/W1628748664","https://openalex.org/W1698967089","https://openalex.org/W1823710886","https://openalex.org/W1870977569","https://openalex.org/W1882262859","https://openalex.org/W1885567588","https://openalex.org/W1910491819","https://openalex.org/W1916156494","https://openalex.org/W1952199403","https://openalex.org/W1956314911","https://openalex.org/W1963577160","https://openalex.org/W1963693664","https://openalex.org/W1963873731","https://openalex.org/W1964996765","https://openalex.org/W1965147820","https://openalex.org/W1965389900","https://openalex.org/W1965550035","https://openalex.org/W1966397808","https://openalex.org/W1966923623","https://openalex.org/W1967067593","https://openalex.org/W1967111894","https://openalex.org/W1968051953","https://openalex.org/W1968148952","https://openalex.org/W1968210490","https://openalex.org/W1969004465","https://openalex.org/W1969122285","https://openalex.org/W1969122757","https://openalex.org/W1969665448","https://openalex.org/W1970151082","https://openalex.org/W1970574672","https://openalex.org/W1971326367","https://openalex.org/W1971778207","https://openalex.org/W1971979491","https://openalex.org/W1972992920","https://openalex.org/W1973262826","https://openalex.org/W1973897761","https://openalex.org/W1974927898","https://openalex.org/W1975308400","https://openalex.org/W1976645698","https://openalex.org/W1977032555","https://openalex.org/W1977682751","https://openalex.org/W1977817124","https://openalex.org/W1978098619","https://openalex.org/W1978340256","https://openalex.org/W1978423213","https://openalex.org/W1978424761","https://openalex.org/W1978425164","https://openalex.org/W1978793506","https://openalex.org/W1979535442","https://openalex.org/W1979594063","https://openalex.org/W1982524216","https://openalex.org/W1982535961","https://openalex.org/W1982556139","https://openalex.org/W1982669236","https://openalex.org/W1982967923","https://openalex.org/W1983985360","https://openalex.org/W1984113160","https://openalex.org/W1984521040","https://openalex.org/W1985842394","https://openalex.org/W1985917760","https://openalex.org/W1986328167","https://openalex.org/W1986383547","https://openalex.org/W1986837796","https://openalex.org/W1987567408","https://openalex.org/W1987794323","https://openalex.org/W1988215967","https://openalex.org/W1990004798","https://openalex.org/W1990473626","https://openalex.org/W1991362023","https://openalex.org/W1991493368","https://openalex.org/W1991511436","https://openalex.org/W1993104435","https://openalex.org/W1993193439","https://openalex.org/W1994318934","https://openalex.org/W1994702880","https://openalex.org/W1995191747","https://openalex.org/W1995716179","https://openalex.org/W1996397101","https://openalex.org/W1996620824","https://openalex.org/W1997183854","https://openalex.org/W1997230948","https://openalex.org/W1998275064","https://openalex.org/W1999434577","https://openalex.org/W1999792210","https://openalex.org/W2000104977","https://openalex.org/W2000293969","https://openalex.org/W2001110041","https://openalex.org/W2001501565","https://openalex.org/W2001679332","https://openalex.org/W2001916137","https://openalex.org/W2002422090","https://openalex.org/W2002490399","https://openalex.org/W2002559713","https://openalex.org/W2002979560","https://openalex.org/W2003534232","https://openalex.org/W2003579541","https://openalex.org/W2004030615","https://openalex.org/W2004100841","https://openalex.org/W2004487691","https://openalex.org/W2004628001","https://openalex.org/W2004914509","https://openalex.org/W2004950164","https://openalex.org/W2004978936","https://openalex.org/W2005045122","https://openalex.org/W2006597186","https://openalex.org/W2007035942","https://openalex.org/W2007616643","https://openalex.org/W2008242718","https://openalex.org/W2008530837","https://openalex.org/W2008560062","https://openalex.org/W2008639647","https://openalex.org/W2009132341","https://openalex.org/W2009394657","https://openalex.org/W2009526570","https://openalex.org/W2009830603","https://openalex.org/W2009952192","https://openalex.org/W2010413751","https://openalex.org/W2011095090","https://openalex.org/W2011265174","https://openalex.org/W2011538447","https://openalex.org/W2011847149","https://openalex.org/W2012692792","https://openalex.org/W2012851706","https://openalex.org/W2013280482","https://openalex.org/W2013911584","https://openalex.org/W2015528067","https://openalex.org/W2015932693","https://openalex.org/W2016915374","https://openalex.org/W2017363310","https://openalex.org/W2017797090","https://openalex.org/W2018304425","https://openalex.org/W2018445065","https://openalex.org/W2019817056","https://openalex.org/W2019870906","https://openalex.org/W2020132098","https://openalex.org/W2020582877","https://openalex.org/W2020862054","https://openalex.org/W2021815999","https://openalex.org/W2022140831","https://openalex.org/W2022516942","https://openalex.org/W2022523341","https://openalex.org/W2022628342","https://openalex.org/W2022662082","https://openalex.org/W2022682828","https://openalex.org/W2022745281","https://openalex.org/W2022993728","https://openalex.org/W2023976710","https://openalex.org/W2024059905","https://openalex.org/W2026667906","https://openalex.org/W2026674234","https://openalex.org/W2027403799","https://openalex.org/W2027452172","https://openalex.org/W2027810203","https://openalex.org/W2027978484","https://openalex.org/W2028020505","https://openalex.org/W2028573455","https://openalex.org/W2029443758","https://openalex.org/W2030261347","https://openalex.org/W2031718525","https://openalex.org/W2031935607","https://openalex.org/W2032107666","https://openalex.org/W2032226013","https://openalex.org/W2032330024","https://openalex.org/W2032950358","https://openalex.org/W2033653810","https://openalex.org/W2033682153","https://openalex.org/W2033827101","https://openalex.org/W2033952333","https://openalex.org/W2034758552","https://openalex.org/W2035069380","https://openalex.org/W2035585204","https://openalex.org/W2036599501","https://openalex.org/W2036740787","https://openalex.org/W2036997305","https://openalex.org/W2037360899","https://openalex.org/W2037708841","https://openalex.org/W2038272035","https://openalex.org/W2038327972","https://openalex.org/W2038676921","https://openalex.org/W2039403847","https://openalex.org/W2039643295","https://openalex.org/W2040751146","https://openalex.org/W2041184080","https://openalex.org/W2041516978","https://openalex.org/W2042684431","https://openalex.org/W2042905880","https://openalex.org/W2043268426","https://openalex.org/W2043986265","https://openalex.org/W2044118737","https://openalex.org/W2044306014","https://openalex.org/W2044627978","https://openalex.org/W2044898311","https://openalex.org/W2044980245","https://openalex.org/W2045416175","https://openalex.org/W2045790905","https://openalex.org/W2046665105","https://openalex.org/W2047384958","https://openalex.org/W2047819781","https://openalex.org/W2048024026","https://openalex.org/W2048830349","https://openalex.org/W2048897966","https://openalex.org/W2049286531","https://openalex.org/W2050786534","https://openalex.org/W2051215316","https://openalex.org/W2051537347","https://openalex.org/W2052211636","https://openalex.org/W2052607444","https://openalex.org/W2053160507","https://openalex.org/W2053649517","https://openalex.org/W2054326641","https://openalex.org/W2054415450","https://openalex.org/W2054438230","https://openalex.org/W2054569628","https://openalex.org/W2055036854","https://openalex.org/W2055308573","https://openalex.org/W2055343238","https://openalex.org/W2055380718","https://openalex.org/W2055446556","https://openalex.org/W2056103318","https://openalex.org/W2056304503","https://openalex.org/W2056374157","https://openalex.org/W2056558623","https://openalex.org/W2057121960","https://openalex.org/W2057170892","https://openalex.org/W2057276513","https://openalex.org/W2057310513","https://openalex.org/W2057709942","https://openalex.org/W2058995563","https://openalex.org/W2059089648","https://openalex.org/W2060086459","https://openalex.org/W2060892573","https://openalex.org/W2061177324","https://openalex.org/W2061209918","https://openalex.org/W2061693123","https://openalex.org/W2063127941","https://openalex.org/W2064004368","https://openalex.org/W2065611603","https://openalex.org/W2066717249","https://openalex.org/W2066828509","https://openalex.org/W2068015577","https://openalex.org/W2069665561","https://openalex.org/W2069832155","https://openalex.org/W2069922387","https://openalex.org/W2070017428","https://openalex.org/W2070029757","https://openalex.org/W2070529575","https://openalex.org/W2071181702","https://openalex.org/W2071459041","https://openalex.org/W2072998862","https://openalex.org/W2073449985","https://openalex.org/W2073760242","https://openalex.org/W2073806180","https://openalex.org/W2074052524","https://openalex.org/W2074813364","https://openalex.org/W2076182555","https://openalex.org/W2076190196","https://openalex.org/W2076265447","https://openalex.org/W2076482929","https://openalex.org/W2078349645","https://openalex.org/W2078376971","https://openalex.org/W2078549368","https://openalex.org/W2078568105","https://openalex.org/W2078924245","https://openalex.org/W2080751623","https://openalex.org/W2080773722","https://openalex.org/W2081330494","https://openalex.org/W2081422510","https://openalex.org/W2082238500","https://openalex.org/W2082425146","https://openalex.org/W2082625844","https://openalex.org/W2082816163","https://openalex.org/W2082912069","https://openalex.org/W2083339401","https://openalex.org/W2084248691","https://openalex.org/W2084299658","https://openalex.org/W2084931895","https://openalex.org/W2085276020","https://openalex.org/W2085524884","https://openalex.org/W2086390365","https://openalex.org/W2086779570","https://openalex.org/W2087075736","https://openalex.org/W2087599743","https://openalex.org/W2088664861","https://openalex.org/W2089435862","https://openalex.org/W2089518139","https://openalex.org/W2089631022","https://openalex.org/W2090098521","https://openalex.org/W2090281724","https://openalex.org/W2090916216","https://openalex.org/W2091404872","https://openalex.org/W2091852463","https://openalex.org/W2092402359","https://openalex.org/W2093427302","https://openalex.org/W2093477805","https://openalex.org/W2096787186","https://openalex.org/W2097777783","https://openalex.org/W2099789269","https://openalex.org/W2100625171","https://openalex.org/W2101119366","https://openalex.org/W2104382960","https://openalex.org/W2104704429","https://openalex.org/W2105280572","https://openalex.org/W2105452080","https://openalex.org/W2106292206","https://openalex.org/W2106392233","https://openalex.org/W2106541390","https://openalex.org/W2107396843","https://openalex.org/W2107518179","https://openalex.org/W2110454327","https://openalex.org/W2110457518","https://openalex.org/W2111148351","https://openalex.org/W2112455323","https://openalex.org/W2112587738","https://openalex.org/W2112777355","https://openalex.org/W2113780113","https://openalex.org/W2114396660","https://openalex.org/W2114655563","https://openalex.org/W2115713105","https://openalex.org/W2116294828","https://openalex.org/W2116294955","https://openalex.org/W2117393206","https://openalex.org/W2117524242","https://openalex.org/W2117772553","https://openalex.org/W2118749287","https://openalex.org/W2120471061","https://openalex.org/W2120802226","https://openalex.org/W2121562021","https://openalex.org/W2122264982","https://openalex.org/W2122341467","https://openalex.org/W2122415389","https://openalex.org/W2123393106","https://openalex.org/W2123913108","https://openalex.org/W2124100859","https://openalex.org/W2124272755","https://openalex.org/W2125068099","https://openalex.org/W2127779357","https://openalex.org/W2128473487","https://openalex.org/W2129223126","https://openalex.org/W2130274731","https://openalex.org/W2132310402","https://openalex.org/W2133148204","https://openalex.org/W2133272695","https://openalex.org/W2133398254","https://openalex.org/W2133865158","https://openalex.org/W2134830538","https://openalex.org/W2135427146","https://openalex.org/W2135890329","https://openalex.org/W2137089455","https://openalex.org/W2138311396","https://openalex.org/W2139093498","https://openalex.org/W2139856185","https://openalex.org/W2141918542","https://openalex.org/W2143268562","https://openalex.org/W2144102286","https://openalex.org/W2144737808","https://openalex.org/W2147804175","https://openalex.org/W2147846966","https://openalex.org/W2148225540","https://openalex.org/W2148573575","https://openalex.org/W2149142681","https://openalex.org/W2149269973","https://openalex.org/W2149402186","https://openalex.org/W2149936227","https://openalex.org/W2151044050","https://openalex.org/W2152276356","https://openalex.org/W2153107624","https://openalex.org/W2155606841","https://openalex.org/W2156118851","https://openalex.org/W2156730660","https://openalex.org/W2156840897","https://openalex.org/W2158695265","https://openalex.org/W2158778370","https://openalex.org/W2158977717","https://openalex.org/W2159390538","https://openalex.org/W2159517143","https://openalex.org/W2162633290","https://openalex.org/W2164670320","https://openalex.org/W2165128853","https://openalex.org/W2165161875","https://openalex.org/W2165845608","https://openalex.org/W2167279371","https://openalex.org/W2167340008","https://openalex.org/W2168452237","https://openalex.org/W2169063473","https://openalex.org/W2169671995","https://openalex.org/W2170780719","https://openalex.org/W2171047055","https://openalex.org/W2184575478","https://openalex.org/W2185332753","https://openalex.org/W2197385252","https://openalex.org/W2212433305","https://openalex.org/W2217855747","https://openalex.org/W2282619066","https://openalex.org/W2285056606","https://openalex.org/W2294172555","https://openalex.org/W2300310216","https://openalex.org/W2327686392","https://openalex.org/W2329808372","https://openalex.org/W2332287052","https://openalex.org/W2334165711","https://openalex.org/W2341935243","https://openalex.org/W2399315069","https://openalex.org/W2400982232","https://openalex.org/W2401045631","https://openalex.org/W2464977649","https://openalex.org/W2473482271","https://openalex.org/W2473678689","https://openalex.org/W2495557463","https://openalex.org/W2505514803","https://openalex.org/W2514699275","https://openalex.org/W2516917815","https://openalex.org/W2518997987","https://openalex.org/W2533858765","https://openalex.org/W2547371084","https://openalex.org/W2554059792","https://openalex.org/W2555006703","https://openalex.org/W2560677115","https://openalex.org/W2563978280","https://openalex.org/W2565578857","https://openalex.org/W2568082326","https://openalex.org/W2571740089","https://openalex.org/W2584311212","https://openalex.org/W2588139401","https://openalex.org/W2592243741","https://openalex.org/W2597615094","https://openalex.org/W2599729768","https://openalex.org/W2603130010","https://openalex.org/W2609085690","https://openalex.org/W2615326292","https://openalex.org/W2620911125","https://openalex.org/W2624770669","https://openalex.org/W2626930474","https://openalex.org/W2743308227","https://openalex.org/W2755408424","https://openalex.org/W2765610314","https://openalex.org/W2768455179","https://openalex.org/W2772629285","https://openalex.org/W2799986334","https://openalex.org/W2800874443","https://openalex.org/W2806400026","https://openalex.org/W2806614570","https://openalex.org/W2808436861","https://openalex.org/W2890247534","https://openalex.org/W2890533887","https://openalex.org/W2895718781","https://openalex.org/W2895753752","https://openalex.org/W2908836327","https://openalex.org/W2912695907","https://openalex.org/W2913318715","https://openalex.org/W2916522026","https://openalex.org/W2923383923","https://openalex.org/W2940371405","https://openalex.org/W2953014442","https://openalex.org/W2956068311","https://openalex.org/W2959502592","https://openalex.org/W2977424156","https://openalex.org/W2998530560","https://openalex.org/W3096720945","https://openalex.org/W4230843137","https://openalex.org/W4241707225","https://openalex.org/W4300538908"],"related_works":["https://openalex.org/W7070543513","https://openalex.org/W3036092513","https://openalex.org/W2515269589","https://openalex.org/W4390609151","https://openalex.org/W4205964389","https://openalex.org/W2510808221","https://openalex.org/W4313824741","https://openalex.org/W2755408424","https://openalex.org/W3144028834","https://openalex.org/W4403934276"],"abstract_inverted_index":{"Parkinson\u2019s":[0],"disease":[1],"(PD)":[2],"is":[3,97],"a":[4,254],"neurodegenerative":[5],"disorder":[6],"characterised":[7],"by":[8,63,89,244],"the":[9,17,34,52,56,75,114,131,134,211,233,238],"progressive":[10],"loss":[11],"of":[12,33,55,78,137,216,237],"dopaminergic":[13],"neurons,":[14],"particularly":[15],"in":[16,30,44,48,51,66,113,125,146,159,207,219,222,232],"ventral":[18],"substantia":[19,53,162,235],"nigra.":[20,163],"Growing":[21],"evidence":[22],"implicates":[23],"biometal":[24,91,245],"dyshomeostasis":[25,231],"and":[26,46,109,117,143,150,157,171,179,248],"subsequent":[27],"metal-catalysed":[28],"neurotoxicity":[29],"vulnerable":[31,234],"regions":[32],"PD":[35,57,115,126,161,239],"brain.":[36,127],"Through":[37],"meta-analysis,":[38],"I":[39,128,201],"confirm":[40],"previously":[41],"reported":[42],"reductions":[43],"Cu,":[45],"elevations":[47],"Fe":[49],"specifically":[50],"nigra":[54,236],"brain,":[58],"which":[59],"are":[60,71],"not":[61],"reflected":[62],"similar":[64,176,184],"changes":[65,70],"biofluid":[67],"tissues.":[68],"These":[69,226],"further":[72],"restricted":[73],"to":[74,148],"soluble":[76,84,99],"fraction":[77],"nigral":[79],"tissue":[80],"\u2013":[81],"suggesting":[82,187],"that":[83,102,169,188,213,229,249],"metalloproteins":[85],"may":[86,118,193,241,251],"be":[87,242],"affected":[88],"these":[90,189],"perturbations.":[92],"Superoxide":[93],"dismutase":[94],"1":[95],"(SOD1)":[96],"one":[98],"Cu-associated":[100],"protein":[101,197],"has":[103],"recently":[104],"demonstrated":[105],"impaired":[106],"antioxidant":[107],"capacity":[108],"altered":[110,122,204,214],"structural":[111],"conformation":[112],"brain":[116,240],"present":[119,252],"with":[120],"an":[121,195,203],"metalation":[123,215],"profile":[124],"describe,":[129],"for":[130,258],"first":[132],"time,":[133],"cutting-edge":[135],"technique":[136],"simultaneous":[138],"synchrotron":[139],"X-ray":[140],"fluorescence":[141],"microscopy":[142],"ptychography":[144],"performed":[145],"situ":[147],"identify":[149],"directly":[151],"image":[152],"Lewy":[153,172,180],"bodies,":[154],"SOD1":[155,170,178,208,217,250],"aggregates":[156,181,192],"neuromelanin":[158],"human":[160],"The":[164],"resulting":[165],"nanoscale":[166],"imaging":[167],"demonstrate":[168,202],"body":[173],"proteinopathies":[174],"share":[175,194],"structures.":[177],"also":[182],"exhibited":[183],"elemental":[185],"compositions,":[186],"distinct":[190],"proteinaceous":[191],"overlapping":[196],"misfolding":[198],"pathway.":[199],"Further,":[200],"Cu:Zn":[205],"ratio":[206],"aggregates,":[209],"supporting":[210],"hypothesis":[212],"results":[218],"aggregate":[220],"formation":[221],"this":[223],"Cu-deficient":[224],"region.":[225],"data":[227],"suggest":[228],"Cu":[230],"attenuated":[243],"modulation":[246],"therapies,":[247],"as":[253],"viable":[255],"therapeutic":[256],"target":[257],"PD.":[259]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-07-16T00:00:00"}