{"id":"https://openalex.org/W3041674758","doi":"https://doi.org/10.1016/s2055-6640(20)30610-5","title":"The role of APOBEC 3G/3F in shaping early HIV-1 reservoir landscapes","display_name":"The role of APOBEC 3G/3F in shaping early HIV-1 reservoir landscapes","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W3041674758","doi":"https://doi.org/10.1016/s2055-6640(20)30610-5","mag":"3041674758"},"language":"en","primary_location":{"id":"doi:10.1016/s2055-6640(20)30610-5","doi":"https://doi.org/10.1016/s2055-6640(20)30610-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)30610-5","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2055664020306105/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2055664020306105/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009331979","display_name":"Kavidha Reddy","orcid":"https://orcid.org/0000-0002-7024-0574","observed_orcids":["https://orcid.org/0000-0002-7024-0574"]},"institutions":[{"id":"https://openalex.org/I4210127310","display_name":"Africa Health Research Institute","ror":"https://ror.org/034m6ke32","country_code":"ZA","type":"facility","lineage":["https://openalex.org/I4210127310","https://openalex.org/I87048295"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"K. Reddy","raw_affiliation_strings":["Africa Health Research Institute, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Africa Health Research Institute, Durban, South Africa","institution_ids":["https://openalex.org/I4210127310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001896468","display_name":"Guinevere Q. Lee","orcid":"https://orcid.org/0000-0002-9412-886X","observed_orcids":["https://orcid.org/0000-0002-9412-886X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.Q. Lee","raw_affiliation_strings":["Ragon Institute of MGH, Massachusettes Institute of Technology and Harvard University, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, Massachusettes Institute of Technology and Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.D. Walker","raw_affiliation_strings":["Ragon Institute of MGH, Massachusettes Institute of Technology and Harvard University, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, Massachusettes Institute of Technology and Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019085141","display_name":"Mathias D. Lichterfeld","orcid":"https://orcid.org/0000-0001-9865-8350","observed_orcids":["https://orcid.org/0000-0001-9865-8350"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.D. Lichterfeld","raw_affiliation_strings":["Ragon Institute of MGH, Massachusettes Institute of Technology and Harvard University, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, Massachusettes Institute of Technology and Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040954811","display_name":"Thumbi Ndung\u2019u","orcid":"https://orcid.org/0000-0003-2962-3992","observed_orcids":["https://orcid.org/0000-0003-2962-3992"]},"institutions":[{"id":"https://openalex.org/I4210127310","display_name":"Africa Health Research Institute","ror":"https://ror.org/034m6ke32","country_code":"ZA","type":"facility","lineage":["https://openalex.org/I4210127310","https://openalex.org/I87048295"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"T. Ndung'u","raw_affiliation_strings":["Africa Health Research Institute, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Africa Health Research Institute, Durban, South Africa","institution_ids":["https://openalex.org/I4210127310"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26096599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":null,"first_page":"27","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":0.8309999704360962},{"id":"https://openalex.org/keywords/apobec3f","display_name":"APOBEC3F","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hiv-1-reservoir","display_name":"HIV-1 reservoir","score":0.9160000085830688},{"id":"https://openalex.org/keywords/primary-hiv-infection","display_name":"primary HIV infection","score":0.6140000224113464},{"id":"https://openalex.org/keywords/within-host-evolution","display_name":"within-host evolution","score":0.5920000076293945},{"id":"https://openalex.org/keywords/hiv-vaccine","display_name":"HIV vaccine","score":0.40400001406669617},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.5590000152587891},{"id":"https://openalex.org/keywords/perinatal-hiv-infection","display_name":"perinatal HIV infection","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C2776162770","wikidata":"https://www.wikidata.org/wiki/Q4653351","display_name":"APOBEC","level":4,"score":0.9038369655609131},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4970429241657257},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.25313878059387207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25231534242630005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09283936023712158},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.049966007471084595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/s2055-6640(20)30610-5","doi":"https://doi.org/10.1016/s2055-6640(20)30610-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)30610-5","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2055664020306105/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:45603c12f0c04990a6b0f37a29115ae6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/45603c12f0c04990a6b0f37a29115ae6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virus Eradication, Vol 3, Iss , Pp 27- (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s2055-6640(20)30610-5","doi":"https://doi.org/10.1016/s2055-6640(20)30610-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)30610-5","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2055664020306105/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3041674758.pdf","grobid_xml":"https://content.openalex.org/works/W3041674758.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3041981284","https://openalex.org/W3042032550","https://openalex.org/W7095650638","https://openalex.org/W2184162818","https://openalex.org/W2526044869","https://openalex.org/W1995231646","https://openalex.org/W7212170908","https://openalex.org/W2076582857","https://openalex.org/W2945468456","https://openalex.org/W2075106941"],"abstract_inverted_index":{"of":[0,6,23,27,73],"within-host":[1],"evolution":[2],"and/or":[3],"vaccine-induced":[4],"selection":[5],"certain":[7],"HIV":[8,13,45,65],"lineages.Conclusions:":[9],"Results":[10],"suggest":[11],"that":[12,34],"vaccines":[14,66],"may":[15,47],"have":[16],"perturbed":[17],"the":[18,43,54,71],"reservoir":[19,35,62,76],"in":[20,30,38,42],"a":[21],"subset":[22],"participants.The":[24],"higher":[25],"burden":[26,37],"Pol":[28],"escape":[29,36,57,79],"perinatal":[31],"infection":[32,51],"suggests":[33],"conserved,":[39],"rather":[40],"than":[41],"variable,":[44],"regions":[46,56],"correlate":[48],"with":[49,64],"untreated":[50],"time":[52],"as":[53],"former":[55],"more":[58],"slowly.Targeting":[59],"reactivated":[60],"latent":[61],"cells":[63],"will":[67],"require":[68],"consideration":[69],"for":[70],"complexity":[72],"within-and":[74],"between-host":[75],"diversity":[77],"and":[78],"burden.PP":[80],"4.13":[81]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-07-16T00:00:00"}