{"id":"https://openalex.org/W3041532002","doi":"https://doi.org/10.1096/fj.202000558rr","title":"Astaxanthin attenuates joint inflammation induced by monosodium urate crystals","display_name":"Astaxanthin attenuates joint inflammation induced by monosodium urate crystals","publication_year":2020,"publication_date":"2020-07-10","ids":{"openalex":"https://openalex.org/W3041532002","doi":"https://doi.org/10.1096/fj.202000558rr","mag":"3041532002","pmid":"https://pubmed.ncbi.nlm.nih.gov/32648603"},"language":"en","primary_location":{"id":"doi:10.1096/fj.202000558rr","doi":"https://doi.org/10.1096/fj.202000558rr","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.202000558rr","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3041532002"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085953543","display_name":"Yi\u2010Jen Peng","orcid":"https://orcid.org/0000-0003-4630-2103","observed_orcids":["https://orcid.org/0000-0003-4630-2103"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi\u2010Jen Peng","raw_affiliation_strings":["Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053985678","display_name":"Jeng\u2010Wei Lu","orcid":"https://orcid.org/0000-0003-2128-2046","observed_orcids":["https://orcid.org/0000-0003-2128-2046"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jeng\u2010Wei Lu","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063841543","display_name":"Feng\u2010Cheng Liu","orcid":"https://orcid.org/0000-0003-1291-8946","observed_orcids":["https://orcid.org/0000-0003-1291-8946","https://orcid.org/0000-0002-7978-8309"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Feng\u2010Cheng Liu","raw_affiliation_strings":["Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009656964","display_name":"Chian\u2010Her Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chian\u2010Her Lee","raw_affiliation_strings":["Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802331550","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111436174","display_name":"Herng\u2010Sheng Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Herng\u2010Sheng Lee","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005003565","display_name":"Yi\u2010Jung Ho","orcid":"https://orcid.org/0009-0006-3931-2302","observed_orcids":["https://orcid.org/0009-0006-3931-2302"]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi\u2010Jung Ho","raw_affiliation_strings":["School of Pharmacy, Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tsung\u2010Hsun Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung\u2010Hsun Hsieh","raw_affiliation_strings":["Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101704467","display_name":"Chia\u2010Chun Wu","orcid":"https://orcid.org/0000-0003-2563-8679","observed_orcids":["https://orcid.org/0000-0003-2563-8679"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia\u2010Chun Wu","raw_affiliation_strings":["Department of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102890066","display_name":"Chih\u2010Chien Wang","orcid":"https://orcid.org/0000-0003-3709-3848","observed_orcids":["https://orcid.org/0000-0003-3709-3848"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chih\u2010Chien Wang","raw_affiliation_strings":["Department of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102890066"],"corresponding_institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":2.2769,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.88774758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"34","issue":"8","first_page":"11215","last_page":"11226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astaxanthin","display_name":"astaxanthin","score":1.0},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.9629999995231628},{"id":"https://openalex.org/keywords/monosodium-urate-crystals","display_name":"monosodium urate crystals","score":0.9829999804496765},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7450000047683716},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.8880000114440918},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8529999852180481},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8059999942779541},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5690000057220459},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7691960334777832},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.6245996952056885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5837042331695557},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5697563290596008},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5504074692726135},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5227774977684021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46295008063316345},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.42630550265312195},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.346083402633667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3255854845046997}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007596","descriptor_name":"Joints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007596","descriptor_name":"Joints","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013585","descriptor_name":"Synovitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013585","descriptor_name":"Synovitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024341","descriptor_name":"Xanthophylls","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1096/fj.202000558rr","doi":"https://doi.org/10.1096/fj.202000558rr","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.202000558rr","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:32648603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32648603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W34602510","https://openalex.org/W1550280299","https://openalex.org/W1611522350","https://openalex.org/W1907909084","https://openalex.org/W1929024384","https://openalex.org/W1966018233","https://openalex.org/W1984395883","https://openalex.org/W1987535382","https://openalex.org/W1996930866","https://openalex.org/W2001640184","https://openalex.org/W2003257415","https://openalex.org/W2007452107","https://openalex.org/W2009435405","https://openalex.org/W2014054401","https://openalex.org/W2020196152","https://openalex.org/W2029577492","https://openalex.org/W2045140018","https://openalex.org/W2050785940","https://openalex.org/W2058214311","https://openalex.org/W2082884271","https://openalex.org/W2083084591","https://openalex.org/W2084825304","https://openalex.org/W2085328948","https://openalex.org/W2090147735","https://openalex.org/W2095324325","https://openalex.org/W2129935236","https://openalex.org/W2143882136","https://openalex.org/W2148283536","https://openalex.org/W2164385726","https://openalex.org/W2170170036","https://openalex.org/W2197043200","https://openalex.org/W2236437672","https://openalex.org/W2237777675","https://openalex.org/W2292442040","https://openalex.org/W2754485818","https://openalex.org/W2781412574","https://openalex.org/W2781757947","https://openalex.org/W2802506986","https://openalex.org/W2807678985","https://openalex.org/W2901812571","https://openalex.org/W2913845592","https://openalex.org/W2970351382","https://openalex.org/W6602440933"],"related_works":["https://openalex.org/W2062501841","https://openalex.org/W3209804203","https://openalex.org/W202378911","https://openalex.org/W4225792051","https://openalex.org/W2911659537","https://openalex.org/W7155380610","https://openalex.org/W4315767661","https://openalex.org/W2751430405","https://openalex.org/W2197043200","https://openalex.org/W2754266919"],"abstract_inverted_index":{"Gouty":[0],"arthritis":[1,9,154],"is":[2,11],"the":[3,6,94,97,118,129,197,211,223,231,242,251],"one":[4],"of":[5,41,57,66,82,96,117,131,165,176,186,225,233,245,253],"most":[7],"painful":[8],"and":[10,27,54,59,93,110,133,138,236],"caused":[12],"by":[13,47,51,141,229],"an":[14,145],"inflammatory":[15,83,237],"reaction.":[16],"This":[17],"study":[18],"investigated":[19],"whether":[20],"astaxanthin":[21],"(AXT),":[22],"which":[23,158,199,213],"has":[24],"documented":[25],"anti-inflammatory":[26,243],"antioxidant":[28],"properties,":[29],"exhibits":[30],"protective":[31],"effects":[32,224],"against":[33],"monosodium":[34],"urate":[35],"(MSU)":[36],"crystal-induced":[37,227,255],"inflammation.":[38],"Cell":[39],"viability":[40],"J774A.1":[42,124],"murine":[43],"macrophages":[44],"was":[45,85,100,121,155,193],"assessed":[46],"AXT":[48,78,91,126,166,177,202,221,246],"dose-dependent":[49],"incubation":[50],"MTT":[52],"assays,":[53],"expression":[55,116],"levels":[56],"iNOS":[58],"COX-2":[60,132],"proteins":[61],"as":[62,64],"well":[63],"secretion":[65],"IL-1\u03b2":[67],"were":[68,105],"also":[69,101,127],"analyzed":[70],"under":[71],"MSU":[72,108,146,169,179,206,215,226,254],"crystals":[73,109],"stimulation":[74,181,208],"with":[75,90,107],"or":[76,172],"without":[77],"treatment.":[79],"The":[80],"production":[81,232],"mediators":[84],"found":[86,114],"to":[87,168,205,210],"significantly":[88,194],"decrease":[89],"treatment,":[92],"formation":[95],"inflammasome":[98],"complex":[99],"attenuated":[102,195],"when":[103],"cells":[104],"co-stimulated":[106],"AXT.":[111],"Furthermore,":[112],"we":[113],"that":[115,191,220,241],"MAPK":[119],"pathway":[120],"downregulated":[122],"in":[123,135,157,196,250],"cells.":[125],"inhibited":[128],"induction":[130],"IL-6":[134],"human":[136],"chondrocytes":[137],"synovial":[139],"fibroblasts":[140],"western":[142],"blots.":[143],"Finally,":[144],"crystal":[147,170,180,207],"intra-articular":[148,174],"injection":[149,203],"rat":[150],"model":[151],"for":[152,182],"gouty":[153],"utilized":[156],"treatment":[159,252],"groups":[160],"received":[161,200,214],"5-daily":[162],"intraperitoneal":[163,201],"injections":[164,175],"prior":[167,204],"stimulation,":[171],"once":[173],"following":[178],"6":[183],"hours.":[184],"Results":[185],"synovitis":[187],"score":[188],"analysis":[189],"revealed":[190],"inflammation":[192,228],"group":[198,212],"compared":[209],"only.":[216],"These":[217],"results":[218],"indicate":[219],"attenuates":[222],"suppressing":[230],"pro-inflammatory":[234],"cytokines":[235],"mediators.":[238],"Our":[239],"findings":[240],"activities":[244],"may":[247],"be":[248],"beneficial":[249],"arthritis.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-07-16T00:00:00"}
