{"id":"https://openalex.org/W3041512876","doi":"https://doi.org/10.1080/25785826.2020.1788229","title":"Fatal fulminant hepatitis induced by combined ipilimumab and nivolumab therapy despite favorable histologic response and confirmed by autopsy in a patient with clear cell renal cell carcinoma","display_name":"Fatal fulminant hepatitis induced by combined ipilimumab and nivolumab therapy despite favorable histologic response and confirmed by autopsy in a patient with clear cell renal cell carcinoma","publication_year":2020,"publication_date":"2020-07-07","ids":{"openalex":"https://openalex.org/W3041512876","doi":"https://doi.org/10.1080/25785826.2020.1788229","mag":"3041512876","pmid":"https://pubmed.ncbi.nlm.nih.gov/32634346"},"language":"en","primary_location":{"id":"doi:10.1080/25785826.2020.1788229","doi":"https://doi.org/10.1080/25785826.2020.1788229","is_oa":true,"landing_page_url":"https://doi.org/10.1080/25785826.2020.1788229","pdf_url":null,"source":{"id":"https://openalex.org/S4306551435","display_name":"Immunological Medicine","issn_l":"2578-5826","issn":["2578-5826"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d","medline","oarl","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1080/25785826.2020.1788229","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066775767","display_name":"Terufumi Kubo","orcid":"https://orcid.org/0000-0001-9274-2551","observed_orcids":["https://orcid.org/0000-0001-9274-2551"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Terufumi Kubo","raw_affiliation_strings":["Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9274-2551","affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047177120","display_name":"Taro Sugawara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124603","display_name":"Sapporo Medical University Hospital","ror":"https://ror.org/02a7zgk95","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124603"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taro Sugawara","raw_affiliation_strings":["Department of Surgical Pathology, Sapporo Medical University Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Pathology, Sapporo Medical University Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210124603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031999236","display_name":"Tomoyo Shinkawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyo Shinkawa","raw_affiliation_strings":["Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111165763","display_name":"Tomoyo Kurisu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyo Kurisu","raw_affiliation_strings":["Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051839234","display_name":"Nodoka Kouzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nodoka Kouzen","raw_affiliation_strings":["Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022418773","display_name":"Toshiaki Tanaka","orcid":"https://orcid.org/0000-0002-1199-9302","observed_orcids":["https://orcid.org/0000-0002-1199-9302"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Tanaka","raw_affiliation_strings":["Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019476401","display_name":"Fumimasa Fukuta","orcid":"https://orcid.org/0000-0002-4332-940X","observed_orcids":["https://orcid.org/0000-0002-4332-940X"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumimasa Fukuta","raw_affiliation_strings":["Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kouji Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouji Yamasaki","raw_affiliation_strings":["Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042869078","display_name":"Shintaro Sugita","orcid":"https://orcid.org/0000-0002-2750-6082","observed_orcids":["https://orcid.org/0000-0002-2750-6082"]},"institutions":[{"id":"https://openalex.org/I4210124603","display_name":"Sapporo Medical University Hospital","ror":"https://ror.org/02a7zgk95","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124603"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shintaro Sugita","raw_affiliation_strings":["Department of Surgical Pathology, Sapporo Medical University Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Pathology, Sapporo Medical University Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210124603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101747943","display_name":"Kazuhiko Matsuo","orcid":"https://orcid.org/0000-0001-5782-5300","observed_orcids":["https://orcid.org/0000-0001-5782-5300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhiko Matsuo","raw_affiliation_strings":["Sapporo Clinical Laboratory Inc., Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapporo Clinical Laboratory Inc., Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043205342","display_name":"Rena Morita","orcid":"https://orcid.org/0009-0007-8361-4436","observed_orcids":["https://orcid.org/0009-0007-8361-4436","https://orcid.org/0000-0003-4203-9440"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rena Morita","raw_affiliation_strings":["Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061939029","display_name":"Yoshihiko Hirohashi","orcid":"https://orcid.org/0000-0002-0608-3914","observed_orcids":["https://orcid.org/0000-0002-0608-3914"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Hirohashi","raw_affiliation_strings":["Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000123851","display_name":"Tomohide Tsukahara","orcid":"https://orcid.org/0000-0002-3678-4359","observed_orcids":["https://orcid.org/0000-0002-3678-4359"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohide Tsukahara","raw_affiliation_strings":["Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053163842","display_name":"Takayuki Kanaseki","orcid":"https://orcid.org/0000-0001-7294-6880","observed_orcids":["https://orcid.org/0000-0001-7294-6880"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Kanaseki","raw_affiliation_strings":["Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090485641","display_name":"Tadashi Hasegawa","orcid":"https://orcid.org/0000-0003-0535-6842","observed_orcids":["https://orcid.org/0000-0003-0535-6842"]},"institutions":[{"id":"https://openalex.org/I4210124603","display_name":"Sapporo Medical University Hospital","ror":"https://ror.org/02a7zgk95","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124603"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Hasegawa","raw_affiliation_strings":["Department of Surgical Pathology, Sapporo Medical University Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Pathology, Sapporo Medical University Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210124603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083918280","display_name":"Naoya Masumori","orcid":"https://orcid.org/0000-0001-6324-0739","observed_orcids":["https://orcid.org/0000-0001-6324-0739"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoya Masumori","raw_affiliation_strings":["Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072637751","display_name":"Toshihiko Torigoe","orcid":"https://orcid.org/0000-0002-9463-5917","observed_orcids":["https://orcid.org/0000-0002-9463-5917"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Torigoe","raw_affiliation_strings":["Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066775767"],"corresponding_institution_ids":["https://openalex.org/I141882310"],"apc_list":null,"apc_paid":null,"fwci":1.0898,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78266266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"2","first_page":"136","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fulminant-hepatitis","display_name":"fulminant hepatitis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8600000143051147},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.5830000042915344},{"id":"https://openalex.org/keywords/tia-1","display_name":"TIA-1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hla-class-i-downregulation","display_name":"HLA class I downregulation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/polyuria","display_name":"polyuria","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.47699999809265137},{"id":"https://openalex.org/keywords/autopsy-findings","display_name":"autopsy findings","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.8280520439147949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.818703293800354},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.6283760070800781},{"id":"https://openalex.org/C2781107259","wikidata":"https://www.wikidata.org/wiki/Q5508364","display_name":"Fulminant","level":2,"score":0.5870616436004639},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5776717066764832},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5447817444801331},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5335453152656555},{"id":"https://openalex.org/C2994395758","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Fulminant hepatitis","level":3,"score":0.44212692975997925},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.43257197737693787},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.42520755529403687},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.3702445328235626},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30815160274505615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2735194265842438},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000074324","descriptor_name":"Ipilimumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000074324","descriptor_name":"Ipilimumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D047508","descriptor_name":"Massive Hepatic Necrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D047508","descriptor_name":"Massive Hepatic Necrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/25785826.2020.1788229","doi":"https://doi.org/10.1080/25785826.2020.1788229","is_oa":true,"landing_page_url":"https://doi.org/10.1080/25785826.2020.1788229","pdf_url":null,"source":{"id":"https://openalex.org/S4306551435","display_name":"Immunological Medicine","issn_l":"2578-5826","issn":["2578-5826"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d","medline","oarl","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Medicine","raw_type":"journal-article"},{"id":"pmid:32634346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32634346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological medicine","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:df76912d07174c658434da11e8f06dbd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/df76912d07174c658434da11e8f06dbd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Immunological Medicine, Vol 44, Iss 2, Pp 136-141 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/25785826.2020.1788229","doi":"https://doi.org/10.1080/25785826.2020.1788229","is_oa":true,"landing_page_url":"https://doi.org/10.1080/25785826.2020.1788229","pdf_url":null,"source":{"id":"https://openalex.org/S4306551435","display_name":"Immunological Medicine","issn_l":"2578-5826","issn":["2578-5826"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d","medline","oarl","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2085247907","https://openalex.org/W2128758225","https://openalex.org/W2166662937","https://openalex.org/W2519279652","https://openalex.org/W2594042408","https://openalex.org/W2605754740","https://openalex.org/W2606795212","https://openalex.org/W2609289346","https://openalex.org/W2773212848","https://openalex.org/W2895326014","https://openalex.org/W2897064819","https://openalex.org/W2904618821","https://openalex.org/W2964133630","https://openalex.org/W2981911914","https://openalex.org/W2992577051"],"related_works":["https://openalex.org/W7138875535","https://openalex.org/W4399808480","https://openalex.org/W4406085342","https://openalex.org/W7148841052","https://openalex.org/W3200631288","https://openalex.org/W2887695437","https://openalex.org/W4289979515","https://openalex.org/W4366368039","https://openalex.org/W4406054147","https://openalex.org/W3115463230"],"abstract_inverted_index":{"Effective":[0],"management":[1],"of":[2,21,38,46,84,108,115,137,162],"immune-related":[3],"adverse":[4],"events":[5],"in":[6,61,91,102,128],"patients":[7],"receiving":[8],"immunotherapy":[9,127],"for":[10,124,173],"cancer":[11],"is":[12,169],"problematic.":[13],"In":[14,131],"this":[15,132,168],"report,":[16],"we":[17],"present":[18],"the":[19,58,62,92,99,103,109,142,160],"case":[20,172],"a":[22,36,88,122],"58-year-old":[23],"man":[24],"with":[25,70,146],"advanced":[26],"clear":[27],"cell":[28,30],"renal":[29],"carcinoma":[31],"who":[32],"responded":[33],"well":[34],"to":[35,156],"combination":[37],"ipilimumab":[39],"and":[40,52,106,141],"nivolumab.":[41],"However,":[42,87],"after":[43],"two":[44],"courses":[45],"treatment,":[47],"he":[48],"developed":[49],"fulminant":[50],"hepatitis":[51],"died.":[53],"An":[54],"autopsy":[55],"confirmed":[56],"that":[57,167],"primary":[59],"lesion":[60,90,105],"left":[63],"kidney":[64,94],"was":[65,144,154],"more":[66,134],"than":[67,135],"99%":[68],"necrotic":[69],"only":[71],"six":[72],"small":[73],"residual":[74,110],"tumor":[75,100,129],"lesions.":[76],"These":[77],"lesions":[78,111],"were":[79,139],"infiltrated":[80,145],"by":[81,159],"large":[82],"numbers":[83],"CD8-positive/TIA-1-positive":[85,147,163],"lymphocytes.":[86,97,148,164],"metastatic":[89,104],"right":[93],"harbored":[95],"few":[96],"Furthermore,":[98],"cells":[101],"one":[107],"showed":[112],"decreased":[113],"expression":[114],"HLA":[116],"class":[117],"I":[118],"molecules,":[119],"which":[120,153],"are":[121],"prerequisite":[123],"cytotoxic":[125],"T-lymphocyte-mediated":[126],"cells.":[130],"patient,":[133],"80%":[136],"hepatocytes":[138],"destroyed":[140],"parenchyma":[143],"The":[149],"patient":[150],"had":[151],"polyuria,":[152],"attributed":[155],"neurohypophysitis":[157],"caused":[158],"infiltration":[161],"We":[165],"believe":[166],"an":[170],"instructive":[171],"immuno-oncologists.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-16T00:00:00"}
