{"id":"https://openalex.org/W3041479968","doi":null,"title":"Stimulation of endoplasmic reticulum (ER) stress by tunicamycin senstizes human non-small cell lung cancer (NSCLC) cells to the EGFR tyrosine kinase inhibitor erlotinib","display_name":"Stimulation of endoplasmic reticulum (ER) stress by tunicamycin senstizes human non-small cell lung cancer (NSCLC) cells to the EGFR tyrosine kinase inhibitor erlotinib","publication_year":2006,"publication_date":"2006-04-15","ids":{"openalex":"https://openalex.org/W3041479968","mag":"3041479968"},"language":"en","primary_location":{"id":"mag:3041479968","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/66/8_Supplement/891.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109232882","display_name":"Yi\u2010He Ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi\u2010He Ling","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077391276","display_name":"Tianhong Li","orcid":"https://orcid.org/0000-0001-7422-3520","observed_orcids":["https://orcid.org/0000-0001-7422-3520"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianhong Li","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":"https://orcid.org/0000-0001-7422-3520","affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108481953","display_name":"Roman Perez-Soler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rom\u00e1n P\u00e9rez-Soler","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35301708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":null,"first_page":"891","last_page":"891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9150000214576721},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9210000038146973},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/egfr-tki-resistance","display_name":"EGFR tyrosine kinase inhibitor resistance","score":0.9309999942779541},{"id":"https://openalex.org/keywords/drug-sensitization","display_name":"drug sensitization","score":0.6790000200271606},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.671999990940094},{"id":"https://openalex.org/keywords/caspase-12","display_name":"caspase-12","score":0.9129999876022339},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9430000185966492},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.765999972820282},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8939999938011169},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2777575526","wikidata":"https://www.wikidata.org/wiki/Q3542091","display_name":"Tunicamycin","level":4,"score":0.8890551328659058},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.792685329914093},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.5965217351913452},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5183587670326233},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47214654088020325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43202945590019226},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4311876893043518},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4190678894519806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37835636734962463},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36608678102493286},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30442845821380615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26036542654037476},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2329092025756836},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.1969175934791565},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15371248126029968},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0838790237903595}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3041479968","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/66/8_Supplement/891.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2023048195","https://openalex.org/W2608627006","https://openalex.org/W2043133404","https://openalex.org/W2154539063","https://openalex.org/W2702831908","https://openalex.org/W2330411541","https://openalex.org/W3012741444","https://openalex.org/W2027216014","https://openalex.org/W2032653567","https://openalex.org/W2071751989"],"abstract_inverted_index":{"3787":[0],"Tunicamycin,":[2],"a":[3,149,219],"naturally":[4],"occurring":[5],"antibiotic,":[6],"has":[7],"been":[8],"shown":[9],"to":[10,61,151,205,209,217,257,267],"induce":[11,218],"endoplasmic":[12],"reticulum":[13],"(ER)":[14],"stress":[15,65],"by":[16,67,99,171,201,280],"inhibiting":[17],"protein":[18],"glycosylation.":[19],"Erlotinib":[20],"(Tarceva,":[21],"OSI-774)":[22],"is":[23],"an":[24],"orally":[25],"active":[26],"EGFR":[27,207,213,236],"tyrosine":[28],"kinase":[29],"inhibitor":[30],"approved":[31],"as":[32,59,148,169,238,240],"second/third":[33],"line":[34,147],"treatment":[35],"for":[36],"patients":[37],"with":[38,197,222,245],"NSCLC.":[39],"In":[40,85],"this":[41],"study,":[42],"we":[43],"used":[44,143],"two":[45,51],"erlotinib-sensitive":[46,104],"(H322":[47],"and":[48,50,57,106,121,126,131,155,175,180,184,193,216,259,284],"H358)":[49],"erlotinib-resistant":[52,119,255],"NSCLC":[53,74],"cell":[54,71,75,146],"lines":[55],"(H1650":[56],"A549)":[58],"models":[60],"determine":[62],"whether":[63],"ER":[64],"induced":[66],"tunicamycin":[68,253],"enhances":[69],"erlotinib-induced":[70],"death":[72],"in":[73,102,109,118,135,232,278],"lines.":[76],"Cytotoxicity":[77],"was":[78,97,195,203,228,276],"assessed":[79,170],"using":[80],"the":[81,86,92,103,110,114,136,144,153,159,166,187,198,211,226],"colorimetric":[82],"tetrazolium-based":[83],"(MTT).":[84],"presence":[87,137],"of":[88,95,138,158,165,173,178,186,189,235,241,270],"1":[89,139],"\u03bcM":[90,128,140],"tunicamycin,":[91],"antiproliferative":[93],"effect":[94,263],"erlotinib":[96,111,115,246,258],"increased":[98],"about":[100,107],"2-fold":[101],"cells":[105,123,256],"10-fold":[108],"resistant":[112],"cells:":[113],"IC50":[116],"values":[117],"H1650":[120,145],"A549":[122],"were":[124],"8.5":[125],"12.3":[127],"vs":[129],"0.63":[130],"1.8":[132],"\u03bcM,":[133],"respectively,":[134],"tunicamycin.":[141],"We":[142],"model":[150],"explore":[152],"cellular":[154],"biochemical":[156],"mechanisms":[157],"synergism":[160],"observed.":[161],"A":[162],"remarkable":[163],"enhancement":[164],"apoptotic":[167],"response":[168,221],"activation":[172],"caspase-12":[174],"caspase-3,":[176],"induction":[177],"PARP":[179],"Bak":[181],"proteins":[182,191],"cleavage,":[183],"down-regulation":[185],"expression":[188],"anti-apoptotic":[190],"Bcl-XL":[192],"survivin":[194],"observed":[196],"combination.":[199],"Tunicamycin":[200],"itself":[202],"found":[204],"inhibit":[206],"glycosylation,":[208],"generate":[210],"truncated":[212],"(130":[214],"kDa),":[215],"survival":[220,272],"AKT/PKB":[223,242],"activation.":[224],"Interestingly,":[225],"combination":[227],"also":[229],"more":[230],"effective":[231],"causing":[233],"inhibition":[234],"phosphorylation,":[237],"well":[239],"when":[243],"compared":[244],"alone.":[247],"Overall,":[248],"our":[249],"results":[250],"demonstrate":[251],"that":[252,260],"sensitizes":[254],"such":[261],"sensitization":[262],"may":[264],"be":[265],"related":[266],"enhanced":[268],"interruption":[269],"EGFR-related":[271],"pathways.":[273],"This":[274],"work":[275],"supported":[277],"part":[279],"NIH":[281],"CA91784,":[282],"CA84119":[283],"OSI":[285],"Pharmaceuticals.":[286]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2020-07-16T00:00:00"}
