{"id":"https://openalex.org/W3041476526","doi":"https://doi.org/10.1164/rccm.201910-2041oc","title":"Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFR\u03b2","display_name":"Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFR\u03b2","publication_year":2020,"publication_date":"2020-07-07","ids":{"openalex":"https://openalex.org/W3041476526","doi":"https://doi.org/10.1164/rccm.201910-2041oc","mag":"3041476526","pmid":"https://pubmed.ncbi.nlm.nih.gov/32634060","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7786813"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.201910-2041oc","doi":"https://doi.org/10.1164/rccm.201910-2041oc","is_oa":true,"landing_page_url":"https://doi.org/10.1164/rccm.201910-2041oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1164/rccm.201910-2041oc","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055656160","display_name":"Christoph M. Zehendner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph M. Zehendner","raw_affiliation_strings":["German Center for Cardiovascular Research, DZHK, Berlin, Germany","Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and; ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and; ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013276220","display_name":"Chanil Valasarajan","orcid":"https://orcid.org/0000-0002-0969-9044","observed_orcids":["https://orcid.org/0000-0002-0969-9044","https://orcid.org/0000-0003-3932-1242"]},"institutions":[{"id":"https://openalex.org/I4210102801","display_name":"Max Planck Institute for Heart and Lung Research","ror":"https://ror.org/0165r2y73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210102801"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Chanil Valasarajan","raw_affiliation_strings":["Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany","institution_ids":["https://openalex.org/I4210102801","https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050299500","display_name":"Astrid Werner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Astrid Werner","raw_affiliation_strings":["Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080632467","display_name":"Jes\u2010Niels Boeckel","orcid":"https://orcid.org/0000-0002-7438-3089","observed_orcids":["https://orcid.org/0000-0002-7438-3089"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jes-Niels Boeckel","raw_affiliation_strings":["German Center for Cardiovascular Research, DZHK, Berlin, Germany","Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073830825","display_name":"Florian C. Bischoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian C. Bischoff","raw_affiliation_strings":["German Center for Cardiovascular Research, DZHK, Berlin, Germany","Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and; ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and; ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005270356","display_name":"David John","orcid":"https://orcid.org/0000-0003-3217-5449","observed_orcids":["https://orcid.org/0000-0003-3217-5449"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David John","raw_affiliation_strings":["German Center for Cardiovascular Research, DZHK, Berlin, Germany","Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052983985","display_name":"Tyler Weirick","orcid":"https://orcid.org/0000-0003-0110-5712","observed_orcids":["https://orcid.org/0000-0003-0110-5712"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210122955","display_name":"Cardiovascular Innovation Institute","ror":"https://ror.org/0230wyg61","country_code":"US","type":"facility","lineage":["https://openalex.org/I142740786","https://openalex.org/I4210122955","https://openalex.org/I4210165260","https://openalex.org/I7287704"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tyler Weirick","raw_affiliation_strings":["Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky","German Center for Cardiovascular Research, DZHK, Berlin, Germany","Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky; German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky","institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210122955"]},{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky; German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210122955","https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016280016","display_name":"Simone-Franziska Glaser","orcid":"https://orcid.org/0000-0002-0808-2659","observed_orcids":["https://orcid.org/0000-0002-0808-2659"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simone F. Glaser","raw_affiliation_strings":["German Center for Cardiovascular Research, DZHK, Berlin, Germany","Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045299495","display_name":"Oliver Ro\u00dfbach","orcid":"https://orcid.org/0000-0002-1172-0359","observed_orcids":["https://orcid.org/0000-0002-1172-0359"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Rossbach","raw_affiliation_strings":["Department of Biology and Chemistry, Institute of Biochemistry, University of Giessen, Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Chemistry, Institute of Biochemistry, University of Giessen, Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067844394","display_name":"Nicolas Ja\u00e9","orcid":"https://orcid.org/0000-0002-0694-7030","observed_orcids":["https://orcid.org/0000-0002-0694-7030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Ja\u00e9","raw_affiliation_strings":["Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022050150","display_name":"Shemsi Demolli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shemsi Demolli","raw_affiliation_strings":["Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067912166","display_name":"Fatemeh Khassafi","orcid":"https://orcid.org/0009-0000-9254-757X","observed_orcids":["https://orcid.org/0009-0000-9254-757X"]},"institutions":[{"id":"https://openalex.org/I4210102801","display_name":"Max Planck Institute for Heart and Lung Research","ror":"https://ror.org/0165r2y73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210102801"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fatemeh Khassafi","raw_affiliation_strings":["Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany","institution_ids":["https://openalex.org/I4210102801","https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055481715","display_name":"Ke Yuan","orcid":"https://orcid.org/0000-0001-8085-5452","observed_orcids":["https://orcid.org/0000-0001-8085-5452"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Yuan","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067917635","display_name":"Vinicio de Jes\u00fas P\u00e9rez","orcid":"https://orcid.org/0000-0001-5532-8247","observed_orcids":["https://orcid.org/0000-0001-5532-8247"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinicio A. de Jesus Perez","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046219444","display_name":"Katharina Michalik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katharina M. Michalik","raw_affiliation_strings":["Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344463","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0002-6857-7696","observed_orcids":["https://orcid.org/0000-0002-6857-7696"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China; and","Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbruck-Centre for Molecular Medicine, Berlin, Germany","Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China; and; Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbruck-Centre for Molecular Medicine, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China; and","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbruck-Centre for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China; and; Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbruck-Centre for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016511599","display_name":"Werner Seeger","orcid":"https://orcid.org/0000-0003-1946-0894","observed_orcids":["https://orcid.org/0000-0003-1946-0894"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210102801","display_name":"Max Planck Institute for Heart and Lung Research","ror":"https://ror.org/0165r2y73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210102801"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Seeger","raw_affiliation_strings":["Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University, Giessen, Germany","Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL), Bad Nauheim, Germany","Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University, Giessen, Germany; Department of Lung Development and Remodeling Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL) Bad Nauheim Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]},{"raw_affiliation_string":"Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL), Bad Nauheim, Germany","institution_ids":["https://openalex.org/I4210102801","https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University, Giessen, Germany; Department of Lung Development and Remodeling Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL) Bad Nauheim Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210102801","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110709590","display_name":"Andreas G\u00fcnther","orcid":"https://orcid.org/0000-0002-2187-0975","observed_orcids":["https://orcid.org/0000-0002-2187-0975"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Guenther","raw_affiliation_strings":["Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus-Liebig University, Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus-Liebig University, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089361907","display_name":"Roxana Maria Wasnick","orcid":"https://orcid.org/0000-0003-1114-7799","observed_orcids":["https://orcid.org/0000-0003-1114-7799"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roxana M. Wasnick","raw_affiliation_strings":["Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus-Liebig University, Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus-Liebig University, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008362023","display_name":"Shizuka Uchida","orcid":"https://orcid.org/0000-0003-4787-8067","observed_orcids":["https://orcid.org/0000-0003-4787-8067"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210122955","display_name":"Cardiovascular Innovation Institute","ror":"https://ror.org/0230wyg61","country_code":"US","type":"facility","lineage":["https://openalex.org/I142740786","https://openalex.org/I4210122955","https://openalex.org/I4210165260","https://openalex.org/I7287704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shizuka Uchida","raw_affiliation_strings":["Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky","Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky","institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210122955"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061907666","display_name":"Andreas Michael Zeiher","orcid":"https://orcid.org/0000-0003-1711-5819","observed_orcids":["https://orcid.org/0000-0003-1711-5819"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas M. Zeiher","raw_affiliation_strings":["German Center for Cardiovascular Research, DZHK, Berlin, Germany","ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","German Center for Cardiovascular Research, DZHK, Berlin, Germany; ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany; ZIM III, Department of Cardiology, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025706940","display_name":"Stefanie Dimmeler","orcid":"https://orcid.org/0000-0002-1045-2436","observed_orcids":["https://orcid.org/0000-0002-1045-2436"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Dimmeler","raw_affiliation_strings":["German Center for Cardiovascular Research, DZHK, Berlin, Germany","Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"German Center for Cardiovascular Research, DZHK, Berlin, Germany; Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, and","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054116239","display_name":"Soni Savai Pullamsetti","orcid":"https://orcid.org/0000-0003-0440-8831","observed_orcids":["https://orcid.org/0000-0003-0440-8831","https://orcid.org/0000-0002-0969-9044"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210102801","display_name":"Max Planck Institute for Heart and Lung Research","ror":"https://ror.org/0165r2y73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210102801"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Soni S. Pullamsetti","raw_affiliation_strings":["Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University, Giessen, Germany","Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL), Bad Nauheim, Germany","Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University, Giessen, Germany; Department of Lung Development and Remodeling Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL) Bad Nauheim Germany"],"raw_orcid":"https://orcid.org/0000-0003-0440-8831","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]},{"raw_affiliation_string":"Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL), Bad Nauheim, Germany","institution_ids":["https://openalex.org/I4210102801","https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University, Giessen, Germany; Department of Lung Development and Remodeling Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL) Bad Nauheim Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210102801","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5054116239"],"corresponding_institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210102801","https://openalex.org/I4210129183","https://openalex.org/I4210131615"],"apc_list":null,"apc_paid":null,"fwci":8.1597,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.98332055,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"202","issue":"10","first_page":"1445","last_page":"1457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-arterial-hypertension","display_name":"idiopathic pulmonary arterial hypertension","score":0.9190000295639038},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/p53-nuclear-translocation","display_name":"p53 nuclear translocation","score":0.968999981880188},{"id":"https://openalex.org/keywords/pericytes","display_name":"pericytes","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pulmonary-artery-smooth-muscle-cells","display_name":"pulmonary artery smooth muscle cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/precision-cut-lung-slices","display_name":"precision-cut lung slices","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8402639627456665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5706337094306946},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5688071846961975},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5570239424705505},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5306533575057983},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.48101621866226196},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4611632227897644},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.45754170417785645},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.45237502455711365},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44912999868392944},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43048587441444397},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4174535274505615},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.35370177030563354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3133855164051056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25529468059539795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19530704617500305},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15183022618293762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11307170987129211},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09767594933509827},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08010277152061462},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020797","descriptor_name":"Receptor, Platelet-Derived Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1164/rccm.201910-2041oc","doi":"https://doi.org/10.1164/rccm.201910-2041oc","is_oa":true,"landing_page_url":"https://doi.org/10.1164/rccm.201910-2041oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7376953","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7786813","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7786813","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7786813","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Crit Care Med","raw_type":"Text"},{"id":"pmid:32634060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32634060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:19117","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/19117/1/19117oa.pdf","pdf_url":"http://edoc.mdc-berlin.de/19117/1/19117oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_3275541","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0007-9F57-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1164/rccm.201910-2041oc","doi":"https://doi.org/10.1164/rccm.201910-2041oc","is_oa":true,"landing_page_url":"https://doi.org/10.1164/rccm.201910-2041oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000882837","display_name":"Endothelial-pericyte interactions in the pathogenesis of pulmonary arterial hypertension","funder_award_id":"R01HL139664","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000888028","display_name":"The Wnt7a/ROR2 axis in the pathogenesis of pulmonary arterial hypertension","funder_award_id":"R01HL134776","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1611419331","https://openalex.org/W1650797637","https://openalex.org/W1964113455","https://openalex.org/W1975693842","https://openalex.org/W1987824602","https://openalex.org/W1990895545","https://openalex.org/W1992496728","https://openalex.org/W2008695914","https://openalex.org/W2015863218","https://openalex.org/W2018005623","https://openalex.org/W2019155483","https://openalex.org/W2026480865","https://openalex.org/W2030288656","https://openalex.org/W2040599383","https://openalex.org/W2051911149","https://openalex.org/W2057154610","https://openalex.org/W2060289544","https://openalex.org/W2061650108","https://openalex.org/W2070777085","https://openalex.org/W2088441464","https://openalex.org/W2091025049","https://openalex.org/W2092466076","https://openalex.org/W2117357690","https://openalex.org/W2121352589","https://openalex.org/W2126504590","https://openalex.org/W2128619556","https://openalex.org/W2141987653","https://openalex.org/W2145931730","https://openalex.org/W2146573461","https://openalex.org/W2146729012","https://openalex.org/W2147944062","https://openalex.org/W2153772231","https://openalex.org/W2161280732","https://openalex.org/W2163141464","https://openalex.org/W2174891444","https://openalex.org/W2282335838","https://openalex.org/W2294967868","https://openalex.org/W2516995615","https://openalex.org/W2587922577","https://openalex.org/W2598871689","https://openalex.org/W2752927240","https://openalex.org/W2753799381","https://openalex.org/W2786224552","https://openalex.org/W2794429875","https://openalex.org/W2803499181","https://openalex.org/W2904543538","https://openalex.org/W2947091876","https://openalex.org/W2960194280","https://openalex.org/W2966288383","https://openalex.org/W2997030934","https://openalex.org/W3020052756"],"related_works":["https://openalex.org/W7030031955","https://openalex.org/W3135589086","https://openalex.org/W3175380347","https://openalex.org/W2923042711","https://openalex.org/W2769763295","https://openalex.org/W4210952114","https://openalex.org/W2995301832","https://openalex.org/W2552591740","https://openalex.org/W2769043712","https://openalex.org/W2755479686"],"abstract_inverted_index":{"Abstract":[0],"Rationale":[1],"Long":[2],"noncoding":[3],"RNAs":[4],"(lncRNAs)":[5],"are":[6],"emerging":[7],"as":[8,37],"important":[9,296,327],"regulators":[10],"of":[11,31,40,159,175,190,204,229,278,293],"diverse":[12],"biological":[13],"functions.":[14],"Their":[15],"role":[16,30,54,328],"in":[17,55,84,90,114,166,177,196,213,218,234,244,329],"pulmonary":[18,60,117],"arterial":[19,61,118],"hypertension":[20],"(PAH)":[21],"remains":[22],"to":[23,51,66,110,123,154,238,290],"be":[24,111],"explored.":[25],"Objectives":[26],"To":[27],"elucidate":[28],"the":[29,135,155,182,197,202,214,219,245,261,272,291,312,333],"TYKRIL":[32,80,107,132,176,242,252,269,288,309,324],"(tyrosine":[33],"kinase":[34],"receptor\u2013inducing":[35],"lncRNA)":[36],"a":[38,231,275],"regulator":[39],"p53/":[41],"PDGFR\u03b2":[42,255],"(platelet-derived":[43],"growth":[44],"factor":[45],"receptor":[46],"\u03b2)":[47],"signaling":[48],"pathway":[49],"and":[50,59,68,89,100,116,125,140,149,201,251,318],"investigate":[52],"its":[53],"PAH.":[56,98,131,173],"Methods":[57],"Pericytes":[58],"smooth":[62,119],"muscle":[63],"cells":[64,88,121,195,212],"exposed":[65,122],"hypoxia":[67,124],"derived":[69,94,126],"from":[70,95,127,170],"patients":[71,96,128,171],"with":[72,77,97,129,172,226,241,301,311],"idiopathic":[73,130,150],"PAH":[74,151,330],"were":[75,164],"analyzed":[76],"RNA":[78,104,280],"sequencing.":[79],"knockdown":[81,133,253,270],"was":[82,108,199,216,236,266],"performed":[83,165],"above-mentioned":[85],"human":[86],"primary":[87],"precision-cut":[91,167,178],"lung":[92,168,179],"slices":[93,169,180],"Measurements":[99],"Main":[101],"Results":[102],"Using":[103],"sequencing":[105],"data,":[106],"identified":[109],"consistently":[112],"upregulated":[113],"pericytes":[115],"muscles":[120],"reversed":[134],"proproliferative":[136],"(n":[137,142,185,248,257,315],"=":[138,143,186,249,258,316],"3)":[139,144,317],"antiapoptotic":[141],"phenotype":[145],"induced":[146],"under":[147],"hypoxic":[148],"conditions.":[152],"Owing":[153],"poor":[156],"species":[157],"conservation":[158],"TYKRIL,":[160],"ex":[161],"vivo":[162],"studies":[163],"Knockdown":[174],"decreased":[181,200,254],"vascular":[183],"remodeling":[184],"5).":[187],"The":[188,303],"number":[189,203],"proliferating":[191],"cell":[192],"nuclear":[193,321],"antigen\u2013positive":[194],"vessels":[198,215],"terminal":[205],"deoxynucleotide":[206],"transferase\u2013mediated":[207],"dUTP":[208],"nick":[209],"end":[210],"label\u2013positive":[211],"increased":[217,271],"LNA":[220],"(locked":[221],"nucleic":[222],"acid)-treated":[223],"group":[224],"compared":[225],"control.":[227],"Expression":[228],"PDGFR\u03b2,":[230],"key":[232],"player":[233],"PAH,":[235],"found":[237],"strongly":[239],"correlate":[240],"expression":[243,256],"patient":[246],"samples":[247],"12),":[250],"3).":[259],"From":[260],"transcription":[262],"factor\u2013screening":[263],"array,":[264],"it":[265],"observed":[267],"that":[268,287,308],"p53":[273,284,294,320],"activity,":[274],"known":[276],"repressor":[277],"PDGFR\u03b2.":[279],"immunoprecipitation":[281],"using":[282],"various":[283],"mutants":[285],"demonstrated":[286],"binds":[289],"N-terminal":[292],"(an":[295],"region":[297],"for":[298],"p300":[299],"interaction":[300,314],"p53).":[302],"proximity":[304],"ligation":[305],"assay":[306],"revealed":[307],"interferes":[310],"p53\u2013p300":[313],"regulates":[319],"translocation.":[322],"Conclusions":[323],"plays":[325],"an":[326],"by":[331],"regulating":[332],"p53/PDGFR\u03b2":[334],"axis.":[335]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-16T00:00:00"}