{"id":"https://openalex.org/W3041151629","doi":"https://doi.org/10.1055/s-0040-01707426","title":"Unprecedented Selectivities in the C7-Hydroxylation of Steroids Enabled by a P450-BM3 Mutant","display_name":"Unprecedented Selectivities in the C7-Hydroxylation of Steroids Enabled by a P450-BM3 Mutant","publication_year":2020,"publication_date":"2020-06-17","ids":{"openalex":"https://openalex.org/W3041151629","doi":"https://doi.org/10.1055/s-0040-01707426","mag":"3041151629"},"language":"en","primary_location":{"id":"doi:10.1055/s-0040-01707426","doi":"https://doi.org/10.1055/s-0040-01707426","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0040-01707426","pdf_url":null,"source":{"id":"https://openalex.org/S135102583","display_name":"Synfacts","issn_l":"1861-194X","issn":["1861-194X","1861-1958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synfacts","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040055598","display_name":"Benjamin List","orcid":"https://orcid.org/0000-0002-9804-599X","observed_orcids":["https://orcid.org/0000-0002-9804-599X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin List","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011243085","display_name":"Benjamin Mitschke","orcid":"https://orcid.org/0000-0002-2942-2448","observed_orcids":["https://orcid.org/0000-0002-2942-2448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Mitschke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"07","first_page":"0840","last_page":"0840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450-bm3","display_name":"cytochrome P450 BM3","score":0.9139999747276306},{"id":"https://openalex.org/keywords/steroid-hydroxylation","display_name":"steroid hydroxylation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/c-h-oxidation","display_name":"C\u2013H oxidation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.8410000205039978},{"id":"https://openalex.org/keywords/enzyme-mutants","display_name":"enzyme mutants","score":0.5379999876022339},{"id":"https://openalex.org/keywords/regioselectivity","display_name":"regioselectivity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/biocatalysis","display_name":"biocatalysis","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9733012914657593},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.9233835935592651},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7272999286651611},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43589967489242554},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.32144275307655334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2208246886730194},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0700160562992096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05038592219352722}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0040-01707426","doi":"https://doi.org/10.1055/s-0040-01707426","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0040-01707426","pdf_url":null,"source":{"id":"https://openalex.org/S135102583","display_name":"Synfacts","issn_l":"1861-194X","issn":["1861-194X","1861-1958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synfacts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W3014400018","https://openalex.org/W3046883793"],"related_works":["https://openalex.org/W2400341945","https://openalex.org/W7123362190","https://openalex.org/W2150680374","https://openalex.org/W3046883793","https://openalex.org/W2042172635","https://openalex.org/W2794262874","https://openalex.org/W2025320442","https://openalex.org/W3035645065","https://openalex.org/W2409707478","https://openalex.org/W2037354613"],"abstract_inverted_index":{"Key":[0],"words":[1],"cytochrome":[2],"P450-BM3":[3],"-":[4,7,10],"C\u2013H":[5],"oxidation":[6],"steroid":[8],"hydroxylation":[9],"directed":[11],"evolution":[12]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2020-07-16T00:00:00"}