{"id":"https://openalex.org/W3041069444","doi":"https://doi.org/10.14309/ctg.0000000000000179","title":"Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma","display_name":"Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3041069444","doi":"https://doi.org/10.14309/ctg.0000000000000179","mag":"3041069444","pmid":"https://pubmed.ncbi.nlm.nih.gov/32677805","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7263646"},"language":"en","primary_location":{"id":"doi:10.14309/ctg.0000000000000179","doi":"https://doi.org/10.14309/ctg.0000000000000179","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000179","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.14309/ctg.0000000000000179","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045968705","display_name":"Masami Yamauchi","orcid":"https://orcid.org/0000-0003-3573-5720","observed_orcids":["https://orcid.org/0000-0003-3573-5720"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4210125056","display_name":"Hiroshima University Hospital","ror":"https://ror.org/038dg9e86","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Yamauchi","raw_affiliation_strings":["Department of Clinical Oncology, Hiroshima University Hospital, Hiroshima, Japan;","Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Hiroshima University Hospital, Hiroshima, Japan;","institution_ids":["https://openalex.org/I4210125056"]},{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053275355","display_name":"Atsushi Ono","orcid":"https://orcid.org/0000-0002-2482-945X","observed_orcids":["https://orcid.org/0000-0002-2482-945X"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Ono","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033741101","display_name":"Akira Ishikawa","orcid":"https://orcid.org/0000-0002-1528-1939","observed_orcids":["https://orcid.org/0000-0002-1528-1939"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Ishikawa","raw_affiliation_strings":["Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050719404","display_name":"Kenichiro Kodama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichiro Kodama","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003790120","display_name":"Shinsuke Uchikawa","orcid":"https://orcid.org/0000-0002-1538-4946","observed_orcids":["https://orcid.org/0000-0002-1538-4946"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinsuke Uchikawa","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028211456","display_name":"Haruna Hatooka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruna Hatooka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143851","display_name":"Peiyi Zhang","orcid":"https://orcid.org/0000-0003-0207-1112","observed_orcids":["https://orcid.org/0000-0003-0207-1112"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Peiyi Zhang","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110349312","display_name":"Yuji Teraoka","orcid":"https://orcid.org/0009-0008-8589-6155","observed_orcids":["https://orcid.org/0009-0008-8589-6155"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Teraoka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074699709","display_name":"Kei Morio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Morio","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053529562","display_name":"Hatsue Fujino","orcid":"https://orcid.org/0000-0002-9691-4960","observed_orcids":["https://orcid.org/0000-0002-9691-4960"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hatsue Fujino","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112313285","display_name":"Takashi Nakahara","orcid":"https://orcid.org/0000-0001-7762-4629","observed_orcids":["https://orcid.org/0000-0001-7762-4629"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakahara","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024813969","display_name":"Eisuke Murakami","orcid":"https://orcid.org/0000-0003-0357-2795","observed_orcids":["https://orcid.org/0000-0003-0357-2795"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eisuke Murakami","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044269436","display_name":"Daiki Miki","orcid":"https://orcid.org/0000-0002-6505-9826","observed_orcids":["https://orcid.org/0000-0002-6505-9826"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daiki Miki","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031469873","display_name":"Tomokazu Kawaoka","orcid":"https://orcid.org/0000-0002-1887-1096","observed_orcids":["https://orcid.org/0000-0002-1887-1096"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomokazu Kawaoka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027695992","display_name":"Masataka Tsuge","orcid":"https://orcid.org/0000-0001-7591-8287","observed_orcids":["https://orcid.org/0000-0001-7591-8287"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masataka Tsuge","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018431544","display_name":"Akira Hiramatsu","orcid":"https://orcid.org/0000-0003-0011-3243","observed_orcids":["https://orcid.org/0000-0003-0011-3243"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Hiramatsu","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022484621","display_name":"Michio Imamura","orcid":"https://orcid.org/0000-0002-0745-991X","observed_orcids":["https://orcid.org/0000-0002-0745-991X"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Imamura","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021393447","display_name":"Clair Nelson Hayes","orcid":"https://orcid.org/0000-0003-1691-3544","observed_orcids":["https://orcid.org/0000-0003-1691-3544"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Clair Nelson Hayes","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006066029","display_name":"Masashi Fujita","orcid":"https://orcid.org/0000-0002-1457-6233","observed_orcids":["https://orcid.org/0000-0002-1457-6233"]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Fujita","raw_affiliation_strings":["Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081957766","display_name":"Hidewaki Nakagawa","orcid":"https://orcid.org/0000-0003-1807-772X","observed_orcids":["https://orcid.org/0000-0003-1807-772X"]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidewaki Nakagawa","raw_affiliation_strings":["Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046204028","display_name":"Wataru Yasui","orcid":"https://orcid.org/0000-0002-8647-8405","observed_orcids":["https://orcid.org/0000-0002-8647-8405"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wataru Yasui","raw_affiliation_strings":["Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037963685","display_name":"Hiroshi Aikata","orcid":"https://orcid.org/0000-0002-3409-2156","observed_orcids":["https://orcid.org/0000-0002-3409-2156"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Aikata","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023958825","display_name":"Kazuaki Chayama","orcid":"https://orcid.org/0000-0002-5530-5341","observed_orcids":["https://orcid.org/0000-0002-5530-5341"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuaki Chayama","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","Institute of Physical and Chemical Research (RIKEN) Center for Integrative Medical Sciences, Yokohama, Japan","Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Institute of Physical and Chemical Research (RIKEN) Center for Integrative Medical Sciences, Yokohama, Japan","institution_ids":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]},{"raw_affiliation_string":"Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan;","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023958825"],"corresponding_institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4210110652","https://openalex.org/I4210150921"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":4.8979,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.96881019,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":"5","first_page":"e00179","last_page":"e00179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.11389999836683273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgfr4","display_name":"FGFR4","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9380000233650208},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9049999713897705},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6869999766349792},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-response","display_name":"tyrosine kinase inhibitor response","score":0.765999972820282},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9369999766349792},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7730000019073486},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2776264508","wikidata":"https://www.wikidata.org/wiki/Q6523413","display_name":"Lenvatinib","level":4,"score":0.9869201183319092},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.81080162525177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.802971601486206},{"id":"https://openalex.org/C66400584","wikidata":"https://www.wikidata.org/wiki/Q5446458","display_name":"Fibroblast growth factor receptor 4","level":5,"score":0.6404707431793213},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.5726366639137268},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5469522476196289},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5098044276237488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4800920784473419},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.45691806077957153},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.42906653881073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41966235637664795},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.4187934994697571},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.41442781686782837},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2911241054534912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1619388461112976},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.13628581166267395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066066","descriptor_name":"Response Evaluation Criteria in Solid Tumors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.14309/ctg.0000000000000179","doi":"https://doi.org/10.14309/ctg.0000000000000179","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000179","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7263646","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7263646/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7263646/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Gastroenterol","raw_type":"Text"},{"id":"pmid:32677805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32677805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational gastroenterology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.14309/ctg.0000000000000179","doi":"https://doi.org/10.14309/ctg.0000000000000179","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000179","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3433535282","display_name":"\u514d\u75ab\u907a\u4f1d\u5b50\u767a\u73fe\u30b7\u30b0\u30cd\u30c1\u30e3\u30fc\u306b\u3088\u308b\u98df\u9053\u304c\u3093\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u594f\u52b9\u4e88\u6e2c","funder_award_id":"19K09206","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4181751868","display_name":"Multi-omics analysis for hepato-biliary-pancreatic cancers","funder_award_id":"18H04049","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3041069444.pdf","grobid_xml":"https://content.openalex.org/works/W3041069444.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1813458856","https://openalex.org/W1828082159","https://openalex.org/W1977859620","https://openalex.org/W2018851752","https://openalex.org/W2063746351","https://openalex.org/W2064387090","https://openalex.org/W2070489177","https://openalex.org/W2078058991","https://openalex.org/W2092262813","https://openalex.org/W2099203036","https://openalex.org/W2116751658","https://openalex.org/W2130410032","https://openalex.org/W2136415416","https://openalex.org/W2141125422","https://openalex.org/W2275678839","https://openalex.org/W2324488473","https://openalex.org/W2368819226","https://openalex.org/W2560322684","https://openalex.org/W2581205085","https://openalex.org/W2605955022","https://openalex.org/W2625559053","https://openalex.org/W2787358630","https://openalex.org/W2789297669","https://openalex.org/W2789705253","https://openalex.org/W2809889937","https://openalex.org/W2885162827","https://openalex.org/W2912945641","https://openalex.org/W2929062492","https://openalex.org/W4324262440"],"related_works":["https://openalex.org/W3117509938","https://openalex.org/W7160645290","https://openalex.org/W7028255979","https://openalex.org/W3166562386","https://openalex.org/W3003135415","https://openalex.org/W3165017392","https://openalex.org/W3027991621","https://openalex.org/W2800499107","https://openalex.org/W4206394113","https://openalex.org/W3026788250"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Biomarkers":[1],"for":[2,34,149],"optimizing":[3],"the":[4,85,96,99,105,110,113,121,184],"outcome":[5],"of":[6,56,87,98,115,146,186,227,245],"treatment":[7,155],"with":[8,12,42,140,158,202],"lenvatinib":[9,116],"in":[10,48,58,81,84,128,151,189,229],"patients":[11,138],"advanced":[13],"hepatocellular":[14,82],"carcinoma":[15,83],"remain":[16],"to":[17,67,104,120,247],"be":[18],"established":[19],"despite":[20],"intensive":[21],"and":[22,117,130,170],"comprehensive":[23],"genomic":[24],"research.":[25],"Lenvatinib":[26],"is":[27,78],"characterized":[28],"by":[29,194],"its":[30,206],"prominent":[31],"inhibitory":[32],"potency":[33],"fibroblast":[35],"growth":[36],"factor":[37],"receptor":[38],"(FGFR)":[39],"4":[40],"compared":[41],"earlier":[43],"tyrosine":[44],"kinase":[45],"inhibitors.":[46],"Thus,":[47],"this":[49,234],"study,":[50],"we":[51,124],"focused":[52],"on":[53],"simplified":[54],"quantification":[55],"FGFR4":[57,75,106,122,150,188,228,239],"tumors":[59,129],"as":[60,192],"a":[61,159,171],"potential":[62],"predictive":[63],"indicator.":[64],"METHODS:":[65],"According":[66],"The":[68,237],"Cancer":[69],"Genome":[70],"Atlas":[71],"data":[72],"set":[73,91],"curation,":[74],"messenger":[76],"RNA":[77,212,225],"broadly":[79],"overexpressed":[80],"absence":[86],"gene":[88],"alteration.":[89],"Gene":[90],"enrichment":[92],"analysis":[93,214],"revealed":[94],"that":[95,223],"aggressiveness":[97],"tumor":[100,118,147,238],"was":[101,156,199,241],"closely":[102],"related":[103],"level.":[107],"To":[108],"confirm":[109],"relationship":[111],"between":[112],"benefits":[114],"addiction":[119],"pathway,":[123],"analyzed":[125],"protein":[126],"levels":[127],"peripheral":[131,190],"blood":[132,191],"obtained":[133],"from":[134],"57":[135],"prospectively":[136],"registered":[137],"treated":[139],"lenvatinib.":[141,248],"RESULTS:":[142],"Positive":[143],"immunohistochemistry":[144],"(>10%":[145],"cells)":[148],"biopsy":[152],"samples":[153],"before":[154],"associated":[157,201],"longer":[160],"progression-free":[161],"survival":[162,203],"(2.5":[163],"vs":[164,177],"5.5":[165],"months,":[166],"P":[167,179],"=":[168,180,220],"0.01)":[169],"favorable":[172],"objective":[173],"response":[174,246],"rate":[175],"(31%":[176],"81%,":[178],"0.006).":[181],"By":[182],"contrast,":[183],"concentration":[185],"soluble":[187],"measured":[193],"an":[195,242],"enzyme-linked":[196],"immunosorbent":[197],"assay":[198],"not":[200],"outcomes,":[204],"because":[205],"fluctuations":[207],"reflect":[208],"hepatic":[209],"fibrosis.":[210],"Additional":[211],"sequencing":[213],"using":[215],"archival":[216],"surgical":[217],"specimens":[218],"(n":[219],"90)":[221],"suggested":[222],"alternative":[224],"splicing":[226],"cancer":[230],"may":[231],"also":[232],"explain":[233],"discrepancy.":[235],"DISCUSSION:":[236],"level":[240],"independent":[243],"predictor":[244]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-07-16T00:00:00"}
