{"id":"https://openalex.org/W3040289352","doi":"https://doi.org/10.1016/j.clineuro.2020.106059","title":"TTF-1 positive posterior pituitary tumor: Limitations of current treatment and potential new hope in BRAF V600E mutation variants","display_name":"TTF-1 positive posterior pituitary tumor: Limitations of current treatment and potential new hope in BRAF V600E mutation variants","publication_year":2020,"publication_date":"2020-06-30","ids":{"openalex":"https://openalex.org/W3040289352","doi":"https://doi.org/10.1016/j.clineuro.2020.106059","mag":"3040289352","pmid":"https://pubmed.ncbi.nlm.nih.gov/32682222"},"language":"en","primary_location":{"id":"doi:10.1016/j.clineuro.2020.106059","doi":"https://doi.org/10.1016/j.clineuro.2020.106059","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clineuro.2020.106059","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086244921","display_name":"Fakhry M. Dawoud","orcid":"https://orcid.org/0000-0001-6034-8242","observed_orcids":["https://orcid.org/0000-0001-6034-8242"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fakhry M. Dawoud","raw_affiliation_strings":["East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA"],"raw_orcid":"https://orcid.org/0000-0001-6034-8242","affiliations":[{"raw_affiliation_string":"East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089319919","display_name":"Ryan M. Naylor","orcid":"https://orcid.org/0000-0003-3067-1000","observed_orcids":["https://orcid.org/0000-0003-3067-1000"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan M. Naylor","raw_affiliation_strings":["Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069689120","display_name":"Caterina Giannini","orcid":"https://orcid.org/0000-0003-2757-6782","observed_orcids":["https://orcid.org/0000-0003-2757-6782"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caterina Giannini","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009670649","display_name":"Amy A. Swanson","orcid":"https://orcid.org/0000-0002-7675-4365","observed_orcids":["https://orcid.org/0000-0002-7675-4365"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy A. Swanson","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001528741","display_name":"Fredric Bruce Meyer","orcid":"https://orcid.org/0000-0002-4310-7962","observed_orcids":["https://orcid.org/0000-0002-4310-7962"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredric B. Meyer","raw_affiliation_strings":["Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025687850","display_name":"Joon H. Uhm","orcid":"https://orcid.org/0009-0003-1048-546X","observed_orcids":["https://orcid.org/0009-0003-1048-546X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joon H. Uhm","raw_affiliation_strings":["Department of Neuro-Oncology, Mayo Clinic, Rochester, MN, USA; Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA. Electronic address: uhm.joon@mayo.edu","Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA","Department of Neuro-Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, Mayo Clinic, Rochester, MN, USA; Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA. Electronic address: uhm.joon@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Neuro-Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025687850"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":1800,"currency":"USD","value_usd":1800},"apc_paid":null,"fwci":0.943,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75411251,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"196","issue":null,"first_page":"106059","last_page":"106059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.972000002861023},{"id":"https://openalex.org/keywords/recurrent-pituitary-tumor","display_name":"recurrent pituitary tumor","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dabrafenib","display_name":"dabrafenib","score":0.9110000133514404},{"id":"https://openalex.org/keywords/trametinib","display_name":"trametinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":1.0},{"id":"https://openalex.org/keywords/targeted-chemotherapy","display_name":"targeted chemotherapy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/genomic-profiling","display_name":"genomic profiling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/treatment-limitations","display_name":"treatment limitations","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8841428160667419},{"id":"https://openalex.org/C2778472372","wikidata":"https://www.wikidata.org/wiki/Q7833138","display_name":"Trametinib","level":4,"score":0.8546294569969177},{"id":"https://openalex.org/C2780297037","wikidata":"https://www.wikidata.org/wiki/Q1503735","display_name":"Posterior pituitary","level":4,"score":0.8102284669876099},{"id":"https://openalex.org/C2778830669","wikidata":"https://www.wikidata.org/wiki/Q3011604","display_name":"Dabrafenib","level":5,"score":0.7991213202476501},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49947142601013184},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.467145174741745},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.43886151909828186},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34499770402908325},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32044717669487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3104936480522156},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.2961966395378113},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.2079111933708191},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.1804344356060028},{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.13633474707603455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10771575570106506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07603415846824646},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.07535353302955627},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07290899753570557},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000074482","descriptor_name":"Thyroid Nuclear Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018249","descriptor_name":"Adenoma, Oxyphilic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018249","descriptor_name":"Adenoma, Oxyphilic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.clineuro.2020.106059","doi":"https://doi.org/10.1016/j.clineuro.2020.106059","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clineuro.2020.106059","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},{"id":"pmid:32682222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32682222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neurology and neurosurgery","raw_type":"Case Reports"},{"id":"pmh:oai:dc.etsu.edu:etsu-works-10397","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/etsu-works/9131","pdf_url":null,"source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETSU Faculty Works","raw_type":"text"},{"id":"pmh:oai:cris.unibo.it:11585/782416","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/782416","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7900000214576721}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2157090777","https://openalex.org/W2921116448","https://openalex.org/W2955942214","https://openalex.org/W2971160962","https://openalex.org/W3017050209","https://openalex.org/W6776328188"],"related_works":["https://openalex.org/W4205491180","https://openalex.org/W4376121483","https://openalex.org/W4206344982","https://openalex.org/W2587811089","https://openalex.org/W3025758075","https://openalex.org/W2802324828","https://openalex.org/W2208625206","https://openalex.org/W2981623459","https://openalex.org/W4210621975","https://openalex.org/W4295836985"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-07-10T00:00:00"}
