{"id":"https://openalex.org/W3040147480","doi":"https://doi.org/10.4049/jimmunol.1901008","title":"Dual Roles of PU.1 in the Expression of PD-L2: Direct Transactivation with IRF4 and Indirect Epigenetic Regulation","display_name":"Dual Roles of PU.1 in the Expression of PD-L2: Direct Transactivation with IRF4 and Indirect Epigenetic Regulation","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3040147480","doi":"https://doi.org/10.4049/jimmunol.1901008","mag":"3040147480","pmid":"https://pubmed.ncbi.nlm.nih.gov/32611724"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1901008","doi":"https://doi.org/10.4049/jimmunol.1901008","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1901008","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016914637","display_name":"Keito Inaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Keito Inaba","raw_affiliation_strings":["Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo , Kashiwa 277-8568 ,","*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and","\u2020Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8568, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo , Kashiwa 277-8568 ,","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"\u2020Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8568, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002089459","display_name":"Takuya Yashiro","orcid":"https://orcid.org/0000-0002-9319-3467","observed_orcids":["https://orcid.org/0000-0002-9319-3467"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takuya Yashiro","raw_affiliation_strings":["Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and"],"raw_orcid":"https://orcid.org/0000-0002-9319-3467","affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046632982","display_name":"Ikumi Hiroki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ikumi Hiroki","raw_affiliation_strings":["Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102971278","display_name":"Ryosuke Watanabe","orcid":"https://orcid.org/0000-0002-9604-3632","observed_orcids":["https://orcid.org/0000-0002-9604-3632"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ryosuke Watanabe","raw_affiliation_strings":["Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and"],"raw_orcid":"https://orcid.org/0000-0002-9604-3632","affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052499192","display_name":"Kazumi Kasakura","orcid":"https://orcid.org/0000-0002-4412-3737","observed_orcids":["https://orcid.org/0000-0002-4412-3737"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazumi Kasakura","raw_affiliation_strings":["Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038090675","display_name":"Chiharu Nishiyama","orcid":"https://orcid.org/0000-0002-4082-9097","observed_orcids":["https://orcid.org/0000-0002-4082-9097"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Chiharu Nishiyama","raw_affiliation_strings":["Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and"],"raw_orcid":"https://orcid.org/0000-0002-4082-9097","affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science , 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585 ,","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"*Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and","institution_ids":["https://openalex.org/I161296585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002089459","https://openalex.org/A5016914637","https://openalex.org/A5038090675","https://openalex.org/A5046632982","https://openalex.org/A5052499192","https://openalex.org/A5102971278"],"corresponding_institution_ids":["https://openalex.org/I161296585","https://openalex.org/I74801974"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.7747,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.66209557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"205","issue":"3","first_page":"822","last_page":"829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.16699999570846558,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.13040000200271606,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pd-l2","display_name":"PD-L2","score":0.8870000243186951},{"id":"https://openalex.org/keywords/irf4","display_name":"IRF4","score":0.8759999871253967},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9210000038146973},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pd-1-ligands","display_name":"PD-1 ligands","score":0.7720000147819519},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.7789999842643738},{"id":"https://openalex.org/keywords/flt3l","display_name":"Flt3L","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/splenic-dendritic-cells","display_name":"splenic dendritic cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.8888897895812988},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6366609334945679},{"id":"https://openalex.org/C12652872","wikidata":"https://www.wikidata.org/wiki/Q18027997","display_name":"IRF4","level":4,"score":0.557384192943573},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.47437483072280884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.357092946767807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3542236089706421},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3518696427345276},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34870991110801697},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26738911867141724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2579687833786011},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.24144256114959717},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17135512828826904},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.09306606650352478},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099218","descriptor_name":"Interferon Regulatory Factor-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099232","descriptor_name":"Proto-Oncogene Protein Spi-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061027","descriptor_name":"Programmed Cell Death 1 Ligand 2 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.1901008","doi":"https://doi.org/10.4049/jimmunol.1901008","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1901008","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:32611724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32611724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1738344560","display_name":"Molecular mechanisms and physiological significance of short chain fatty acid- and polyunsaturated fatty acid-mediated regulation of mast cell function","funder_award_id":"20H02939","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5950448438","display_name":"Immunosuppressive function of unsaturated fatty acid produced by lactic acid bacteria.","funder_award_id":"19K05884","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320323626","display_name":"Tojuro Iijima Foundation for Food Science and Technology","ror":"https://ror.org/031ww6378"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1483582136","https://openalex.org/W1497894656","https://openalex.org/W1526182144","https://openalex.org/W1584203472","https://openalex.org/W1592326302","https://openalex.org/W1963617750","https://openalex.org/W1967253651","https://openalex.org/W1974505259","https://openalex.org/W1984198270","https://openalex.org/W1999274330","https://openalex.org/W2003150683","https://openalex.org/W2004092007","https://openalex.org/W2041778457","https://openalex.org/W2049750787","https://openalex.org/W2061538006","https://openalex.org/W2096757412","https://openalex.org/W2101990345","https://openalex.org/W2102849896","https://openalex.org/W2105089699","https://openalex.org/W2107752337","https://openalex.org/W2121496836","https://openalex.org/W2123480703","https://openalex.org/W2135558550","https://openalex.org/W2141925741","https://openalex.org/W2145857936","https://openalex.org/W2162889226","https://openalex.org/W2175229202","https://openalex.org/W2336251014","https://openalex.org/W2510121660","https://openalex.org/W2528296337","https://openalex.org/W2589249573","https://openalex.org/W2612185660","https://openalex.org/W2745139482","https://openalex.org/W2900136354","https://openalex.org/W3017047018"],"related_works":["https://openalex.org/W2900136354","https://openalex.org/W2589249573","https://openalex.org/W2041778457","https://openalex.org/W2175229202","https://openalex.org/W7095773517","https://openalex.org/W2528296337","https://openalex.org/W3108843745","https://openalex.org/W2336076245","https://openalex.org/W2002921999","https://openalex.org/W4313385257"],"abstract_inverted_index":{"Abstract":[0],"PD-L2,":[1],"which":[2,38,65,75,156,181],"has":[3,157],"been":[4,40,51,158],"identified":[5],"as":[6,224],"a":[7,225],"PD-1":[8,34],"ligand,":[9],"is":[10,69],"specifically":[11],"expressed":[12],"in":[13,46,54,79,98,187,193,209,231],"dendritic":[14],"cells":[15],"(DCs)":[16],"and":[17,35,81,93,109,117,131,167,190,204,227],"macrophages.":[18],"The":[19,84,148,199],"transcription":[20,90],"factors":[21,91],"that":[22,115,217],"determine":[23],"the":[24,55,62,87,122,134,141,145,151,165,171,177],"cell":[25,48],"type-specific":[26],"expression":[27,68,97,166,223],"of":[28,57,86,144,150,170,201],"PD-L2":[29,96],"are":[30],"largely":[31],"unknown,":[32],"although":[33],"its":[36],"ligands,":[37],"have":[39,50],"shown":[41],"to":[42,121,160],"play":[43,76],"important":[44],"roles":[45,78],"T":[47],"suppression,":[49],"vigorously":[52],"analyzed":[53],"field":[56],"cancer":[58],"immunology.":[59],"To":[60],"reveal":[61],"mechanism":[63],"by":[64,184],"Pdcd1lg2":[66,123,135,146,172,178,221],"gene":[67,124,179,222],"regulated,":[70],"we":[71],"focused":[72],"on":[73],"DCs,":[74],"key":[77],"innate":[80],"acquired":[82],"immunity.":[83],"knockdown":[85,139,149],"hematopoietic":[88],"cell\u2013specific":[89],"PU.1":[92,116,138,188,218],"IRF4":[94,118],"decreased":[95,164],"GM-CSF\u2013induced":[99],"mouse":[100,195,210],"bone":[101,196],"marrow\u2013derived":[102,197],"DCs.":[103,198,212,232],"Chromatin":[104],"immunoprecipitation":[105],"assays,":[106,108],"luciferase":[107],"electrophoretic":[110],"mobility":[111],"shift":[112],"assays":[113],"demonstrated":[114],"bound":[119],"directly":[120],"via":[125],"an":[126,185,228],"Ets-IRF":[127],"composite":[128],"element":[129],"sequence":[130],"coordinately":[132],"transactivated":[133],"gene.":[136,147,173],"Furthermore,":[137],"reduced":[140],"histone":[142,153,191],"acetylation":[143,169,192],"typical":[152],"acetyltransferase":[154],"p300,":[155],"reported":[159],"interact":[161],"with":[162],"PU.1,":[163,202],"H3K27":[168],"GM-CSF":[174],"stimulation":[175],"upregulated":[176],"expression,":[180],"was":[182],"accompanied":[183],"increase":[186],"binding":[189],"Flt3L-generated":[194],"involvement":[200],"IRF4,":[203],"p300":[205],"were":[206],"also":[207],"observed":[208],"splenic":[211],"Overall,":[213],"these":[214],"results":[215],"indicate":[216],"positively":[219],"regulates":[220],"transactivator":[226],"epigenetic":[229],"regulator":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-07-10T00:00:00"}