{"id":"https://openalex.org/W3039760232","doi":"https://doi.org/10.7176/jnsr/10-12-03","title":"Characterization of Immunogenic Soluble Crude Proteins from Biomphalaria Pfeifferi Against Schistosoma mansoni","display_name":"Characterization of Immunogenic Soluble Crude Proteins from Biomphalaria Pfeifferi Against Schistosoma mansoni","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3039760232","doi":"https://doi.org/10.7176/jnsr/10-12-03","mag":"3039760232"},"language":"en","primary_location":{"id":"doi:10.7176/jnsr/10-12-03","doi":"https://doi.org/10.7176/jnsr/10-12-03","is_oa":true,"landing_page_url":"https://doi.org/10.7176/jnsr/10-12-03","pdf_url":"https://iiste.org/Journals/index.php/JNSR/article/download/53025/54794","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Sciences Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://iiste.org/Journals/index.php/JNSR/article/download/53025/54794","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077904066","display_name":"Kennedy M. Kuria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133159679","display_name":"Murang'a University of Technology","ror":"https://ror.org/057k4ej49","country_code":"KE","type":"education","lineage":["https://openalex.org/I3133159679"]}],"countries":["KE"],"is_corresponding":false,"raw_author_name":"Kennedy M. Kuria","raw_affiliation_strings":[".Department of Medical Laboratory Science, Murang'a University of Technology, Box 75-10200, Murang'a, Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":".Department of Medical Laboratory Science, Murang'a University of Technology, Box 75-10200, Murang'a, Kenya","institution_ids":["https://openalex.org/I3133159679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029978292","display_name":"Sylvia Awino Opiyo","orcid":"https://orcid.org/0000-0002-7355-6355","observed_orcids":["https://orcid.org/0000-0002-7355-6355"]},"institutions":[{"id":"https://openalex.org/I3133159679","display_name":"Murang'a University of Technology","ror":"https://ror.org/057k4ej49","country_code":"KE","type":"education","lineage":["https://openalex.org/I3133159679"]}],"countries":["KE"],"is_corresponding":false,"raw_author_name":"Sylvia A. Opiyo","raw_affiliation_strings":[".Department of Physical and Biological Sciences, Murang'a University of Technology, Box 75-10200, Murang'a, Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":".Department of Physical and Biological Sciences, Murang'a University of Technology, Box 75-10200, Murang'a, Kenya","institution_ids":["https://openalex.org/I3133159679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3133159679"],"apc_list":null,"apc_paid":null,"fwci":1.0141,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.67702422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomphalaria-pfeifferi","display_name":"Biomphalaria pfeifferi","score":0.9229999780654907},{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.996999979019165},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/digestive-gland","display_name":"digestive gland","score":0.6079999804496765},{"id":"https://openalex.org/keywords/protein-composition","display_name":"protein composition","score":0.7149999737739563},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.6510000228881836},{"id":"https://openalex.org/keywords/molluscicides","display_name":"molluscicides","score":0.4880000054836273},{"id":"https://openalex.org/keywords/molluscicidal-activity","display_name":"molluscicidal activity","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2778969155","wikidata":"https://www.wikidata.org/wiki/Q409304","display_name":"Methylamine","level":2,"score":0.6753220558166504},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.6125488877296448},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5114697217941284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48634272813796997},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.46938440203666687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44011297821998596},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39695703983306885},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.36093658208847046},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.15727105736732483},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15206533670425415}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7176/jnsr/10-12-03","doi":"https://doi.org/10.7176/jnsr/10-12-03","is_oa":true,"landing_page_url":"https://doi.org/10.7176/jnsr/10-12-03","pdf_url":"https://iiste.org/Journals/index.php/JNSR/article/download/53025/54794","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Sciences Research","raw_type":"journal-article"},{"id":"pmh:oai:ojs.localhost:article/53025","doi":null,"is_oa":true,"landing_page_url":"https://iiste.org/Journals/index.php/JNSR/article/view/53025","pdf_url":null,"source":{"id":"https://openalex.org/S4306401197","display_name":"Journals & Books Hosting (International Knowledge Sharing Platform)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Natural Sciences Research; Vol 10, No 12 (2020); 28-34","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.7176/jnsr/10-12-03","doi":"https://doi.org/10.7176/jnsr/10-12-03","is_oa":true,"landing_page_url":"https://doi.org/10.7176/jnsr/10-12-03","pdf_url":"https://iiste.org/Journals/index.php/JNSR/article/download/53025/54794","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Sciences Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3039760232.pdf","grobid_xml":"https://content.openalex.org/works/W3039760232.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1134042321","https://openalex.org/W1535503205","https://openalex.org/W1759977888","https://openalex.org/W1974890932","https://openalex.org/W2013836603","https://openalex.org/W2038121449","https://openalex.org/W2136673891","https://openalex.org/W2144541429","https://openalex.org/W2162331245","https://openalex.org/W2181773835","https://openalex.org/W2316007877","https://openalex.org/W2327633541","https://openalex.org/W2474080303","https://openalex.org/W2477446060","https://openalex.org/W2484883538","https://openalex.org/W2605656991","https://openalex.org/W2610737238","https://openalex.org/W2749162461","https://openalex.org/W2762624541","https://openalex.org/W2766692585","https://openalex.org/W2797483065","https://openalex.org/W2887353384","https://openalex.org/W2914665419","https://openalex.org/W2942877326","https://openalex.org/W2965969696","https://openalex.org/W2985602734","https://openalex.org/W2990254496","https://openalex.org/W2997156395","https://openalex.org/W3010967024","https://openalex.org/W3031552755"],"related_works":["https://openalex.org/W2942877326","https://openalex.org/W2227100302","https://openalex.org/W6981034500","https://openalex.org/W2762624541","https://openalex.org/W2271793736","https://openalex.org/W4288033601","https://openalex.org/W2263777604","https://openalex.org/W2972727531","https://openalex.org/W2031130016","https://openalex.org/W2566327713"],"abstract_inverted_index":{"Schistosomiasis":[0],"is":[1,88,259],"the":[2,9,18,29,42,46,54,76,81,85,103,148,156,171,178,218,224,250],"second":[3],"most":[4],"prevalent":[5],"tropical":[6],"disease":[7,30],"in":[8,128,147,155,170,177,223,249],"world":[10],"after":[11],"malaria.":[12],"Chemotherapy":[13],"and":[14,53,68,98,105,124,131,143,166,202,254],"molluscicides":[15],"which":[16],"are":[17],"main":[19],"methods":[20],"of":[21,45,56,62,84,92,102,114,220,235,246],"control":[22],"do":[23],"not":[24],"give":[25],"lasting":[26],"protection":[27],"as":[28],"continues":[31],"to":[32,34,96,257],"spread":[33],"other":[35],"new":[36],"regions.":[37],"Previous":[38],"studies":[39,243],"have":[40],"demonstrated":[41],"immunogenic":[43],"properties":[44],"digestive":[47],"gland":[48],"(DG),":[49],"foot":[50],"parts":[51],"(FT)":[52],"rest":[55],"body":[57],"tissue":[58],"(RT)":[59],"soluble":[60,86,107,133,150,173,225,238,252],"protein":[61,151,174,226,240],"Biomphalaria":[63,110,236,264],"pfeifferi":[64,237],"against":[65,75],"Schistosoma":[66],"parasite":[67],"therefore":[69],"possible":[70],"candidates":[71],"for":[72],"vaccine":[73],"development":[74],"parasite.":[77],"However,":[78],"information":[79],"about":[80],"chemical":[82,100],"composition":[83,101],"proteins":[87,108,253],"scanty.":[89],"The":[90],"objective":[91],"this":[93,230],"study":[94,231],"was":[95],"characterize":[97],"determine":[99],"DG":[104,130,149,179],"FT":[106,132,157,172],"from":[109,229],"pfeifferi.":[111],"A":[112],"total":[113],"twelve":[115],"compounds":[116,269],"were":[117,126,145,153,168],"identified":[118],"using":[119],"GC-MS.":[120],"N-tert":[121],"-butyl":[122],"methylamine":[123],"penicillamine":[125],"present":[127,146,169],"both":[129],"proteins.":[134],"Butylamine":[135],"S,":[136],"valine,":[137],"amino":[138,221],"heptanoic":[139],"acid,":[140],"1,1-dimethylamino-1":[141],"butane":[142],"valienamine":[144],"but":[152,175],"missing":[154,176],"extracts.":[158,180,227,241],"Tert-butylamine,":[159],"heptylamine,":[160],"cycloheptane":[161],"methylamine,":[162],"erythro-":[163],"O":[164],"-methylthreonine":[165],"leucine":[167],"FTIR":[181],"analysis":[182],"showed":[183],"N-H":[184,197],"stretch":[185,192],"at":[186,193,199,205,213],"3100":[187],"cm":[188,207],"-1":[189,195,201,208],",":[190,196],"C=O":[191],"1700cm":[194],"bending":[198],"1600cm":[200],"O-H":[203],"peak":[204],"3500":[206],"while":[209],"UV":[210],"absorption":[211],"occurred":[212],"240-300":[214],"nm":[215],"thus":[216],"confirmed":[217],"presence":[219],"acids":[222],"Results":[228],"justifies":[232],"medicinal":[233],"activity":[234],"crude":[239,251],"Further":[242],"involving":[244],"isolation":[245],"individual":[247],"constituents":[248],"subjecting":[255],"them":[256],"bioassay":[258],"highly":[260],"recommended.":[261],"Keywords:":[262],"Schistosomiasis;":[263],"pfeifferi;":[265],"Protein":[266],"extracts;":[267],"Chemical":[268],"DOI:":[270],"10.7176/JNSR/10-12-03":[271],"Publication":[272],"date:":[273],"June":[274],"30th":[275],"2020":[276]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-10T00:00:00"}