{"id":"https://openalex.org/W3039724993","doi":"https://doi.org/10.2147/rrcc.s258978","title":"Efficacy and Safety Outcome of Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) in Patients with Heart Failure and Preserved Ejection Fraction (HFpEF): Preliminary Results","display_name":"Efficacy and Safety Outcome of Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) in Patients with Heart Failure and Preserved Ejection Fraction (HFpEF): Preliminary Results","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3039724993","doi":"https://doi.org/10.2147/rrcc.s258978","mag":"3039724993"},"language":"en","primary_location":{"id":"doi:10.2147/rrcc.s258978","doi":"https://doi.org/10.2147/rrcc.s258978","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrcc.s258978","pdf_url":"https://www.dovepress.com/getfile.php?fileID=59497","source":{"id":"https://openalex.org/S2765035434","display_name":"Research Reports in Clinical Cardiology","issn_l":"1179-8475","issn":["1179-8475"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Reports in Clinical Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=59497","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109543661","display_name":"Fayez Elshaer","orcid":"https://orcid.org/0000-0002-1031-4017","observed_orcids":["https://orcid.org/0000-0002-1031-4017"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]},{"id":"https://openalex.org/I4210151270","display_name":"National Heart Institute","ror":"https://ror.org/055273664","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210151270"]}],"countries":["EG","SA"],"is_corresponding":true,"raw_author_name":"Fayez Elshaer","raw_affiliation_strings":["King Fahad Cardiac Center, Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh, Saudi Arabia","National Heart Institute, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Fahad Cardiac Center, Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"National Heart Institute, Cairo, Egypt","institution_ids":["https://openalex.org/I4210151270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001542007","display_name":"Samih R. Lawand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samih Lawand","raw_affiliation_strings":["Dallah Hospital, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dallah Hospital, Riyadh, Saudi Arabia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohamed Zayed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Zayed","raw_affiliation_strings":["Dallah Hospital, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dallah Hospital, Riyadh, Saudi Arabia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113718596","display_name":"Fakhr Al Ayoubi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Fakhr Al Ayoubi","raw_affiliation_strings":["King Fahad Cardiac Center, Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Fahad Cardiac Center, Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090447709","display_name":"Yassmin Hanfi","orcid":"https://orcid.org/0000-0002-0354-1641","observed_orcids":["https://orcid.org/0000-0002-0354-1641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yassmin Hanfi","raw_affiliation_strings":["Dallah Hospital, Riyadh, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-0354-1641","affiliations":[{"raw_affiliation_string":"Dallah Hospital, Riyadh, Saudi Arabia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101443501","display_name":"Abdullah Ali AlQarni","orcid":"https://orcid.org/0000-0002-4267-1182","observed_orcids":["https://orcid.org/0000-0002-4267-1182"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]},{"id":"https://openalex.org/I4210136004","display_name":"University of Bisha","ror":"https://ror.org/040548g92","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210136004"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Ali S Alqarni","raw_affiliation_strings":["Department of Medicine, University of Bisha, Bisha, Saudi Arabia","King Fahad Cardiac Center, Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Bisha, Bisha, Saudi Arabia","institution_ids":["https://openalex.org/I4210136004"]},{"raw_affiliation_string":"King Fahad Cardiac Center, Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109543661"],"corresponding_institution_ids":["https://openalex.org/I28022161","https://openalex.org/I4210151270"],"apc_list":{"value":1806,"currency":"USD","value_usd":1806},"apc_paid":{"value":1806,"currency":"USD","value_usd":1806},"fwci":0.3094,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60556437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"Volume 11","issue":null,"first_page":"39","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":0.9789999723434448},{"id":"https://openalex.org/keywords/angiotensin-receptor-neprilysin-inhibitors","display_name":"angiotensin receptor-neprilysin inhibitors","score":0.9520000219345093},{"id":"https://openalex.org/keywords/acute-decompensated-heart-failure","display_name":"acute decompensated heart failure","score":0.8190000057220459},{"id":"https://openalex.org/keywords/nyha-functional-class","display_name":"NYHA functional class","score":0.8379999995231628},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9459999799728394},{"id":"https://openalex.org/keywords/serum-sodium","display_name":"serum sodium","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hyperkalemia","display_name":"hyperkalemia","score":0.8169999718666077},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.3970000147819519},{"id":"https://openalex.org/keywords/pulmonary-crackles","display_name":"pulmonary crackles","score":0.5920000076293945},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.929024338722229},{"id":"https://openalex.org/C2776754050","wikidata":"https://www.wikidata.org/wiki/Q17811448","display_name":"Sacubitril","level":4,"score":0.7826311588287354},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7825581431388855},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7517179250717163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7498477101325989},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.726982057094574},{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.6912189722061157},{"id":"https://openalex.org/C2775999527","wikidata":"https://www.wikidata.org/wiki/Q17811448","display_name":"Sacubitril, Valsartan","level":4,"score":0.5570846796035767},{"id":"https://openalex.org/C2781117629","wikidata":"https://www.wikidata.org/wiki/Q424280","display_name":"Loop diuretic","level":3,"score":0.5469260215759277},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.5007882118225098},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.4719620943069458},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3671918511390686},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.31676316261291504}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2147/rrcc.s258978","doi":"https://doi.org/10.2147/rrcc.s258978","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrcc.s258978","pdf_url":"https://www.dovepress.com/getfile.php?fileID=59497","source":{"id":"https://openalex.org/S2765035434","display_name":"Research Reports in Clinical Cardiology","issn_l":"1179-8475","issn":["1179-8475"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Reports in Clinical Cardiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7c709b919b8b4d7b95c42fa78dc8c55b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c709b919b8b4d7b95c42fa78dc8c55b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Reports in Clinical Cardiology, Vol Volume 11, Pp 39-47 (2020)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/55143","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/efficacy-and-safety-outcome-of-angiotensin-receptor-neprilysin-inhibit-peer-reviewed-article-RRCC","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/rrcc.s258978","doi":"https://doi.org/10.2147/rrcc.s258978","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrcc.s258978","pdf_url":"https://www.dovepress.com/getfile.php?fileID=59497","source":{"id":"https://openalex.org/S2765035434","display_name":"Research Reports in Clinical Cardiology","issn_l":"1179-8475","issn":["1179-8475"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Reports in Clinical Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3039724993.pdf","grobid_xml":"https://content.openalex.org/works/W3039724993.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1935070434","https://openalex.org/W1989353963","https://openalex.org/W2004547553","https://openalex.org/W2004760663","https://openalex.org/W2034557166","https://openalex.org/W2041725514","https://openalex.org/W2057275108","https://openalex.org/W2062377062","https://openalex.org/W2068519950","https://openalex.org/W2098418963","https://openalex.org/W2098780362","https://openalex.org/W2113284399","https://openalex.org/W2113698123","https://openalex.org/W2136642260","https://openalex.org/W2143094666","https://openalex.org/W2181206143","https://openalex.org/W2292493149","https://openalex.org/W2338104356","https://openalex.org/W2380447421","https://openalex.org/W2397911846","https://openalex.org/W2427094903","https://openalex.org/W2469843799","https://openalex.org/W2474345330","https://openalex.org/W2478829584","https://openalex.org/W2565435617","https://openalex.org/W2609605008","https://openalex.org/W2751884637","https://openalex.org/W2824420644","https://openalex.org/W2888477424","https://openalex.org/W2899841238","https://openalex.org/W2970357473","https://openalex.org/W2971294569","https://openalex.org/W2982376826","https://openalex.org/W2984370648","https://openalex.org/W2989425857","https://openalex.org/W3200126149","https://openalex.org/W3209204398","https://openalex.org/W4211082352"],"related_works":["https://openalex.org/W4229043611","https://openalex.org/W3215670232","https://openalex.org/W4287444555","https://openalex.org/W2165626962","https://openalex.org/W3215980470","https://openalex.org/W2143094666","https://openalex.org/W2649240144","https://openalex.org/W2471366643","https://openalex.org/W2470693201","https://openalex.org/W2331352037"],"abstract_inverted_index":{"Purpose:":[0],"This":[1],"study":[2,38,246],"analyzes":[3],"the":[4,79,102,160,166,183],"safety":[5],"and":[6,18,27,33,53,75,122,176,191,195],"efficacy":[7],"of":[8,13,47,133,180,182,270],"LCZ696":[9,59,85,231],"(valsartan/sacubitril),":[10],"a":[11,42,71,244,258],"combination":[12],"angiotensin":[14],"II":[15,125,154],"receptor":[16],"blocker":[17],"neprilysin":[19],"inhibitor":[20],"(ARNI),":[21],"in":[22,78,131,137,147,239],"patients":[23,50,83,240],"with":[24,144,241],"heart":[25,90,172],"failure":[26,91,173],"preserved":[28],"ejection":[29],"fraction":[30],"(HFpEF).":[31],"Patients":[32,106,156],"Methods:":[34],"An":[35],"observational":[36],"pilot":[37],"was":[39,56,66,99,129,142],"conducted":[40],"using":[41],"prospective":[43],"design.":[44],"A":[45],"sample":[46],"50":[48],"HFpEF":[49],"(27":[51],"females":[52],"23":[54],"males)":[55],"included":[57],"on":[58],"(50":[60],"mg":[61],"orally,":[62],"twice":[63],"daily),":[64],"which":[65],"then":[67],"titrated":[68],"up":[69,77],"to":[70,151,171,235,249,254],"maximum":[72],"tolerated":[73],"dose,":[74],"followed":[76,100],"outpatient":[80],"clinic.":[81],"Thirty-seven":[82],"received":[84],"during":[86],"hospitalization":[87],"for":[88,101,165,207,257],"decompensated":[89],"or":[92,178,227],"before":[93],"their":[94],"discharge":[95],"while":[96,135],"same":[97],"titration":[98],"remaining":[103],"patients.":[104],"Results:":[105],"were":[107,197],"classified":[108],"as":[109],"New":[110],"York":[111],"Heart":[112,188],"Association":[113],"(NYHA)":[114],"class":[115,119,124,149,153],"III":[116],"(64%),":[117],"NYHA":[118,123,148,152],"IV":[120],"(22%),":[121],"(14%).":[126],"Diabetes":[127],"mellitus":[128],"found":[130,143],"74%":[132],"patients,":[134],"hypertension":[136],"94%.":[138],"Rapid":[139],"clinical":[140,237],"improvement":[141,177],"significant":[145,236],"reduction":[146],"down":[150],"(p=0.018).":[155],"had":[157],"cleared":[158],"off":[159],"fine":[161],"basal":[162],"crackles":[163],"(specific":[164],"interstitial":[167],"pulmonary":[168],"disease)":[169],"secondary":[170],"(p<":[174,186],"0.001)":[175],"disappearance":[179],"edema":[181],"lower":[184],"limbs":[185],"0.001).":[187],"rate":[189],"response":[190],"jugular":[192],"venous":[193],"pressure":[194],"NT-pro-BNP":[196],"reduced":[198],"significantly":[199,221],"(p-value":[200],"<":[201],"0.001,":[202],"0.005,":[203],"respectively).":[204],"Echocardiographic":[205],"criteria":[206],"diastolic":[208,275],"LV":[209],"dysfunction":[210],"(primarily":[211],"E/A":[212],"ratio)":[213],"improved":[214,220],"(p=0.001).":[215],"Serum":[216],"sodium":[217],"(NA)":[218],"levels":[219],"(p=0.015),":[222],"without":[223],"worsening":[224],"renal":[225],"function":[226],"limiting":[228],"hyperkalemia.":[229],"Conclusion:":[230],"(sacubitril/valsartan;":[232],"ARNI)":[233],"led":[234],"improvements":[238],"HFpEF.":[242],"Further,":[243],"randomized":[245],"is":[247],"needed":[248],"test":[250],"whether":[251],"it":[252],"leads":[253],"positive":[255],"outcomes":[256],"larger":[259],"sample.":[260],"Ethical":[261],"Approval:":[262],"Project":[263],"No.":[264],"E-17-2414,":[265],"King":[266],"Saud":[267],"University,":[268],"Kingdom":[269],"Saudi":[271],"Arabia.":[272],"Keywords:":[273],"impaired":[274],"relaxation,":[276],"left":[277,282],"ventricular":[278,283],"hypertrophy,":[279],"LVH,":[280],"subtle":[281],"systolic":[284],"dysfunction,":[285],"ventricular-vascular":[286]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-07-10T00:00:00"}
