{"id":"https://openalex.org/W3039723113","doi":"https://doi.org/10.1021/acsinfecdis.0c00190","title":"Structure\u2013Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells","display_name":"Structure\u2013Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells","publication_year":2020,"publication_date":"2020-07-03","ids":{"openalex":"https://openalex.org/W3039723113","doi":"https://doi.org/10.1021/acsinfecdis.0c00190","mag":"3039723113","pmid":"https://pubmed.ncbi.nlm.nih.gov/32619094","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7485602"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.0c00190","doi":"https://doi.org/10.1021/acsinfecdis.0c00190","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.0c00190","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7485602","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025772510","display_name":"Xukai Jiang","orcid":"https://orcid.org/0000-0002-3624-8732","observed_orcids":["https://orcid.org/0000-0002-3624-8732"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xukai Jiang","raw_affiliation_strings":["Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0017-7952","affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450367","display_name":"Shuo Zhang","orcid":"https://orcid.org/0000-0002-3388-2797","observed_orcids":["https://orcid.org/0000-0002-3388-2797"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shuo Zhang","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110678105","display_name":"Mohammad Abul Kalam Azad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mohammad A. K. Azad","raw_affiliation_strings":["Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060920867","display_name":"Kade D. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kade D. Roberts","raw_affiliation_strings":["Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045027872","display_name":"Lin Sheng Wan","orcid":"https://orcid.org/0000-0003-2627-8775","observed_orcids":["https://orcid.org/0000-0003-2627-8775"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Wan","raw_affiliation_strings":["School of Software, Shandong University, Jinan 250101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Shandong University, Jinan 250101, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079312541","display_name":"Bin Gong","orcid":"https://orcid.org/0000-0001-9820-4762","observed_orcids":["https://orcid.org/0000-0001-9820-4762","https://orcid.org/0009-0007-4958-4974"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Gong","raw_affiliation_strings":["School of Software, Shandong University, Jinan 250101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Shandong University, Jinan 250101, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079696118","display_name":"Kai Yang","orcid":"https://orcid.org/0000-0002-2472-5984","observed_orcids":["https://orcid.org/0000-0002-2472-5984","https://orcid.org/0009-0000-5477-1802"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Yang","raw_affiliation_strings":["Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060496984","display_name":"Bing Yuan","orcid":"https://orcid.org/0000-0001-8418-9274","observed_orcids":["https://orcid.org/0000-0001-8418-9274"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Yuan","raw_affiliation_strings":["Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China"],"raw_orcid":"https://orcid.org/0000-0001-8418-9274","affiliations":[{"raw_affiliation_string":"Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003284231","display_name":"Md Hemayet Uddin","orcid":"https://orcid.org/0000-0003-3618-9653","observed_orcids":["https://orcid.org/0000-0003-3618-9653"]},"institutions":[{"id":"https://openalex.org/I2799275616","display_name":"Melbourne Centre for Nanofabrication","ror":"https://ror.org/022mtcz62","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2799275616"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hemayet Uddin","raw_affiliation_strings":["Melbourne Centre for Nanofabrication, Clayton, Melbourne, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne Centre for Nanofabrication, Clayton, Melbourne, Victoria 3168, Australia","institution_ids":["https://openalex.org/I2799275616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038802973","display_name":"Jingliang Li","orcid":"https://orcid.org/0000-0003-0709-2246","observed_orcids":["https://orcid.org/0000-0003-0709-2246"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jingliang Li","raw_affiliation_strings":["Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia","Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032907078","display_name":"Philip Evan Thompson","orcid":"https://orcid.org/0000-0002-5910-7625","observed_orcids":["https://orcid.org/0000-0002-5910-7625"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Philip E. Thompson","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Melbourne, Victoria 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0002-5910-7625","affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Melbourne, Victoria 3052, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020748618","display_name":"Tony Velkov","orcid":"https://orcid.org/0000-0002-0017-7952","observed_orcids":["https://orcid.org/0000-0002-0017-7952"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tony Velkov","raw_affiliation_strings":["Department of Pharmacology & Therapeutics, University of Melbourne, Melbourne, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, University of Melbourne, Melbourne, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728020","display_name":"Jing Wen Fu","orcid":"https://orcid.org/0000-0002-7752-5417","observed_orcids":["https://orcid.org/0000-0002-7752-5417"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jing Fu","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0002-7752-5417","affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108572322","display_name":"Lushan Wang","orcid":"https://orcid.org/0009-0000-8159-6886","observed_orcids":["https://orcid.org/0009-0000-8159-6886"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4391767886","display_name":"State Key Laboratory of Microbial Technology","ror":"https://ror.org/03x08qn04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lushan Wang","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402427","display_name":"Jian Li","orcid":"https://orcid.org/0000-0001-7953-8230","observed_orcids":["https://orcid.org/0000-0001-7953-8230"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jian Li","raw_affiliation_strings":["Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia","Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia"],"raw_orcid":"https://orcid.org/0000-0001-7953-8230","affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia","institution_ids":["https://openalex.org/I149704539"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100402427"],"corresponding_institution_ids":["https://openalex.org/I149704539","https://openalex.org/I56590836"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.5186,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.88140126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"6","issue":"8","first_page":"2110","last_page":"2119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.07580000162124634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymyxins","display_name":"polymyxins","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polymyxin-b1","display_name":"polymyxin B1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/membrane-insertion","display_name":"membrane insertion","score":0.5709999799728394},{"id":"https://openalex.org/keywords/hydrophobicity","display_name":"hydrophobicity","score":0.6039999723434448},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"stereochemistry","score":0.8169999718666077},{"id":"https://openalex.org/keywords/membrane-defects","display_name":"membrane defects","score":0.6240000128746033},{"id":"https://openalex.org/keywords/multidrug-resistant-gram-negative-bacteria","display_name":"multidrug-resistant Gram-negative bacteria","score":0.843999981880188},{"id":"https://openalex.org/keywords/last-resort-antibiotics","display_name":"last-resort antibiotics","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.8106141090393066},{"id":"https://openalex.org/C3020395395","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Human kidney","level":3,"score":0.579254686832428},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.44659700989723206},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.412801057100296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3941440284252167},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38653549551963806},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38339146971702576},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.17558598518371582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0798196792602539}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acsinfecdis.0c00190","doi":"https://doi.org/10.1021/acsinfecdis.0c00190","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.0c00190","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:32619094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32619094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7485602","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7485602","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/20698480","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Structure_Interaction_Relationship_of_Polymyxins_with_the_Membrane_of_Human_Kidney_Proximal_Tubular_Cells/20698480","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7485602","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7485602","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7529013017","display_name":"Targeting the Urgent Need for New Antibiotics against Gram-negative \u2018Superbugs\u2019","funder_award_id":"R01AI132154","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1988515368","https://openalex.org/W1988549330","https://openalex.org/W1991794210","https://openalex.org/W1993044982","https://openalex.org/W2004428159","https://openalex.org/W2004918900","https://openalex.org/W2006484084","https://openalex.org/W2021520922","https://openalex.org/W2022315563","https://openalex.org/W2027795131","https://openalex.org/W2041638382","https://openalex.org/W2041791898","https://openalex.org/W2043528043","https://openalex.org/W2048226924","https://openalex.org/W2051334858","https://openalex.org/W2067174909","https://openalex.org/W2081693079","https://openalex.org/W2086276567","https://openalex.org/W2116660179","https://openalex.org/W2119109208","https://openalex.org/W2121893424","https://openalex.org/W2126934372","https://openalex.org/W2128572087","https://openalex.org/W2136635915","https://openalex.org/W2150502003","https://openalex.org/W2152861632","https://openalex.org/W2162661622","https://openalex.org/W2164032940","https://openalex.org/W2171268876","https://openalex.org/W2178925859","https://openalex.org/W2358053226","https://openalex.org/W2402789472","https://openalex.org/W2471612261","https://openalex.org/W2667907301","https://openalex.org/W2767353752","https://openalex.org/W2913227771","https://openalex.org/W2965517512","https://openalex.org/W2965524911","https://openalex.org/W2966535838","https://openalex.org/W4211056710"],"related_works":["https://openalex.org/W4293702568","https://openalex.org/W4386467583","https://openalex.org/W7105794743","https://openalex.org/W7036548228","https://openalex.org/W2790612863","https://openalex.org/W7135271536","https://openalex.org/W7214916264","https://openalex.org/W2562144350","https://openalex.org/W7135960098","https://openalex.org/W4241444353"],"abstract_inverted_index":{"Multidrug-resistant":[0],"Gram-negative":[1],"bacteria":[2],"are":[3,12],"a":[4,18,126],"serious":[5],"global":[6],"threat":[7],"to":[8,21],"human":[9,88],"health.":[10],"Polymyxins":[11],"increasingly":[13],"used":[14],"in":[15],"patients":[16],"as":[17],"last-line":[19],"therapy":[20],"treat":[22],"infections":[23],"caused":[24],"by":[25,154],"these":[26],"life-threatening":[27],"\u2018superbugs\u2019.":[28],"Unfortunately,":[29],"polymyxin-induced":[30,211],"nephrotoxicity":[31,212],"is":[32,41],"the":[33,44,53,60,80,85,98,102,119,123,131,160,168,180,195,200,214,220],"major":[34],"dose-limiting":[35],"factor":[36],"and":[37,73,84,148,189,217],"understanding":[38],"its":[39],"mechanism":[40],"crucial":[42],"for":[43],"development":[45,221],"of":[46,59,79,87,101,122,163,171,197,222],"novel,":[47],"safer":[48],"polymyxins.":[49,224],"Here,":[50],"we":[51],"undertook":[52],"first":[54],"all-atom":[55],"molecular":[56],"dynamics":[57],"simulations":[58],"interaction":[61],"between":[62],"four":[63],"naturally":[64],"occurring":[65],"polymyxins":[66,94,134,172,198],"A":[67,75,114],"1,":[68,70],"B":[69],"M":[71],"1":[72,115],"colistin":[74],"(representative":[76],"structural":[77],"variations":[78],"polymyxin":[81],"core":[82],"structure)":[83],"membrane":[86,103,124,146,165,182],"kidney":[89],"proximal":[90],"tubular":[91],"cells.":[92],"All":[93],"inserted":[95,136],"spontaneously":[96],"into":[97,118,141,210],"hydrophobic":[99,120],"region":[100,121],"where":[104],"they":[105],"were":[106,152],"retained,":[107],"although":[108],"their":[109,137],"insertion":[110],"abilities":[111],"varied.":[112],"Polymyxin":[113],"completely":[116],"penetrated":[117],"with":[125,199],"unique":[127],"folded":[128],"conformation,":[129],"whereas":[130],"other":[132],"three":[133],"only":[135],"fatty":[138],"acyl":[139],"tails":[140],"this":[142],"region.":[143],"Furthermore,":[144],"local":[145],"defects":[147],"increased":[149],"water":[150],"penetration":[151],"induced":[153],"each":[155],"polymyxin,":[156],"which":[157],"may":[158],"represent":[159],"initial":[161],"stage":[162],"cellular":[164],"damage.":[166],"Finally,":[167],"structure\u2013interaction":[169],"relationship":[170],"was":[173],"investigated":[174],"based":[175],"on":[176],"atomic":[177,215],"interactions":[178,196],"at":[179,186,191,213],"cell":[181,201],"level.":[183],"The":[184],"hydrophobicity":[185],"positions":[187],"6/7":[188],"stereochemistry":[190],"position":[192],"3":[193],"regulated":[194],"membrane.":[202],"Collectively,":[203],"our":[204],"results":[205],"provide":[206],"new":[207],"mechanistic":[208],"insights":[209],"level":[216],"will":[218],"facilitate":[219],"new-generation":[223]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-07-10T00:00:00"}
