{"id":"https://openalex.org/W3039468532","doi":"https://doi.org/10.1172/jci.insight.136706","title":"Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1","display_name":"Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1","publication_year":2020,"publication_date":"2020-06-30","ids":{"openalex":"https://openalex.org/W3039468532","doi":"https://doi.org/10.1172/jci.insight.136706","mag":"3039468532","pmid":"https://pubmed.ncbi.nlm.nih.gov/32603314","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7455085"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.136706","doi":"https://doi.org/10.1172/jci.insight.136706","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.136706","pdf_url":"http://insight.jci.org/articles/view/136706/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/136706/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040899814","display_name":"Tomoki Maekawa","orcid":"https://orcid.org/0000-0002-4597-1316","observed_orcids":["https://orcid.org/0000-0002-4597-1316"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tomoki Maekawa","raw_affiliation_strings":["Center for Advanced Oral Science,","Division of Microbiology and Infectious Diseases,","Division of Periodontology, and"],"raw_orcid":"https://orcid.org/0000-0002-4597-1316","affiliations":[{"raw_affiliation_string":"Center for Advanced Oral Science,","institution_ids":[]},{"raw_affiliation_string":"Division of Microbiology and Infectious Diseases,","institution_ids":[]},{"raw_affiliation_string":"Division of Periodontology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042609226","display_name":"Hikaru Tamura","orcid":"https://orcid.org/0000-0002-6769-5287","observed_orcids":["https://orcid.org/0000-0002-6769-5287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hikaru Tamura","raw_affiliation_strings":["Center for Advanced Oral Science,","Division of Microbiology and Infectious Diseases,","Division of Periodontology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Oral Science,","institution_ids":[]},{"raw_affiliation_string":"Division of Microbiology and Infectious Diseases,","institution_ids":[]},{"raw_affiliation_string":"Division of Periodontology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015097325","display_name":"Hisanori Domon","orcid":"https://orcid.org/0000-0002-2911-826X","observed_orcids":["https://orcid.org/0000-0002-2911-826X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisanori Domon","raw_affiliation_strings":["Center for Advanced Oral Science,","Division of Microbiology and Infectious Diseases,"],"raw_orcid":"https://orcid.org/0000-0002-2911-826X","affiliations":[{"raw_affiliation_string":"Center for Advanced Oral Science,","institution_ids":[]},{"raw_affiliation_string":"Division of Microbiology and Infectious Diseases,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010972158","display_name":"Takumi Hiyoshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takumi Hiyoshi","raw_affiliation_strings":["Center for Advanced Oral Science,","Division of Microbiology and Infectious Diseases,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Oral Science,","institution_ids":[]},{"raw_affiliation_string":"Division of Microbiology and Infectious Diseases,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037505925","display_name":"Toshihito Isono","orcid":"https://orcid.org/0000-0002-8676-3302","observed_orcids":["https://orcid.org/0000-0002-8676-3302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshihito Isono","raw_affiliation_strings":["Division of Microbiology and Infectious Diseases,"],"raw_orcid":"https://orcid.org/0000-0002-8676-3302","affiliations":[{"raw_affiliation_string":"Division of Microbiology and Infectious Diseases,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045921843","display_name":"Daisuke Yonezawa","orcid":"https://orcid.org/0000-0001-8469-8060","observed_orcids":["https://orcid.org/0000-0001-8469-8060"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Yonezawa","raw_affiliation_strings":["Center for Advanced Oral Science,","Division of Oral Science for Health Promotion, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Oral Science,","institution_ids":[]},{"raw_affiliation_string":"Division of Oral Science for Health Promotion, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009776528","display_name":"Naoki Hayashi","orcid":"https://orcid.org/0000-0001-8779-3610","observed_orcids":["https://orcid.org/0000-0001-8779-3610"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Hayashi","raw_affiliation_strings":["Department of Microbiology and Infection Control Sciences, Kyoto Pharmaceutical University, Yamashina, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infection Control Sciences, Kyoto Pharmaceutical University, Yamashina, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043935976","display_name":"Naoki Takahashi","orcid":"https://orcid.org/0000-0001-8952-7260","observed_orcids":["https://orcid.org/0000-0001-8952-7260"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Takahashi","raw_affiliation_strings":["Division of Periodontology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Periodontology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010230060","display_name":"Koichi Tabeta","orcid":"https://orcid.org/0000-0002-7019-1872","observed_orcids":["https://orcid.org/0000-0002-7019-1872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koichi Tabeta","raw_affiliation_strings":["Division of Periodontology, and"],"raw_orcid":"https://orcid.org/0000-0002-7019-1872","affiliations":[{"raw_affiliation_string":"Division of Periodontology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101878211","display_name":"Takeyasu Maeda","orcid":"https://orcid.org/0000-0001-5317-7510","observed_orcids":["https://orcid.org/0000-0001-5317-7510"]},"institutions":[{"id":"https://openalex.org/I205133468","display_name":"Universitas Airlangga","ror":"https://ror.org/04ctejd88","country_code":"ID","type":"education","lineage":["https://openalex.org/I205133468"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Takeyasu Maeda","raw_affiliation_strings":["Center for Advanced Oral Science,","Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-5317-7510","affiliations":[{"raw_affiliation_string":"Center for Advanced Oral Science,","institution_ids":[]},{"raw_affiliation_string":"Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia","institution_ids":["https://openalex.org/I205133468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089931496","display_name":"Masataka Oda","orcid":"https://orcid.org/0000-0001-7435-8361","observed_orcids":["https://orcid.org/0000-0001-7435-8361"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masataka Oda","raw_affiliation_strings":["Department of Microbiology and Infection Control Sciences, Kyoto Pharmaceutical University, Yamashina, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7435-8361","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infection Control Sciences, Kyoto Pharmaceutical University, Yamashina, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110662335","display_name":"Athanasios Ziogas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Athanasios Ziogas","raw_affiliation_strings":["Institute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004023214","display_name":"Vasileia Ismini Alexaki","orcid":"https://orcid.org/0000-0003-3935-8985","observed_orcids":["https://orcid.org/0000-0003-3935-8985"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vasileia Ismini Alexaki","raw_affiliation_strings":["Institute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086672334","display_name":"Triantafyllos Chavakis","orcid":"https://orcid.org/0000-0002-1869-5141","observed_orcids":["https://orcid.org/0000-0002-1869-5141"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Triantafyllos Chavakis","raw_affiliation_strings":["Centre for Cardiovascular Science, Queen\u2019s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom","Institute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cardiovascular Science, Queen\u2019s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046070504","display_name":"Yutaka Terao","orcid":"https://orcid.org/0000-0002-4450-5583","observed_orcids":["https://orcid.org/0000-0002-4450-5583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaka Terao","raw_affiliation_strings":["Center for Advanced Oral Science,","Division of Microbiology and Infectious Diseases,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Oral Science,","institution_ids":[]},{"raw_affiliation_string":"Division of Microbiology and Infectious Diseases,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084031628","display_name":"George Hajishengallis","orcid":"https://orcid.org/0000-0001-7392-8852","observed_orcids":["https://orcid.org/0000-0001-7392-8852"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Hajishengallis","raw_affiliation_strings":["Laboratory of Innate Immunity and Inflammation, Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-7392-8852","affiliations":[{"raw_affiliation_string":"Laboratory of Innate Immunity and Inflammation, Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5040899814"],"corresponding_institution_ids":[],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":4.3371,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.94737835,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"15","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.4503999948501587,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.4503999948501587,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.17159999907016754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.121799997985363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":1.0},{"id":"https://openalex.org/keywords/macrolide-antibiotics","display_name":"macrolide antibiotics","score":0.9639999866485596},{"id":"https://openalex.org/keywords/del-1","display_name":"Del-1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.8180000185966492},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.953000009059906},{"id":"https://openalex.org/keywords/growth-hormone-secretagogue-receptor","display_name":"growth hormone secretagogue receptor","score":0.8190000057220459},{"id":"https://openalex.org/keywords/jak2-signaling","display_name":"JAK2 signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9110000133514404},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.8709999918937683},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7070000171661377},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6505728363990784},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6435916423797607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48431769013404846},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4647606611251831},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4183446168899536},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.41568365693092346},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35210520029067993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30087578296661377},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.2955433428287506},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2647414803504944},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25385215878486633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2071666419506073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci.insight.136706","doi":"https://doi.org/10.1172/jci.insight.136706","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.136706","pdf_url":"http://insight.jci.org/articles/view/136706/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7455085","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7455085","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:32603314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32603314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.136706","doi":"https://doi.org/10.1172/jci.insight.136706","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.136706","pdf_url":"http://insight.jci.org/articles/view/136706/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1270009640","display_name":"New strategies for preventing undernutrition in the elderly-tailor-made nutrition guidance method tailored to denture guidance-","funder_award_id":"20K10290","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1580275863","display_name":"Elucidation of the TRP-TLR interaction in the pathogenesis of inflammatory diseases","funder_award_id":"18KK0434","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1762246372","display_name":"\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u6539\u5909\u4f53\u306e\u6297\u708e\u75c7Del-1\u5206\u5b50\u8a98\u5c0e\u306b\u3088\u308b\u708e\u75c7\u6027\u9aa8\u5438\u53ce\u5236\u5fa1\u6cd5\u306e\u691c\u7d22","funder_award_id":"20J15490","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G183177274","display_name":"Elucidation of effectiveness and mechanism of new water-soluble glycolipids in bacterial pneumonia control","funder_award_id":"18H02657","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1913415251","display_name":"Therapeutic strategies against inflammation and bone loss associated with Del-1 production","funder_award_id":"19H03828","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2045909891","display_name":null,"funder_award_id":"20K09903","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2332894968","display_name":"Del-1: Molecular and Cellular Targets in Periodontitis","funder_award_id":"R01DE024716","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3225577680","display_name":"Challenges to the identification of neutrophil subsets involved in the development and remission of inflammation","funder_award_id":"19K22706","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3249644310","display_name":"Establishment and development of metagenomics-based priodontitis diagnostic platform","funder_award_id":"17K19747","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3319228230","display_name":null,"funder_award_id":"SFB1181","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3548458114","display_name":null,"funder_award_id":"16H06272E","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5391660184","display_name":null,"funder_award_id":"DE024716","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6265314926","display_name":"Next step in the oral-gut connection: Do swallowed periodontopathogenic bacteria exacerbate colitis?","funder_award_id":"19K10126","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6661578372","display_name":"Periodontal disease and the risk factors for atherosclerosis among subjects who received general medical check-ups","funder_award_id":"17K17366","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G692634027","display_name":null,"funder_award_id":"SFB-TR205","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7003581978","display_name":"Integrated understanding of Del-1 functions on osteobiology and Inflammation","funder_award_id":"17KK0165","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7470882566","display_name":"Aging and dysfunction of progenitor niches: Role of Del-1","funder_award_id":"R01DE028561","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G7631702783","display_name":null,"funder_award_id":"SFB-TR 205,SFB1181","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7745759350","display_name":null,"funder_award_id":"17KK0165, 17K19747, 19H03828, 19K22706","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G9000876385","display_name":"Local endogenous regulators of functional immune plasticity in the periodontium","funder_award_id":"R37DE026152","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320325387","display_name":"Senri Life Science Foundation","ror":"https://ror.org/046m7f751"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3039468532.pdf","grobid_xml":"https://content.openalex.org/works/W3039468532.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W181839489","https://openalex.org/W1483929525","https://openalex.org/W1559266775","https://openalex.org/W1589876756","https://openalex.org/W1889115072","https://openalex.org/W1923894169","https://openalex.org/W1963123255","https://openalex.org/W1978416618","https://openalex.org/W1988887783","https://openalex.org/W1993128745","https://openalex.org/W1999422673","https://openalex.org/W2000658565","https://openalex.org/W2001077637","https://openalex.org/W2001235644","https://openalex.org/W2003833311","https://openalex.org/W2012757704","https://openalex.org/W2018904543","https://openalex.org/W2018922281","https://openalex.org/W2021337215","https://openalex.org/W2021838232","https://openalex.org/W2031141671","https://openalex.org/W2036860335","https://openalex.org/W2045758206","https://openalex.org/W2049438316","https://openalex.org/W2051051813","https://openalex.org/W2056469487","https://openalex.org/W2061556445","https://openalex.org/W2065827975","https://openalex.org/W2068375079","https://openalex.org/W2071219973","https://openalex.org/W2084800734","https://openalex.org/W2086247606","https://openalex.org/W2091434654","https://openalex.org/W2096373158","https://openalex.org/W2096667163","https://openalex.org/W2108571057","https://openalex.org/W2126263666","https://openalex.org/W2131368844","https://openalex.org/W2137969357","https://openalex.org/W2139137636","https://openalex.org/W2140720587","https://openalex.org/W2144489715","https://openalex.org/W2144537497","https://openalex.org/W2144622655","https://openalex.org/W2147331510","https://openalex.org/W2148554608","https://openalex.org/W2148645653","https://openalex.org/W2153335875","https://openalex.org/W2157350274","https://openalex.org/W2163865122","https://openalex.org/W2217775969","https://openalex.org/W2219423687","https://openalex.org/W2270494031","https://openalex.org/W2284179751","https://openalex.org/W2324009466","https://openalex.org/W2484900834","https://openalex.org/W2578450947","https://openalex.org/W2594001718","https://openalex.org/W2637253428","https://openalex.org/W2747776510","https://openalex.org/W2789668995","https://openalex.org/W2791163322","https://openalex.org/W2796143894","https://openalex.org/W2802300814","https://openalex.org/W2888855736","https://openalex.org/W2894117246","https://openalex.org/W2895751573","https://openalex.org/W2896857921","https://openalex.org/W2898908588","https://openalex.org/W2899909210","https://openalex.org/W2921848354","https://openalex.org/W2922399346","https://openalex.org/W2956655325","https://openalex.org/W2967751307","https://openalex.org/W3000776202","https://openalex.org/W3015519256","https://openalex.org/W6633538041"],"related_works":["https://openalex.org/W2108904221","https://openalex.org/W2040165586","https://openalex.org/W2145060061","https://openalex.org/W2138885527","https://openalex.org/W7095091139","https://openalex.org/W2787899239","https://openalex.org/W2397022912","https://openalex.org/W1999422673","https://openalex.org/W2155682059","https://openalex.org/W2054702311"],"abstract_inverted_index":{"Macrolide":[0],"antibiotics":[1],"exert":[2],"antiinflammatory":[3,36],"effects;":[4],"however,":[5],"little":[6],"is":[7,41],"known":[8],"regarding":[9],"their":[10],"immunomodulatory":[11],"mechanisms.":[12],"In":[13],"this":[14],"study,":[15],"using":[16],"2":[17],"distinct":[18],"mouse":[19],"models":[20],"of":[21,38,45,60,102,147,179,193],"mucosal":[22],"inflammatory":[23,95,172,194],"disease":[24],"(LPS-induced":[25],"acute":[26],"lung":[27,122],"injury":[28],"and":[29,71,87,94,117,136,174,195],"ligature-induced":[30],"periodontitis),":[31],"we":[32],"demonstrated":[33],"that":[34,130,153],"the":[35,46,56,69,72,112,177,191],"action":[37,59],"erythromycin":[39],"(ERM)":[40],"mediated":[42,132],"through":[43],"upregulation":[44],"secreted":[47],"homeostatic":[48],"protein":[49],"developmental":[50],"endothelial":[51,61,124],"locus-1":[52],"(DEL-1).":[53],"Consistent":[54],"with":[55,111,175],"anti-neutrophil":[57],"recruitment":[58],"cell-derived":[62],"DEL-1,":[63],"ERM":[64,79,103,126,143,180],"inhibited":[65],"neutrophil":[66],"infiltration":[67],"in":[68,74,106,120,150,171],"lungs":[70],"periodontium":[73],"a":[75,151,187],"DEL-1-dependent":[76],"manner.":[77],"Whereas":[78],"(but":[80],"not":[81,156],"other":[82],"antibiotics,":[83],"such":[84],"as":[85],"josamycin":[86],"penicillin)":[88],"protected":[89],"against":[90],"lethal":[91],"pulmonary":[92],"inflammation":[93],"periodontal":[96],"bone":[97],"loss,":[98],"these":[99],"protective":[100],"effects":[101],"were":[104],"abolished":[105],"Del1-deficient":[107],"mice.":[108],"By":[109],"interacting":[110],"growth":[113],"hormone":[114],"secretagogue":[115],"receptor":[116],"activating":[118],"JAK2":[119,159],"human":[121],"microvascular":[123],"cells,":[125],"induced":[127],"DEL-1":[128,148,166,183],"transcription":[129],"was":[131,137,154],"by":[133],"MAPK":[134],"p38":[135],"CCAAT/enhancer":[138],"binding":[139],"protein-\u03b2":[140],"dependent.":[141],"Moreover,":[142],"reversed":[144],"IL-17-induced":[145],"inhibition":[146],"transcription,":[149],"manner":[152],"dependent":[155],"only":[157],"on":[158,162],"but":[160],"also":[161],"PI3K/AKT":[163],"signaling.":[164],"Because":[165],"levels":[167],"are":[168],"severely":[169],"reduced":[170],"conditions":[173],"aging,":[176],"ability":[178],"to":[181,186],"upregulate":[182],"may":[184],"lead":[185],"novel":[188],"approach":[189],"for":[190],"treatment":[192],"aging-related":[196],"diseases.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-07-10T00:00:00"}
