{"id":"https://openalex.org/W3039014233","doi":"https://doi.org/10.36547/nbc.v19i1.575","title":"In silico assessment of Rhanterium adpressum sesquiterpenes inhibitory effect on 3 and 15-O-trichothecene acetyltransferases","display_name":"In silico assessment of Rhanterium adpressum sesquiterpenes inhibitory effect on 3 and 15-O-trichothecene acetyltransferases","publication_year":2020,"publication_date":"2020-06-30","ids":{"openalex":"https://openalex.org/W3039014233","doi":"https://doi.org/10.36547/nbc.v19i1.575","mag":"3039014233"},"language":"en","primary_location":{"id":"doi:10.36547/nbc.v19i1.575","doi":"https://doi.org/10.36547/nbc.v19i1.575","is_oa":true,"landing_page_url":"https://doi.org/10.36547/nbc.v19i1.575","pdf_url":"https://journals.scicell.org/index.php/NBC/article/download/575/477","source":{"id":"https://openalex.org/S2738368846","display_name":"Nova Biotechnologica et Chimica","issn_l":"1338-6905","issn":["1338-6905","1339-004X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nova Biotechnologica et chimica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.scicell.org/index.php/NBC/article/download/575/477","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044250866","display_name":"Fatiha Elhouiti","orcid":"https://orcid.org/0000-0001-8191-1428","observed_orcids":["https://orcid.org/0000-0001-8191-1428"]},"institutions":[{"id":"https://openalex.org/I50219554","display_name":"Amar Telidji University of Laghouat","ror":"https://ror.org/018bbh535","country_code":"DZ","type":"education","lineage":["https://openalex.org/I50219554"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Fatiha Elhouiti","raw_affiliation_strings":["University of Amar TELIDJI of Laghouat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Amar TELIDJI of Laghouat","institution_ids":["https://openalex.org/I50219554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081772612","display_name":"Djilali Tahri","orcid":"https://orcid.org/0000-0002-9408-6188","observed_orcids":["https://orcid.org/0000-0002-9408-6188"]},"institutions":[{"id":"https://openalex.org/I50219554","display_name":"Amar Telidji University of Laghouat","ror":"https://ror.org/018bbh535","country_code":"DZ","type":"education","lineage":["https://openalex.org/I50219554"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Djilali Tahri","raw_affiliation_strings":["University of Amar TELIDJI of Laghouat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Amar TELIDJI of Laghouat","institution_ids":["https://openalex.org/I50219554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041350611","display_name":"Mohamed Ouinten","orcid":"https://orcid.org/0000-0003-3720-7251","observed_orcids":["https://orcid.org/0000-0003-3720-7251"]},"institutions":[{"id":"https://openalex.org/I50219554","display_name":"Amar Telidji University of Laghouat","ror":"https://ror.org/018bbh535","country_code":"DZ","type":"education","lineage":["https://openalex.org/I50219554"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Mohamed Ouinten","raw_affiliation_strings":["University of Amar TELIDJI of Laghouat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Amar TELIDJI of Laghouat","institution_ids":["https://openalex.org/I50219554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024139158","display_name":"Mohamed Yousfi","orcid":"https://orcid.org/0000-0003-3947-9867","observed_orcids":["https://orcid.org/0000-0003-3947-9867"]},"institutions":[{"id":"https://openalex.org/I50219554","display_name":"Amar Telidji University of Laghouat","ror":"https://ror.org/018bbh535","country_code":"DZ","type":"education","lineage":["https://openalex.org/I50219554"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Mohamed Yousfi","raw_affiliation_strings":["University of Amar TELIDJI of Laghouat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Amar TELIDJI of Laghouat","institution_ids":["https://openalex.org/I50219554"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I50219554"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"1","first_page":"30","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.48660001158714294,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.48660001158714294,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.15710000693798065,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sesquiterpenes","display_name":"sesquiterpenes","score":0.968999981880188},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.7609999775886536},{"id":"https://openalex.org/keywords/trichothecene-biosynthesis","display_name":"trichothecene biosynthesis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/fusarium-culmorum","display_name":"Fusarium culmorum","score":0.8460000157356262},{"id":"https://openalex.org/keywords/fusarium-graminearum","display_name":"Fusarium graminearum","score":1.0},{"id":"https://openalex.org/keywords/mycotoxin-inhibition","display_name":"mycotoxin inhibition","score":0.753000020980835},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6909999847412109},{"id":"https://openalex.org/keywords/protein-structure-modeling","display_name":"protein structure modeling","score":0.699999988079071},{"id":"https://openalex.org/keywords/alpha-eudesmol","display_name":"\u03b1-eudesmol","score":0.9419999718666077},{"id":"https://openalex.org/keywords/deoxynivalenol","display_name":"deoxynivalenol","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mycelial-growth-inhibition","display_name":"mycelial growth inhibition","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2776889654","wikidata":"https://www.wikidata.org/wiki/Q257954","display_name":"Trichothecene","level":3,"score":0.9701712131500244},{"id":"https://openalex.org/C2776211264","wikidata":"https://www.wikidata.org/wiki/Q80218","display_name":"Sesquiterpene","level":2,"score":0.6965680122375488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.687168300151825},{"id":"https://openalex.org/C2778145600","wikidata":"https://www.wikidata.org/wiki/Q2712591","display_name":"Fusarium culmorum","level":3,"score":0.6610943078994751},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5858725309371948},{"id":"https://openalex.org/C2779649592","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferase","level":4,"score":0.5564000606536865},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4922586977481842},{"id":"https://openalex.org/C84699730","wikidata":"https://www.wikidata.org/wiki/Q422449","display_name":"Mycotoxin","level":2,"score":0.4788386821746826},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4501386880874634},{"id":"https://openalex.org/C2910274206","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferases","level":4,"score":0.44669270515441895},{"id":"https://openalex.org/C2778867309","wikidata":"https://www.wikidata.org/wiki/Q131672","display_name":"Fusarium","level":2,"score":0.4396442174911499},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.42380988597869873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3432776927947998},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.18459805846214294},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.1831657588481903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1682058572769165},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.14222246408462524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08846595883369446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.36547/nbc.v19i1.575","doi":"https://doi.org/10.36547/nbc.v19i1.575","is_oa":true,"landing_page_url":"https://doi.org/10.36547/nbc.v19i1.575","pdf_url":"https://journals.scicell.org/index.php/NBC/article/download/575/477","source":{"id":"https://openalex.org/S2738368846","display_name":"Nova Biotechnologica et Chimica","issn_l":"1338-6905","issn":["1338-6905","1339-004X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nova Biotechnologica et chimica","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.36547/nbc.v19i1.575","doi":"https://doi.org/10.36547/nbc.v19i1.575","is_oa":true,"landing_page_url":"https://doi.org/10.36547/nbc.v19i1.575","pdf_url":"https://journals.scicell.org/index.php/NBC/article/download/575/477","source":{"id":"https://openalex.org/S2738368846","display_name":"Nova Biotechnologica et Chimica","issn_l":"1338-6905","issn":["1338-6905","1339-004X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nova Biotechnologica et chimica","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3039014233.pdf","grobid_xml":"https://content.openalex.org/works/W3039014233.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1562049809","https://openalex.org/W1733515972","https://openalex.org/W1967363201","https://openalex.org/W1975269539","https://openalex.org/W1982715544","https://openalex.org/W1987824691","https://openalex.org/W2049532733","https://openalex.org/W2079256367","https://openalex.org/W2089085945","https://openalex.org/W2105638686","https://openalex.org/W2111071897","https://openalex.org/W2116985836","https://openalex.org/W2130111617","https://openalex.org/W2132493058","https://openalex.org/W2316799651","https://openalex.org/W2472731030","https://openalex.org/W2563649124","https://openalex.org/W2734621703","https://openalex.org/W2893739823","https://openalex.org/W2930895158","https://openalex.org/W3031797782","https://openalex.org/W4205166547"],"related_works":["https://openalex.org/W2734621703","https://openalex.org/W1967917297","https://openalex.org/W3210703179","https://openalex.org/W4387028229","https://openalex.org/W2093590413","https://openalex.org/W2009346309","https://openalex.org/W2946557678","https://openalex.org/W2009505651","https://openalex.org/W2752962655","https://openalex.org/W3110731283"],"abstract_inverted_index":{"Essential":[0],"oils":[1,48],"(EO)":[2],"from":[3,81],"leaves":[4],"and":[5,17,28,67,74,100,107,123,131,149,154,181],"flowers":[6],"of":[7,25,36,42,62,88,120,146,160,166,174,178],"Rhanterium":[8],"adpressum":[9,168],"have":[10,76],"shown":[11],"to":[12,83,129],"inhibit":[13],"the":[14,59,77,118,163,172],"mycelial":[15],"growth":[16],"type":[18],"B":[19],"trichothecenes":[20],"production.":[21],"The":[22,39,158],"four":[23],"strains":[24],"Fusarium":[26,29],"culmorum":[27,180],"graminearum":[30],"were":[31,92],"inhibited":[32],"with":[33,96,138,143],"0.25":[34],"\u03bcL.mL-1":[35],"each":[37],"oil.":[38],"inhibitory":[40,164],"activity":[41],"11":[43],"sesquiterpenes":[44,137,170],"identified":[45],"in":[46,52,58],"these":[47,89],"was":[49],"here":[50],"examined":[51],"silico":[53],"against":[54],"two":[55,90],"key":[56],"enzymes":[57,91,173],"biosynthesis":[60,176],"pathway":[61,177],"trichotecenes":[63],"namely:":[64],"15-O-trichothecene":[65,115],"acetyltransferase":[66,106],"3-O-trichothecene":[68,105],"acetyltransferase.":[69,116],"In":[70],"sesquiterpene":[71],"composition,":[72],"T-Muurolol":[73,122,156],"\u03b1-Eudesmol":[75,124],"highest":[78],"percentages":[79],"ranging":[80],"1.4":[82],"2.75":[84],"%.":[85],"Three-dimensional":[86],"structures":[87],"modeled":[93],"using":[94],"SWISS-MODEL":[95],"GMQE":[97,108],"=":[98,102,109,112],"0.93":[99],"QMEAN":[101,111],"-0.45":[103],"for":[104,114],"0.93,":[110],"-0.58":[113],"By":[117],"results":[119,159],"docking,":[121],"showed":[125],"high":[126],"affinity":[127],"compared":[128],"15-Decalonectrin":[130],"Deoxynivalenol.":[132],"These":[133],"molecules":[134],"are":[135],"all":[136],"no":[139],"major":[140],"conformational":[141],"difference":[142],"an":[144],"RMSD":[145],"3.7":[147],"\u00c5":[148,151],"3.5":[150],"between":[152],"15-decalonectrin":[153],"\u03b1-Eudesmol,":[155],"respectively.":[157],"docking":[161],"prove":[162],"effect":[165],"R.":[167],"EO":[169],"on":[171],"mycotoxins":[175],"F.":[179,182],"graminearum.":[183]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-10T00:00:00"}