{"id":"https://openalex.org/W3039004374","doi":"https://doi.org/10.1016/j.jcmgh.2020.06.011","title":"Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis","display_name":"Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3039004374","doi":"https://doi.org/10.1016/j.jcmgh.2020.06.011","mag":"3039004374","pmid":"https://pubmed.ncbi.nlm.nih.gov/32629119","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7498829"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcmgh.2020.06.011","doi":"https://doi.org/10.1016/j.jcmgh.2020.06.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.06.011","pdf_url":"http://www.cmghjournal.org/article/S2352345X20301065/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cmghjournal.org/article/S2352345X20301065/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007640893","display_name":"Alexandra A. Wolfarth","orcid":"https://orcid.org/0000-0001-7902-8935","observed_orcids":["https://orcid.org/0000-0001-7902-8935"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra A. Wolfarth","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0000-0001-7902-8935","affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331734","display_name":"Xu Liu","orcid":"https://orcid.org/0000-0003-2252-7148","observed_orcids":["https://orcid.org/0000-0003-2252-7148"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu Liu","raw_affiliation_strings":["Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0000-0003-2252-7148","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089789086","display_name":"Trevor M. Darby","orcid":"https://orcid.org/0000-0002-7379-3836","observed_orcids":["https://orcid.org/0000-0002-7379-3836"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor M. Darby","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0000-0002-7379-3836","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079655617","display_name":"Darra Boyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darra J. Boyer","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011259708","display_name":"Jocelyn B. Spizman","orcid":"https://orcid.org/0000-0003-4948-6593","observed_orcids":["https://orcid.org/0000-0003-4948-6593"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jocelyn B. Spizman","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068450657","display_name":"Joshua A. Owens","orcid":"https://orcid.org/0000-0001-7315-2898","observed_orcids":["https://orcid.org/0000-0001-7315-2898"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua A. Owens","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0000-0001-7315-2898","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063302307","display_name":"Bindu P. Chandrasekharan","orcid":"https://orcid.org/0000-0003-2943-3902","observed_orcids":["https://orcid.org/0000-0003-2943-3902"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bindu Chandrasekharan","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056153030","display_name":"Crystal R. Naudin","orcid":"https://orcid.org/0000-0001-6171-2640","observed_orcids":["https://orcid.org/0000-0001-6171-2640"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal R. Naudin","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038852703","display_name":"Krisztina Z. Hanley","orcid":"https://orcid.org/0000-0002-7841-4700","observed_orcids":["https://orcid.org/0000-0002-7841-4700"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krisztina Z. Hanley","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090028003","display_name":"Brian Scott Robinson","orcid":"https://orcid.org/0000-0002-4344-9575","observed_orcids":["https://orcid.org/0000-0002-4344-9575"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian S. Robinson","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042492247","display_name":"Eric A. Ortlund","orcid":"https://orcid.org/0000-0001-8855-3029","observed_orcids":["https://orcid.org/0000-0001-8855-3029"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric A. Ortlund","raw_affiliation_strings":["Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0000-0001-8855-3029","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057779997","display_name":"Rheinallt M. Jones","orcid":"https://orcid.org/0000-0002-0415-9487","observed_orcids":["https://orcid.org/0000-0002-0415-9487"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rheinallt M. Jones","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, Georgia","Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia","Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0000-0002-0415-9487","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078257803","display_name":"Andrew Scott Neish","orcid":"https://orcid.org/0000-0002-7090-0237","observed_orcids":["https://orcid.org/0000-0002-7090-0237"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew S. Neish","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, Georgia. Electronic address: aneish@emory.edu","Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia","Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, Georgia. Electronic address: aneish@emory.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078257803"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":1.0716,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.77365764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"4","first_page":"713","last_page":"727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.8289999961853027},{"id":"https://openalex.org/keywords/radiation-induced-apoptosis","display_name":"radiation-induced apoptosis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.4569999873638153},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.8209999799728394},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.5099999904632568},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.703000009059906},{"id":"https://openalex.org/keywords/enteroids","display_name":"enteroids","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6809999942779541},{"id":"https://openalex.org/keywords/lactobacillus-rhamnosus-gg","display_name":"Lactobacillus rhamnosus GG","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.7991557121276855},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.69803786277771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6578503847122192},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.614258885383606},{"id":"https://openalex.org/C2908762490","wikidata":"https://www.wikidata.org/wiki/Q17145339","display_name":"Gastrointestinal epithelium","level":3,"score":0.6074873805046082},{"id":"https://openalex.org/C2776651480","wikidata":"https://www.wikidata.org/wiki/Q1607640","display_name":"Lactobacillus rhamnosus","level":4,"score":0.5879186391830444},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.5051241517066956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4982421398162842},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4576179087162018},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.44988375902175903},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4127132296562195},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.16983744502067566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1642036736011505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11526158452033997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.108519047498703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09111186861991882},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jcmgh.2020.06.011","doi":"https://doi.org/10.1016/j.jcmgh.2020.06.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.06.011","pdf_url":"http://www.cmghjournal.org/article/S2352345X20301065/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7498829","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7498829","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Gastroenterol Hepatol","raw_type":"Text"},{"id":"pmid:32629119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32629119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4a0ec09a3c3648728968dcc3d9a1343a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4a0ec09a3c3648728968dcc3d9a1343a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 713-727 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jcmgh.2020.06.011","doi":"https://doi.org/10.1016/j.jcmgh.2020.06.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.06.011","pdf_url":"http://www.cmghjournal.org/article/S2352345X20301065/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1218847028","display_name":"Targeting LRH-1 - Phospholipid Signaling in Metabolic Pathways","funder_award_id":"R01DK095750","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1382143525","display_name":"Structure-function of tafazzin in cardiac muscle wasting","funder_award_id":"17POST33660110","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G1842366043","display_name":null,"funder_award_id":"640471","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"},{"id":"https://openalex.org/G2342152677","display_name":"Control of Epithelial Proliferation by the Microbiota","funder_award_id":"R01CA179424","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5429538309","display_name":null,"funder_award_id":"455159","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"},{"id":"https://openalex.org/G678901585","display_name":"Microbial Influence on Mucosal Homeostasis","funder_award_id":"R01AI064462","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7136269247","display_name":"The molecular mechanisms of intestinal homeostasis.","funder_award_id":"R01DK098391","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8056379973","display_name":"Intestinal cell response to bacterial apoptotic signals","funder_award_id":"R01DK071604","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G922626974","display_name":"Beneficial bacteria enhance cardiovascular health by modulating inflammation and Nrf2 pathway signaling","funder_award_id":"19POST34370006","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3039004374.pdf","grobid_xml":"https://content.openalex.org/works/W3039004374.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W146278846","https://openalex.org/W1599222651","https://openalex.org/W1918288286","https://openalex.org/W1973496588","https://openalex.org/W1974101573","https://openalex.org/W1981327571","https://openalex.org/W1998072426","https://openalex.org/W2006262026","https://openalex.org/W2006322736","https://openalex.org/W2012669917","https://openalex.org/W2015115860","https://openalex.org/W2022892655","https://openalex.org/W2025770819","https://openalex.org/W2025938842","https://openalex.org/W2038859574","https://openalex.org/W2053820259","https://openalex.org/W2055043387","https://openalex.org/W2064854992","https://openalex.org/W2074098782","https://openalex.org/W2079347181","https://openalex.org/W2122292170","https://openalex.org/W2130927464","https://openalex.org/W2133676458","https://openalex.org/W2133808995","https://openalex.org/W2155674292","https://openalex.org/W2267180887","https://openalex.org/W2272226344","https://openalex.org/W2281531600","https://openalex.org/W2344704755","https://openalex.org/W2411108422","https://openalex.org/W2442662470","https://openalex.org/W2510423734","https://openalex.org/W2529915577","https://openalex.org/W2571040143","https://openalex.org/W2765195199","https://openalex.org/W2781977913","https://openalex.org/W2884529146","https://openalex.org/W2890723100","https://openalex.org/W2944348781","https://openalex.org/W2968616252","https://openalex.org/W2970492078","https://openalex.org/W4247412012"],"related_works":["https://openalex.org/W3174117496","https://openalex.org/W3082664824","https://openalex.org/W4205544494","https://openalex.org/W2038859574","https://openalex.org/W2886921109","https://openalex.org/W4389683775","https://openalex.org/W7099142087","https://openalex.org/W2461145092","https://openalex.org/W143025028","https://openalex.org/W2066749300"],"abstract_inverted_index":{"Background":[0],"&":[1],"Aims":[2],"The":[3],"intestinal":[4,47,199,224],"epithelium":[5,101,238],"must":[6],"be":[7],"resilient":[8],"to":[9,12,45,109,130,152,198,244],"physiochemical":[10],"stress":[11],"uphold":[13],"the":[14,18,22,28,56,64,72,85,100,103,154,178,181,205,222,236,246],"physiological":[15],"barrier":[16,247],"separating":[17],"systemic":[19],"compartment":[20],"from":[21,248],"microbial":[23],"and":[24,36,106,125,142,218,239],"antigenic":[25],"components":[26],"of":[27,55,66,102,119,180],"gut":[29],"lumen.":[30],"Identifying":[31],"proteins":[32],"that":[33,52],"mediate":[34],"protection":[35],"enhancing":[37],"their":[38],"expression":[39,65,173,220],"is":[40,94,161,228],"therefore":[41],"a":[42,95,162,213],"clear":[43],"approach":[44],"promote":[46],"health.":[48],"We":[49],"previously":[50,81],"reported":[51],"oral":[53],"ingestion":[54],"probiotic":[57],"Lactobacillus":[58],"rhamnosus":[59],"GG":[60],"not":[61],"only":[62,189],"induced":[63],"several":[67],"recognized":[68],"cytoprotective":[69],"factors":[70],"in":[71,99,113,133,177,216,221],"murine":[73],"colon,":[74],"but":[75],"also":[76],"many":[77],"genes":[78],"with":[79,144,167,212],"no":[80,168],"described":[82],"function,":[83],"including":[84],"gene":[86],"encoding":[87],"proline-rich":[88],"acidic":[89],"protein":[90,98,166,232],"1":[91],"(PRAP1).":[92],"PRAP1":[93,121,126,160,172,227],"highly":[96,196,233],"expressed":[97,234],"gastrointestinal":[104,237],"tract":[105],"we":[107],"sought":[108],"define":[110],"its":[111],"function":[112],"this":[114],"tissue.":[115],"Methods":[116],"Purified":[117],"preparations":[118],"recombinant":[120],"were":[122,128,138,150,175,195],"analyzed":[123],"biochemically":[124],"antisera":[127],"used":[129],"visualize":[131],"localization":[132],"tissues.":[134],"Prap1":[135,185,206],"-/-":[136,186,207],"mice":[137,187,208],"characterized":[139],"at":[140,192,241],"baseline":[141],"challenged":[143],"total":[145],"body":[146],"irradiation,":[147,204],"then":[148],"enteroids":[149],"generated":[151],"recapitulate":[153],"irradiation":[155],"challenge":[156],"ex":[157],"vivo.":[158],"Results":[159],"17-kilodalton":[163],"intrinsically":[164,230],"disordered":[165,231],"recognizable":[169],"sequence":[170],"homology.":[171],"levels":[174],"high":[176],"epithelia":[179],"small":[182,223],"intestine.":[183],"Although":[184],"presented":[188],"mild":[190],"phenotypes":[191],"baseline,":[193],"they":[194],"susceptible":[197],"injury":[200],"upon":[201],"challenge.":[202],"After":[203],"showed":[209],"accelerated":[210],"death":[211],"significant":[214],"increase":[215],"apoptosis":[217],"p21":[219],"epithelium.":[225],"Conclusions":[226],"an":[229],"by":[235],"functions":[240],"exposed":[242],"surfaces":[243],"protect":[245],"oxidative":[249],"insult.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-10T00:00:00"}