{"id":"https://openalex.org/W3038779485","doi":"https://doi.org/10.1097/pas.0000000000001533","title":"Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis","display_name":"Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis","publication_year":2020,"publication_date":"2020-06-30","ids":{"openalex":"https://openalex.org/W3038779485","doi":"https://doi.org/10.1097/pas.0000000000001533","mag":"3038779485","pmid":"https://pubmed.ncbi.nlm.nih.gov/32618599","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7942811"},"language":"en","primary_location":{"id":"doi:10.1097/pas.0000000000001533","doi":"https://doi.org/10.1097/pas.0000000000001533","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pas.0000000000001533","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7942811","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101044626","display_name":"Jia Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800015068","display_name":"VA NY Harbor Healthcare System","ror":"https://ror.org/03s5r4e84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2800015068","https://openalex.org/I4210094901"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jia Qin","raw_affiliation_strings":["Department of Pathology, The Department of Veteran Affairs New York Harbor Healthcare System, Brooklyn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Department of Veteran Affairs New York Harbor Healthcare System, Brooklyn","institution_ids":["https://openalex.org/I2800015068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102264371","display_name":"Takaaki Higashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Higashi","raw_affiliation_strings":["Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056749064","display_name":"Shigeki Nakagawa","orcid":"https://orcid.org/0000-0003-3994-4028","observed_orcids":["https://orcid.org/0000-0003-3994-4028"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Nakagawa","raw_affiliation_strings":["Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026873736","display_name":"Naoto Fujiwara","orcid":"https://orcid.org/0000-0002-4109-3421","observed_orcids":["https://orcid.org/0000-0002-4109-3421"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Naoto Fujiwara","raw_affiliation_strings":["Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan","Department of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086141994","display_name":"Yo\u2010ichi Yamashita","orcid":"https://orcid.org/0000-0001-8439-6660","observed_orcids":["https://orcid.org/0000-0001-8439-6660"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yo-ichi Yamashita","raw_affiliation_strings":["Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043888846","display_name":"Toru Beppu","orcid":"https://orcid.org/0000-0001-9046-0454","observed_orcids":["https://orcid.org/0000-0001-9046-0454"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Beppu","raw_affiliation_strings":["Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111579896","display_name":"Hideo Baba","orcid":"https://orcid.org/0000-0002-4270-7675","observed_orcids":["https://orcid.org/0000-0002-4270-7675"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Baba","raw_affiliation_strings":["Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107335404","display_name":"Masahiro Kobayashi","orcid":"https://orcid.org/0000-0002-6645-860X","observed_orcids":["https://orcid.org/0000-0002-6645-860X"]},"institutions":[{"id":"https://openalex.org/I4210166463","display_name":"Toranomon Hospital","ror":"https://ror.org/05rkz5e28","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166463"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Kobayashi","raw_affiliation_strings":["Department of Hepatology, Toranomon Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Toranomon Hospital","institution_ids":["https://openalex.org/I4210166463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108642276","display_name":"Hiromitsu Kumada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166463","display_name":"Toranomon Hospital","ror":"https://ror.org/05rkz5e28","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166463"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Kumada","raw_affiliation_strings":["Department of Hepatology, Toranomon Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Toranomon Hospital","institution_ids":["https://openalex.org/I4210166463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101572019","display_name":"Ganesh Gunasekaran","orcid":"https://orcid.org/0000-0003-4192-793X","observed_orcids":["https://orcid.org/0000-0003-4192-793X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ganesh Gunasekaran","raw_affiliation_strings":["Liver Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035293166","display_name":"Thomas D. Schiano","orcid":"https://orcid.org/0000-0003-1878-5101","observed_orcids":["https://orcid.org/0000-0003-1878-5101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas D. Schiano","raw_affiliation_strings":["Medicine, Division of Liver Diseases, Recanati-Miller Transplantation Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Division of Liver Diseases, Recanati-Miller Transplantation Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088943845","display_name":"Swan N. Thung","orcid":"https://orcid.org/0000-0003-4407-2295","observed_orcids":["https://orcid.org/0000-0003-4407-2295"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Swan N. Thung","raw_affiliation_strings":["The Department of Pathology, Molecular, and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, Molecular, and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022761217","display_name":"Maria Isabel Fiel","orcid":"https://orcid.org/0000-0002-7314-6313","observed_orcids":["https://orcid.org/0000-0002-7314-6313"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maria Isabel Fiel","raw_affiliation_strings":["The Department of Pathology, Molecular, and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, Molecular, and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007607351","display_name":"Yujin Hoshida","orcid":"https://orcid.org/0000-0001-9430-1426","observed_orcids":["https://orcid.org/0000-0001-9430-1426"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yujin Hoshida","raw_affiliation_strings":["Department of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102761665","display_name":"Stephen C. Ward","orcid":"https://orcid.org/0000-0002-2008-5334","observed_orcids":["https://orcid.org/0000-0002-2008-5334"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen C. Ward","raw_affiliation_strings":["The Department of Pathology, Molecular, and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, Molecular, and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5022761217","https://openalex.org/A5088943845","https://openalex.org/A5101044626","https://openalex.org/A5102761665"],"corresponding_institution_ids":["https://openalex.org/I2800015068","https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":2.6453,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.90864757,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"44","issue":"10","first_page":"1406","last_page":"1412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholic-steatohepatitis","display_name":"alcoholic steatohepatitis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8289999961853027},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7559999823570251},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-morphology","display_name":"tumor morphology","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8880672454833984},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.815058171749115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7572250366210938},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7365530729293823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.704004168510437},{"id":"https://openalex.org/C3018708256","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic steatohepatitis","level":5,"score":0.5931467413902283},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4757354259490967},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.36633843183517456},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.18758484721183777},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06126135587692261}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005235","descriptor_name":"Fatty Liver, Alcoholic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/pas.0000000000001533","doi":"https://doi.org/10.1097/pas.0000000000001533","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pas.0000000000001533","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:32618599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32618599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of surgical pathology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7374148","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7942811","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7942811","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7942811","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Surg Pathol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7374148","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7942811","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2448124205","display_name":"Molecular Prognostic Indicators in Liver Cirrhosis and Cancer","funder_award_id":"R01DK099558","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6924983015","display_name":"LINE-1methylation in nonhepatitis virus hepatocellular carcinoma","funder_award_id":"19K07777","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7392301715","display_name":"Reverse-engineering precision liver cancer chemoprevention","funder_award_id":"R01CA233794","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8172277632","display_name":"Glycopathology of HCC: identification of the source cells of serum fucosylation","funder_award_id":"U01CA226052","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1776128289","https://openalex.org/W1964829819","https://openalex.org/W1976388380","https://openalex.org/W1984423490","https://openalex.org/W2008072646","https://openalex.org/W2016808647","https://openalex.org/W2067740038","https://openalex.org/W2079146692","https://openalex.org/W2084014691","https://openalex.org/W2087829753","https://openalex.org/W2106061083","https://openalex.org/W2121833624","https://openalex.org/W2136415416","https://openalex.org/W2235284735","https://openalex.org/W2320516452","https://openalex.org/W2333335337","https://openalex.org/W2401321240","https://openalex.org/W2417077670","https://openalex.org/W2594613560","https://openalex.org/W2605644052","https://openalex.org/W2734724639","https://openalex.org/W2751505630","https://openalex.org/W2905001800","https://openalex.org/W2954505564","https://openalex.org/W3001487707","https://openalex.org/W3127015740","https://openalex.org/W4211105405"],"related_works":["https://openalex.org/W3149638233","https://openalex.org/W4285361352","https://openalex.org/W1984423490","https://openalex.org/W3000189319","https://openalex.org/W2905001800","https://openalex.org/W4403479612","https://openalex.org/W2000416315","https://openalex.org/W4247387413","https://openalex.org/W3203404882","https://openalex.org/W2046719161"],"abstract_inverted_index":{"Steatohepatitic":[0],"hepatocellular":[1,8],"carcinoma":[2,9],"(SH-HCC)":[3],"is":[4,25,222],"a":[5,98,202],"variant":[6],"of":[7,31,41,113,139,151,170,183,198,207,248],"(HCC)":[10],"with":[11,14,21,57,64,92,158,209,214,237],"established":[12],"association":[13,20,206],"nonalcoholic":[15],"steatohepatitis":[16,23],"(NASH),":[17],"while":[18,66,119],"its":[19],"alcoholic":[22],"(ASH)":[24],"unclear.":[26],"We":[27,166],"studied":[28],"2":[29],"cohorts":[30],"patients":[32,56,63,90,105,157],"who":[33],"underwent":[34],"resection":[35],"for":[36],"HCC":[37],"in":[38,53,60,73,76,83,123,132,136,153,180,224,250],"the":[39,69,77,84,133,173,181,190,246],"setting":[40],"steatohepatitis.":[42],"In":[43,142],"our":[44,143],"Mount":[45],"Sinai":[46],"(New":[47],"York)":[48],"cohort,":[49,145],"we":[50,108,146],"found":[51,110,148,177],"SH-HCC":[52,67,114,120,152,221,249],"17/24":[54],"(71%)":[55],"NASH":[58,78,154,193,213,228],"and":[59,80,155,162,176,186,192,212,227,229],"14/19":[61],"(74%)":[62],"ASH,":[65],"was":[68,121,201],"predominant":[70,122],"tumor":[71],"morphology":[72],"12/24":[74],"(50%)":[75],"group":[79],"9/19":[81],"(47%)":[82],"ASH":[85,93,156,191,208,226,251],"group.":[86],"Upon":[87],"review,":[88],"12/19":[89],"diagnosed":[91],"also":[94,147],"had":[95],"diabetes":[96],"and/or":[97],"body":[99],"mass":[100],"index":[101],">30.":[102],"When":[103],"these":[104,140],"were":[106,130],"removed,":[107],"still":[109],"similar":[111,149,238],"rates":[112,150],"(6/7":[115],"[86%]":[116],"showed":[117],"SH-HCC,":[118,199],"3/7":[124],"[43%].":[125],"Interestingly,":[126],"glycogenated":[127],"hepatocyte":[128],"nuclei":[129],"seen":[131],"nontumor":[134],"liver":[135,233],"4/7":[137],"(57%)":[138],"cases.":[141],"Japan":[144,174],"HCC,":[159],"15/58":[160],"(26%),":[161],"16/45":[163],"(36%),":[164],"respectively.":[165],"determined":[167],"molecular":[168,239],"subclassification":[169],"tumors":[171,236],"from":[172],"cohort":[175],"no":[178],"difference":[179],"distribution":[182],"S1,":[184],"S2":[185],"S3":[187,215],"subclasses":[188],"among":[189,196],"groups,":[194],"though,":[195],"cases":[197],"there":[200],"trend":[203],"toward":[204],"an":[205],"S1":[210],"(P=0.054)":[211],"(P=0.052).":[216],"Our":[217],"study":[218],"shows":[219],"that":[220,230],"common":[223],"both":[225,231],"underlying":[232],"diseases":[234],"produce":[235],"profiles,":[240],"though":[241],"different":[242],"pathways":[243],"may":[244],"underlie":[245],"development":[247],"versus":[252],"NASH.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-07-10T00:00:00"}