{"id":"https://openalex.org/W3038359441","doi":"https://doi.org/10.1152/ajpgi.00084.2020","title":"Epigenetic regulation of intestinal stem cell differentiation","display_name":"Epigenetic regulation of intestinal stem cell differentiation","publication_year":2020,"publication_date":"2020-07-06","ids":{"openalex":"https://openalex.org/W3038359441","doi":"https://doi.org/10.1152/ajpgi.00084.2020","mag":"3038359441","pmid":"https://pubmed.ncbi.nlm.nih.gov/32628072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7500269"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00084.2020","doi":"https://doi.org/10.1152/ajpgi.00084.2020","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00084.2020","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00084.2020","source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00084.2020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037665705","display_name":"Michael Paul Verzi","orcid":"https://orcid.org/0000-0003-4082-4330","observed_orcids":["https://orcid.org/0000-0003-4082-4330"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael P. Verzi","raw_affiliation_strings":["Cancer Institute of New Jersey and Human Genetics Institute of New Jersey, Piscataway, New Jersey","Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of New Jersey and Human Genetics Institute of New Jersey, Piscataway, New Jersey","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055619783","display_name":"Ramesh A. Shivdasani","orcid":"https://orcid.org/0000-0002-2828-1727","observed_orcids":["https://orcid.org/0000-0002-2828-1727"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramesh A. Shivdasani","raw_affiliation_strings":["Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts","Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts","Harvard Stem Cell Institute, Cambridge, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-2828-1727","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5037665705","https://openalex.org/A5055619783"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210157861","https://openalex.org/I4390039325"],"apc_list":null,"apc_paid":null,"fwci":0.2439,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.20653725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"319","issue":"2","first_page":"G189","last_page":"G196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.16359999775886536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-stem-cells","display_name":"intestinal stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.800000011920929},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.8859999775886536},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":1.0},{"id":"https://openalex.org/keywords/enhancer-promoter-interactions","display_name":"enhancer-promoter interactions","score":0.8090000152587891},{"id":"https://openalex.org/keywords/nucleosome-modification","display_name":"nucleosome modification","score":0.9599999785423279},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.6489999890327454},{"id":"https://openalex.org/keywords/disease-risk-variants","display_name":"disease risk variants","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8955632448196411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7595099806785583},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5683184862136841},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5614545345306396},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5589340925216675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5354499816894531},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5299816131591797},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4993398189544678},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.484224796295166},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.46972405910491943},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.44339823722839355},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.42367109656333923},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.42156484723091125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4046531021595001},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3657247722148895},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24063289165496826}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00084.2020","doi":"https://doi.org/10.1152/ajpgi.00084.2020","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00084.2020","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00084.2020","source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7500269","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7500269","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"},{"id":"pmid:32628072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32628072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1152/ajpgi.00084.2020","doi":"https://doi.org/10.1152/ajpgi.00084.2020","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00084.2020","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00084.2020","source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1026775581","display_name":"Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center","funder_award_id":"U24DK085532","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1644425607","display_name":"Anatomic and functional characterization of the intestinal crypt-villus niche","funder_award_id":"U01DK103152","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2772846243","display_name":"Transcriptional control of gut epithelial homeostasis and regeneration","funder_award_id":"R01DK081113","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3038359441.pdf","grobid_xml":"https://content.openalex.org/works/W3038359441.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W971294011","https://openalex.org/W1942669039","https://openalex.org/W1964963969","https://openalex.org/W1977921523","https://openalex.org/W1981030303","https://openalex.org/W1982603620","https://openalex.org/W1989940296","https://openalex.org/W1992570553","https://openalex.org/W1994216131","https://openalex.org/W2003299661","https://openalex.org/W2011964577","https://openalex.org/W2015416439","https://openalex.org/W2024121049","https://openalex.org/W2039053594","https://openalex.org/W2045265674","https://openalex.org/W2045960652","https://openalex.org/W2050610306","https://openalex.org/W2068205741","https://openalex.org/W2072466432","https://openalex.org/W2076540892","https://openalex.org/W2081365502","https://openalex.org/W2092407833","https://openalex.org/W2099847814","https://openalex.org/W2105147745","https://openalex.org/W2107429180","https://openalex.org/W2112364863","https://openalex.org/W2117374458","https://openalex.org/W2117757143","https://openalex.org/W2119059014","https://openalex.org/W2120060263","https://openalex.org/W2123564569","https://openalex.org/W2128062921","https://openalex.org/W2128602608","https://openalex.org/W2133899877","https://openalex.org/W2134959578","https://openalex.org/W2142014131","https://openalex.org/W2145518488","https://openalex.org/W2146883005","https://openalex.org/W2151591434","https://openalex.org/W2158610627","https://openalex.org/W2164222087","https://openalex.org/W2168602111","https://openalex.org/W2262448048","https://openalex.org/W2284100402","https://openalex.org/W2342153705","https://openalex.org/W2402793322","https://openalex.org/W2463708289","https://openalex.org/W2555375113","https://openalex.org/W2567946031","https://openalex.org/W2594423320","https://openalex.org/W2611717200","https://openalex.org/W2616198309","https://openalex.org/W2665902468","https://openalex.org/W2729843964","https://openalex.org/W2753494459","https://openalex.org/W2761896392","https://openalex.org/W2784570320","https://openalex.org/W2807022503","https://openalex.org/W2898283625","https://openalex.org/W2898577086","https://openalex.org/W2902462655","https://openalex.org/W2923571344","https://openalex.org/W2936734599","https://openalex.org/W2952452404","https://openalex.org/W2952664869","https://openalex.org/W2963772215","https://openalex.org/W2969784858","https://openalex.org/W2980980519","https://openalex.org/W2991164245","https://openalex.org/W2994932230","https://openalex.org/W2999019483","https://openalex.org/W3008445071","https://openalex.org/W3013167866","https://openalex.org/W4297933854"],"related_works":["https://openalex.org/W2651436262","https://openalex.org/W2594423320","https://openalex.org/W2323162166","https://openalex.org/W2994932230","https://openalex.org/W3005420876","https://openalex.org/W7097720282","https://openalex.org/W1992788426","https://openalex.org/W3047108949","https://openalex.org/W7209550882","https://openalex.org/W2519096090"],"abstract_inverted_index":{"To":[0],"fulfill":[1],"the":[2,23,106,114,124,137],"lifelong":[3],"need":[4],"to":[5,54,103],"supply":[6],"diverse":[7],"epithelial":[8,76],"cells,":[9],"intestinal":[10],"stem":[11],"cells":[12],"(ISCs)":[13],"rely":[14],"on":[15],"executing":[16],"accurate":[17],"transcriptional":[18],"programs.":[19,28],"This":[20],"review":[21,113],"addresses":[22],"mechanisms":[24],"that":[25,30,94,127],"control":[26,77],"those":[27],"Genes":[29],"define":[31],"cell":[32],"behaviors":[33],"and":[34,49,74,92,131,136],"identities":[35],"are":[36,86],"regulated":[37],"principally":[38],"through":[39],"thousands":[40],"of":[41,56,90,109,117,139],"dispersed":[42],"enhancers,":[43,123],"each":[44],"individually":[45],"<1":[46],"kb":[47],"long":[48],"positioned":[50],"from":[51,59,66],"a":[52],"few":[53],"hundreds":[55],"kilobases":[57],"away":[58],"transcription":[60,141],"start":[61],"sites,":[62],"upstream":[63],"or":[64,69],"downstream":[65],"coding":[67],"genes":[68],"within":[70],"introns.":[71],"Wnt,":[72],"Notch,":[73],"other":[75],"signals":[78],"feed":[79],"into":[80],"these":[81],"cis-regulatory":[82],"DNA":[83],"elements,":[84],"which":[85],"also":[87],"common":[88],"loci":[89],"polymorphisms":[91],"mutations":[93],"confer":[95],"disease":[96],"risk.":[97],"Cell-specific":[98],"gene":[99],"activity":[100],"requires":[101],"promoters":[102],"interact":[104],"with":[105],"correct":[107],"combination":[108],"signal-responsive":[110],"enhancers.":[111],"We":[112],"current":[115],"state":[116],"knowledge":[118],"in":[119],"ISCs":[120],"regarding":[121],"active":[122],"nucleosome":[125],"modifications":[126],"may":[128],"enable":[129],"appropriate":[130],"hinder":[132],"inappropriate":[133],"enhancer-promoter":[134],"contacts,":[135],"roles":[138],"lineage-restricted":[140],"factors.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-10T00:00:00"}