{"id":"https://openalex.org/W3038118317","doi":"https://doi.org/10.3390/jcm9062012","title":"Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results","display_name":"Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results","publication_year":2020,"publication_date":"2020-06-26","ids":{"openalex":"https://openalex.org/W3038118317","doi":"https://doi.org/10.3390/jcm9062012","mag":"3038118317","pmid":"https://pubmed.ncbi.nlm.nih.gov/32604946","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7356307"},"language":"en","primary_location":{"id":"doi:10.3390/jcm9062012","doi":"https://doi.org/10.3390/jcm9062012","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/jcm9062012","pdf_url":"https://www.mdpi.com/2077-0383/9/6/2012/pdf?version=1593180944","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3038118317"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/9/6/2012/pdf?version=1593180944","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012057708","display_name":"Folke Brinkmann","orcid":"https://orcid.org/0000-0002-4307-4232","observed_orcids":["https://orcid.org/0000-0002-4307-4232"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Folke Brinkmann","raw_affiliation_strings":["University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076038356","display_name":"Beatrice Hanusch","orcid":"https://orcid.org/0000-0003-3495-4614","observed_orcids":["https://orcid.org/0000-0003-3495-4614"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Beatrice Hanusch","raw_affiliation_strings":["University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015555168","display_name":"Manfred Ballmann","orcid":"https://orcid.org/0000-0003-4480-1312","observed_orcids":["https://orcid.org/0000-0003-4480-1312"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I4210136182","display_name":"Universit\u00e4tsmedizin Rostock","ror":"https://ror.org/04dm1cm79","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210136182"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Ballmann","raw_affiliation_strings":["Paediatric Clinic, University Medicine Rostock, 18057 Rostock, Germany","University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Clinic, University Medicine Rostock, 18057 Rostock, Germany","institution_ids":["https://openalex.org/I4210136182"]},{"raw_affiliation_string":"University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049740913","display_name":"Sebene Mayorandan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebene Mayorandan","raw_affiliation_strings":["Department of Paediatrics, Hannover Medical School, 30623 Hannover, Germany","Department of Paediatrics, University Clinic M\u00fcnster, 48149 M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Hannover Medical School, 30623 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Department of Paediatrics, University Clinic M\u00fcnster, 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016096010","display_name":"Alexander Bollenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Bollenbach","raw_affiliation_strings":["Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034824332","display_name":"Kristine Chobanyan-J\u00fcrgens","orcid":"https://orcid.org/0000-0002-9118-9464","observed_orcids":["https://orcid.org/0000-0002-9118-9464"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kristine Chobanyan-J\u00fcrgens","raw_affiliation_strings":["Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Department of General Pediatrics, Neuropediatrics, Metabolism, Gastroenterology, Nephrology, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany","Department of Paediatrics, Hannover Medical School, 30623 Hannover, Germany","Pediatric Clinical-Pharmacological Trial Center (paedKliPS), Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Department of General Pediatrics, Neuropediatrics, Metabolism, Gastroenterology, Nephrology, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Department of Paediatrics, Hannover Medical School, 30623 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Pediatric Clinical-Pharmacological Trial Center (paedKliPS), Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108238322","display_name":"Kathrin Jansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Jansen","raw_affiliation_strings":["University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039263700","display_name":"Anjona Roy Choudhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anjona Schmidt-Choudhury","raw_affiliation_strings":["University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090138985","display_name":"Nico Derichs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nico Derichs","raw_affiliation_strings":["Department of Paediatrics, Hannover Medical School, 30623 Hannover, Germany","KinderPneumologieDerichs, Pediatric Pneumology and Allergology, CFTR & Pulmonary Research Center, 30173 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Hannover Medical School, 30623 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"KinderPneumologieDerichs, Pediatric Pneumology and Allergology, CFTR & Pulmonary Research Center, 30173 Hannover, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044012246","display_name":"Dimitrios Tsikas","orcid":"https://orcid.org/0000-0001-6320-0956","observed_orcids":["https://orcid.org/0000-0001-6320-0956"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dimitrios Tsikas","raw_affiliation_strings":["Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6320-0956","affiliations":[{"raw_affiliation_string":"Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111506197","display_name":"Thomas L\u00fccke","orcid":"https://orcid.org/0000-0001-6875-6582","observed_orcids":["https://orcid.org/0000-0001-6875-6582"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas L\u00fccke","raw_affiliation_strings":["University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital, Ruhr University, 44791 Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5076038356"],"corresponding_institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2324},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2324},"fwci":1.0481,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.8004872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"6","first_page":"2012","last_page":"2012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/l-arginine-nitric-oxide-pathway","display_name":"L-arginine-nitric oxide pathway","score":0.9399999976158142},{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dimethylamine","display_name":"dimethylamine","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nitrate","display_name":"nitrate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/malnutrition","display_name":"malnutrition","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pancreatic-insufficiency","display_name":"pancreatic insufficiency","score":0.9369999766349792},{"id":"https://openalex.org/keywords/liver-involvement","display_name":"liver involvement","score":0.9319999814033508},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6499999761581421},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.6840000152587891},{"id":"https://openalex.org/keywords/risk-factors-for-malnutrition","display_name":"risk factors for malnutrition","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9663710594177246},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.768612265586853},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6579688787460327},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.5162327289581299},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49369606375694275},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.45739635825157166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42382991313934326},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34408435225486755},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.2815587520599365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15735027194023132},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jcm9062012","doi":"https://doi.org/10.3390/jcm9062012","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/jcm9062012","pdf_url":"https://www.mdpi.com/2077-0383/9/6/2012/pdf?version=1593180944","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmid:32604946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32604946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7356307","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7356307/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmh:oai:hss-opus.ub.ruhr-uni-bochum.de:7589","doi":null,"is_oa":true,"landing_page_url":"http://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/7589","pdf_url":null,"source":{"id":"https://openalex.org/S4306400167","display_name":"Dokumentenrepositorium der RUB (Ruhr University Bochum)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I904495901","host_organization_name":"Ruhr University Bochum","host_organization_lineage":["https://openalex.org/I904495901"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jcm9062012","doi":"https://doi.org/10.3390/jcm9062012","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/jcm9062012","pdf_url":"https://www.mdpi.com/2077-0383/9/6/2012/pdf?version=1593180944","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323326","display_name":"Medizinischen Hochschule Hannover","ror":"https://ror.org/00f2yqf98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3038118317.pdf","grobid_xml":"https://content.openalex.org/works/W3038118317.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W601382097","https://openalex.org/W1119734502","https://openalex.org/W1234121601","https://openalex.org/W1583601846","https://openalex.org/W1867236303","https://openalex.org/W1965605404","https://openalex.org/W1969427484","https://openalex.org/W1970937302","https://openalex.org/W1972530899","https://openalex.org/W1973239890","https://openalex.org/W1977040514","https://openalex.org/W1981691650","https://openalex.org/W1985747103","https://openalex.org/W1989725750","https://openalex.org/W2000241372","https://openalex.org/W2000940740","https://openalex.org/W2003196001","https://openalex.org/W2005587846","https://openalex.org/W2006555339","https://openalex.org/W2010792745","https://openalex.org/W2012651694","https://openalex.org/W2013498311","https://openalex.org/W2022774440","https://openalex.org/W2028146960","https://openalex.org/W2035344879","https://openalex.org/W2035414969","https://openalex.org/W2035949542","https://openalex.org/W2036644365","https://openalex.org/W2040233646","https://openalex.org/W2040438303","https://openalex.org/W2042848449","https://openalex.org/W2045730622","https://openalex.org/W2050758338","https://openalex.org/W2053429397","https://openalex.org/W2053693562","https://openalex.org/W2054282930","https://openalex.org/W2058385357","https://openalex.org/W2058655939","https://openalex.org/W2061039308","https://openalex.org/W2065374983","https://openalex.org/W2066911960","https://openalex.org/W2067352549","https://openalex.org/W2071367248","https://openalex.org/W2072556756","https://openalex.org/W2072950261","https://openalex.org/W2073594487","https://openalex.org/W2075941602","https://openalex.org/W2076186944","https://openalex.org/W2077512143","https://openalex.org/W2077882846","https://openalex.org/W2086935091","https://openalex.org/W2087285715","https://openalex.org/W2089124568","https://openalex.org/W2090724842","https://openalex.org/W2094312349","https://openalex.org/W2108775728","https://openalex.org/W2110519338","https://openalex.org/W2116490273","https://openalex.org/W2119785686","https://openalex.org/W2119948190","https://openalex.org/W2129424433","https://openalex.org/W2134986164","https://openalex.org/W2135584427","https://openalex.org/W2136326878","https://openalex.org/W2140130028","https://openalex.org/W2142565126","https://openalex.org/W2144586195","https://openalex.org/W2145642904","https://openalex.org/W2152191963","https://openalex.org/W2161221966","https://openalex.org/W2166937516","https://openalex.org/W2169513794","https://openalex.org/W2210026871","https://openalex.org/W2216025744","https://openalex.org/W2232790004","https://openalex.org/W2236245555","https://openalex.org/W2300224114","https://openalex.org/W2311996461","https://openalex.org/W2328664855","https://openalex.org/W2329773427","https://openalex.org/W2366087637","https://openalex.org/W2406439825","https://openalex.org/W2413373203","https://openalex.org/W2485255970","https://openalex.org/W2523322985","https://openalex.org/W2528866509","https://openalex.org/W2532093456","https://openalex.org/W2547613834","https://openalex.org/W2560589035","https://openalex.org/W2589285747","https://openalex.org/W2589424183","https://openalex.org/W2605061201","https://openalex.org/W2613771696","https://openalex.org/W2625556521","https://openalex.org/W2766933782","https://openalex.org/W2768725023","https://openalex.org/W2781933653","https://openalex.org/W2787604034","https://openalex.org/W2788049144","https://openalex.org/W2800107333","https://openalex.org/W2802569467","https://openalex.org/W2805046895","https://openalex.org/W2884271132","https://openalex.org/W2897698853","https://openalex.org/W2907707733","https://openalex.org/W2947471232","https://openalex.org/W2948060644","https://openalex.org/W2973975811","https://openalex.org/W2985210409","https://openalex.org/W2998840683","https://openalex.org/W3106798016","https://openalex.org/W6630405109"],"related_works":["https://openalex.org/W3108576210","https://openalex.org/W3042667112","https://openalex.org/W2067352549","https://openalex.org/W1885399803","https://openalex.org/W2406439825","https://openalex.org/W2099905545","https://openalex.org/W2042848449","https://openalex.org/W2332623992","https://openalex.org/W1867236303"],"abstract_inverted_index":{"Cystic":[0],"fibrosis":[1],"(CF;":[2],"OMIM":[3],"219700)":[4],"is":[5,260,276],"a":[6,12,85,240],"rare":[7],"genetic":[8],"disorder":[9],"caused":[10],"by":[11,124],"chloride":[13],"channel":[14],"defect,":[15],"resulting":[16],"in":[17,34,39,57,106,204,245,262],"lung":[18],"disease,":[19],"pancreas":[20],"insufficiency":[21],"and":[22,38,60,65,82,89,99,108,116,128,168,192,257,267,283],"liver":[23,268],"impairment.":[24],"Altered":[25],"L-arginine":[26],"(Arg)/nitric":[27],"oxide":[28],"(NO)":[29],"metabolism":[30,259],"has":[31],"been":[32],"observed":[33,133],"CF":[35,63,114,206,212,230,248,264],"patients\u2019":[36],"lungs":[37],"connection":[40],"with":[41,73,214,278],"malnutrition.":[42,74],"The":[43],"aim":[44],"of":[45,53,62,111,220,226],"the":[46,54,58,77,92,205,221],"present":[47],"study":[48],"was":[49],"to":[50,66,209,224],"investigate":[51],"markers":[52],"Arg/NO":[55,271],"pathway":[56],"plasma":[59,107,135,218],"urine":[61,109],"patients":[64,115,207,213,231],"identify":[67],"possible":[68],"risk":[69],"factors,":[70],"especially":[71],"associated":[72,277],"We":[75,132,250],"measured":[76],"major":[78,101],"NO":[79,90,93,242,253,280],"metabolites":[80],"nitrite":[81,160],"nitrate,":[83],"Arg,":[84],"semi-essential":[86],"amino":[87],"acid":[88],"precursor,":[91],"synthesis":[94,243,281],"inhibitor":[95],"asymmetric":[96],"dimethylarginine":[97],"(ADMA)":[98],"its":[100],"urinary":[102,182],"metabolite":[103],"dimethylamine":[104],"(DMA)":[105],"samples":[110],"70":[112],"pediatric":[113,263],"78":[117],"age-matched":[118],"healthy":[119,210,227],"controls.":[120,211,228],"Biomarkers":[121],"were":[122],"determined":[123],"gas":[125],"chromatography\u2013mass":[126],"spectrometry":[127],"high-performance":[129],"liquid":[130],"chromatography.":[131],"higher":[134,181,241,279],"Arg":[136],"(90.3":[137],"vs.":[138,146,155,162,171,185,195],"75.6":[139],"\u00b5M,":[140,148,164,173],"p":[141,149,157,165,174,189,199],"<":[142,175,190],"0.0001),":[143],"ADMA":[144,258],"(0.62":[145],"0.57":[147],"=":[150,158,166,200,237],"0.03),":[151],"Arg/ADMA":[152,234],"ratio":[153],"(148":[154],"135,":[156],"0.01),":[159],"(2.07":[161],"1.95":[163],"0.03)":[167],"nitrate":[169,193],"(43.3":[170],"33.1":[172],"0.001)":[176,191,201],"concentrations,":[177],"as":[178,180],"well":[179],"DMA":[183],"(57.9":[184],"40.7":[186],"\u00b5M/mM":[187,197],"creatinine,":[188,198],"(159":[194],"115":[196],"excretion":[202],"rates":[203],"compared":[208],"pancreatic":[215],"sufficiency":[216],"showed":[217],"concentrations":[219],"biomarkers":[222],"comparable":[223],"those":[225],"Malnourished":[229],"had":[232],"lower":[233,284],"ratios":[235],"(p":[236],"0.02),":[238],"indicating":[239],"capacity":[244,282],"sufficiently":[246],"nourished":[247],"patients.":[249,265],"conclude":[251],"that":[252],"production,":[254],"protein-arginine":[255,285],"dimethylation,":[256],"increased":[261],"Pancreas":[266],"function":[269],"influence":[270],"metabolism.":[272],"Good":[273],"nutritional":[274],"status":[275],"dimethylation.":[286]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2020-07-02T00:00:00"}
