{"id":"https://openalex.org/W3037813166","doi":"https://doi.org/10.18097/pbmc20206603241","title":"Modeling of drug-drug interactions between omeprazole and erythromycin with cytochrome P450 3A4 in vitro assay","display_name":"Modeling of drug-drug interactions between omeprazole and erythromycin with cytochrome P450 3A4 in vitro assay","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3037813166","doi":"https://doi.org/10.18097/pbmc20206603241","mag":"3037813166","pmid":"https://pubmed.ncbi.nlm.nih.gov/32588830"},"language":"ru","primary_location":{"id":"doi:10.18097/pbmc20206603241","doi":"https://doi.org/10.18097/pbmc20206603241","is_oa":false,"landing_page_url":"https://doi.org/10.18097/pbmc20206603241","pdf_url":null,"source":{"id":"https://openalex.org/S4306504416","display_name":"Biomeditsinskaya Khimiya","issn_l":"2310-6905","issn":["2310-6905","2310-6972"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I4210152028","host_organization_name":"Institute of Biomedical Chemistry","host_organization_lineage":["https://openalex.org/I4210152028"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomeditsinskaya Khimiya","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028036113","display_name":"Polina I. Koroleva","orcid":"https://orcid.org/0000-0003-2802-5747","observed_orcids":["https://orcid.org/0000-0003-2802-5747"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"P.I. Koroleva","raw_affiliation_strings":["Institute of Biomedical Chemistry, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086205267","display_name":"Alexey V. Kuzikov","orcid":"https://orcid.org/0000-0002-8772-3214","observed_orcids":["https://orcid.org/0000-0002-8772-3214"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.V. Kuzikov","raw_affiliation_strings":["Institute of Biomedical Chemistry, Moscow, Russia; Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia","Institute of Biomedical Chemistry, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia; Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia","institution_ids":["https://openalex.org/I337778094","https://openalex.org/I4210152028"]},{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016472720","display_name":"Rami A. Masamrekh","orcid":"https://orcid.org/0000-0002-9964-8717","observed_orcids":["https://orcid.org/0000-0002-9964-8717"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"R.A. Masamrekh","raw_affiliation_strings":["Institute of Biomedical Chemistry, Moscow, Russia; Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia","Institute of Biomedical Chemistry, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia; Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia","institution_ids":["https://openalex.org/I337778094","https://openalex.org/I4210152028"]},{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050528382","display_name":"Dmitry A. Filimonov","orcid":"https://orcid.org/0000-0002-0339-8478","observed_orcids":["https://orcid.org/0000-0002-0339-8478"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D.A. Filimonov","raw_affiliation_strings":["Institute of Biomedical Chemistry, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021812000","display_name":"Alexander V. Dmitriev","orcid":"https://orcid.org/0000-0002-2431-3429","observed_orcids":["https://orcid.org/0000-0002-2431-3429"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.V. Dmitriev","raw_affiliation_strings":["Institute of Biomedical Chemistry, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004241553","display_name":"Maria G. Zavialova","orcid":"https://orcid.org/0000-0003-0761-2299","observed_orcids":["https://orcid.org/0000-0003-0761-2299"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.G. Zaviyalova","raw_affiliation_strings":["Institute of Biomedical Chemistry, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086935030","display_name":"S. M. Rikova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S.M. Rikova","raw_affiliation_strings":["Sechenov First Moscow Medical State University (Sechenov University), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sechenov First Moscow Medical State University (Sechenov University), Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065492315","display_name":"E. V. Shich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.V. Shich","raw_affiliation_strings":["Sechenov First Moscow Medical State University (Sechenov University), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sechenov First Moscow Medical State University (Sechenov University), Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068318646","display_name":"\u0410.\u0410. \u041c\u0430\u0445\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-9817-9886","observed_orcids":["https://orcid.org/0000-0001-9817-9886"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.A. Makhova","raw_affiliation_strings":["Sechenov First Moscow Medical State University (Sechenov University), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sechenov First Moscow Medical State University (Sechenov University), Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109558255","display_name":"Tatiana V. Bulko","orcid":"https://orcid.org/0009-0000-3732-2394","observed_orcids":["https://orcid.org/0009-0000-3732-2394"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T.V. Bulko","raw_affiliation_strings":["Institute of Biomedical Chemistry, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047895835","display_name":"Andrei A. Gilep","orcid":"https://orcid.org/0000-0002-3621-6482","observed_orcids":["https://orcid.org/0000-0002-3621-6482"]},"institutions":[{"id":"https://openalex.org/I151823869","display_name":"National Academy of Sciences of Belarus","ror":"https://ror.org/02j8pe645","country_code":"BY","type":"government","lineage":["https://openalex.org/I151823869"]},{"id":"https://openalex.org/I4210138171","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/03r493e52","country_code":"BY","type":"facility","lineage":["https://openalex.org/I151823869","https://openalex.org/I4210130740","https://openalex.org/I4210138171"]}],"countries":["BY"],"is_corresponding":false,"raw_author_name":"A.A. Gilep","raw_affiliation_strings":["Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk, Belarus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk, Belarus","institution_ids":["https://openalex.org/I151823869","https://openalex.org/I4210138171"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038643888","display_name":"Victoria V. Shumyantseva","orcid":"https://orcid.org/0000-0002-1509-7218","observed_orcids":["https://orcid.org/0000-0002-1509-7218"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.V. Shumyantseva","raw_affiliation_strings":["Institute of Biomedical Chemistry, Moscow, Russia; Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia","Institute of Biomedical Chemistry, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia; Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia","institution_ids":["https://openalex.org/I337778094","https://openalex.org/I4210152028"]},{"raw_affiliation_string":"Institute of Biomedical Chemistry, Moscow, Russia","institution_ids":["https://openalex.org/I4210152028"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3073,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.45216654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"66","issue":"3","first_page":"241","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9369999766349792},{"id":"https://openalex.org/keywords/omeprazole","display_name":"omeprazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":1.0},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/n-demethylation","display_name":"N-demethylation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/helicobacter-pylori-eradication-therapy","display_name":"H. pylori eradication therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/macrolide-antibiotics","display_name":"macrolide antibiotics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C2777498785","wikidata":"https://www.wikidata.org/wiki/Q422210","display_name":"Omeprazole","level":2,"score":0.907370924949646},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.8484323024749756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6857271194458008},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5918858647346497},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.5107131004333496},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5055637359619141},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.4593008756637573},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4296985864639282},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.41192543506622314},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.25063005089759827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18649449944496155},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.15324559807777405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13903018832206726}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.18097/pbmc20206603241","doi":"https://doi.org/10.18097/pbmc20206603241","is_oa":false,"landing_page_url":"https://doi.org/10.18097/pbmc20206603241","pdf_url":null,"source":{"id":"https://openalex.org/S4306504416","display_name":"Biomeditsinskaya Khimiya","issn_l":"2310-6905","issn":["2310-6905","2310-6972"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I4210152028","host_organization_name":"Institute of Biomedical Chemistry","host_organization_lineage":["https://openalex.org/I4210152028"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomeditsinskaya Khimiya","raw_type":"journal-article"},{"id":"pmid:32588830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32588830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomeditsinskaia khimiia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1806194750","https://openalex.org/W1966273481","https://openalex.org/W1969244937","https://openalex.org/W1985801504","https://openalex.org/W1987542967","https://openalex.org/W2000605264","https://openalex.org/W2020689947","https://openalex.org/W2022059841","https://openalex.org/W2047031607","https://openalex.org/W2055557876","https://openalex.org/W2067778052","https://openalex.org/W2079814086","https://openalex.org/W2093107388","https://openalex.org/W2093807489","https://openalex.org/W2120098852","https://openalex.org/W2120771508","https://openalex.org/W2121102924","https://openalex.org/W2125562160","https://openalex.org/W2145558842","https://openalex.org/W2153165213","https://openalex.org/W2319147433","https://openalex.org/W2739189454","https://openalex.org/W2799918419","https://openalex.org/W2803963452","https://openalex.org/W2888589312","https://openalex.org/W2896450462","https://openalex.org/W2904913230","https://openalex.org/W2949976809","https://openalex.org/W2961148205","https://openalex.org/W2964927008","https://openalex.org/W2971864007","https://openalex.org/W2974228962","https://openalex.org/W2982617433","https://openalex.org/W3007357110","https://openalex.org/W4211247432","https://openalex.org/W4235118812","https://openalex.org/W4249191875"],"related_works":["https://openalex.org/W3134052561","https://openalex.org/W2076623243","https://openalex.org/W2113005281","https://openalex.org/W2022059841","https://openalex.org/W2065269053","https://openalex.org/W7009327684","https://openalex.org/W2157851012","https://openalex.org/W2961148205","https://openalex.org/W2964927008","https://openalex.org/W2000605264"],"abstract_inverted_index":{"In":[0,145],"the":[1,4,17,60,64,91,127,167],"present":[2],"study":[3],"electrochemical":[5,128],"system":[6],"based":[7],"on":[8,96],"recombinant":[9],"cytochrome":[10,51],"P450":[11,52],"3A4":[12],"(CYP3A4)":[13],"was":[14,56],"used":[15],"for":[16,27],"investigation":[18],"of":[19,38,62,66,69,76,83,93,110,119,130,142,148,169],"potential":[20,149],"drug-drug":[21,151],"interaction":[22],"between":[23],"medicinal":[24],"preparations":[25],"employed":[26],"Helicobacter":[28],"pylori":[29],"eradication":[30],"therapy.":[31],"Drug":[32],"interactions":[33,152],"were":[34],"demonstrated":[35,90],"in":[36,59,154,157,166],"association":[37],"omeprazole":[39,63,84,98],"as":[40,86],"a":[41,87],"proton":[42],"pump":[43],"inhibitor":[44],"(PPI)":[45],"and":[46,163],"macrolide":[47],"antibiotic":[48],"erythromycin":[49,72,94],"during":[50],"3A4-mediated":[53],"metabolism.":[54,99],"It":[55],"shown":[57],"that":[58,118],"presence":[61],"rate":[65],"N-demethylase":[67],"activity":[68],"CYP3A4":[70],"to":[71,137],"measured":[73],"by":[74,105],"means":[75],"product":[77],"(formaldehyde)":[78],"formation":[79],"decreased.":[80],"Mass-spectrometry":[81],"analysis":[82],"sulfone":[85],"CYP3A4-mediated":[88,139,150],"metabolite":[89],"absence":[92],"influence":[95],"CYP3A4-dependent":[97],"This":[100],"phenomenon":[101],"may":[102],"be":[103],"explained":[104],"lower":[106],"spectral":[107],"dissociation":[108],"constant":[109],"CYP3A4-omeprazole":[111],"complex":[112,121],"(Kd":[113,122],"=":[114,123],"18\u00b12":[115],"\u03bcM)":[116],"than":[117],"CYP3A4-erythromycin":[120],"52":[124],"\u03bcM).":[125],"Using":[126],"model":[129],"electrochemically-driven":[131],"drug":[132],"metabolism":[133],"it":[134],"is":[135],"possible":[136],"register":[138],"catalytic":[140],"conversion":[141],"certain":[143],"drugs.":[144],"vitro":[146],"experiments":[147],"are":[153],"accordance":[155],"with":[156,160],"silico":[158],"modeling":[159],"program":[161],"PASS":[162],"PoSMNA":[164],"descriptors":[165],"case":[168],"omeprazole/erythromycin":[170],"combinations.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-07-02T00:00:00"}
