{"id":"https://openalex.org/W3037048898","doi":"https://doi.org/10.1038/s41598-020-67300-2","title":"Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle","display_name":"Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle","publication_year":2020,"publication_date":"2020-06-26","ids":{"openalex":"https://openalex.org/W3037048898","doi":"https://doi.org/10.1038/s41598-020-67300-2","mag":"3037048898","pmid":"https://pubmed.ncbi.nlm.nih.gov/32591558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7319979"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-67300-2","doi":"https://doi.org/10.1038/s41598-020-67300-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-67300-2","pdf_url":"https://www.nature.com/articles/s41598-020-67300-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-67300-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055531215","display_name":"Andrew J. Leber","orcid":"https://orcid.org/0000-0001-9765-4702","observed_orcids":["https://orcid.org/0000-0001-9765-4702"]},"institutions":[{"id":"https://openalex.org/I4405278754","display_name":"NIMML Institute","ror":"https://ror.org/00g7grr70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405278754"]},{"id":"https://openalex.org/I4405280916","display_name":"BioTherapeutics, Inc. (United States)","ror":"https://ror.org/03kr39981","country_code":"US","type":"company","lineage":["https://openalex.org/I4405280916"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Leber","raw_affiliation_strings":["BioTherapeutics, Blacksburg, VA, 24060, USA","NIMML Institute, Blacksburg, VA, 24060, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405280916"]},{"raw_affiliation_string":"NIMML Institute, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405278754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087379114","display_name":"Raquel Hontecillas","orcid":"https://orcid.org/0000-0003-2942-6294","observed_orcids":["https://orcid.org/0000-0003-2942-6294","https://orcid.org/0000-0001-9586-9953"]},"institutions":[{"id":"https://openalex.org/I4405278754","display_name":"NIMML Institute","ror":"https://ror.org/00g7grr70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405278754"]},{"id":"https://openalex.org/I4405280916","display_name":"BioTherapeutics, Inc. (United States)","ror":"https://ror.org/03kr39981","country_code":"US","type":"company","lineage":["https://openalex.org/I4405280916"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raquel Hontecillas","raw_affiliation_strings":["BioTherapeutics, Blacksburg, VA, 24060, USA","NIMML Institute, Blacksburg, VA, 24060, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405280916"]},{"raw_affiliation_string":"NIMML Institute, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405278754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091762977","display_name":"Nuria Tubau\u2010Juni","orcid":"https://orcid.org/0000-0002-5787-8055","observed_orcids":["https://orcid.org/0000-0002-5787-8055","https://orcid.org/0009-0002-7497-4580"]},"institutions":[{"id":"https://openalex.org/I4405278754","display_name":"NIMML Institute","ror":"https://ror.org/00g7grr70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405278754"]},{"id":"https://openalex.org/I4405280916","display_name":"BioTherapeutics, Inc. (United States)","ror":"https://ror.org/03kr39981","country_code":"US","type":"company","lineage":["https://openalex.org/I4405280916"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nuria Tubau-Juni","raw_affiliation_strings":["BioTherapeutics, Blacksburg, VA, 24060, USA","NIMML Institute, Blacksburg, VA, 24060, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405280916"]},{"raw_affiliation_string":"NIMML Institute, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405278754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051063909","display_name":"Victoria Zoccoli-Rodriguez","orcid":"https://orcid.org/0000-0002-5487-6521","observed_orcids":["https://orcid.org/0000-0002-5487-6521"]},"institutions":[{"id":"https://openalex.org/I4405278754","display_name":"NIMML Institute","ror":"https://ror.org/00g7grr70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405278754"]},{"id":"https://openalex.org/I4405280916","display_name":"BioTherapeutics, Inc. (United States)","ror":"https://ror.org/03kr39981","country_code":"US","type":"company","lineage":["https://openalex.org/I4405280916"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Zoccoli-Rodriguez","raw_affiliation_strings":["BioTherapeutics, Blacksburg, VA, 24060, USA","NIMML Institute, Blacksburg, VA, 24060, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405280916"]},{"raw_affiliation_string":"NIMML Institute, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405278754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069121445","display_name":"Bret H. Goodpaster","orcid":"https://orcid.org/0000-0003-1275-5147","observed_orcids":["https://orcid.org/0000-0003-1275-5147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bret Goodpaster","raw_affiliation_strings":["AdventHealth Research Institute, Orlando, FL, 32804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AdventHealth Research Institute, Orlando, FL, 32804, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101801206","display_name":"Josep Bassaganya-Riera","orcid":"https://orcid.org/0000-0003-2969-2197","observed_orcids":["https://orcid.org/0000-0003-2969-2197","https://orcid.org/0000-0001-8967-6012","https://orcid.org/0000-0003-2053-650X"]},"institutions":[{"id":"https://openalex.org/I4405278754","display_name":"NIMML Institute","ror":"https://ror.org/00g7grr70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405278754"]},{"id":"https://openalex.org/I4405280916","display_name":"BioTherapeutics, Inc. (United States)","ror":"https://ror.org/03kr39981","country_code":"US","type":"company","lineage":["https://openalex.org/I4405280916"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Josep Bassaganya-Riera","raw_affiliation_strings":["BioTherapeutics, Blacksburg, VA, 24060, USA. jbassaganya@biotherapeuticsinc.com","NIMML Institute, Blacksburg, VA, 24060, USA. jbassaganya@biotherapeuticsinc.com","BioTherapeutics, Blacksburg, VA, 24060, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics, Blacksburg, VA, 24060, USA. jbassaganya@biotherapeuticsinc.com","institution_ids":["https://openalex.org/I4405280916"]},{"raw_affiliation_string":"NIMML Institute, Blacksburg, VA, 24060, USA. jbassaganya@biotherapeuticsinc.com","institution_ids":["https://openalex.org/I4405278754"]},{"raw_affiliation_string":"BioTherapeutics, Blacksburg, VA, 24060, USA","institution_ids":["https://openalex.org/I4405280916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101801206"],"corresponding_institution_ids":["https://openalex.org/I4405278754","https://openalex.org/I4405280916"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":2.806,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.914867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"10463","last_page":"10463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abscisic-acid","display_name":"abscisic acid","score":1.0},{"id":"https://openalex.org/keywords/lancl2","display_name":"LANCL2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.6449999809265137},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.906000018119812},{"id":"https://openalex.org/keywords/skeletal-muscle-metabolism","display_name":"skeletal muscle metabolism","score":0.8330000042915344},{"id":"https://openalex.org/keywords/metabolic-flexibility","display_name":"metabolic flexibility","score":0.7289999723434448},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/glycogen-synthesis","display_name":"glycogen synthesis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.7900000214576721},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.8109999895095825},{"id":"https://openalex.org/keywords/plant-hormones","display_name":"plant hormones","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2779591172","wikidata":"https://www.wikidata.org/wiki/Q332211","display_name":"Abscisic acid","level":3,"score":0.6666341423988342},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.6545275449752808},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6494813561439514},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.5878527760505676},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5762469172477722},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5160069465637207},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48126810789108276},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45205163955688477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3921281397342682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3441883325576782},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3212657570838928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24430808424949646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000040","descriptor_name":"Abscisic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028044","descriptor_name":"Phosphate-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030681","descriptor_name":"Ficus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-020-67300-2","doi":"https://doi.org/10.1038/s41598-020-67300-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-67300-2","pdf_url":"https://www.nature.com/articles/s41598-020-67300-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:32591558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32591558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7319979","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7319979/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-67300-2","doi":"https://doi.org/10.1038/s41598-020-67300-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-67300-2","pdf_url":"https://www.nature.com/articles/s41598-020-67300-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6711498353","display_name":"Effects of Abscisic Acid on Insulin Sensitivity","funder_award_id":"R44DK120338","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3037048898.pdf","grobid_xml":"https://content.openalex.org/works/W3037048898.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1102580029","https://openalex.org/W1973019813","https://openalex.org/W1974102265","https://openalex.org/W1975713644","https://openalex.org/W1976861911","https://openalex.org/W1985886300","https://openalex.org/W2012116123","https://openalex.org/W2017435131","https://openalex.org/W2025841257","https://openalex.org/W2032108215","https://openalex.org/W2039278288","https://openalex.org/W2044131015","https://openalex.org/W2052235807","https://openalex.org/W2068843607","https://openalex.org/W2070658923","https://openalex.org/W2078579141","https://openalex.org/W2085464341","https://openalex.org/W2088620463","https://openalex.org/W2091741421","https://openalex.org/W2091894244","https://openalex.org/W2091993254","https://openalex.org/W2094101866","https://openalex.org/W2114416343","https://openalex.org/W2120852510","https://openalex.org/W2128184967","https://openalex.org/W2141104999","https://openalex.org/W2144651037","https://openalex.org/W2148769969","https://openalex.org/W2149015395","https://openalex.org/W2209954776","https://openalex.org/W2307714472","https://openalex.org/W2341717561","https://openalex.org/W2410431959","https://openalex.org/W2531313400","https://openalex.org/W2739307379","https://openalex.org/W2765588083","https://openalex.org/W2965070472"],"related_works":["https://openalex.org/W6943156338","https://openalex.org/W2809521962","https://openalex.org/W6942795096","https://openalex.org/W3171673427","https://openalex.org/W7129104945","https://openalex.org/W4405736415","https://openalex.org/W2626663610","https://openalex.org/W3034271437","https://openalex.org/W4281704718","https://openalex.org/W1102580029"],"abstract_inverted_index":{"Abscisic":[0],"acid":[1,106,117],"is":[2,11],"a":[3,40],"phytohormone":[4],"found":[5],"in":[6,14,46,68,124,140,161,170,189],"fruits":[7],"and":[8,10,18,64,72,82,107,111,121,134,174,197],"vegetables":[9],"endogenously":[12],"produced":[13],"mammals.":[15],"In":[16,76],"humans":[17],"mice,":[19],"lanthionine":[20],"synthetase":[21],"C-like":[22],"2":[23,195],"(LANCL2)":[24],"has":[25],"been":[26],"characterized":[27],"as":[28],"the":[29,37,92,152,165,171,184,190],"natural":[30],"receptor":[31],"for":[32],"ABA.":[33],"Herein,":[34],"we":[35],"characterize":[36],"efficacy":[38],"of":[39,44,95,100,115,154,159,167,187,192],"fig":[41],"fruit":[42],"extract":[43,90,169],"ABA":[45,89,97,145,168,188],"promoting":[47],"glycemic":[48,84],"control.":[49],"This":[50,180],"ABA-enriched":[51],"extract,":[52],"at":[53],"0.125":[54],"\u00b5g":[55],"ABA/kg":[56],"body":[57],"weight,":[58],"improves":[59],"glucose":[60,67,119,178],"tolerance,":[61],"insulin":[62,148],"sensitivity":[63],"fasting":[65,176],"blood":[66,177],"diet-induced":[69],"obesity":[70],"(DIO)":[71],"db/db":[73],"mouse":[74],"models.":[75],"addition":[77],"to":[78,149],"decreasing":[79],"systemic":[80],"inflammation":[81],"providing":[83],"control":[85],"without":[86],"increasing":[87],"insulin,":[88],"modulates":[91],"metabolic":[93,122,198],"activity":[94],"muscle.":[96],"increases":[98,112],"expression":[99],"important":[101],"glycogen":[102,155],"synthase,":[103],"glucose,":[104],"fatty":[105,116],"mitochondrial":[108,135],"metabolism":[109],"genes":[110],"direct":[113],"measures":[114],"oxidation,":[118],"oxidation":[120],"flexibility":[123],"soleus":[125],"muscle":[126,163],"cells":[127],"from":[128],"ABA-treated":[129,141],"mice":[130],"with":[131,147],"DIO.":[132],"Glycolytic":[133],"ATP":[136],"production":[137],"were":[138],"increased":[139,175],"human":[142],"myotubes.":[143],"Further,":[144],"synergized":[146],"dramatically":[150],"increase":[151],"rate":[153],"synthesis.":[156],"The":[157],"loss":[158],"LANCL2":[160],"skeletal":[162],"abrogated":[164],"effect":[166],"DIO":[172],"model":[173],"levels.":[179],"data":[181],"further":[182],"supports":[183],"clinical":[185],"development":[186],"treatment":[191],"pre-diabetes,":[193],"type":[194],"diabetes":[196],"syndrome.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-07-02T00:00:00"}
