{"id":"https://openalex.org/W3036966716","doi":null,"title":"Host-Parasite Interactions in the Pathogenesis of Severe Plasmodium falciparum Malaria","display_name":"Host-Parasite Interactions in the Pathogenesis of Severe Plasmodium falciparum Malaria","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3036966716","mag":"3036966716"},"language":"en","primary_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/240610","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/240610","pdf_url":"http://hdl.handle.net/11343/240610","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11343/240610","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012828048","display_name":"Digjaya Utama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Digjaya Utama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012828048"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.7350000143051147},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":1.0},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.9710000157356262},{"id":"https://openalex.org/keywords/variant-surface-antigens","display_name":"variant surface antigens","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pfemp1","display_name":"PfEMP1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/rifin","display_name":"RIFIN","score":0.9919999837875366},{"id":"https://openalex.org/keywords/stevor","display_name":"STEVOR","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rosette-formation","display_name":"rosette formation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cytoadhesion","display_name":"cytoadhesion","score":0.8379999995231628},{"id":"https://openalex.org/keywords/abo-blood-group","display_name":"ABO blood group system","score":0.7409999966621399},{"id":"https://openalex.org/keywords/host-genetic-polymorphisms","display_name":"host genetic polymorphisms","score":0.6230000257492065},{"id":"https://openalex.org/keywords/protective-antibodies","display_name":"protective antibodies","score":0.7360000014305115},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5899999737739563},{"id":"https://openalex.org/keywords/papua-new-guinea","display_name":"Papua New Guinea","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8133607506752014},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7824676036834717},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.5850865840911865},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5458869934082031},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4934757947921753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4845511019229889},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.46664169430732727},{"id":"https://openalex.org/C2910455041","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Severe Malaria","level":4,"score":0.41731947660446167},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41219139099121094},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3891397714614868},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3352670967578888},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17377951741218567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14305925369262695},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.056481897830963135}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/240610","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/240610","pdf_url":"http://hdl.handle.net/11343/240610","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},{"id":"mag:3036966716","doi":null,"is_oa":false,"landing_page_url":"https://minerva-access.unimelb.edu.au/handle/11343/240610","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/240610","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/240610","pdf_url":"http://hdl.handle.net/11343/240610","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3036966716.pdf","grobid_xml":"https://content.openalex.org/works/W3036966716.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W65176043","https://openalex.org/W920975095","https://openalex.org/W1501124055","https://openalex.org/W1515527087","https://openalex.org/W1624420511","https://openalex.org/W1673362020","https://openalex.org/W1787600336","https://openalex.org/W1856276538","https://openalex.org/W1871536933","https://openalex.org/W1892986689","https://openalex.org/W1963513251","https://openalex.org/W1966356931","https://openalex.org/W1966921870","https://openalex.org/W1967015536","https://openalex.org/W1967992739","https://openalex.org/W1968708504","https://openalex.org/W1972494418","https://openalex.org/W1973449439","https://openalex.org/W1976414518","https://openalex.org/W1976685031","https://openalex.org/W1977845940","https://openalex.org/W1978059376","https://openalex.org/W1978734850","https://openalex.org/W1980137882","https://openalex.org/W1982892335","https://openalex.org/W1984347606","https://openalex.org/W1991246785","https://openalex.org/W1991323583","https://openalex.org/W1993441829","https://openalex.org/W1993646556","https://openalex.org/W1993756013","https://openalex.org/W1996974432","https://openalex.org/W2010506910","https://openalex.org/W2013399821","https://openalex.org/W2013857802","https://openalex.org/W2015082048","https://openalex.org/W2018469646","https://openalex.org/W2018871060","https://openalex.org/W2019851585","https://openalex.org/W2022307600","https://openalex.org/W2031662614","https://openalex.org/W2035712449","https://openalex.org/W2039227742","https://openalex.org/W2040754029","https://openalex.org/W2041863951","https://openalex.org/W2045151339","https://openalex.org/W2046267069","https://openalex.org/W2048286705","https://openalex.org/W2049659301","https://openalex.org/W2050154595","https://openalex.org/W2054685453","https://openalex.org/W2055085510","https://openalex.org/W2055321091","https://openalex.org/W2061377789","https://openalex.org/W2062069878","https://openalex.org/W2067428749","https://openalex.org/W2071271263","https://openalex.org/W2072715844","https://openalex.org/W2072975902","https://openalex.org/W2076443493","https://openalex.org/W2078717447","https://openalex.org/W2082880400","https://openalex.org/W2086011308","https://openalex.org/W2087643895","https://openalex.org/W2090613637","https://openalex.org/W2092543202","https://openalex.org/W2099561441","https://openalex.org/W2102156985","https://openalex.org/W2103171514","https://openalex.org/W2104418232","https://openalex.org/W2104565879","https://openalex.org/W2104727798","https://openalex.org/W2105748597","https://openalex.org/W2106457106","https://openalex.org/W2107934195","https://openalex.org/W2109205591","https://openalex.org/W2110366566","https://openalex.org/W2110383454","https://openalex.org/W2112159173","https://openalex.org/W2114007704","https://openalex.org/W2114104545","https://openalex.org/W2114272562","https://openalex.org/W2116931446","https://openalex.org/W2119050650","https://openalex.org/W2120734332","https://openalex.org/W2120873510","https://openalex.org/W2121500204","https://openalex.org/W2121563923","https://openalex.org/W2121615155","https://openalex.org/W2123005998","https://openalex.org/W2125867369","https://openalex.org/W2126990638","https://openalex.org/W2127166169","https://openalex.org/W2128880918","https://openalex.org/W2129324587","https://openalex.org/W2130078103","https://openalex.org/W2130481907","https://openalex.org/W2131840480","https://openalex.org/W2132255041","https://openalex.org/W2133724824","https://openalex.org/W2135240508","https://openalex.org/W2136630640","https://openalex.org/W2142000853","https://openalex.org/W2143541247","https://openalex.org/W2143869563","https://openalex.org/W2144207524","https://openalex.org/W2144481965","https://openalex.org/W2145290669","https://openalex.org/W2145427843","https://openalex.org/W2146150853","https://openalex.org/W2150064115","https://openalex.org/W2152054371","https://openalex.org/W2156022009","https://openalex.org/W2156535651","https://openalex.org/W2158310427","https://openalex.org/W2160345138","https://openalex.org/W2160705317","https://openalex.org/W2165158644","https://openalex.org/W2165374829","https://openalex.org/W2167363154","https://openalex.org/W2170226740","https://openalex.org/W2171719289","https://openalex.org/W2187521544","https://openalex.org/W2187572130","https://openalex.org/W2187639828","https://openalex.org/W2189047836","https://openalex.org/W2209914257","https://openalex.org/W2256152233","https://openalex.org/W2265434995","https://openalex.org/W2313884214","https://openalex.org/W2340145826","https://openalex.org/W2403302911","https://openalex.org/W2415324593","https://openalex.org/W2428777223","https://openalex.org/W2463298498","https://openalex.org/W2564303295","https://openalex.org/W2756127351","https://openalex.org/W2759448220","https://openalex.org/W2764044352","https://openalex.org/W2767157846","https://openalex.org/W2770628073","https://openalex.org/W2790950849","https://openalex.org/W2801980266","https://openalex.org/W2803759292","https://openalex.org/W2884989927","https://openalex.org/W2899466432","https://openalex.org/W2916178565","https://openalex.org/W2924057663","https://openalex.org/W2942654515","https://openalex.org/W2945382350","https://openalex.org/W2950464315","https://openalex.org/W2953968471","https://openalex.org/W2987951717"],"related_works":["https://openalex.org/W2405822897","https://openalex.org/W3136280029","https://openalex.org/W4248881101","https://openalex.org/W4304187505","https://openalex.org/W4213014677","https://openalex.org/W2019431720","https://openalex.org/W7203847125","https://openalex.org/W4233117306","https://openalex.org/W7098696211","https://openalex.org/W2033211611"],"abstract_inverted_index":{"Severe":[0],"Plasmodium":[1],"falciparum":[2,61,136],"malaria":[3],"has":[4],"been":[5,109],"attributed":[6],"to":[7,15,80,111],"cytoadhesion":[8],"and":[9,18,40,47,71,97,106,133,169],"sequestration":[10],"of":[11,20,154],"infected":[12,130],"erythrocytes":[13,129],"(IEs)":[14],"microvascular":[16],"endothelium,":[17],"rosetting":[19,132],"IEs":[21,39],"with":[22,175],"other":[23],"non-infected":[24],"erythrocytes.These":[25],"mechanisms":[26],"are":[27,49,59],"mediated":[28],"by":[29,123,131],"the":[30,38,44,83,86,95,114,128,152],"interaction":[31],"between":[32],"variant":[33],"surface":[34],"antigens":[35],"(VSAs)":[36],"on":[37,43,127,144],"host":[41,87,141],"receptors":[42,92],"endothelial":[45],"cells":[46],"erythrocytes.There":[48],"at":[50],"least":[51],"three":[52,119],"VSAs":[53,120,158],"important":[54],"for":[55],"this":[56],"process,":[57],"which":[58],"P.":[60,135],"Erythrocyte":[62],"Membrane":[63],"Protein-1":[64],"(PfEMP-1),":[65],"Repeat":[66],"Interspersed":[67],"Family":[68],"protein":[69],"(RIFIN),":[70],"Subtelomeric":[72],"Variant":[73],"Open":[74],"Reading":[75],"Frame":[76],"(STEVOR).This":[77],"study":[78],"aimed":[79],"investigate":[81],"whether":[82,171],"polymorphisms":[84],"in":[85,138,161],"genome":[88],"that":[89],"encode":[90],"VSA":[91],"may":[93],"influence":[94],"pathogenesis":[96],"mediate":[98,112],"protection":[99,176],"against":[100,156,177],"severe":[101,178],"malaria.Secondly,":[102],"as":[103],"PfEMP1,":[104],"RIFIN,":[105],"STEVOR":[107],"have":[108],"shown":[110],"rosetting,":[113],"potential":[115],"co-expression":[116],"among":[117],"these":[118],"were":[121,159,173],"investigated":[122],"comparing":[124],"their":[125],"expression":[126],"non-rosetting":[134],"parasites":[137],"two":[139],"different":[140],"environments":[142],"based":[143],"ABO":[145],"blood":[146],"types":[147],"(A+":[148],"vs":[149],"O+":[150],"erythrocytes).Thirdly,":[151],"development":[153],"antibody":[155],"rosetting-mediating":[157],"screened":[160],"longitudinal":[162],"cohort":[163],"children":[164],"from":[165],"Papua":[166],"New":[167],"Guinea,":[168],"determined":[170],"they":[172],"associated":[174],"malaria.":[179]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2020-06-25T00:00:00"}