{"id":"https://openalex.org/W3036915671","doi":"https://doi.org/10.1186/s13550-020-00657-7","title":"PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP","display_name":"PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP","publication_year":2020,"publication_date":"2020-06-22","ids":{"openalex":"https://openalex.org/W3036915671","doi":"https://doi.org/10.1186/s13550-020-00657-7","mag":"3036915671","pmid":"https://pubmed.ncbi.nlm.nih.gov/32572592","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7310027"},"language":"en","primary_location":{"id":"doi:10.1186/s13550-020-00657-7","doi":"https://doi.org/10.1186/s13550-020-00657-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13550-020-00657-7","pdf_url":"https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-020-00657-7","source":{"id":"https://openalex.org/S2764570898","display_name":"EJNMMI Research","issn_l":"2191-219X","issn":["2191-219X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJNMMI Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-020-00657-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081278059","display_name":"Yong Du","orcid":"https://orcid.org/0000-0002-0237-6154","observed_orcids":["https://orcid.org/0000-0002-0237-6154"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong Du","raw_affiliation_strings":["Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA. duyong@jhu.edu","Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA"],"raw_orcid":"https://orcid.org/0000-0002-0237-6154","affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA. duyong@jhu.edu","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013319420","display_name":"Il Minn","orcid":"https://orcid.org/0000-0002-7822-662X","observed_orcids":["https://orcid.org/0000-0002-7822-662X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Il Minn","raw_affiliation_strings":["Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027774891","display_name":"Catherine A. Foss","orcid":"https://orcid.org/0000-0001-8870-5993","observed_orcids":["https://orcid.org/0000-0001-8870-5993"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Foss","raw_affiliation_strings":["Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069386815","display_name":"Wojciech G. Lesniak","orcid":"https://orcid.org/0000-0003-0734-4685","observed_orcids":["https://orcid.org/0000-0003-0734-4685"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wojciech G. Lesniak","raw_affiliation_strings":["Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Hu","raw_affiliation_strings":["Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021803422","display_name":"Robert F. Dannals","orcid":"https://orcid.org/0000-0002-5483-5914","observed_orcids":["https://orcid.org/0000-0002-5483-5914"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert F. Dannals","raw_affiliation_strings":["Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049568817","display_name":"Martin G. Pomper","orcid":"https://orcid.org/0000-0001-6753-3010","observed_orcids":["https://orcid.org/0000-0001-6753-3010"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin G. Pomper","raw_affiliation_strings":["Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090150971","display_name":"Andrew G. Horti","orcid":"https://orcid.org/0000-0003-2290-488X","observed_orcids":["https://orcid.org/0000-0003-2290-488X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew G. Horti","raw_affiliation_strings":["Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA. ahorti1@jhmi.edu","Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA"],"raw_orcid":"https://orcid.org/0000-0003-2290-488X","affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA. ahorti1@jhmi.edu","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081278059","https://openalex.org/A5090150971"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.3918,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76084263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"67","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.2904999852180481,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.06689999997615814,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-epoxide-hydrolase","display_name":"soluble epoxide hydrolase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/baboon-brain","display_name":"baboon brain","score":0.8429999947547913},{"id":"https://openalex.org/keywords/radiometabolites","display_name":"radiometabolites","score":0.7889999747276306},{"id":"https://openalex.org/keywords/radiation-dosimetry","display_name":"radiation dosimetry","score":0.7929999828338623},{"id":"https://openalex.org/keywords/seh-inhibitors","display_name":"sEH inhibitors","score":0.5410000085830688},{"id":"https://openalex.org/keywords/binding-specificity","display_name":"binding specificity","score":0.6309999823570251},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.6079999804496765},{"id":"https://openalex.org/keywords/radioligand-binding","display_name":"radioligand binding","score":0.4729999899864197},{"id":"https://openalex.org/keywords/epoxyeicosatrienoic-acids","display_name":"epoxyeicosatrienoic acids","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neurovascular-coupling","display_name":"neurovascular coupling","score":0.7839999794960022},{"id":"https://openalex.org/keywords/vascular-cognitive-impairment","display_name":"vascular cognitive impairment","score":0.6420000195503235},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8911070823669434},{"id":"https://openalex.org/C2776127602","wikidata":"https://www.wikidata.org/wiki/Q5038319","display_name":"Cardiac imaging","level":2,"score":0.6366567015647888},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.4794672727584839},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24344617128372192},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19350016117095947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13550-020-00657-7","doi":"https://doi.org/10.1186/s13550-020-00657-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13550-020-00657-7","pdf_url":"https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-020-00657-7","source":{"id":"https://openalex.org/S2764570898","display_name":"EJNMMI Research","issn_l":"2191-219X","issn":["2191-219X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJNMMI Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7310027","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7310027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJNMMI Res","raw_type":"Text"},{"id":"pmid:32572592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32572592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJNMMI research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e7c8b691e87349a285de9b14fa0975b5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e7c8b691e87349a285de9b14fa0975b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13550-020-00657-7","doi":"https://doi.org/10.1186/s13550-020-00657-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13550-020-00657-7","pdf_url":"https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-020-00657-7","source":{"id":"https://openalex.org/S2764570898","display_name":"EJNMMI Research","issn_l":"2191-219X","issn":["2191-219X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJNMMI Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7754938670","display_name":"PET imaging of soluble epoxide hydrolase (sEH) in human subjects","funder_award_id":"R21AG054802","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000021958","display_name":null,"funder_award_id":"AG054802","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G920913866","display_name":"PET imaging of soluble epoxide hydrolase (sEH) in human subjects","funder_award_id":"R33AG054802","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3036915671.pdf","grobid_xml":"https://content.openalex.org/works/W3036915671.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1946923111","https://openalex.org/W1976921912","https://openalex.org/W1978379622","https://openalex.org/W1985808875","https://openalex.org/W2006634108","https://openalex.org/W2012122483","https://openalex.org/W2017731124","https://openalex.org/W2031368339","https://openalex.org/W2037211078","https://openalex.org/W2039849701","https://openalex.org/W2052091534","https://openalex.org/W2063017390","https://openalex.org/W2065971285","https://openalex.org/W2082655966","https://openalex.org/W2093250429","https://openalex.org/W2102927661","https://openalex.org/W2103315238","https://openalex.org/W2108772785","https://openalex.org/W2112278807","https://openalex.org/W2126130609","https://openalex.org/W2126453856","https://openalex.org/W2129693217","https://openalex.org/W2135910732","https://openalex.org/W2138076149","https://openalex.org/W2142310620","https://openalex.org/W2144006306","https://openalex.org/W2148012276","https://openalex.org/W2155827125","https://openalex.org/W2157972347","https://openalex.org/W2163323735","https://openalex.org/W2167366602","https://openalex.org/W2173280183","https://openalex.org/W2182137010","https://openalex.org/W2297518964","https://openalex.org/W2462498491","https://openalex.org/W2510913709","https://openalex.org/W2749613778","https://openalex.org/W2760910605","https://openalex.org/W2789124288","https://openalex.org/W2802361441","https://openalex.org/W2806697406","https://openalex.org/W2893139511","https://openalex.org/W2901188304","https://openalex.org/W2912068478","https://openalex.org/W2913013970","https://openalex.org/W2957612446","https://openalex.org/W2995956111","https://openalex.org/W4213425433","https://openalex.org/W4236533258"],"related_works":["https://openalex.org/W3130668764","https://openalex.org/W4213425433","https://openalex.org/W2418449478","https://openalex.org/W4384558421","https://openalex.org/W2790350886","https://openalex.org/W2802361441","https://openalex.org/W2036612609","https://openalex.org/W2117891587","https://openalex.org/W2163323735","https://openalex.org/W2904370560"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Soluble":[2],"epoxide":[3],"hydrolase":[4],"(sEH)":[5],"is":[6,263,269],"a":[7,51,163,172,264],"promising":[8],"candidate":[9],"positron":[10],"emission":[11],"tomography":[12],"(PET)":[13],"imaging":[14,55,62,274],"biomarker":[15],"altered":[16],"in":[17,47,63,101,134,155,240,259,275],"various":[18],"disorders,":[19],"including":[20],"vascular":[21],"cognitive":[22],"impairment":[23],"(VCI),":[24],"Alzheimer\u2019s":[25],"disease":[26,29],"(AD),":[27],"Parkinson\u2019s":[28],"(PD),":[30],"stroke,":[31],"and":[32,42,69,83,103,137,151,171,216,242],"depression,":[33],"known":[34],"to":[35,93,284],"regulate":[36],"levels":[37],"of":[38,87,99,116,130,166,176,201,225,250],"epoxyeicosatrienoic":[39],"acids":[40],"(EETs)":[41],"play":[43],"an":[44,228],"important":[45],"role":[46],"neurovascular":[48],"coupling.":[49],"[18F]FNDP,":[50],"PET":[52,61,77,121,273],"radiotracer":[53,267],"for":[54,207,213,220,232,271,282],"sEH,":[56],"was":[57,118,132,142,190],"evaluated":[58],"through":[59],"quantitative":[60,272],"the":[64,88,138,251,254,276],"baboon":[65,277],"brain,":[66],"radiometabolite":[67],"analysis,":[68],"radiation":[70],"dosimetry":[71],"estimate.":[72],"Methods":[73],"Baboon":[74],"[18F]FNDP":[75,100,117,131,148,159,226,236,262,279],"dynamic":[76],"studies":[78],"were":[79,105,203],"performed":[80],"at":[81],"baseline":[82,164],"with":[84,162],"blocking":[85,174],"doses":[86],"selective":[89],"sEH":[90,95],"inhibitor":[91],"AR-9281":[92,157,202],"evaluate":[94],"binding":[96,183],"specificity.":[97],"Radiometabolites":[98],"mice":[102],"baboons":[104],"measured":[106],"by":[107],"high-performance":[108],"liquid":[109],"chromatography.":[110],"Regional":[111],"brain":[112,153,256],"distribution":[113,129],"volume":[114],"(VT)":[115],"computed":[119],"from":[120],"using":[122,144],"radiometabolite-corrected":[123],"arterial":[124],"input":[125],"functions.":[126],"Full":[127],"body":[128],"studied":[133],"CD-1":[135],"mice,":[136],"human":[139,285],"effective":[140,229],"dose":[141,230],"estimated":[143,191,198],"OLINDA/EXM":[145],"software.":[146],"Results":[147],"exhibited":[149],"high":[150],"rapid":[152],"uptake":[154,160],"baboons.":[156],"blocked":[158],"dose-dependently":[161],"VT":[165,175],"10.9":[167],"\u00b1":[168,178,186,194,205,211,218],"2.4":[169],"mL/mL":[170],"high-dose":[173],"1.0":[177],"0.09":[179],"mL/mL,":[180],"indicating":[181],"substantial":[182],"specificity":[184],"(91.70":[185],"1.74%).":[187],"The":[188,197],"VND":[189],"as":[192],"0.865":[193],"0.066":[195],"mL/mL.":[196],"occupancy":[199],"values":[200],"99.2":[204],"1.1%":[206],"1":[208],"mg/kg,":[209,215],"88.6":[210],"1.3%":[212],"0.1":[214],"33.8":[217],"3.8%":[219],"0.02":[221],"mg/kg.":[222],"Murine":[223],"biodistribution":[224],"enabled":[227],"estimate":[231],"humans":[233],"(0.032":[234],"mSv/MBq).":[235],"forms":[237],"hydrophilic":[238],"radiometabolites":[239,252],"murine":[241],"non-human":[243],"primate":[244],"plasma.":[245],"However,":[246],"only":[247],"minute":[248],"amounts":[249],"entered":[253],"animal":[255],"(<":[257],"2%":[258],"mice).":[260],"Conclusions":[261],"highly":[265],"sEH-specific":[266],"that":[268],"suitable":[270],"brain.":[278],"holds":[280],"promise":[281],"translation":[283],"subjects.":[286]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-06-25T00:00:00"}