{"id":"https://openalex.org/W3036797012","doi":"https://doi.org/10.7554/elife.59990","title":"Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes","display_name":"Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes","publication_year":2020,"publication_date":"2020-10-27","ids":{"openalex":"https://openalex.org/W3036797012","doi":"https://doi.org/10.7554/elife.59990","mag":"3036797012","pmid":"https://pubmed.ncbi.nlm.nih.gov/33107819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7661038"},"language":"en","primary_location":{"id":"doi:10.7554/elife.59990","doi":"https://doi.org/10.7554/elife.59990","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.59990","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.59990","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102876780","display_name":"Danielle Yi","orcid":"https://orcid.org/0000-0003-3310-5151","observed_orcids":["https://orcid.org/0000-0003-3310-5151"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle Yi","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","Endocrinology Program, University of California, Berkeley, Berkeley, United States","University of California\u2013Berkeley"],"raw_orcid":"https://orcid.org/0000-0003-3310-5151","affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Endocrinology Program, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California\u2013Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102821539","display_name":"Hai P. Nguyen","orcid":"https://orcid.org/0000-0001-8071-0886","observed_orcids":["https://orcid.org/0000-0001-8071-0886"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai P Nguyen","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","Endocrinology Program, University of California, Berkeley, Berkeley, United States","University of California\u2013Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Endocrinology Program, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California\u2013Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040127325","display_name":"Jennie Dinh","orcid":"https://orcid.org/0000-0002-1744-7226","observed_orcids":["https://orcid.org/0000-0002-1744-7226"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennie Dinh","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","University of California\u2013Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California\u2013Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027194539","display_name":"Jose Abraham Viscarra","orcid":"https://orcid.org/0000-0003-1273-4098","observed_orcids":["https://orcid.org/0000-0003-1273-4098"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose A Viscarra","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","University of California\u2013Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California\u2013Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101404982","display_name":"Ying Xie","orcid":"https://orcid.org/0000-0002-8553-0566","observed_orcids":["https://orcid.org/0000-0002-8553-0566"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Xie","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","University of California\u2013Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California\u2013Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Frances Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances Lin","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","University of California\u2013Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California\u2013Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Madeleine Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeleine Zhu","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","University of California\u2013Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California\u2013Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084852441","display_name":"Jon M. Dempersmier","orcid":"https://orcid.org/0000-0001-9741-2180","observed_orcids":["https://orcid.org/0000-0001-9741-2180"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon M Dempersmier","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","University of California\u2013Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California\u2013Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330366","display_name":"Yuhui Wang","orcid":"https://orcid.org/0000-0003-2936-3377","observed_orcids":["https://orcid.org/0000-0003-2936-3377"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhui Wang","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038863786","display_name":"Hei Sook Sul","orcid":"https://orcid.org/0000-0002-3372-5097","observed_orcids":["https://orcid.org/0000-0002-3372-5097"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hei Sook Sul","raw_affiliation_strings":["Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States"],"raw_orcid":"https://orcid.org/0000-0002-3372-5097","affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038863786"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":1.5012,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.81501601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"9","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dot1l","display_name":"DOT1L","score":0.968999981880188},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9710000157356262},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/transcriptional-coactivation","display_name":"transcriptional coactivation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/h3k79-methylation","display_name":"H3K79 methylation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.9900000095367432},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.9789999723434448},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.8650000095367432},{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.7254184484481812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5786937475204468},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.48004186153411865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46451535820961},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4624166190624237},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.43191948533058167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41612058877944946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2544572353363037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18878665566444397},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1532285511493683},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10259628295898438}],"mesh":[{"descriptor_ui":"D000071256","descriptor_name":"Uncoupling Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071256","descriptor_name":"Uncoupling Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.7554/elife.59990","doi":"https://doi.org/10.7554/elife.59990","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.59990","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2020.06.22.154963","doi":"https://doi.org/10.1101/2020.06.22.154963","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.22.154963","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/07/14/2020.06.22.154963.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7661038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7661038","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:33107819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33107819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8291e8d55a79464fb91118053d19a7ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8291e8d55a79464fb91118053d19a7ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 9 (2020)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0ds3x3xh","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0ds3x3xh","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.59990","doi":"https://doi.org/10.7554/elife.59990","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.59990","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3501723944","display_name":"Novel transcriptional regulators for thermogenic program","funder_award_id":"R01DK120075","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3941383334","display_name":null,"funder_award_id":"DK120075","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1965079305","https://openalex.org/W1967887313","https://openalex.org/W1970956961","https://openalex.org/W1971578941","https://openalex.org/W1978521773","https://openalex.org/W1979157667","https://openalex.org/W1992256913","https://openalex.org/W2004761725","https://openalex.org/W2005827500","https://openalex.org/W2008632158","https://openalex.org/W2012460974","https://openalex.org/W2039940539","https://openalex.org/W2040328785","https://openalex.org/W2048613921","https://openalex.org/W2049491436","https://openalex.org/W2060446536","https://openalex.org/W2063020711","https://openalex.org/W2094498537","https://openalex.org/W2104082208","https://openalex.org/W2104827888","https://openalex.org/W2104954848","https://openalex.org/W2118369587","https://openalex.org/W2132358997","https://openalex.org/W2136070507","https://openalex.org/W2138553782","https://openalex.org/W2154607830","https://openalex.org/W2155813475","https://openalex.org/W2165504342","https://openalex.org/W2263803825","https://openalex.org/W2412507621","https://openalex.org/W2437490503","https://openalex.org/W2502052998","https://openalex.org/W2513354960","https://openalex.org/W2524821145","https://openalex.org/W2556440865","https://openalex.org/W2609941990","https://openalex.org/W2773178162","https://openalex.org/W2784108659","https://openalex.org/W2791712220","https://openalex.org/W2906273947","https://openalex.org/W2955798639","https://openalex.org/W2974637121","https://openalex.org/W2991216600","https://openalex.org/W2998959889","https://openalex.org/W3013214515","https://openalex.org/W4240014023","https://openalex.org/W4299912881"],"related_works":["https://openalex.org/W2948193310","https://openalex.org/W3133175900","https://openalex.org/W2991216600","https://openalex.org/W3150778368","https://openalex.org/W7053177696","https://openalex.org/W2273769037","https://openalex.org/W2049491436","https://openalex.org/W4281900374","https://openalex.org/W1929186871","https://openalex.org/W4386120677"],"abstract_inverted_index":{"ABSTRACT":[0],"Brown":[1],"adipose":[2],"tissue":[3],"is":[4,50,74,93],"a":[5,46,64,129,140],"metabolically":[6],"beneficial":[7],"organ":[8],"capable":[9],"of":[10,33,58,111],"dissipating":[11],"chemical":[12],"energy":[13,18,122],"into":[14],"heat,":[15],"thereby":[16],"increasing":[17],"expenditure.":[19],"Here,":[20],"we":[21,100],"identify":[22],"Dot1L,":[23],"the":[24,38,55,133],"only":[25],"known":[26],"H3K79":[27,90],"methyltransferase,":[28],"as":[29,63,139],"an":[30],"interacting":[31],"partner":[32],"Zc3h10":[34,53],"that":[35,72,86,102],"transcriptionally":[36],"activates":[37],"UCP1":[39,112],"promoter":[40,56],"and":[41,81,85,88,113,121,136],"other":[42,114],"BAT":[43],"genes.":[44],"Through":[45],"direct":[47],"interaction,":[48],"Dot1L":[49,73,87,103,127],"recruited":[51],"by":[52,66,82],"to":[54,61,117],"regions":[57],"thermogenic":[59,96,119,134],"genes":[60,116],"function":[62],"coactivator":[65],"methylating":[67],"H3K79.":[68],"We":[69],"also":[70],"show":[71],"induced":[75],"during":[76],"brown":[77],"fat":[78],"cell":[79],"differentiation":[80],"cold":[83],"exposure":[84],"its":[89],"methyltransferase":[91],"activity":[92],"required":[94],"for":[95,143],"gene":[97],"program.":[98],"Furthermore,":[99],"demonstrate":[101],"ablation":[104],"in":[105,132],"mice":[106],"using":[107],"UCP1-Cre":[108],"prevents":[109],"activation":[110],"target":[115,142],"reduce":[118],"capacity":[120],"expenditure,":[123],"promoting":[124],"adiposity.":[125],"Hence,":[126],"plays":[128],"critical":[130],"role":[131],"program":[135],"may":[137],"present":[138],"future":[141],"obesity":[144],"therapeutics.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-06-25T00:00:00"}