{"id":"https://openalex.org/W3036749531","doi":"https://doi.org/10.3390/biomedicines8060170","title":"ROR1 is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells","display_name":"ROR1 is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells","publication_year":2020,"publication_date":"2020-06-23","ids":{"openalex":"https://openalex.org/W3036749531","doi":"https://doi.org/10.3390/biomedicines8060170","mag":"3036749531","pmid":"https://pubmed.ncbi.nlm.nih.gov/32586008","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7344684"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines8060170","doi":"https://doi.org/10.3390/biomedicines8060170","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines8060170","pdf_url":"https://www.mdpi.com/2227-9059/8/6/170/pdf","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/8/6/170/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023147776","display_name":"Amineh Ghaderi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Amineh Ghaderi","raw_affiliation_strings":["Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062624667","display_name":"Amir Hossein Daneshmanesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Amir Hossein Daneshmanesh","raw_affiliation_strings":["Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040702936","display_name":"Ali Moshfegh","orcid":"https://orcid.org/0000-0002-2128-7202","observed_orcids":["https://orcid.org/0000-0002-2128-7202"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210112557","display_name":"Kancera (Sweden)","ror":"https://ror.org/01sqjdr55","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210112557"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ali Moshfegh","raw_affiliation_strings":["Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","Kancera AB, Karolinska Institute Science Park, 171 48 Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Kancera AB, Karolinska Institute Science Park, 171 48 Solna, Sweden","institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210112557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050210583","display_name":"Parviz Kokhaei","orcid":"https://orcid.org/0000-0001-6544-4209","observed_orcids":["https://orcid.org/0000-0001-6544-4209"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210154083","display_name":"Semnan University of Medical Sciences","ror":"https://ror.org/05y44as61","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210154083"]}],"countries":["IR","SE"],"is_corresponding":false,"raw_author_name":"Parviz Kokhaei","raw_affiliation_strings":["Department of Immunology, Semnan University of Medical Sciences, Semnan 35147-99442, Iran","Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Semnan University of Medical Sciences, Semnan 35147-99442, Iran","institution_ids":["https://openalex.org/I4210154083"]},{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081992897","display_name":"Jan V\u00e5gberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210112557","display_name":"Kancera (Sweden)","ror":"https://ror.org/01sqjdr55","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210112557"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan V\u00e5gberg","raw_affiliation_strings":["Kancera AB, Karolinska Institute Science Park, 171 48 Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kancera AB, Karolinska Institute Science Park, 171 48 Solna, Sweden","institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210112557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000797680","display_name":"Johan Schultz","orcid":"https://orcid.org/0000-0002-8211-1681","observed_orcids":["https://orcid.org/0000-0002-8211-1681"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210112557","display_name":"Kancera (Sweden)","ror":"https://ror.org/01sqjdr55","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210112557"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan Schultz","raw_affiliation_strings":["Kancera AB, Karolinska Institute Science Park, 171 48 Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kancera AB, Karolinska Institute Science Park, 171 48 Solna, Sweden","institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210112557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019921022","display_name":"Thomas Olin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210112557","display_name":"Kancera (Sweden)","ror":"https://ror.org/01sqjdr55","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210112557"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Thomas Olin","raw_affiliation_strings":["Kancera AB, Karolinska Institute Science Park, 171 48 Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kancera AB, Karolinska Institute Science Park, 171 48 Solna, Sweden","institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210112557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079092383","display_name":"Sara Harrysson","orcid":"https://orcid.org/0000-0003-4955-4728","observed_orcids":["https://orcid.org/0000-0003-4955-4728"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sara Harrysson","raw_affiliation_strings":["Department of Hematology, Karolinska University Hospital Solna, 171 77 Stockholm, Sweden","Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4955-4728","affiliations":[{"raw_affiliation_string":"Department of Hematology, Karolinska University Hospital Solna, 171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020784348","display_name":"Karin Ekstrom Ekstroem Smedby","orcid":"https://orcid.org/0000-0002-2104-3320","observed_orcids":["https://orcid.org/0000-0002-2104-3320"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karin E Smedby","raw_affiliation_strings":["Department of Hematology, Karolinska University Hospital Solna, 171 77 Stockholm, Sweden","Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Karolinska University Hospital Solna, 171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048706579","display_name":"Elias Drakos","orcid":"https://orcid.org/0000-0002-4692-5389","observed_orcids":["https://orcid.org/0000-0002-4692-5389"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["GR","SE"],"is_corresponding":false,"raw_author_name":"Elias Drakos","raw_affiliation_strings":["Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","Department of Pathology, Medical School, University of Crete, 71110 Heraklion Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pathology, Medical School, University of Crete, 71110 Heraklion Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023811461","display_name":"Georgios Z. Rassidakis","orcid":"https://orcid.org/0000-0002-9082-4091","observed_orcids":["https://orcid.org/0000-0002-9082-4091"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Georgios Z. Rassidakis","raw_affiliation_strings":["Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049924304","display_name":"Anders \u00d6sterborg","orcid":"https://orcid.org/0000-0001-6489-4865","observed_orcids":["https://orcid.org/0000-0001-6489-4865"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders \u00d6sterborg","raw_affiliation_strings":["Department of Hematology, Karolinska University Hospital Solna, 171 77 Stockholm, Sweden","Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Karolinska University Hospital Solna, 171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111724902","display_name":"H\u00e1kan Mellstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"H\u00e5kan Mellstedt","raw_affiliation_strings":["Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072254947","display_name":"Mohammad Hojjat\u2010Farsangi","orcid":"https://orcid.org/0000-0002-0589-5523","observed_orcids":["https://orcid.org/0000-0002-0589-5523"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mohammad Hojjat-Farsangi","raw_affiliation_strings":["Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-0589-5523","affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital Solna and Karolinska Institutet, 17164 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5111724902"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1479},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1479},"fwci":3.6931,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.94216549,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":"6","first_page":"170","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ror1","display_name":"ROR1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.699999988079071},{"id":"https://openalex.org/keywords/refractory-lymphoma","display_name":"refractory lymphoma","score":0.781000018119812},{"id":"https://openalex.org/keywords/richter-syndrome","display_name":"Richter syndrome","score":0.9819999933242798},{"id":"https://openalex.org/keywords/transformed-follicular-lymphoma","display_name":"transformed follicular lymphoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.7910000085830688},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7310000061988831},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.7960000038146973},{"id":"https://openalex.org/keywords/casein-kinase-1-delta","display_name":"CK1\u03b4","score":0.9559999704360962},{"id":"https://openalex.org/keywords/zebrafish-xenograft-model","display_name":"zebrafish xenograft","score":0.8299999833106995},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6641740798950195},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.6082807183265686},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.5668609738349915},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5281845331192017},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.5226476192474365},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.4779408276081085},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.42230895161628723},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.421995609998703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3962664306163788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34905850887298584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3438831567764282},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.28206735849380493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2813294529914856},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.2596255838871002},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.25428158044815063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12723878026008606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06798699498176575}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines8060170","doi":"https://doi.org/10.3390/biomedicines8060170","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines8060170","pdf_url":"https://www.mdpi.com/2227-9059/8/6/170/pdf","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7344684","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7344684","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:32586008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32586008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d36a9e454ef446bc87fdc28c52d68ddd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d36a9e454ef446bc87fdc28c52d68ddd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 8, Iss 6, p 170 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines8060170","doi":"https://doi.org/10.3390/biomedicines8060170","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines8060170","pdf_url":"https://www.mdpi.com/2227-9059/8/6/170/pdf","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1255246044","display_name":null,"funder_award_id":"2016/5, 2017/63, 2018/63, 2019/189, 2020/258 (A\u00d6); 2017/64, 2018/140, 2019/194, 2020/260 (HM)","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G127866367","display_name":null,"funder_award_id":"CAN 2018/499","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G1337878728","display_name":null,"funder_award_id":"20150070","funder_id":"https://openalex.org/F4320322570","funder_display_name":"Stockholms L\u00e4ns Landsting"},{"id":"https://openalex.org/G1411048331","display_name":null,"funder_award_id":"164122","funder_id":"https://openalex.org/F4320324250","funder_display_name":"Cancerf\u00f6reningen i Stockholm"},{"id":"https://openalex.org/G1497876401","display_name":null,"funder_award_id":"2018/140","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G1764558217","display_name":null,"funder_award_id":"2018/63","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G1868002818","display_name":null,"funder_award_id":"2019-00396","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G1960764132","display_name":null,"funder_award_id":"CAN2018","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G2235302706","display_name":null,"funder_award_id":"2017/64","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G2265974063","display_name":null,"funder_award_id":"2018/63","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G2429026302","display_name":null,"funder_award_id":"151313","funder_id":"https://openalex.org/F4320324250","funder_display_name":"Cancerf\u00f6reningen i Stockholm"},{"id":"https://openalex.org/G262460027","display_name":null,"funder_award_id":"2018/140","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G2680726699","display_name":null,"funder_award_id":"2017/63","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G2712330807","display_name":null,"funder_award_id":"CAN 2015/408","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G2733291238","display_name":null,"funder_award_id":"2017/64","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G3002039942","display_name":null,"funder_award_id":"2016/5","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G3097906881","display_name":null,"funder_award_id":"2020/260","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G3437762602","display_name":null,"funder_award_id":"CAN 2015/408","funder_id":"https://openalex.org/F4320324250","funder_display_name":"Cancerf\u00f6reningen i Stockholm"},{"id":"https://openalex.org/G3610870064","display_name":null,"funder_award_id":"2019/189","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G385079633","display_name":null,"funder_award_id":"2017/63","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G3947436491","display_name":null,"funder_award_id":"2019/194","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G4739314962","display_name":null,"funder_award_id":"2019/194","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G4982163756","display_name":null,"funder_award_id":"130054","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G5624735717","display_name":null,"funder_award_id":"2015/408","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G6066774452","display_name":null,"funder_award_id":"2016/5","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G6265702644","display_name":null,"funder_award_id":"2019-","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G6605981093","display_name":null,"funder_award_id":"184203","funder_id":"https://openalex.org/F4320324250","funder_display_name":"Cancerf\u00f6reningen i Stockholm"},{"id":"https://openalex.org/G7337925764","display_name":null,"funder_award_id":"2020/258","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G7422029548","display_name":null,"funder_award_id":"2020/260","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G7547549784","display_name":null,"funder_award_id":"20150070","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G7554451302","display_name":null,"funder_award_id":"CAN 2018/499","funder_id":"https://openalex.org/F4320324250","funder_display_name":"Cancerf\u00f6reningen i Stockholm"},{"id":"https://openalex.org/G7651964190","display_name":null,"funder_award_id":"144142","funder_id":"https://openalex.org/F4320324250","funder_display_name":"Cancerf\u00f6reningen i Stockholm"},{"id":"https://openalex.org/G7662144654","display_name":null,"funder_award_id":"CAN 2015/408","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G8032889326","display_name":null,"funder_award_id":"130054 (A\u00d6)","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G813857448","display_name":null,"funder_award_id":"2017-00436","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G8161138012","display_name":null,"funder_award_id":"20180030","funder_id":"https://openalex.org/F4320321413","funder_display_name":"AFA F\u00f6rs\u00e4kring"},{"id":"https://openalex.org/G8304620099","display_name":null,"funder_award_id":"2020/258","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"},{"id":"https://openalex.org/G8586481939","display_name":null,"funder_award_id":"CAN 2018/499","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G8713312220","display_name":null,"funder_award_id":"CAN 2015/","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G8764480902","display_name":null,"funder_award_id":"2019/189","funder_id":"https://openalex.org/F4320316497","funder_display_name":"Insamlingsstiftelsen Cancer- och Allergifonden"}],"funders":[{"id":"https://openalex.org/F4320316497","display_name":"Insamlingsstiftelsen Cancer- och Allergifonden","ror":"https://ror.org/00z8rf270"},{"id":"https://openalex.org/F4320321413","display_name":"AFA F\u00f6rs\u00e4kring","ror":"https://ror.org/02e1fjy29"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322570","display_name":"Stockholms L\u00e4ns Landsting","ror":"https://ror.org/02zrae794"},{"id":"https://openalex.org/F4320324250","display_name":"Cancerf\u00f6reningen i Stockholm","ror":"https://ror.org/00m8d6786"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3036749531.pdf","grobid_xml":"https://content.openalex.org/works/W3036749531.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W925209273","https://openalex.org/W1596905443","https://openalex.org/W1682502310","https://openalex.org/W1822418390","https://openalex.org/W1971176502","https://openalex.org/W1975711182","https://openalex.org/W1981550827","https://openalex.org/W1982984451","https://openalex.org/W1983054966","https://openalex.org/W1984384507","https://openalex.org/W2000421454","https://openalex.org/W2009684443","https://openalex.org/W2022505715","https://openalex.org/W2062974600","https://openalex.org/W2067604250","https://openalex.org/W2086297371","https://openalex.org/W2092864627","https://openalex.org/W2100771206","https://openalex.org/W2115757359","https://openalex.org/W2145132518","https://openalex.org/W2146651952","https://openalex.org/W2152715911","https://openalex.org/W2166836693","https://openalex.org/W2210752542","https://openalex.org/W2283666401","https://openalex.org/W2546952157","https://openalex.org/W2547412310","https://openalex.org/W2556226634","https://openalex.org/W2583355944","https://openalex.org/W2606817100","https://openalex.org/W2614852340","https://openalex.org/W2615287735","https://openalex.org/W2762450632","https://openalex.org/W2766029952","https://openalex.org/W2795252718","https://openalex.org/W2806532541","https://openalex.org/W2807587898","https://openalex.org/W2916005137","https://openalex.org/W2921072067","https://openalex.org/W2946424828","https://openalex.org/W2946874599","https://openalex.org/W2947340802","https://openalex.org/W2967121126","https://openalex.org/W6637387100","https://openalex.org/W6732982441"],"related_works":["https://openalex.org/W2988548380","https://openalex.org/W4306937560","https://openalex.org/W7005673634","https://openalex.org/W2916005137","https://openalex.org/W3165455749","https://openalex.org/W2412373751","https://openalex.org/W2772012175","https://openalex.org/W2997258551","https://openalex.org/W4362610941","https://openalex.org/W2341184572"],"abstract_inverted_index":{"The":[0,118],"receptor":[1],"tyrosine":[2],"kinase":[3],"ROR1":[4,28,35,68,97,201],"is":[5],"absent":[6],"in":[7,14,29,37,44,55,73],"most":[8],"normal":[9],"adult":[10],"tissues,":[11],"but":[12,81,112],"overexpressed":[13],"several":[15],"malignancies.":[16],"In":[17,171],"this":[18],"study,":[19],"we":[20],"explored":[21],"clinical":[22],"and":[23,50,57,79,88,122,143,145,152,165],"functional":[24],"inhibitory":[25],"aspects":[26],"of":[27,67,77,83,86,102,120,131,141,150,191],"diffuse":[30],"large":[31],"B-cell":[32],"lymphoma":[33,53],"(DLBCL).":[34],"expression":[36,69],"tumor":[38,185],"cells":[39],"was":[40,70,136],"more":[41],"often":[42],"observed":[43,72],"primary":[45],"refractory":[46],"DLBCL,":[47],"Richter\u2019s":[48],"syndrome":[49],"transformed":[51],"follicular":[52],"than":[54,194],"relapsed":[56],"non-relapsed":[58],"DLBCL":[59,104,132,178,198],"patients":[60,75],"(p":[61],"<":[62],"0.001).":[63],"A":[64,92],"survival":[65],"effect":[66],"preliminarily":[71],"relapsed/refractory":[74],"independent":[76],"gender":[78],"stage":[80],"not":[82],"age,":[84],"cell":[85,105,133,179],"origin":[87],"international":[89],"prognostic":[90],"index.":[91],"second":[93],"generation":[94],"small":[95],"molecule":[96],"inhibitor":[98],"(KAN0441571C)":[99],"induced":[100,127,182],"apoptosis":[101],"ROR1+":[103,177],"lines,":[106],"similar":[107],"to":[108,114],"venetoclax":[109,123],"(BCL-2":[110],"inhibitor)":[111],"superior":[113],"ibrutinib":[115],"(BTK":[116],"inhibitor).":[117],"combination":[119],"KAN0441571C":[121,181],"at":[124],"EC50":[125],"concentrations":[126],"almost":[128],"complete":[129],"killing":[130],"lines.":[134],"Apoptosis":[135],"accompanied":[137],"by":[138,147],"the":[139,148],"downregulation":[140],"BCL-2":[142],"MCL-1":[144],"confirmed":[146],"cleavage":[149],"PARP":[151],"caspases":[153],"3,":[154],"8,":[155],"9.":[156],"PI3K\u03b4/AKT/mTOR":[157],"(non-canonical":[158],"Wnt":[159],"pathway)":[160,168],"as":[161,163],"well":[162],"\u03b2-catenin":[164],"CK1\u03b4":[166],"(canonical":[167],"were":[169],"inactivated.":[170],"zebra":[172],"fishes":[173],"transplanted":[174],"with":[175,189],"a":[176,183,205],"line,":[180],"significant":[184],"reduction.":[186],"New":[187],"drugs":[188],"mechanisms":[190],"action":[192],"other":[193],"those":[195],"available":[196],"for":[197],"are":[199],"warranted.":[200],"inhibitors":[202],"might":[203],"represent":[204],"novel":[206],"promising":[207],"approach.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-25T00:00:00"}
