{"id":"https://openalex.org/W3036708564","doi":"https://doi.org/10.1007/s00109-020-01926-7","title":"Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1\u03b2 and IL-17 upregulation in alcoholic hepatitis mice","display_name":"Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1\u03b2 and IL-17 upregulation in alcoholic hepatitis mice","publication_year":2020,"publication_date":"2020-06-18","ids":{"openalex":"https://openalex.org/W3036708564","doi":"https://doi.org/10.1007/s00109-020-01926-7","mag":"3036708564","pmid":"https://pubmed.ncbi.nlm.nih.gov/32556367","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7810220"},"language":"en","primary_location":{"id":"doi:10.1007/s00109-020-01926-7","doi":"https://doi.org/10.1007/s00109-020-01926-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00109-020-01926-7","pdf_url":null,"source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7810220","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003273106","display_name":"Akiko Eguchi","orcid":"https://orcid.org/0000-0002-0555-2707","observed_orcids":["https://orcid.org/0000-0002-0555-2707"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Akiko Eguchi","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan. akieguchi@clin.medic.mie-u.ac.jp","Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. akieguchi@clin.medic.mie-u.ac.jp","JST, PRETO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. akieguchi@clin.medic.mie-u.ac.jp","Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. akieguchi@clin.medic.mie-u.ac.jp","Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0555-2707","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan. akieguchi@clin.medic.mie-u.ac.jp","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. akieguchi@clin.medic.mie-u.ac.jp","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"JST, PRETO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. akieguchi@clin.medic.mie-u.ac.jp","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. akieguchi@clin.medic.mie-u.ac.jp","institution_ids":[]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Yan","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA","Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042089998","display_name":"Stephanie Q. Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Q Pan","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA","Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061855434","display_name":"Raymond P. Wu","orcid":"https://orcid.org/0000-0002-6178-4094","observed_orcids":["https://orcid.org/0000-0002-6178-4094"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Wu","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA","Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377785","display_name":"Jihoon Kim","orcid":"https://orcid.org/0000-0001-7091-8050","observed_orcids":["https://orcid.org/0000-0001-7091-8050","https://orcid.org/0000-0002-9217-4483"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihoon Kim","raw_affiliation_strings":["Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066183857","display_name":"Yibu Chen","orcid":"https://orcid.org/0000-0002-7889-6850","observed_orcids":["https://orcid.org/0000-0002-7889-6850"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yibu Chen","raw_affiliation_strings":["Bioinformatics Services, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Services, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90007, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068615364","display_name":"Charles K. Ansong","orcid":"https://orcid.org/0000-0001-5793-8559","observed_orcids":["https://orcid.org/0000-0001-5793-8559"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Ansong","raw_affiliation_strings":["Pacific Northwest National Laboratory, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023982706","display_name":"Richard D. Smith","orcid":"https://orcid.org/0000-0002-2381-2349","observed_orcids":["https://orcid.org/0000-0002-2381-2349"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Smith","raw_affiliation_strings":["Pacific Northwest National Laboratory, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019140592","display_name":"Mina Tempaku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mina Tempaku","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084415954","display_name":"Lucila Ohno-machado A","orcid":"https://orcid.org/0000-0002-8005-7327","observed_orcids":["https://orcid.org/0000-0002-8005-7327"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucila Ohno-Machado","raw_affiliation_strings":["Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102401127","display_name":"Yoshiyuki Takei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Takei","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112039617","display_name":"Ariel E. Feldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariel E. Feldstein","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, La Jolla, CA, USA","Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039882439","display_name":"Hidekazu Tsukamoto","orcid":"https://orcid.org/0000-0002-6833-2998","observed_orcids":["https://orcid.org/0000-0002-6833-2998"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hidekazu Tsukamoto","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu","Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA. htsukamo@med.usc.edu","Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. htsukamo@med.usc.edu","Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA. htsukamo@med.usc.edu","institution_ids":["https://openalex.org/I4210156876"]},{"raw_affiliation_string":"Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. htsukamo@med.usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003273106","https://openalex.org/A5039882439"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I178574317","https://openalex.org/I36258959","https://openalex.org/I4210086780","https://openalex.org/I4210156876"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":2.3272,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.90086847,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"98","issue":"7","first_page":"1021","last_page":"1034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholic-hepatitis","display_name":"alcoholic hepatitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/nr1d2","display_name":"NR1D2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mir-27a","display_name":"miR-27a","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mir-181","display_name":"miR-181","score":1.0},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.753000020980835},{"id":"https://openalex.org/keywords/liver-macrophages","display_name":"hepatic macrophages","score":0.8579999804496765},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9470000267028809},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":1.0},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.9319999814033508},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.6209999918937683},{"id":"https://openalex.org/keywords/col1a1","display_name":"COL1A1","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.8486692905426025},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8165947198867798},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.662717342376709},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6418322324752808},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5231928825378418},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49135270714759827},{"id":"https://openalex.org/C2777482401","wikidata":"https://www.wikidata.org/wiki/Q469057","display_name":"Damp","level":2,"score":0.4866700768470764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47224777936935425},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45939964056015015},{"id":"https://openalex.org/C2780732942","wikidata":"https://www.wikidata.org/wiki/Q3144986","display_name":"Alcoholic hepatitis","level":4,"score":0.4466349482536316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.320664644241333},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.28129321336746216},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.2745963931083679},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2467116117477417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23632395267486572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1889834702014923},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1768973171710968},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11105814576148987},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.08512794971466064},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006519","descriptor_name":"Hepatitis, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00109-020-01926-7","doi":"https://doi.org/10.1007/s00109-020-01926-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00109-020-01926-7","pdf_url":null,"source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:32556367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32556367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular medicine (Berlin, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7810220","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7810220","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Mol Med (Berl)","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6j3482sz","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6j3482sz","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Medicine, vol 98, iss 7","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7810220","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7810220","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Mol Med (Berl)","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1129383904","display_name":null,"funder_award_id":"R01 AA022489","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2566442100","display_name":"iDASH: Integrating Data for Analysis, Anonymization, and Sharing","funder_award_id":"U54HL108460","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G416200035","display_name":null,"funder_award_id":"IK6BX004205","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4209599059","display_name":"Caspase Dependent Cell Death in Nonalcoholic Fatty Liver Disease","funder_award_id":"R01DK082451","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4840839812","display_name":"Investigation of arteriosclerosis associating with liver derived extracellular vesicles in alcohlic liver disease","funder_award_id":"17K09419","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5080949777","display_name":"Hepatocyte-derived extracellular vesicles in alcoholic liver disease","funder_award_id":"R01AA028134","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5504292436","display_name":"Epigenetic Regulation of Alcoholic Liver Fibrosis","funder_award_id":"U01AA018663","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5608475838","display_name":null,"funder_award_id":"P41-GM103493","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5703790034","display_name":"A Research Resource for Ultra-sensitive High Throughput Proteomics","funder_award_id":"5p41gm103493-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6484410932","display_name":"Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors","funder_award_id":"U01AA027681","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6518303818","display_name":"Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver Injury","funder_award_id":"U01AA022489","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6749120500","display_name":"Encapsulated RNAs in extracellular vesicles contribute ALD progression","funder_award_id":"R21AA023574","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7682127687","display_name":"The hepatosomes released from damaged hepatocytes will contribute the progression of ALD","funder_award_id":"16H06872","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G789427952","display_name":null,"funder_award_id":"I01 BX001991","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8037927564","display_name":null,"funder_award_id":"R01AA018663","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G841711958","display_name":"JEOL JEM-1400Plus Transmission Electron Microscope","funder_award_id":"1s10od023527-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000122217","display_name":null,"funder_award_id":"P41-GM103493","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000889466","display_name":"Integrative Liver Cell Core","funder_award_id":"R24AA012885","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000899538","display_name":"Southern California Research Center for ALPD and Cirrhosis","funder_award_id":"P50AA011999","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W311219321","https://openalex.org/W1523706442","https://openalex.org/W1598280943","https://openalex.org/W1609044025","https://openalex.org/W1970987512","https://openalex.org/W1998404710","https://openalex.org/W2005119615","https://openalex.org/W2011549104","https://openalex.org/W2044975783","https://openalex.org/W2055562316","https://openalex.org/W2092677426","https://openalex.org/W2100309552","https://openalex.org/W2102199676","https://openalex.org/W2103018087","https://openalex.org/W2110065044","https://openalex.org/W2111185320","https://openalex.org/W2117327695","https://openalex.org/W2123609276","https://openalex.org/W2124841074","https://openalex.org/W2126144577","https://openalex.org/W2137631404","https://openalex.org/W2148311385","https://openalex.org/W2152239989","https://openalex.org/W2158421611","https://openalex.org/W2164180982","https://openalex.org/W2165047972","https://openalex.org/W2170852633","https://openalex.org/W2258862002","https://openalex.org/W2259003342","https://openalex.org/W2296538017","https://openalex.org/W2297268579","https://openalex.org/W2520827869","https://openalex.org/W2559279353","https://openalex.org/W2582893389","https://openalex.org/W2595165596","https://openalex.org/W2734311840","https://openalex.org/W2767773677","https://openalex.org/W2789982303","https://openalex.org/W2871249511","https://openalex.org/W2884486379","https://openalex.org/W2910709942","https://openalex.org/W2937651489","https://openalex.org/W3005481769"],"related_works":["https://openalex.org/W2559279353","https://openalex.org/W2799991971","https://openalex.org/W4281391257","https://openalex.org/W4404957610","https://openalex.org/W4407295902","https://openalex.org/W3189418074","https://openalex.org/W3213406127","https://openalex.org/W2137631404","https://openalex.org/W2951096071","https://openalex.org/W3211037457"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-06-25T00:00:00"}
