{"id":"https://openalex.org/W3036668571","doi":"https://doi.org/10.1017/s0424820100153221","title":"Imaging of ribosomal RNA-protein interactions by dark-field STEM","display_name":"Imaging of ribosomal RNA-protein interactions by dark-field STEM","publication_year":1989,"publication_date":"1989-08-06","ids":{"openalex":"https://openalex.org/W3036668571","doi":"https://doi.org/10.1017/s0424820100153221","mag":"3036668571"},"language":"en","primary_location":{"id":"doi:10.1017/s0424820100153221","doi":"https://doi.org/10.1017/s0424820100153221","is_oa":false,"landing_page_url":"http://doi.org/10.1017/s0424820100153221","pdf_url":null,"source":{"id":"https://openalex.org/S4210239783","display_name":"Proceedings annual meeting Electron Microscopy Society of America","issn_l":"0424-8201","issn":["0424-8201","2690-1315"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings, annual meeting, Electron Microscopy Society of America","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114259319","display_name":"Miloslav Boubl\u00edk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Boublik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001449677","display_name":"Valsan Mandiyan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Mandiyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052522653","display_name":"Santa J. Tumminia","orcid":"https://orcid.org/0000-0003-2940-444X","observed_orcids":["https://orcid.org/0000-0003-2940-444X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Tumminia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103093436","display_name":"James F. Hainfeld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.F. Hainfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113873033","display_name":"J.S. Wall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.S. Wall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38154897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":null,"first_page":"250","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.1185000017285347,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/30s-ribosomal-subunit-assembly","display_name":"30S ribosomal subunit assembly","score":0.9929999709129333},{"id":"https://openalex.org/keywords/radius-of-gyration","display_name":"radius of gyration","score":0.9300000071525574},{"id":"https://openalex.org/keywords/molecular-weight-determination","display_name":"molecular weight determination","score":0.5920000076293945},{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.4560000002384186},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.6548389196395874},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.6257702708244324},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.6005258560180664},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5215508937835693},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.45916423201560974},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4218665063381195},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.3771713972091675},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3735816478729248},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.32848504185676575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2680053114891052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21644791960716248},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1017/s0424820100153221","doi":"https://doi.org/10.1017/s0424820100153221","is_oa":false,"landing_page_url":"http://doi.org/10.1017/s0424820100153221","pdf_url":null,"source":{"id":"https://openalex.org/S4210239783","display_name":"Proceedings annual meeting Electron Microscopy Society of America","issn_l":"0424-8201","issn":["0424-8201","2690-1315"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings, annual meeting, Electron Microscopy Society of America","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life on land","score":0.5199999809265137}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W160014972","https://openalex.org/W1966457666","https://openalex.org/W2056865532"],"related_works":["https://openalex.org/W3035774315","https://openalex.org/W2090609413","https://openalex.org/W3036044588","https://openalex.org/W2078758045","https://openalex.org/W3036852480","https://openalex.org/W941106411","https://openalex.org/W4235483368","https://openalex.org/W2019160551","https://openalex.org/W3035824827","https://openalex.org/W3036178931"],"abstract_inverted_index":{"Success":[0],"in":[1,40,164,176,335],"protein-free":[2],"deposition":[3],"of":[4,11,21,65,77,81,88,106,114,119,125,133,147,155,160,187,204,224,231,247,253,261,267,272],"native":[5,326],"nucleic":[6,22,34],"acid":[7,23,35],"molecules":[8,36],"from":[9,173,179],"solutions":[10],"selected":[12],"ionic":[13],"conditions":[14],"prompted":[15],"attempts":[16],"for":[17,318],"high":[18],"resolution":[19],"imaging":[20,87],"interactions":[24,308],"with":[25,211,258,309],"proteins,":[26],"not":[27,316],"attainable":[28],"by":[29,47,91],"conventional":[30],"EM.":[31],"Since":[32],"the":[33,41,50,63,104,111,115,131,134,144,148,161,165,174,212,214,218,222,228,232,245,251,273,282,300,310,325,336],"can":[37,59],"be":[38,60],"visualized":[39],"dark-field":[42],"STEM":[43,92],"mode":[44],"without":[45],"contrasting":[46],"heavy":[48],"atoms,":[49],"established":[51],"linearity":[52],"between":[53],"scattering":[54],"cross-section":[55],"and":[56,75,137,139,157,207,217,264,304],"molecular":[57,67],"weight":[58],"applied":[61,101],"to":[62,93,102,130,143,151,181,241,250,330],"determination":[64],"their":[66],"mass":[68,73,156,225,256,266],"(M)":[69],"linear":[70],"density":[71],"(M/L),":[72],"distribution":[74],"radius":[76],"gyration":[78],"(RG).":[79],"Determination":[80],"these":[82],"parameters":[83],"promotes":[84],"electron":[85],"microscopic":[86],"biological":[89],"macromolecules":[90],"a":[94,152,236,254,259,265,284],"quantitative":[95],"analytical":[96],"level.":[97],"This":[98,168],"technique":[99],"is":[100,171],"study":[103],"mechanism":[105],"16S":[107,135,162,293,319],"rRNA":[108,136,163,320],"folding":[109],"during":[110,299],"assembly":[112,303],"process":[113],"30S":[116,301,327],"ribosomal":[117],"subunit":[118,302],"E.":[120],"coli.":[121],"The":[122,202,270],"sequential":[123],"addition":[124],"protein":[126],"S4":[127],"which":[128,141,209],"binds":[129],"5'end":[132],"S8":[138],"S15":[140],"bind":[142],"central":[145,215],"domain":[146,216],"molecule":[149],"leads":[150,249],"corresponding":[153],"increase":[154,240],"increased":[158,169],"coiling":[159,321],"core":[166,233],"particles.":[167],"compactness":[170],"evident":[172],"decrease":[175],"RG":[177,229],"values":[178,230],"114\u00c5":[180],"91\u00c5":[182],"(in":[183],"\u201cribosomal\u201d":[184],"buffer":[185],"consisting":[186],"10":[188],"mM":[189,194,200],"Hepes":[190],"pH":[191],"7.6,":[192],"60":[193],"KCl,":[195],"2":[196],"m":[197],"Mg(OAc)2,":[198],"1":[199],"DTT).":[201],"binding":[203,246,313],"S20,":[205],"S17":[206],"S7":[208,248],"interact":[210],"5'domain,":[213],"3'domain,":[219],"respectively,":[220],"continues":[221],"trend":[223],"increase.":[226],"However,":[227],"particles":[234,323],"exhibit":[235],"reverse":[237],"trend,":[238],"an":[239],"108\u00c5.":[242],"In":[243],"addition,":[244],"formation":[252],"globular":[255],"cluster":[257],"diameter":[260],"about":[262,275],"115\u00c5":[263],"\u223d300":[268],"kDa.":[269],"rest":[271],"mass,":[274],"330":[276],"kDa,":[277],"remains":[278],"loosely":[279],"coiled":[280],"giving":[281],"particle":[283],"\u201cmedusa-like\u201d":[285],"appearance.":[286],"These":[287],"results":[288],"provide":[289],"direct":[290],"evidence":[291],"that":[292,306],"RNA":[294],"undergoes":[295],"significant":[296],"structural":[297],"reorganization":[298],"show":[305],"its":[307],"six":[311],"primary":[312],"proteins":[314],"are":[315],"sufficient":[317],"into":[322],"resembling":[324],"subunit,":[328],"contrary":[329],"what":[331],"has":[332],"been":[333],"reported":[334],"literature.":[337]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-06-25T00:00:00"}
