{"id":"https://openalex.org/W3036615896","doi":"https://doi.org/10.1017/s0424820100146643","title":"Intelligent computational 3-D microscopy: New results in segmentation, noise removal, cell counting, and automated neuron tracing","display_name":"Intelligent computational 3-D microscopy: New results in segmentation, noise removal, cell counting, and automated neuron tracing","publication_year":1993,"publication_date":"1993-08-01","ids":{"openalex":"https://openalex.org/W3036615896","doi":"https://doi.org/10.1017/s0424820100146643","mag":"3036615896"},"language":"en","primary_location":{"id":"doi:10.1017/s0424820100146643","doi":"https://doi.org/10.1017/s0424820100146643","is_oa":false,"landing_page_url":"http://doi.org/10.1017/s0424820100146643","pdf_url":null,"source":{"id":"https://openalex.org/S4210239783","display_name":"Proceedings annual meeting Electron Microscopy Society of America","issn_l":"0424-8201","issn":["0424-8201","2690-1315"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings, annual meeting, Electron Microscopy Society of America","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090480130","display_name":"Badrinath Roysam","orcid":"https://orcid.org/0000-0002-8310-1389","observed_orcids":["https://orcid.org/0000-0002-8310-1389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Badrinath Roysam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012493778","display_name":"Anoop K. Bhattacharjya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anoop K. Bhattacharjya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049422887","display_name":"Hakan Ancin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hakan Ancin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038423276","display_name":"Andrew R. Cohen","orcid":"https://orcid.org/0000-0002-7707-5970","observed_orcids":["https://orcid.org/0000-0002-7707-5970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew R. Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023300192","display_name":"Robert W. Mackin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert W. Mackin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109464426","display_name":"Douglas E. Becker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas E. Becker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110700884","display_name":"Carlos Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-9156-5327","observed_orcids":["https://orcid.org/0000-0002-9156-5327","https://orcid.org/0000-0002-4396-4016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Rodriguez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37969402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":null,"first_page":"160","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/image-segmentation","display_name":"image segmentation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/noise-reduction","display_name":"noise reduction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-counting","display_name":"cell counting","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuronal-tracing","display_name":"neural tracing","score":0.8610000014305115},{"id":"https://openalex.org/keywords/automatic-pattern-recognition","display_name":"automatic pattern recognition","score":0.7649999856948853},{"id":"https://openalex.org/keywords/computer-vision","display_name":"computer vision","score":0.8899999856948853},{"id":"https://openalex.org/keywords/confocal-microscopy","display_name":"confocal microscopy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/bright-field-microscopy","display_name":"bright-field microscopy","score":0.9300000071525574},{"id":"https://openalex.org/keywords/brain-tissue","display_name":"brain tissue","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pap-test","display_name":"Pap smear","score":0.9649999737739563},{"id":"https://openalex.org/keywords/unsupervised-image-analysis","display_name":"unsupervised image analysis","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.7001203298568726},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6565045118331909},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6506272554397583},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.643515944480896},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6303669810295105},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5556151270866394},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.46731680631637573},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.44308051466941833},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.43329334259033203},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.42709824442863464},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3734530806541443},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.2241332232952118},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.21201732754707336},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08497616648674011},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1017/s0424820100146643","doi":"https://doi.org/10.1017/s0424820100146643","is_oa":false,"landing_page_url":"http://doi.org/10.1017/s0424820100146643","pdf_url":null,"source":{"id":"https://openalex.org/S4210239783","display_name":"Proceedings annual meeting Electron Microscopy Society of America","issn_l":"0424-8201","issn":["0424-8201","2690-1315"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings, annual meeting, Electron Microscopy Society of America","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W650370848","https://openalex.org/W1999137045","https://openalex.org/W2009862838","https://openalex.org/W2013356520","https://openalex.org/W2089777803"],"related_works":["https://openalex.org/W2006360372","https://openalex.org/W4310892381","https://openalex.org/W2039585333","https://openalex.org/W1559621309","https://openalex.org/W3036008504","https://openalex.org/W2141786681","https://openalex.org/W2125432434","https://openalex.org/W2795250730","https://openalex.org/W3164139555","https://openalex.org/W3139184162"],"abstract_inverted_index":{"This":[0,20,136],"paper":[1],"presents":[2],"a":[3],"review":[4],"of":[5,15,27,46,62,65,69,94,100,134,153],"recent":[6],"advances":[7],"made":[8],"by":[9],"us":[10],"in":[11,39,77,117],"the":[12,23,141],"broad":[13,44],"area":[14],"intelligent":[16],"computational":[17,52],"3-D":[18,40,67,89],"microscopy.":[19,42,91],"research":[21],"involves":[22],"development":[24],"and":[25,33,59,88,108,112,150],"application":[26],"automated":[28],"pattern":[29],"recognition,":[30],"computer":[31],"vision":[32],"image":[34,142],"interpretation":[35],"algorithms":[36],"to":[37,50],"problems":[38],"biological":[41,71],"The":[43,73,92],"goal":[45],"this":[47,78],"work":[48,79],"is":[49,126,138,144,151],"develop":[51],"tools":[53],"for":[54,131],"rapid,":[55],"unsupervised,":[56],"flexible,":[57],"quantitative":[58],"unbiased":[60],"analysis":[61],"large":[63,103],"sets":[64],"complex":[66],"images":[68],"thick":[70,98],"specimens.":[72],"imaging":[74],"modalities":[75],"used":[76],"have":[80,96],"thus":[81],"far":[82],"involved":[83],"laser-scanning":[84],"confocal":[85],"microscopy":[86],"(LSCM)":[87],"brightfield":[90],"specimens":[93],"interest":[95],"been":[97],"slices":[99],"brain":[101],"tissue,":[102],"selectively-stained":[104],"neurons,":[105],"indocyanin":[106],"green":[107],"fluorescein":[109],"retinal":[110],"angiograms,":[111],"duck":[113],"overlapping":[114],"cell":[115],"clusters":[116],"cytological":[118],"preparations":[119],"such":[120],"as":[121],"Papanicolaou":[122],"smears.":[123],"Image":[124],"segmentation":[125],"an":[127],"essential":[128],"first":[129],"step":[130],"most":[132],"forms":[133],"analysis.":[135],"task":[137],"straightforward":[139],"when":[140],"data":[143],"isotropic,":[145],"has":[146],"uniform":[147],"high":[148],"contrast,":[149],"free":[152],"noise.":[154]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-06-25T00:00:00"}